naproxen Sodium ER (BAYH6689) / Bayer - LARVOL DELTA

Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents. (PubMed, Mater Sci Eng C Mater Biol Appl) - "The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix. In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug."

Journal

Naproxen and Diclofenac Attenuate Atorvastatin-induced Preconditioning of the Myocardium. (PubMed) - Cureus - "The difference in IS between the atorvastatin+naproxen group and the atorvastatin+diclofenac group showed a strong trend in reaching statistical significance (P = 0.058), but was not found to be significant. Our results suggest relatively small, but noticeable differences among non-selective NSAIDs in their potential to attenuate statin-mediated preconditioning."

Journal • Biosimilar • Cardiovascular • Gene Therapies • Immunology • Reperfusion Injury

The effect of hydraulic retention time in onsite wastewater treatment and removal of pharmaceuticals, hormones and phenolic utility substances. (PubMed, Sci Total Environ) - "...Average effluent concentrations of Simvastatin, Estrone, Estradiol and Ethinylestradiol were above the indicative critical-effect concentration of pharmacological effect on fish in all facilities. Average effluent concentrations of both Diclofenac and Estradiol were higher than the Environmental Quality Standards applied in Sweden (190-240 times and 9-35 times respectively)...Removal of Caffeine, Ibuprofen, Estrone, Naproxen and Estradiol, was strongly correlated to the sludge and particles removal. Thus, the efficiency of the tested OWTFs could be improved by adjusting the technical methods and increasing the hydraulic retention time."

Journal • Biosimilar

Risk of fatal/non-fatal events in patients with previous coronary heart disease/acute myocardial infarction and treatment with non-steroidal anti-inflammatory drugs (PubMed, Semergen) - "The consumption of various NSAIDs and their relationship to increased risk of fatal and non-fatal acute coronary syndrome is classified by years. Consumption increases the risk regardless of the time elapsed in relation to those that did not take them, with the figures remaining virtually stable for five years. Diclofenac and cyclooxygenase-2 inhibitors (especially Rofecoxib) showed an increased risk, unlike naproxen, which had a lower risk. However, naproxen, and because of its greater capacity to generate gastrointestinal bleeding, increased for this reason, fatal events and comorbidity in these patients. Despite this, it still has the best cardiovascular safety profile."

Journal • Review • Acute Coronary Syndrome • Biosimilar • Cardiovascular • Heart Failure • Pain

NSAIDS FOR PREVENTION OF POST-ERCP PANCREATITIS: AN UPDATED META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS (DDW 2017) - "...Different NSAIDs and routes were used in the studies: Diclofenac (50-100 mg; rectal, oral or IM; 9 studies), Indomethacin (100 mg; rectal; 7 studies), Naproxen (500 mg; rectal; 1 study), Ketoprofen (100 mg; IV; 1 study), Valdecoxib (20 mg; IV; 1 study)... NSAIDs decrease the risk of post-ERCP pancreatitis. Current evidence supports the use of rectal route of administration of NSAIDs for the prevention of post-ERCP pancreatitis."

Head-to-Head • Retrospective data • Biosimilar • Immunology • Pancreatitis

Development of Fluorescence Surrogates to Predict the Photochemical Transformation of Pharmaceuticals in Wastewater Effluents. (PubMed) - Environ Sci Technol - "The tryptophan-like peak is associated with 3EfOM*-labile PPCPs, such as clenbuterol, metoprolol, venlafaxine, bisphenol A, propranolol, ractopamine, salbutamol, roxithromycin, clarithromycin, azithromycin, famotidine, terbutaline, and erythromycin. The humic-like fluorescence peak is linked to direct photolysis-labile PPCPs, such as naproxen, ronidazole, diclofenac, ornidazole, tinidazole, chloramphenicol, flumequine, ciprofloxacin, methadone, and dimetridazole. The tyrosine-like EEM peak is associated with HO•/CO3•--labile PPCPs, such as trimethoprim, ibuprofen, gemfibrozil, atenolol, carbamazepine, and cephalexin. The solar-driven removal of EEM fluorescence was applied to predict the attenuation of 11 PPCPs in five field samples. A close correlation between the predicted results and the experimental results suggests that fluorescence may be a suitable surrogate for monitoring the solar-driven photodegradation of PPCPs in effluents."

Journal • Biosimilar

Severe ocular side effects with acetazolamide: case report. (PubMed) - "This was an iatrogenic case of acute angle closure induced by an anterior displacement of the irido-lenticular complex, secondary to the use of acetazolamide. The treatment of this condition involves suspending the drug responsible and applying topical corticosteroids, hypotensive and cycloplegic eye drops, with the aim of lowering the eye pressure and the degree of myopia due to the re-positioning of the irido-lenticular complex."

