NB004
/ Ningbo Tai Kang, Roche
- LARVOL DELTA
Home
Next
Prev
1 to 5
Of
5
Go to page
1
December 26, 2024
Sensitive liquid biopsy monitoring correlates with outcome in the prospective international GPOH-DCOG high-risk neuroblastoma RT-qPCR validation study.
(PubMed, J Exp Clin Cancer Res)
- "This study validates the association of not clearing of BM metastases by sensitive RT-qPCR detection with very poor outcome. We therefore propose implementation of RT-qPCR for minimal residual disease testing in neuroblastoma to guide therapy."
Biomarker • Journal • Liquid biopsy • CNS Tumor • Neuroblastoma • Oncology • Pediatrics • Solid Tumor • HOXB6 • PHOX2B
March 06, 2024
Preclinical antitumor activity and first-in-human phase I study of NB004/GDC-0570, a novel pan-PIM kinase inhibitor, in patients with advanced solid tumors
(AACR 2024)
- P1 | "Remarkably, in NSCLC PDX models with acquired resistance to KRASis, strong combination efficacy was observed between NB004 and sotorasib, resulting in complete tumor regression. These results warrant further evaluation of this drug in combination with other therapeutic agents. The combination part of the trial is currently open for enrollment (NCT05036291)."
Metastases • P1 data • Preclinical • Hematological Malignancies • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • KRAS • PIM1
March 12, 2024
Lead Optimization Yielding a pan-Pim Inhibitor GDC-0570/NB004 for Cancer Treatment in the Clinical Testing
(ACS-Sp 2024)
- "The structure of GDC-0570 has not been disclosed. Currently, GDC-0570 is in active Phase 1 clinical trial."
Clinical • Hematological Malignancies • Multiple Myeloma • Oncology
June 24, 2023
Discovery of GDC-0570/NB004 as a second-generation pan-Pim inhibitor through extensive optimization for cancer treatment
(ACS-Fall 2023)
- "This is the first time that the structure of GDC-0570 will be fully disclosed. Currently, GDC-0570 is in active phase 1 clinical trial."
Hematological Malignancies • Multiple Myeloma • Oncology
January 27, 2020
Newly added product
(Businesswire)
- Preclinical, Oncology, MM, Prostate Cancer
Pipeline update
1 to 5
Of
5
Go to page
1