benzylpenicillin / Generic mfg. - LARVOL DELTA

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines for antimicrobial and non-steroidal anti-inflammatory drug use in bovine respiratory disease. (PubMed, Open Res Eur) - "The panel conditionally suggests penicillin G, oxytetracycline, or florfenicol as first-line empirical treatment, guided by local susceptibility data, herd treatment history, product authorization, withdrawal periods, and suspicion of Mycoplasmopsis bovis infection. These guidelines prioritize effective BRD treatment while reducing unnecessary use of higher-priority antimicrobials. Local adoption or adaptation using GRADE-ADOLOPMENT is recommended."

Journal • Infectious Disease • Respiratory Diseases

Missed Antibiotic Doses, Microbiology Diagnostic Results, and Antibiotic Prescribing Patterns at Discharge at Two Paediatric Tertiary Hospitals in Zambia: Implications for Antimicrobial Stewardship. (PubMed, Antibiotics (Basel)) - "Significant AMS gaps exist, including frequent missed doses, limited diagnostic support, and high discharge antibiotic use. Strengthening medication administration systems, improving laboratory capacity and turnaround times, and optimizing discharge prescribing are critical for enhancing pediatric AMS and reducing AMR."

Journal • Pediatrics

Isolation and Preliminary In Vitro Characterization of a Honey-Derived Bacillus licheniformis Isolate. (PubMed, Antibiotics (Basel)) - " In vitro assays revealed that Blhoney exhibits robust tolerance to simulated gastrointestinal stress, including extreme acidity (pH 1-3), bile salts (0.3-1%), pepsin, and pancreatin, maintaining viability for up to 24 h. Phenotypic antimicrobial testing demonstrated measurable inhibition zones for erythromycin, kanamycin, chloramphenicol, ampicillin, tetracycline, gentamicin, streptomycin, and spectinomycin, whereas no measurable inhibition zones were observed for penicillin G, rifampicin, ciprofloxacin, or ceftazidime. Overall, these findings indicate that the honey-derived Blhoney isolate exhibits preliminary probiotic-associated characteristics under the tested in vitro conditions. However, further strain-level genomic and safety characterization is required before its potential probiotic application can be established."

Journal • Preclinical

Transient Anti-Mitochondrial Antibody Positivity in Secondary Syphilis Presenting as Cholestatic Hepatitis (ACG 2026) - "Case Description/ A 22-year-old transgender female with recent diagnosis of SS treated with penicillin G, presented with three weeks of nausea, epigastric pain, decreased oral intake, and weight loss...Initially positive AMA results should be interpreted with caution in patients with active syphilis to avoid misdiagnosis of autoimmune cholestatic disease and unnecessary diagnostic workups. Figure: Figure 1: MRCP 3D Reconstruction of biliary ducts without ductal dilation."

Cholestasis • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure

When Infection Masquerades as Cancer: Syphilitic Proctitis in an HIV-Positive Patient (ACG 2026) - "The patient was treated with intravenous piperacillin-tazobactam during hospitalization, followed by doxycycline daily and intramuscular penicillin G once weekly for three weeks. Panel B shows one of multiple soft tissue nodules/masses within the perirectal region/presacral fat. Panels C and D show prominent mesenteric and retroperitoneal lymph nodes in left pelvic side wall and left groin."

Clinical • Beta-Thalassemia • Colorectal Cancer • Cytomegalovirus Infection • Gastroenterology • Genetic Disorders • Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Oncology • Rectal Cancer • Sickle Cell Disease • Solid Tumor • CD4

The Great Imitator Strikes Twice: Concurrent Rectal Syphilis and Otosyphilis in a Single Patient (ACG 2026) - "Early recognition and prompt high-dose intravenous penicillin G are essential to preventing irreversible complications. Figure: Colonoscopy showing mild rectal mucosal erythema and edema Figure: Colonoscopy showing diffuse rectal mucosal inflammation with erythema, friability, and loss of vascular pattern, consistent with syphilitic proctitis confirmed on biopsy demonstrating spirochetes."

Clinical • Cardiovascular • CNS Disorders • Dyslipidemia • Gastrointestinal Disorder • Hepatology • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Metabolic Disorders • Mucositis • Otorhinolaryngology

Multimodal Imaging of Iris Roseola/Papulosa: An Unusual Manifestation of Syphilitic Uveitis. (PubMed, Ocul Immunol Inflamm) - "Treatment with aqueous crystalline penicillin G was initiated for 21 days, and supplemented with oral prednisone 24 h later, after development of a Jarisch-Herxheimer reaction. Multimodal imaging may be of help for better characterization of their vascular component, as well as for delineating other subtle inflammatory changes that may go unnoticed. Antibiotic treatment supplemented with steroids is curative in the short term."

Journal • Achromatopsia • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology • Pain • Uveitis

Bacterial diversity, antimicrobial resistance profiles, and farm-level risk factors in bovine mastitis: A retrospective cohort study in dairy herds. (PubMed, Res Vet Sci) - "showed the highest resistance rates, particularly to cloxacillin (42.9%), benzylpenicillin (25.0%) and macrolides (21.4%). No significant predictors of co-resistance were identified. Antibiotic resistance patterns observed in mastitis pathogens support the implementation of culture-guided antimicrobial therapy and provide baseline data for regional AMR surveillance within a One Health approach."

Journal • Retrospective data • Infectious Disease

SPR-based screening identifies luteolin from Artemisia scoparia as a potential PBP2a inhibitor with β-lactam-potentiating activity against MRSA. (PubMed, Phytomedicine) - "Luteolin is a potential PBP2a-targeting compound with β-lactam-potentiating activity against MRSA. Its effects may involve PBP2a interaction and broader metabolic and regulatory perturbations, although direct inhibition of PBP2a enzymatic activity remains unconfirmed."

Journal • Infectious Disease

Multidisciplinary management of severe odontogenic maxillofacial multi-space infection in a patient with HIV-syphilis coinfection and advanced immunosuppression: a case report. (PubMed, Front Cell Infect Microbiol) - "Emergency tracheostomy and incision and drainage were followed by multidisciplinary management comprising sequential antibacterial therapy, intravenous aqueous penicillin G, early antiretroviral therapy, and trimethoprim-sulfamethoxazole prophylaxis. At four-month follow-up, the infection had not recurred, the CD4+ T-cell count reached 415.36 cells/μL, and the RPR had reverted to negative. In patients with advanced immunosuppression, odontogenic multi-space infection mandates prompt airway control, adequate surgical drainage, sequenced pathogen-specific pharmacotherapy, and multidisciplinary collaboration."

Journal • Human Immunodeficiency Virus • Infectious Disease • CD4 • CRP

Infected thoracoabdominal aortic aneurysm with vertebral osteomyelitis caused by invasive pneumococcal disease successfully managed with rifampicin-soaked in situ graft replacement. (PubMed, J Vasc Surg Cases Innov Tech) - "Both blood and tissue cultures yielded Streptococcus pneumoniae sensitive to penicillin G. Emergency in situ thoracoabdominal aortic replacement using a rifampicin-soaked four-branched prosthetic graft under cardiopulmonary bypass was performed successfully. At 3 months postoperatively, the patient remains under follow-up with no evidence of graft reinfection. This case underscores the importance of early cross-sectional imaging in patients with persistent fever and back pain, the diagnostic value of culture-positive confirmation, and the role of preventable risk factors including smoking and lack of pneumococcal vaccination."

Journal • Back Pain • Cardiovascular • Infectious Disease • Inflammation • Musculoskeletal Pain • Orthopedics • Pain • Pneumococcal Infections • Pneumonia

Antimicrobial and probiotic potential of Lactobacillus from traditional dairy products against uropathogenic gram-negative bacteria. (PubMed, Antonie Van Leeuwenhoek) - "Most isolates showed susceptibility or intermediate responses to several clinically relevant antibiotics, while resistance was mainly observed to vancomycin, penicillin G, piperacillin, and nalidixic acid. This repeated regimen also significantly controlled the inflammatory host response, with leukocyte counts decreasing from greater than 104 cells/mL to approximately 4 × 103 cells/mL by day 11, while successfully preventing kidney dissemination and minimizing bladder tissue damage. These findings highlight their potential as complementary strategies to prevent or mitigate UTIs."

