CE120 / Cello Therap - LARVOL DELTA

Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors. (PubMed, Nat Commun) - "Moreover, treatment of an aggressive breast cancer model with intratumoral PNP-R848 delays tumor growth and inhibits lung metastasis. Our findings highlight the promise of locally delivering immunostimulatory payloads using biomimetic nanocarriers, which possess advantages such as enhanced biocompatibility and natural targeting affinities."

Journal • Breast Cancer • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Cello Therapeutics’ Platelet Membrane-Coated Nanoparticles Offer a Novel Platform for the Delivery of Immunotherapy in Cancer Treatment (GlobeNewswire) - “In a new study published today in Nature Communications, Cello Therapeutics shows how semisynthetic nanoparticles coated in platelet membrane can effectively inhibit tumor growth and metastasis in multiple mouse models of solid tumors. Cello collects the membrane of human platelets and coats them onto synthetic nanoscale particle cores loaded with a toll-like receptor (TLR) agonist to create a formulation dubbed ‘PNP-R848’…Localized intratumoral injection of PNP-R848 effectively eliminated or inhibited tumor growth in two separate mouse models of cancer. In a colorectal cancer model, PNP-R848 not only entirely eradicated the tumor, but also induced a sustained long term immunity.”

Clinical • Preclinical • Breast Cancer • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor