benzylpenicillin / Generic mfg. - LARVOL DELTA

Penicillin Allergy Evaluation in Pediatric Patients: Safety of Testing without MDM and the Role of Testing to Ampicillin and Duplicate PrePen® (AAAAI 2026) - "Among 265 patients with negative skin testing who underwent oral challenge to a penicillin (primarily Conclusions Penicillin skin testing using penicillin G, PrePen®, and ampicillin—without MDM testing—demonstrated a NPV of 98%. Inclusion of ampicillin identified an additional 33 patients (26.4%) with positive results. These findings suggest MDM may not be necessary in pediatric penicillin allergy testing protocols and that ampicillin should be considered an essential component of penicillin testing."

Clinical • Allergy • Immunology • Pediatrics

A Case of Facial Nerve Palsy As the Initial Presentation of Early Neurosyphilis: A Diagnostic Challenge. (PubMed, Cureus) - "The patient showed rapid clinical improvement following treatment with intravenous penicillin G, though his course was complicated by a Jarisch-Herxheimer reaction. This case emphasizes the importance of considering neurosyphilis in the differential diagnosis of cranial neuropathies, particularly in at-risk populations, as early recognition and appropriate antimicrobial therapy are vital for optimal neurological outcomes."

Journal • CNS Disorders • Infectious Disease • Pain

Differences in β-lactamase activity and carbapenem resistance among the Bacillus cereus group. (PubMed, Antimicrob Agents Chemother) - "Although all B. luti isolates lacked carbapenemase genes, they exhibited higher minimum inhibitory concentration (MIC) ranges for ampicillin and meropenem...All B. luti isolates and some B. mosaicus and B. cereus s.s. isolates displayed constitutive enzyme activity for penicillin G, whereas most B. mosaicus and B. cereus s.s. isolates displayed inducible activity, and five displayed silent activity...This is the first study to demonstrate interspecies variability within the B. cereus group regarding the presence of carbapenemase genes and β-lactam resistance profiles. These findings provide crucial insights into β-lactam resistance mechanisms in this bacterial group and provide a foundation for further research."

Journal • Infectious Disease

Progressive exacerbation of neurological symptoms in a patient with neurosyphilis following T9-T10 intradural space-occupying lesion resection: a case report. (PubMed, Front Immunol) - "The patient received a 14-day course of intravenous benzylpenicillin, which resulted in significant symptomatic improvement and restoration of most functions at discharge...The immunosuppressed state may contribute to the reactivation of syphilis spirochetes; therefore, it is important to consider this potential risk and take appropriate precautions when performing surgical treatments such as spinal surgery. Penicillin remains the therapeutic agent of choice for neurosyphilis, and early diagnosis and treatment are critical to the patient's prognosis."

Journal • CNS Disorders • Infectious Disease • Pain

Prevalence and phenotypic expression of blaZ-mediated penicillin G resistance in invasive methicillin-susceptible Staphylococcus aureus in Belgium national hospital surveillance (2022–2023) (ESCMID Global 2026) - No abstract available

Clinical

A population pharmacokinetic model of benzylpenicillin in patients with infective endocarditis to support individualised dosing strategies (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Cardiovascular

External quality assessment in antimicrobial susceptibility testing (EUCAST disc diffusion methodology) of five anaerobic strains - performance of 35 laboratories in Germany and Austria, 2024. (PubMed, Anaerobe) - "A panel of five anaerobic bacterial strains (two Bacteroides fragilis, and one each of Phocaeicola vulgatus, Clostridium perfringens and Fusobacterium necrophorum) was tested by the participating laboratories against a panel of antibiotics (piperacillin-tazobactam, meropenem, metronidazole, clindamycin and/or benzylpenicillin) using the EUCAST disc diffusion methodology. This method was evaluated in comparison with the standard reference method, and categorical agreement with expected results was high (≥90%), with notable exceptions for piperacillin-tazobactam (88.6% and 80.0% in two of the five strains, respectively). The observed discrepancies underscore that the method requires local technical expertise in combination not only with continuous internal quality control but also with external quality assurance."

Journal

Antimicrobial resistance in bacterial meningitis caused by Streptococcus pneumoniae, Neisseria meningitidis, or Haemophilus influenzae (2010-24): a systematic review and meta-analysis. (PubMed, Lancet Microbe) - "Treatment of bacterial meningitis is challenged by a rise of antimicrobial-resistant pathogens, particularly affecting patients in LMICs where access to effective treatment might be limited. Our findings call for the strengthening of national antimicrobial resistance surveillance systems to better tailor treatment guidelines and public health interventions."