Journal • Infectious Disease • Inflammation • Nephrology • Pneumonia • Renal Disease

Clinical and Microbiological Characteristics of Invasive Group A Streptococcus Infection: Four Case Series of Re-Emerging Pathogens. (PubMed, Acute Med Surg) - "All four patients received penicillin G and clindamycin as definitive antimicrobial therapy, with two developing severe drug-related adverse events. This case series documents the identification of the M1UK lineage among critically ill patients with iGAS infections in Japan. Our findings support the need for continued molecular surveillance while reinforcing the importance of prompt surgical source control and appropriate antimicrobial therapy in the management of severe iGAS."

Journal • Critical care • Infectious Disease • Novel Coronavirus Disease • Oncology • Ovarian Cancer • Septic Shock • Solid Tumor

Allergic products from penicillin G transformation driven by CuII species-catalyzed sequential hydrolysis and oxidation: Mechanism and kinetic model. (PubMed, J Environ Sci (China)) - "Complexation spectral analysis indicated that CuII coordinates with the carboxyl group on the five-membered ring of PG and the amide nitrogen of the lactam ring, which is responsible for rapid hydrolysis of β-lactam ring. Meanwhile, a species-dependent kinetic model supported the hypothesis of sequential hydrolysis followed by oxidation with quantitatively global kinetic fitting of PG-PA-PAA pathway."

Journal

Antimicrobial Resistance Profiles of Bacterial Isolates from Purulent Specimens in Women and Children: A Six-Year Retrospective Study in Central China. (PubMed, Infect Drug Resist) - "Escherichia coli exhibited the highest resistance rates, particularly to ampicillin (79.9%), and Staphylococcus aureus to penicillin G (95.4%), while carbapenems and amikacin retained high in vitro activity against the major Gram-negative isolates. coli and S. aureus are core pathogens; the observed increase in P. aeruginosa isolation over the study period warrants continued surveillance. Individualized therapy should be based on age and AMR data."

Journal • Retrospective data • Infectious Disease

Transmission dynamics of Neisseria gonorrhoeae in Greenland: a 55-year retrospective observational study. (PubMed, J Glob Antimicrob Resist) - "The importation of the first AMR high-risk lineage (NG-STAR CC158, ST158) into Greenland threatened historical high antimicrobial susceptibility. Re-established gonococcal AMR surveillance, with genomic surveillance, improved clinical management of gonorrhoea, targeted public health interventions, and enhanced tailored sexual health education are imperative in Greenland."

Journal • Observational data • Retrospective data • Infectious Disease

Occurrence, Species Distribution, and Antimicrobial Resistance of Listeria spp. in Foods from Retail and Farm Outlets in North Carolina, USA. (PubMed, Microorganisms) - "Phenotypic resistance was most frequent to Penicillin G (33.82%). Multidrug resistance (MDR) was identified in 64.71% of isolates, encompassing 84.62% of pathogenic and 60.00% of non-pathogenic species. Raw agricultural commodities serve as critical reservoirs for resistant Listeria, emphasizing the need for integrated surveillance frameworks."

Journal

Pelvic Actinomycosis Mimicking Gynecologic Malignancy: CT and Histopathologic Correlation. (PubMed, Diagnostics (Basel)) - "The patient recovered after surgical drainage and antibiotics penicillin G for 4 weeks, followed by doxycycline (200 mg) twice daily for 3 months. This case highlights the important radiologic features of pelvic actinomycosis mimicking gynecologic malignancy, particularly in women with prolonged intrauterine device use and the management in refractory pelvic actinomycosis."

Journal • Gynecologic Cancers • Gynecology • Long-acting Reversible Contraceptives • Oncology • Ovarian Cancer • Pain • Solid Tumor • CRP

Clinical characteristics and antimicrobial susceptibility of Aerococcus urinae isolates recovered from urine and blood cultures at a Japanese tertiary care hospital. (PubMed, New Microbes New Infect) - "Penicillin G, ceftriaxone, and levofloxacin susceptibility rates were 100%, 98.9%, and 76.8%, respectively. Aerococcus urinae was more commonly identified as a possible rather than a primary urinary pathogen. The high susceptibility to β-lactam antibiotics supports their continued use as appropriate treatment options for suspected A. urinae UTI."