Journal • Biosimilar • Migraine • Ocular Inflammation

Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators. (PubMed) - Molecules - "Four drugs were used as models: three NSAIDS (diclofenac, naproxen, and piroxicam) and glycyrrhizic acid. All of these findings confirm that alkyl glycerols have an absorption retarding effect on the drugs tested. Such effects are expected to give rise to important applications in the pharmaceutical and cosmetic sectors, in cases where it is desirable for the drug to remain in the superficial layers of the skin to achieve a local effect."

Journal • Biosimilar

"Yep. All the post surgery: moprphine, demoral, Vicodin. And I've taken naproxen. AND excedrin migraine. I give up." (@crystalsloth)

Biosimilar • Migraine

Who Turned the Lights Down? (ACG 2016) - "The patient reported occasional naproxen ingestion for joint pain. The predominant pigments deposited in PMD are iron sulfi de and hemosid- erin in the macrophages of the lamina propria that most likely suggests a clinical iron overload. Our case highlights the endoscopic appearance of PMD, however its clinical signifi cance still remains to be determined."

Clinical • Biosimilar • Cardiovascular • Diabetes • Diabetic Nephropathy • Heart Failure • Immunology • Myositis • Pain • Renal Disease • Reperfusion Injury

Iron-impregnated zeolite catalyst for efficient removal of micropollutants at very low concentration from Meurthe river. (PubMed, Environ Sci Pollut Res Int) - "...Except for sulfamethoxazole and PFOA, the concentrations of all the other microcontaminants (bisphenol A, carbamazepine, carbamazepine-10,11-epoxide, clarithromycin, diclofenac, estrone, ibuprofen, ketoprofen, lidocaine, naproxen, PFOS, triclosan, etc.) became lower than the limit of quantification of the LC-MS/MS after 30 min or 6 h of photo-Fenton treatment depending on their initial concentrations. The photo-Fenton degradation of PFOA can be neglected. The photo-Fenton degradation of sulfamethoxazole obeys first-order kinetics in the presence of the cocktail of the other micropollutants."

Journal • Biosimilar

Medication Use and Overuse Patterns in Curelator Headache US and UK Users (AHS 2017) - "In the US, top medications overused were ibuprofen (19.3%), oxycodone (16.6%), sumatriptan -0.152 and tramadol (11.9%), while in the UK these were ibuprofen (33.1%), paracetamol/codeine (21.4%), naproxen -0.138 and zolmitriptan (12.1%). Curelator Headache identified MO in 114 migraine subjects and could be used to alert patients and their clinicians, which is clinically useful (1). US and UK medication use and overuse patterns are different but within literature-reported rates. An electronic diary system may complement previous studies investigating the role of MO in developing chronic migraine or MOH."

Clinical • Biosimilar • Migraine • Pain

International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors. (PubMed, Pharmacol Rev) - "There are also approaches where existing, clinically approved drugs of various classes (e.g., nonsteroidal anti-inflammatories) are coupled with H2S-donating groups (the most advanced compound in clinical trials is ATB-346, an H2S-donating derivative of the non-steroidal anti-inflammatory compound naproxen). Moreover, some of these compounds (e.g., cell-permeable prodrugs of the CBS inhibitor aminooxyacetate, or benserazide, a potentially repurposable CBS inhibitor) may serve as starting points for future clinical translation. The present article overviews the currently known H2S donors and H2S biosynthesis inhibitors, delineates their mode of action, and offers examples for their biologic effects and potential therapeutic utility."

Journal • Review • Biosimilar • Cardiovascular • Gene Therapies • Immunology • Oncology • Reperfusion Injury

Ferrate(VI) oxidation of pharmaceuticals in hydrolyzed urine: Enhancement effects from ammonia, bicarbonate, and creatinine (ACS-Sp 2018) - "...This study investigates the application of ferrate (Fe(VI)) oxidation to degrade pharmaceuticals (carbamazepine (CBZ), naproxen (NAP), sulfamethoxazole (SMX) and trimethoprim (TMP)) in synthetic hydrolyzed human urine...Creatine and hippuric acid show limited scavenging effects. Overall, the powerful oxidation capability of Fe(VI) and the enhancement effects from multiple urine components (e.g., ammonia, bicarbonate and creatinine) render Fe(VI) a promising advanced oxidation technology for removal of pharmaceuticals in hydrolyzed urine."

Biosimilar

"Triple therapy clarithromycin, naproxen reduced mortality more than oseltamivir alone in patients admitted for severe influenza infection 10/17/17 Andreatos, & Mylonakis @AnnalsofIM https://t.co/Kd6rrRtkNA HT @BuckeyeMyeloma" (@mtmdphd)

Clinical • Biosimilar • Hematological Malignancies • Immunology • Multiple Myeloma • Oncology

"@TomCruise see theology of mind abuse treatment practices NPS is naproxen sodium. Salt/ pro / salt na+ @neiltyson find ur book pro xen" (@NurseRabbi)

Biosimilar

Amphiphilic naproxen prodrugs: differential scanning calorimetry study on their interaction with phospholipid bilayers. (PubMed, J Pharm Pharmacol) - "Variation of LAA portion can modulate the naproxen prodrugs affinity towards the biological membrane as well as towards the lipophilic carrier."

