fasoracetam (NB-001) / Avalo Therap, Nobias Therap - LARVOL DELTA

Uncovering Oxidative Stress Mechanisms in Multiple Sclerosis Lesions: Insights from Transcriptomics (ACTRIMS Forum 2025) - "Single-cell RNA sequencing analysis of spinal cord samples from EAE at both onset and peak disability revealed the expression of key oxidative stress signature genes including Cybb, Cyba, Cycs, Nfc1, Nfc2, Nfc4, Rac1 and Rac2 which encode p91phox, p22phox, Cytochrome C, p47phox, p67phox or p40phox, Rac Family Small GTPase 1 and 2, respectively... The consistent expression of core oxidative stress signature genes, particularly NOX2, in all datasets underscores their pivotal role in EAE and MS. Products of demyelination elicits expression of NOX2 in microglia, which can in turn generate oxidative stress that may exacerbate myelin and axonal injury. The results suggest NOX2 as a potential target for therapeutic intervention in MS."

Oxidative stress • CNS Disorders • Multiple Sclerosis • Solid Tumor • RAC1 • RAC2

Comparative histomorphological assessment of the osteoinductive capacity of a nanofibrillated cellulose-based composite and autologous blood clot. (PubMed, J Exp Orthop) - "The rats were divided into three groups: (1) with filling of the defect with an ABC, (2) NFC-1-with filling of both the cortical plate and intramedullary space in the defect area, and (3) NFC-2-with filling of only the intramedullary space in the defect area...This study demonstrated that the NFC-based composite, which is located below the level of the cortical plate, tamponing only the intramedullary space (NFC-2), improves bone tissue repair at the site of a bone defect of the cortical plate and has the potential of prolonged osteoinductivity. Not applicable."

Journal • Thrombosis

Unveiling the Chemotherapeutic Potential of Endophytic Penicillium Setosum from Withania somnifera for Breast Cancer Therapeutics (ASM Microbe 2024) - "Secondary metabolite profiling revealed that P. setosum could synthesize a mass array of bioactive compounds comprehending Patulin, Cyclo (L-Leu L-Phe), Gancidin W, Fasoracetam, 3 Methoxycatechol, Thyronine etc. Molecular docking studies inferred that Patulin, Thyronine and Cyclo (L-Leu L-Phe) were the lead compounds that could effectively interact with the five selected target receptors, further surpassing the positive controls analyzed...The activation of caspases 3/7 and the utilization of Annexin V-FITC/PI staining, as analyzed through Flow Cytometry, provided additional validation that the fundamental mechanism of Patulin's anticancer activity involved the apoptotic cell death pathway in breast cancer cells. In conclusion, the present study discloses Patulin depicting great potential for the development of novel chemotherapeutic drug formulations for breast cancer therapeutics."

Breast Cancer • Oncology • Solid Tumor • ANXA5 • CASP7

Molecular authentication, metabolite profiling and in silico-in vitro cytotoxicity screening of endophytic Penicillium ramusculum from Withania somnifera for breast cancer therapeutics. (PubMed, 3 Biotech) - "Chemotaxonomic profiling elucidated the ability of P. ramusculum to synthesize a diverse array of bioactive compounds, including Fasoracetam, Tryprostatin B, Odorinol, Thyronine, Brevianamide F, Proglumide, Perlolyrine, Tyrphostin B48, Baptifoline, etc. Molecular docking studies inferred that Baptifoline, Brevianamide F, Odorinol, Perlolyrine, Thyronine, Tryphostin B48, and Tryprostatin B were the lead compounds that could effectively interact with the five selected target receptors of breast cancer, further surpassing the positive controls analyzed...ramusculum SVWS3 can be an authentic source for developing novel chemotherapeutic drug formulations. The online version contains supplementary material available at 10.1007/s13205-023-03906-3."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome (clinicaltrials.gov) - P2 | N=37 | Completed | Sponsor: Nobias Therapeutics, Inc. | Active, not recruiting ➔ Completed

Trial completion

Optimization of Fermentation Conditions and Product Identification of a Saponin-Producing Endophytic Fungus. (PubMed, Microorganisms) - "The endophytic fungus Trametes versicolor strain NSJ105 has potential application value in saponin production."