Journal • Infectious Disease • Nephrology

Phenotypic resistance to life-saving antimicrobials in Gram-positive bacteria isolated from wild birds in Northern Italy: a One Health surveillance perspective. (PubMed, One Health) - "Isolates were identified by MALDI-TOF MS and characterized by disk diffusion susceptibility testing following validated international breakpoints; supplementary phenotypic tests were applied for vancomycin susceptibility (MIC strips), methicillin-resistance (MR; cefoxitin disk), high-level aminoglycoside resistance (HLAR; gentamicin disk), and beta-lactamase production (penicillin G morphology and nitrocefin test)...Among Lactobacillales, resistance to rifampicin (35.7%) and tetracycline (29.6%) was most prevalent...Furthermore, as characterization was exclusively phenotypic, the genetic basis of the resistance profiles detected remains to be confirmed by molecular analysis. Nonetheless, this study provides original phenotypic data across a broad taxonomic diversity of avian hosts, contributing to the evidence base for the integration of wild birds as environmental sentinels within One Health AMR surveillance frameworks."

Journal • Infectious Disease

Clinical and laboratory features of pediatric Mycoplasma pneumoniae Pneumonia with viral versus bacterial co-infection. (PubMed, Ital J Pediatr) - "The two groups differed in age, season, clinical features, and several biomarkers. Viral coinfection was associated with higher SAA and D-dimer, while bacterial coinfection with higher PCT. However, the discriminatory value of these markers is limited, and they should be used in conjunction with other clinical data. Local pathogens were dominated by rhinovirus and S. pneumoniae, with the latter exhibiting complete erythromycin resistance, highlighting the need for surveillance and rational antibiotic use."

Clinical • Journal • Retrospective data • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

A Case of Adult-onset Presumed Congenital Syphilitic Keratitis: A Multidisciplinary Management Approach. (PubMed, Eye Contact Lens) - "This case highlights the diagnostic and therapeutic complexity of adult-onset presumed congenital syphilitic interstitial keratitis. In cases where a definitive diagnosis cannot be confirmed, close collaboration among infectious disease, ophthalmology, and optometry is needed to navigate treatment decisions, manage refractory inflammation, and guide visual rehabilitation. This case demonstrates that specialty contact lens fitting and sustained interdisciplinary care are essential in restoring functional vision."

Journal • Corneal Abrasion • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Prudent use of antibiotics in bovine mastitis: The Swedish approach. (PubMed, J Dairy Sci) - "Based on prevalence and antibiotic resistance of intramammary infectious agents, benzylpenicillin is the drug of choice...To further reduce the use of antibiotics and improve udder health in dairy herds, measures to prevent new IMI, such as good external and internal biosecurity, are essential. Prevention is always better than cure as healthy cows have no need for antibiotics."

Journal

Genomic characterization of an unusual bloodstream Weissella viridescens isolate obtained from a Bulgarian intensive care unit patient. (PubMed, Mol Biol Rep) - "To the best of our knowledge, this is the third documented case of a clinical W. viridescens isolate worldwide and the first for which a genome sequence is publicly available. Therefore, its genome constitutes a valuable resource for fundamental research on rare infectious agents of public health significance, as well as for the safety assessment and development of Weissella-based probiotics."

Journal • Critical care • Oncology

Case Report: Congenital syphilis presenting with respiratory symptoms in an infant. (PubMed, Front Pediatr) - "He received intravenous penicillin G sodium at 50,000 U/kg per dose every 6 h for 14 days, together with supportive care...Complete physical examination and review of maternal serology are especially important when prenatal care or transfer of maternal medical information has been incomplete. Early recognition, penicillin treatment, and structured follow-up are essential to prevent late sequelae."

Journal • Hematological Disorders • Hepatology • Infectious Disease • Inflammation • Liver Failure • Pneumonia • Renal Disease • Respiratory Diseases • Thrombocytopenia