Journal • Retrospective data • CNS Disorders • Infectious Disease • Influenza • Meningococcal Infections • Pneumococcal Infections • Pneumonia • Respiratory Diseases

PNEUmonia DOSing in Critically Ill Patients (PNEUDOS) (clinicaltrials.gov) - P=N/A | N=179 | Completed | Sponsor: The University of Queensland | Recruiting ➔ Completed | N=80 ➔ 179

Enrollment change • Trial completion • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Culture-Based Wastewater Surveillance for the Detection and Monitoring of Antimicrobial Resistance in Staphylococcal Species. (PubMed, Vet Sci) - "Resistance was highest to benzylpenicillin (88%) and fusidic acid (82%), whereas all isolates remained susceptible to glycopeptides, tigecycline, and linezolid. Wastewater is a reservoir of diverse multidrug-resistant staphylococci, underscoring One Health relevance reflecting the potential for circulation between humans, animals, and the shared environment. WBS can support population-level AMR monitoring to inform public health and veterinary interventions."

Journal • Gene Therapies • Infectious Disease

Severe Generalized Tetanus in a Chimpanzee (Pan troglodytes) Under Human Care: A Case Report from the Republic of Congo. (PubMed, Vet Sci) - "This included meticulous wound debridement and irrigation, passive immunization with antitoxin, initiation of active immunization, metronidazole with adjunctive penicillin G, diazepam-based spasm control, multimodal analgesia, and low-stimulation nursing with oxygen supplementation, enteral nutrition, and temporary urinary catheterization. By week 8, he had made a full clinical recovery and was successfully reintegrated into his group. This case supports the use of pragmatic, sanctuary-adapted protocols and systematic vaccination."

Journal • CNS Disorders • Hematological Disorders • Infectious Disease • Leukopenia • Neutropenia • Tetanus • Thrombocytopenia

Jarisch-Herxheimer reaction as a complication of penicillin G and ceftriaxone treatment in neurosyphilis. (PubMed, BMC Infect Dis) - No abstract available

Journal

Detection of Penicillium-Toxins in Nuts Commercialized in Italy Through LC-MS/MS Analyses. (PubMed, Toxins (Basel)) - "Specifically, secondary metabolites produced by Penicillium spp., including ochratoxin A, patulin, citrinin, cyclopiazonic acid, citreoviridin, griseofulvin, meleagrin, mycophenolic acid, penitrem A, roquefortine C, penicillins G and V, sulochrin, andrastin A, asterriquinone, chaetoglobosin A, cyclopenin, cyclopenol, and viridicatin, were investigated. Besides Penicillium-toxins, aflatoxins were also analyzed with another validated LC-MS/MS method, but they were not detected in any sample. Although most Penicillium-toxins, and in particular patulin in nuts, are not currently regulated in the international legislation, they exert toxic effects on humans and animals, and their occurrence can represent a food safety risk."

Journal

Impact of a multidisciplinary antimicrobial stewardship programme on piperacillin-tazobactam use at a Danish university hospital: A pre-post interventional study. (PubMed, J Hosp Infect) - "A multidisciplinary AMS programme was associated with reduced TZP use and improved prescribing quality in participating departments without adverse effects on safety indicators. These findings support AMS as an effective strategy to optimise antibiotic use."

Journal

Comparative insights into molecular characterization and resistance profiling of methicillin-resistant Staphylococcus aureus across dairy livestock in Pakistan. (PubMed, Vet Res Commun) - "Antibiogram of MRSA isolates revealed that dairy animals exhibited high resistance to penicillin G, cefoxitin, and gentamicin, but remained susceptible to ciprofloxacin and moxifloxacin. MRSA of sheep origin showed distinct resistance patterns, showing more sensitivity towards gentamicin and amoxicillin...In-silico analysis showed that all dairy animals in Pakistan shared conserved nucleotide and amino acid motifs. This study concludes that MRSA represents a serious threat to livestock health due to its multidrug-resistant properties, and antibiogram profiling can provide a valuable tool for guiding effective therapeutic interventions against MRSA infections."

Clinical • Journal • Infectious Disease

Iterative discovery of potent polymeric antibiotics via multi-stage and multi-task learning against antimicrobial resistance. (PubMed, Nat Commun) - "These SANPs also serve as adjuvant antibiotic carriers, restoring bacterial sensitivity to penicillin G. In vivo studies demonstrate their therapeutic efficacy both as monotherapies and in combination therapies with antibiotics. PolyCLOVER may become a powerful framework for discovery of new polymeric biomaterials without reliance on external datasets."

Journal • Infectious Disease

Intracardiac mass in a 3-month-old boy revealing a congenital syphilis. (PubMed, Braz J Infect Dis) - "The Treponemal Hemagglutination Assay (TPHA) and non-treponemal test (Venereal Disease Research Laboratory, VDRL) were highly positive. Prolonged antibiotic therapy with penicillin G resulted in good clinical evolution, disappearance of lymphocytosis and total disappearance of the mass at 20-months' follow-up."

