XEN D0101 / Xention - LARVOL DELTA

Species dependent differences in the inhibition of various potassium currents and in their effects on repolarization in cardiac ventricular muscle. (PubMed, Can J Physiol Pharmacol) - "On the contrary, IKr inhibition (50 nM dofetilide) significantly prolonged repolarization in human, rabbit, and dog, but not in rat. Inhibition of the IKur current (1 µM XEN-D0101) only prolonged rat ventricular repolarization, and had no effect in human or dog. Inhibition of the IKs (500 nM HMR-1556) and Ito currents (100 µM chromanol-293B) elicited similar effects in all investigated species. We conclude that dog ventricular preparations have the strongest, and rat ventricular preparations have the weakest translational value in cardiac electrophysiological experiments."

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