Journal

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome (clinicaltrials.gov) - P2 | N=34 | Active, not recruiting | Sponsor: Nobias Therapeutics, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome (clinicaltrials.gov) - P2 | N=34 | Recruiting | Sponsor: Nobias Therapeutics, Inc. | Trial completion date: Jan 2023 ➔ May 2023 | Trial primary completion date: Dec 2022 ➔ Apr 2023

Trial completion date • Trial primary completion date

Synchronization of rumen degradable protein with non-fiber carbohydrate on microbial protein synthesis and dairy ration digestibility. (PubMed, Vet World) - "The first factor was RDPR (RDPR1=50:50; RDPR2=55:45; RDPR3=60:40) and the second factor was NFC levels (NFC1=30%, NFC2=35%, NFC3=40%)...NFC affected the dry matter and organic matter digestibility (DMD and OMD), with treatment NFC3 resulting in the highest DMD and OMD. The combination of a 60:40 RDPR with 35% NFC resulted in the best synchronization of protein and energy available for MPS and digestion activity in the rumen."

Journal

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome (clinicaltrials.gov) - P2 | N=34 | Recruiting | Sponsor: Nobias Therapeutics, Inc.

New P2 trial

"https://t.co/eME2nFC31B https://t.co/nIMlYhz5Di https://t.co/CzOpQYDYv4 https://t.co/8M5N3YHJlg" (@gcfmd)

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NCF1 Heterozygosity: A Pathological Footprint for Very Early Onset Inflammatory Bowel Disease (AAAAI 2022) - "Genetic analysis identified her as a heterozygous for a pathologic variant in the NFC1 gene. NCF1 encodes for a subunit of the NADPH oxidase and its heterozygous genotype has been associated with increased susceptibility for VEOIBD."

Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Primary Immunodeficiency • NF1

Calcium-Enriched Nanofibrillated Cellulose/Poloxamer in-situ Forming Hydrogel Scaffolds as a Controlled Delivery System of Raloxifene HCl for Bone Engineering. (PubMed, Int J Nanomedicine) - "The selected formulation "Ca-IHS4" composed of TONFC+15% P407+10% TCP showed the most prolonged release pattern for 12 days with the least burst effect (about 25% within 24 h). Cytocompatibility studies of formulation "Ca-IHS4" revealed the biocompatibility as well as improved cell adhesion, alkaline phosphatase enzyme activity and calcium ion deposition. The outcomes suggest that Ca-IHS4 presents a simple, safe-line and non-invasive strategy for bone regeneration."

Journal

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Comparison of electrolized water and multiple chemical sanitizer action against heat-resistant molds (HRM). (PubMed, Int J Food Microbiol) - "An ortho-phenylphenol-based smoke generator sanitizer, liquid chemical sanitizers (benzalkonium chloride, biguanide, iodine, peracetic acid, and sodium hypochlorite), and acidic and alkaline electrolyzed water were used against Aspergillus australensis (MB 2579; NFF 02), Aspergillus aureoluteus (NFC1), Paecilomyces fulvus (PFF 01), Paecilomyces niveus (PNT 01; PNDC 01; PNB1 01), and Paecilomyces variotii (PV 01; PV 01; PVCH 03)...Notably, the two most effective commercial sanitizers against the heat-resistant strains were ineffective against the filamentous fungi recommended for sanitizer testing (A. brasiliensis ATCC 16404), which demonstrates the relevance of testing fungal isolates that cause spoilage to choose the most effective compound and obtain the best results of fungal control."

Journal

[VIRTUAL] COMPARISON OF SURGICAL RIB FIXATION BETWEEN PATIENTS WITH AND WITHOUT FLAIL CHEST (AAST 2020) - "Surgical rib fixation was used more frequently in FC (1042/6,578, 15.8% vs NFC 1349/143,762, 0.9%, P < 0.001), and 1167 (49%) were performed at university hospitals (FC 50.1% vs NFC 47%, NS), and the majority were men (74.2%, no difference between the two groups)... In our analysis of a recent national sample of patients with rib fractures, surgical rib fixation is still potentially under-utilized, especially among patients with non-flail chest, who fared comparably well. There was a low rate of reported complications and mortality. The observed higher mortality in patients with flail chest appears to be due to differences between the groups in injury severity and not directly related to rib fixation."

Clinical • Infectious Disease • Mood Disorders • Musculoskeletal Diseases • Orthopedics • Pain • Pneumonia • Respiratory Diseases

Flippases play specific but distinct roles in the development, pathogenicity, and secondary metabolism of Fusarium graminearum. (PubMed, Mol Plant Pathol) - "Herein, we identified five flippases (FgDnfA, FgDnfB, FgDnfC1, FgDnfC2, and FgDnfD) in F. graminearum and established their specific and redundant functions in the development and pathogenicity of this phytopathogenic fungus...In addition, FgDnfB and FgDnfD have redundant functions in the regulation of phosphatidylcholine transport, and double deletion of FgDNFB and FgDNFD showed serious defects in fungal development, DON synthesis, and virulence. Collectively, our findings reveal the distinct and specific functions of flippase family members in F. graminearum and principally demonstrate that FgDnfA, FgDnfD, and FgDnfB have specific spatiotemporal roles during toxisome biogenesis."

Journal

Beyond stimulants: a systematic review of randomised controlled trials assessing novel compounds for ADHD. (PubMed, Expert Rev Neurother) - "Expert opinion: The authors found 28 pertinent RCTs of compounds acting on a variety of biological targets, including Dasotraline, Viloxazine (SPN-812), Centanafadine SR (CTN SR), OPC-64005, Fasoracetam (NFC-1, AEVI-001), Metadoxine (MDX), Vortioxetine, Tipepidine Hibenzate, Oxytocin, Sativex (delta-9-tetrahydrocannabinol (THC) plus cannabidiol), Mazindol, and Molindone hydrochloride (SPN-810)...However, they may offer comparable or better tolerability. Additionally, agents acting on etiopathophysiological targets disrupted in specific subgroups of patients with ADHD will move forward the pharmacotherapy of ADHD from a "one size fits all" to a "precision medicine" approach."

Clinical • Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

"@YouTube @ARMYPEDIA @Young_foreverV @BigHitEnt @bts_nanak @minsugacheonye @bts_bighit @rkivesyoongi @jimanfc1306 @D2MinYoon @BYFMfw8RJ6w1oms @stofysugar @ko6sea @Mochiii0109 #BTSARMY #ARMY #bts2020 #StayGoldMV #stay #ARMYS #방탄소년단제이홉" (@stillwithyou22)

Aging indicators for stored carioca beans. (PubMed, Food Res Int) - "The contrasting genotypes for bean darkening and hardening (BRS Estilo and BRS Pontal: rapid darkening and hardening; BRSMG Madrepérola and CNFC 10467: slow darkening and partially resistant to hardening; and a Canadian genotype of the Pinto Bean type resistant to darkening (negative control)) were evaluated right after harvest and after six months storage at 20.3 ± 0.2 °C and 78.9 ± 6.0% RH, with respect to their physicochemical, biochemical and morphological attributes...Quantification of the bivalent ions in the bean fractions, together with the degree of membrane damage was positively associated with bean darkening, independent of the group. Thus, aging of the carioca beans could be triggered by a complex mechanism involving diverse intrinsic factors in different degrees according to the genotype and the post-harvest period, but some parameters could serve as indicators, as cooking time, hardness and color, to differentiate between rapid and slow..."

Journal

Oxygen reduction reaction with efficient, metal-free nitrogen, fluoride-codoped carbon electrocatalysts derived from melamine hydrogen fluoride salt. (PubMed, J Colloid Interface Sci) - "N adsorption-desorption analysis reveals that the as-prepared NFC1000 has a high surface area of 1169 m g. This study provides a feasible approach to synthesize low-cost and highly efficient metal-free heteroatom-doped carbon-based electrocatalysts."

Journal • Biosimilar

Aevi Genomic Medicine provides update on sample size re-estimation for phase 2 ASCEND trial in ADHD (PRNewswire) - "Aevi Genomic Medicine...announced that it will increase the sample size for Part A of its Phase 2 ASCEND clinical trial, which is enrolling a mGluR mutation positive genetic subset of pediatric and adolescent patients with Attention Deficit Hyperactivity Disorder...to confirm response to AEVI-001 in these patients...the sample size will be increased from 42 to 64 patients...announcing topline results in 4Q18."

Enrollment status • P2 data • Attention Deficit Hyperactivity Disorder • CNS Disorders

Aevi Genomic Medicine announces top-line results from placebo-controlled ASCEND trial (parts A & B) of AEVI-001 in children with ADHD (PRNewswire) - P2, N=69; ASCEND (NCT03265119); Sponsor: Aevi Genomic Medicine; "Aevi Genomic Medicine...today announced that the ASCEND trial...did not achieve statistical significance on the primary endpoint of reduction of ADHD-RS in either Part A or Part B after 6 weeks of treatment with AEVI-001. AEVI-001 was safe and well tolerated. Reported adverse events were minimal and similar across both Part A and Part B treatment groups."

P2 data • Attention Deficit Hyperactivity Disorder • CNS Disorders

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