Journal • Hematological Disorders • Hepatology • Infectious Disease • Pediatrics • CRP

Constitutional symptoms and response to Penicillin G in erysipelas and cellulitis - a monocentric, retrospective, explorative study. (PubMed, J Dtsch Dermatol Ges) - "Our findings suggest that early constitutional symptoms and characteristic erythema are reliable indicators for erysipelas. Erysipelas do not tend to heal promptly and spontaneously but respond reliably to penicillin."

Journal • Retrospective data • Dermatology • Infectious Disease

Ai derivation and exploration of antibiotic class spaces. (PubMed, J Cheminform) - "Our fragment-based pipeline demonstrates the feasibility of systematically exploring antibiotic chemical spaces through computational reconstruction of historical development pathways and generation of hybrid molecules with with predicted multi-target binding profiles. All results represent computational predictions requiring experimental validation."

Journal • MAPK8

Dual-ligand-functionalized gold nanoparticles on ZIF-8: A bimodal ratiometric sensor for sensitive detection of penicillin G. (PubMed, Talanta) - "Notably, the dual-emission ratiometric is able to read-out mitigates matrix effects without sophisticated sample pretreatment, indicating robustness against turbidity and autofluorescence. This work proposes a new approach to fabricate high-performance ratiometric fluorescence sensors for sensitive detection of penicillin G in food and environment."

Journal

A rare brain abscess caused by co-infection with Fusobacterium nucleatum and Actinomyces meyeri : Case report and a literature review. (PubMed, Wien Med Wochenschr) - "The patient was successfully treated with surgical drainage and high-dose penicillin G combined with metronidazole followed by oral therapy, with no recurrence observed at 3 months. This case emphasizes the role of odontogenic infections as a source of intracranial abscesses and highlights the importance of microbiological and molecular methods for accurate pathogen identification and therapeutic guidance."

Journal • CNS Disorders • Infectious Disease • Pain

Prolonged membrane rupture at term: benefits of antibioprophylaxis for reducing intrauterine infection in the absence of streptococcus B (PubMed, Gynecol Obstet Fertil Senol) - "Administering antibiotic prophylaxis starting 18 hours after membrane rupture in term patients with term prelabor rupture of membranes and a negative Group B Streptococcus screening appears to reduce the rate of intrauterine infection."

Journal • Anesthesia • Cardiovascular • Endometriosis • Gynecology • Infectious Disease • Musculoskeletal Pain • Pain

Customizable NAND Logic-Gate Biosensing System Enabled by an Engineered Methylation-CRISPR/Cas12a Consensus Sequence for Ultrasensitive DNA Methyltransferase Detection. (PubMed, Anal Chem) - "The system exhibited a broad linear detection range with an ultralow detection limit of 0.00032 U mL-1, outstanding selectivity toward nontarget MTases, and satisfactory recoveries (98.16-100.03%) in human serum samples. Furthermore, it enabled quantitative evaluation of Dam inhibitors, revealing IC50 values of 1.75 μM for 5-fluorouracil and 11.9 μM for penicillin G. This strategy provides a universal molecular computation-driven biosensing framework for enzyme activity analysis and inhibitor screening in complex biological systems."

Journal

Neurosyphilis Diagnosed on the Basis of Pupillary Abnormalities: A Case Report. (PubMed, Cureus) - "Both pupils exhibited mild constriction after 0.1% pilocarpine. The patient was treated with high-dose intravenous penicillin G and three courses of methylprednisolone pulse therapy, resulting in improvement of ocular alignment and motility and partial recovery of pupillary function. This case illustrates that neurosyphilis can present with pupillary abnormalities and oculomotor nerve involvement, even at an early stage. Neurosyphilis should be considered in the differential diagnosis of unexplained pupillary changes."

Journal • Ataxia • Infectious Disease • Movement Disorders • Ophthalmology • Strabismus

Evaluation of enzymatic activity, hemolytic safety, and antibiotic susceptibility of Bacillus spp. isolated from giant freshwater prawn (Macrobrachium rosenbergii) farms in Kalasin Province, Thailand. (PubMed, Vet World) - "Antibiotic susceptibility profiles indicated broad sensitivity to penicillin G, tetracycline, streptomycin, erythromycin, and chloramphenicol. Moderate susceptibility to vancomycin was observed in B. pseudomycoides and B. safensis, while B. infantis remained fully susceptible...These native isolates may serve as sustainable, locally adapted alternatives to antibiotics, contributing to improved feed efficiency, growth, and disease resistance in freshwater prawn aquaculture. Further in vivo validation and genomic safety analyses are recommended to confirm their efficacy under commercial conditions."

Journal • Hematological Disorders