benzylpenicillin / Generic mfg. - LARVOL DELTA

Bacterial responses to antibiotics determine the pattern of manganese biomineralization. (PubMed, J Hazard Mater) - "Manganese biomineralization was primarily promoted through enhancing intracellular ROS accumulation to stimulate manganese oxidation induced by bactericidal antibiotic (e.g. penicillin G, PG). In contrast, BioMnOx formation was reduced by bacteriostatic antibiotic (e.g. erythromycin, ERY) due to its significant inhibition of enzymatic synthesis, while antibacterial antibiotics (e.g. ciprofloxacin, CIP) completely suppressed bacterial proliferation and manganese biomineralizing capacity due to its potent antibacterial effects. Furthermore, in multi-antibiotic coexisting systems, manganese biomineralization efficiency depended on the decisive interference of the dominant antibiotic. Our findings elucidate the long-overlooked interplay between microbial physiology and mineral evolution under antibiotic stress, provide a theoretical support for improving the continuous operation of BioMnOx-generated system under antibiotic stress, which is a timely contribution to the..."

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CPC03 Unusual cases of scalp ulceration: two distinct diagnoses. (PubMed, Br J Dermatol) - "She was treated with injectable steroids and cyclophosphamide, leading to peripheral healing of the lesions and significant improvement...The patient was treated initially with injectable ceftriaxone for 3 weeks, followed by oral penicillin G due to the unavailability of penicillin injections...Treatment modalities differ significantly, with GP requiring immunosuppressive therapy, and actinomycosis responding to prolonged antibiotic treatment. These cases highlight the diverse differential diagnoses of scalp ulceration and the need for a multidisciplinary approach to accurately identify and manage these rare conditions."

Journal • Immunology • Infectious Disease • Mood Disorders • Oncology • Otorhinolaryngology • Rare Diseases • Respiratory Diseases • Rheumatology • Vasculitis

Evaluation of resistance modulation in MDR Pseudomonas aeruginosa and Klebsiella pneumoniae using peppermint oil nanoemulsion: integrating antibacterial assays and molecular modeling. (PubMed, Front Microbiol) - "The bacterial isolates were resistant to Levofloxacin, Penicillin G, Ceftazidime, and amoxicillin-clavulanic acid (AMC). These results position PEONE as a promising, plant-based alternative for combating antibiotic-resistant urinary tract infections. Further in vivo studies are warranted to explore its clinical applicability and safety profile."

Journal • Infectious Disease • Nephrology • Pneumonia

New approach to overcoming antimicrobial resistance of by combining Guanghuoxiang () and Penicillin G Sodium treatments. (PubMed, J Tradit Chin Med) - "Combining Guanghuoxiang (Herba Pogostemonis) with antibiotics could improve the sensitivity of drug-resistant bacteria, provided a new direction for solving the problem of AMR, and offered a valuable strategy for clinical response to MRSA."

Journal • Infectious Disease

Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in Staphylococcus aureus Isolated from Burn Wounds. (PubMed, Iran J Med Sci) - "The 50 selected isolates were resistant to cefoxitin, amoxicillin, benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, and azithromycin. No significant changes were seen in fnbA and ftsZ. Nanocurcumin inhibits S. aureus virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on fnbA and ftsZ, requiring further research."

Journal • Infectious Disease

Neisseria meningitidis serogroup B causing invasive disease, Italy, 2010-2021. (PubMed, PLoS One) - "MenB isolates were susceptible to antimicrobials except for 4 isolates, of which 2 resistant to penicillin G, 1 to rifampicin and 1 to ciprofloxacin. Despite the low incidence of IMD in Italy, MenB increased in specific age groups during the study period. Continuous genomic surveillance, including MenDeVAR monitoring, remains essential to detect changes in circulating MenB and predict vaccine coverage."

Journal • Infectious Disease • Meningococcal Infections

Pathogen distribution, antimicrobial resistance and attributable cost analysis of neonatal sepsis in neonatal intensive care units: a propensity score matching study. (PubMed, Front Pediatr) - "Antimicrobial resistance analysis revealed high resistance rates of Gram-positive bacteria to penicillin G (94.6%) and oxacillin (89.3%). Gram-negative pathogens exhibited high resistance to levofloxacin (75.0%), ceftriaxone (66.7%), cefepime (66.7%), and meropenem (58.3%)...NS significantly increases the hospitalization resource consumption in NICUs. This study provides key evidence for optimizing antibiotic use strategies and advancing precision healthcare payment reform, and calls for integrating resistance surveillance with cost-control measures to reduce the health economic impact of NS."

HEOR • Journal • Critical care • Infectious Disease • Septic Shock

Revealing the most contaminated stages and spots of foodborne pathogens and antibiotic resistance along the whole fish production chain in Greek aquaculture. (PubMed, Food Microbiol) - "These potential pathogens, mainly isolated from surfaces and water of weaning and pre-fattening tanks, fish feeds, working surfaces, fish transport boxes, concrete floors and fish especially from transport boxes and harvesting, presented a noteworthy resistance to most antibiotics tested (e.g., Clindamycin, Nalidixic acid, Streptomycin, Sulphonamides, Ceftazidime, Erythromycin, Vancomycin, Penicillin G, and Cefoxitin). The findings underscore the importance of early detection and intervention strategies to mitigate ARB transmission, thereby enhancing the safety and quality of aquaculture products."

Journal • Infectious Disease • Pneumonia

Penile mass with a past: Tertiary syphilis presenting as a penile gumma. (PubMed, Urol Case Rep) - "He was treated with penicillin G, though the gumma showed minimal response and surgical extirpation was recommended. This case highlights the limitations of traditional RPR-first screening in syphilis and underscores the importance of a broad differential diagnosis when addressing penile masses."

Journal • Genito-urinary Cancer • Infectious Disease • Oncology • Penile Cancer • Solid Tumor

Infectious aortic aneurysm caused by Streptococcus pneumoniae serotype 10: A case report. (PubMed, IDCases) - "Although the strain was susceptible to penicillin G and blood cultures collected on day 6 were negative after initiation of antibiotic treatment, the aneurysm did not respond to antimicrobial therapy and continued to enlarge, requiring open surgical graft explantation...Despite no evident immunodeficiencies, the patient was unvaccinated, reflecting Japan's current policy for adults under 65. The involvement of a non-vaccine serotype highlights the potential value of re-examining vaccination strategies and gaining more insight into rare manifestations like pneumococcal IAA."

Journal • Cardiovascular • Infectious Disease • Pain • Pneumococcal Infections • Pneumonia

Antimicrobial resistance profiles in septic arthritis of native knee and shoulder joints from 2007 to 2024: a single center retrospective study. (PubMed, Front Med (Lausanne)) - "A significant decline in resistance to Penicillin G was observed (p = 0.004), along with significant variations in clindamycin susceptibility, which showed a peak in resistance from 2013 to 2018 at 40.82% (p = 0.014). Further, the age-related distribution of pathogens in our cohort, with S. aureus predominating in younger adults and Streptococcus spp. more frequent in older patients, is in line with previously reported trends."

Journal • Retrospective data • Allergy • Immunology • Infectious Disease • Rheumatology

Inhibition of GABA metabolism by β-lactam antibiotics affects encystation in Acanthamoeba. (PubMed, Biomed Pharmacother) - "Cefotaxime, carbenicillin, and penicillin G significantly inhibited cyst formation without inducing cytotoxicity, whereas non-β-lactam antibiotics showed no such effect. These findings suggest that the inhibitory effect is associated with the β-lactam ring structure and may involve interference with GABA-mediated signaling pathways. Collectively, our study reveals a critical role of GABA metabolism in Acanthamoeba encystation and highlights β-lactam antibiotics as potential adjunctive agents for overcoming cyst-associated drug resistance in AK treatment."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Pain

Bacterial Profile and Antibiotic Resistance of ESKAPEE Pathogens Isolated in Intensive Care Units from Blood Cultures: A Cross-Sectional Study from Abu Dhabi, United Arab Emirates (2018-2022). (PubMed, Antibiotics (Basel)) - "Acinetobacter baumannii exhibited high resistance to Amikacin (81%), Meropenem (72%), and Imipenem (87%). Escherichia coli demonstrated resistance to Imipenem (42%) and Cefotaxime (54%)...Staphylococcus aureus showed resistance to Penicillin G (80%), Oxacillin (4%), and Ciprofloxacin (54%)...This brings into focus the need for appropriate infection control measures and strong antibiotic stewardship programs. The findings of the study support the ongoing efforts to deploy a better diagnostic tool for rapid pathogen identification, which is key in the targeted management of patients with bloodstream infection, especially in ICUs."

