KD-496
/ KAEDI
- LARVOL DELTA
Home
Next
Prev
1 to 4
Of
4
Go to page
1
July 24, 2025
A phase I trial of KD-496, a CLDN18.2/NKG2D dual targeting CAR-T, in patients with gastrointestinal cancers
(ESMO 2025)
- P1 | "Following lymphodepletion (fludarabine 25 mg/m 2 d1-2 + cyclophosphamide 250 mg/m 2 d1-3, nab-paclitaxel 100 mg day2), patients received KD-496 infusion at escalating doses: 1×10 8 (DL1), 3×10 8 (DL2), or 5×10 8 (DL3) CAR + cells. Conclusions These initial data demonstrate a favorable safety profile and promising antitumor activity for KD-496 CAR-T cells, warrants further evaluation in larger cohorts. These findings support KD-496 as a strategic approach for NKG2DL/CLDN18.2 positive gastric and pancreatic cancers."
Clinical • P1 data • Gastric Cancer • Gastrointestinal Cancer • Oncology • Pancreatic Cancer • Solid Tumor • CLDN18 • NKG2D
November 25, 2024
Patients with advanced gastric cancer have been treated with the world's first dual-targeted KD-496 CAR-T cell and have been consistently confirmed to respond [Google translation]
(bydrug.pharmcube.com)
- P1 | N=12 | NCT06134960 | "In the clinical study of KD-496 CAR-T cells conducted by the Department of Gastroenterology of Peking University Cancer Hospital, two gastric cancer patients have received low-dose KD-496 CAR-T cell infusions so far, and the patients have well tolerated them and have no obvious gastrointestinal reactions, which may be due to the dual-target design of the product...a second tumor assessment was performed 8 weeks after treatment, the tumor continued to shrink, and the patient achieved a sustained confirmed response (PR) 3 months after treatment, and the second patient also achieved a reduced SD 4 weeks after treatment."
P1 data • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor
November 19, 2023
NKG2D/CLDN18.21 CAR-T(KD-496) in the Treatment of Advanced NKG2DL+/CLDN18.2+ Solid Tumor
(clinicaltrials.gov)
- P1 | N=12 | Not yet recruiting | Sponsor: Peking University
Metastases • New P1 trial • Gastric Cancer • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor
October 17, 2022
NKG2D/CLDN18.2 CAR-T(KD-496) in the Treatment of Advanced NKG2DL+/CLDN18.2+ Solid Tumors
(clinicaltrials.gov)
- P1 | N=18 | Recruiting | Sponsor: jianming xu
New P1 trial • Gastric Cancer • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor • CLDN18
1 to 4
Of
4
Go to page
1