Journal • Alzheimer's Disease • Biosimilar • CNS Disorders

Naproxen Is Transformed Via Acetogenesis and Syntrophic Acetate Oxidation by a Methanogenic Wastewater Consortium. (PubMed, Microb Ecol) - "Combined with the biotransformation data, this suggests the enriched consortium performs aromatic O-demethylation through a syntrophic relationship between specific acetogens, acetate oxidizers, and methanogens. The proposed model of carbon transfer through the anaerobic food web highlights the significance of linked community interactions in the anaerobic transformation of aromatic O-methyl compounds such as naproxen."

Journal • Biosimilar

A Case of the Crowned Dens Syndrome - An Important Cause of Neck Pain (BSR 2017) - "She reported rapid resolution, upon treatment with naproxen, of a broad range of symptoms including fatigue, nausea, anorexia, breathing difficulty and pain on deep inspiration, blurred vision and ‘mental dullness’. CDS is an important differential in the patient with neck pain. The typical presentation with severe pain and dramatic inflammatory response, often with fever and systemic symptoms, commonly raises suspicion of other inflammatory, infectious and malignant conditions including giant cell arteritis, polymyalgia rheumatica, bacterial meningitis, cervical myelopathy, spinal metastasis and localised infection. Patients can be exposed to unnecessary and invasive procedures, e.g. lumbar puncture, inappropriate treatment such as empirical antibiotics and prolonged glucocorticoid therapy, and delay in diagnosis."

Clinical • Biosimilar • Hematological Malignancies • Immunology • Multiple Myeloma • Oncology • Ophthalmology • Pain

"Don't use #Naxproxen or #NaproxenSodiumm. If you have any in your medicine cabinet, throw it in the trash (not the toilet)!" (@ljsylvain)

Biosimilar

Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or COX-2 inhibitors. (PubMed, Bioorg Chem) - "...In this study, novel and successfully synthesized naproxen-derivatives indicated powerful anti-inflammatory properties as potent of COX-1 and/or COX-2 inhibitors are reported...Furthermore, twenty of the synthesized derivatives have been selected by the NCI, USA for anti-cancer screening and some of the tested compounds showed good% growth inhibition and some selectivity against some cell lines such as melanoma, non-small cell lung and colon cancer with GI% values ranging from 60.9 to 82.8%. Structure activity relationship has been performed and molecular modeling studies and molecular dynamic simulations have been performed for more explanation of the action of the synthesized compounds."

Journal • Biosimilar • Colorectal Cancer • Gastrointestinal Cancer • Immunology • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Hand Ground Nanoscale Zn(II)-Coordination Polymers Derived from NSAIDs: Cell Migration Inhibition of Human Breast Cancer Cells. (PubMed) - Chemistry - "Hand grinding in laboratory mortar and pastel resulted in nano-scale coordination polymers, for the first time, suitable for biological studies. Two such hand ground nano-scale coordination polymers namely NCP1a and NCP2a containing naproxen (a well-studied NSAID) were successfully internalized within the human breast cancer cells MDA-MD-231 as evident from cellular imaging using fluorescence microscope, were able to kill the cancer cells (MTT assay) more efficiently than the corresponding mother drug naproxen and most importantly inhibited significantly the cancer cell migration thereby displaying anti-cancer activity."

Journal • Biosimilar • Breast Cancer • Oncology

Improved tolerance to transplanting injury and chilling stress in rice seedlings treated with orysastrobin. (PubMed) - Plant Physiol Biochem - "This stress alleviation was eliminated by the application of naproxen, a putative abscisic acid biosynthesis inhibitor. These results suggested that orysastrobin improved tolerance against transplanting injury and chilling stress in rice seedlings by inducing water-retaining activity through the suppression of transpiration, and also by inducing reactive oxygen scavenging activity thus inhibiting reactive oxygen species accumulation."

Journal • Biosimilar

In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates. (PubMed, Molecules) - "The permeability of naproxen across monolayers of Caco-2 cells was significantly increased by its conjugation to either G3 or G0 PAMAM dendrimers. Lauroyl-G0 conjugates displayed considerably lower cytotoxicity than G3 conjugates and may be preferable for use as a drug carrier for low soluble drugs such as naproxen."

Journal • Biosimilar

Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment. (PubMed, Water Sci Technol) - "Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen. With redox-mediator addition, the enzymatic chiral inversion of both (R)- and (S)-profens remained unchanged, although the overall conversion became enantioselective; except for (S)-naproxen, the addition of redox mediator promoted the degradation of (R)-profens only."

Journal • Biosimilar