P1201-07 / Piramal Phytocare, Eli Lilly - LARVOL DELTA

Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Bacterial Viruses Subcommittee, 2025. (PubMed, J Gen Virol) - "Key updates include the creation of new orders and families that include existing taxa to better reflect genomic and evolutionary relationships. As sequencing and bioinformatics approaches continue to advance, further expansion and refinements in viral taxonomy can be anticipated in the coming years."

Journal • Infectious Disease

PC1201 Towards a truly global HIV cure Session 1: Opening and setting the scene (AIDS 2024) - "Organized by IAS - the International AIDS Society. The pre-conference will reflect on current research directions, scientific and structural challenges associated with conducting HIV cure research and the importance of expanding and coordinating efforts across countries and regions."

Clinical • Human Immunodeficiency Virus • Infectious Disease

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201. (PubMed, mLife) - "Finally, C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal (PQS) QS signaling systems. Therefore, we propose a new model of the QS regulatory network in PA1201, in which RsaL represents a superior player acting at the top of the hierarchy."

Journal • ELANE

Fructose promotes pyoluteorin biosynthesis via the CbrAB-CrcZ-Hfq/Crc pathway in the biocontrol strain Pseudomonas PA1201. (PubMed, Synth Syst Biotechnol) - "The small RNA binding protein Hfq and Crc negatively regulated fructose-induced Plt. Taken together, this study provides a new model of fructose-dependent Plt production in PA1201 that can help improve Plt yield by biosynthetic approaches."

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H-NS family protein MvaU downregulates phenazine-1-carboxylic acid (PCA) biosynthesis via binding to an AT-rich region within the promoter of the phz2 gene cluster in the rhizobacterium Pseudomonas strain PA1201. (PubMed, Synth Syst Biotechnol) - "MvaU repression of PCA biosynthesis was independent of QscR and OxyR in PA1201 and neither PCA or HO were the environmental signals that induced mvaU expression. These findings detail a new MvaU-dependent regulatory pathway of PCA biosynthesis in PA1201 and provide a foundation to increase PCA fermentation titer by genetic engineering."

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A variant in the RP1L1 gene in a family with occult macular dystrophy in a predicted intrinsically disordered region. (PubMed, Ophthalmic Genet) - "Although, the major pathogenic variant of OMD is p.Arg45Trp, multiple reports indicate that the region between p.1194 and p.1201 is another hot spot of OMD. The PONDR analysis predicted that the RP1L1 molecule is one of the intrinsically disordered proteins. It is speculated that the region around p.1200 is essential for the normal function of the RP1L1 molecule, and the missense variants of that area cause the development of OMD."

Journal • Age-related Macular Degeneration • Macular Degeneration

Identification of a strong quorum sensing- and thermo-regulated promoter for the biosynthesis of a new metabolite pesticide phenazine-1-carboxamide in Pseudomonas strain PA1201. (PubMed, ACS Synth Biol) - "After three rounds of promoter editing and swapping by PrhlI, a new PCN-overproducing strain UP46 was generated. The optimal fermentation temperature for PCN biosynthesis in UP46 was increased from 28C to 37C and the PCN fermentation titer increased 179.5-fold, reaching 14.1 g/L, the highest ever reported."

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