Journal • Observational data • Critical care • Infectious Disease • Pneumonia

Infected left ventricular thrombus confirmed by FDG PET/CT presenting as persistent Streptococcus anginosus bacteraemia in ischaemic cardiomyopathy: a case report. (PubMed, Eur Heart J Case Rep) - "He was managed with 6 weeks of intravenous benzylpenicillin followed by 6 months of oral amoxicillin, alongside warfarin anticoagulation. This case represents one of the few PET-confirmed infected LV thrombus presenting with persistent S. anginosus bacteraemia. It highlights the diagnostic value of multimodal imaging, particularly PET/CT in distinguishing infected thrombus from sterile thrombus and endocarditis, and underscores the importance of prolonged antibiotic therapy, anticoagulation, and multidisciplinary management."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Septic Shock • Thrombosis

ElastoMeric Infusion Pumps for Hospital AntibioTICs (EMPHATIC): A Feasibility Study. (PubMed, Antibiotics (Basel)) - "This proof of concept feasibility study shows that it may be feasible to use EMPs in the inpatient setting. There is potential to improve patient and staff experience; however, cost and residual volume are potential barriers to implementation, with further studies required."

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Aerobic Pathogens and Antimicrobial Susceptibility in Odontogenic Infections: A One-Year Observational Study from Southwestern Romania. (PubMed, Medicina (Kaunas)) - "remained susceptible to penicillin G (82.3%), amoxicillin-clavulanate (76.4%), and clindamycin (70.5%), but only 55.0% to erythromycin. Most S. aureus isolates were methicillin-susceptible (92.9%), while coagulase-negative staphylococci showed high methicillin resistance (59.3%) yet full susceptibility to linezolid, vancomycin, and teicoplanin. Enterobacterales were resistant to ampicillin (90%) and amoxicillin-clavulanate (65%) but remained susceptible to ceftriaxone (80%) and ciprofloxacin (85%)...aeruginosa isolates were fully susceptible to piperacillin-tazobactam, ceftazidime, cefepime, and meropenem...Surgical drainage remains central to management, and antibiotic therapy should be guided by local susceptibility patterns. These data provide baseline information to inform empirical therapy and stewardship efforts and highlight the need for multicenter studies including anaerobic and molecular analyses."

Journal • Observational data • Infectious Disease

The Domination of Penicillin G Degradation in Natural Surface Water: Effect of Calcium Ion and Biological Dissolved Organic Matter. (PubMed, Antibiotics (Basel)) - "The hydrolysis reaction mainly involved the cleavage of the ester bond in the β-lactam ring and a decarboxylation process, while photolysis degradation principally included the hydroxylation of the benzene ring and destruction of the thiazole ring. This study demonstrates the significant factors influencing hydrolysis and photolysis of penicillin antibiotics in an aquatic ecosystem, which can improve the estimates of ecological risk of antibiotic pharmaceuticals in a realistic environment."

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Genomic Characterization and Antimicrobial Resistance Profile of Streptococcus uberis Strains Isolated from Cows with Mastitis from Northwestern Spain. (PubMed, Antibiotics (Basel)) - "Susceptibility to 9 antibiotics (penicillin G, ampicillin, tetracycline, erythromycin, clindamycin, cefotaxime, ceftriaxone, levofloxacin, and moxifloxacin) was determined with VITEK®2. The use of antimicrobials to treat bovine mastitis has reduced the susceptibility of this microorganism to several antibiotics, underscoring the importance of monitoring antimicrobial use in veterinary practice. The results also highlight the high genetic diversity of the isolates, suggesting a strong capacity to adapt to different environmental conditions."

Journal • Infectious Disease

Anchoring MoO3 on magnetic nickel ferrite: A sustainable green nanocatalyst in conjunction with UV light irradiation toward efficient degradation of Penicillin G in water environments. (PubMed, IEEE Trans Nanobioscience) - "Various parameters such as pH, catalyst dosage, penicillin G concentration, and contact time were optimized to enhance the efficiency of the NiFe2O4@MoO3 nanocomposite in removing penicillin G. About 68% of penicillin G was decomposed under optimal conditions (pH = 9, nanocomposite dose: 0.8 g/L and penicillin G concentration: 10 mg/L). The results suggest that the photocatalytic process using the NiFe2O4@MoO3 nanocomposite is a promising method for the removal of penicillin G antibiotics from water."

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The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane-Anchored N-terminal Domain. (PubMed, Angew Chem Int Ed Engl) - "Saturation transfer difference (STD) Nuclear Magnetic Resonance experiments confirmed vancomycin, ampicillin and penicillin G binding to VraS, with the involvement of aryl protons from the antibiotics. VraS p-azido-L-phenylalanine mutants demonstrated participation of the extracellular loop of VraS in β-lactam binding. These results demonstrate that vancomycin and penicillins directly interact with VraS, an interaction that could be involved in activation of the cell wall stress stimulon and the mechanisms underlying antibiotic resistance."

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Susceptibility to Penicillin G and Ceftriaxone in Three Clinical Treponema pallidum Isolates is not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein. (PubMed, bioRxiv) - "We report that three modern Treponem a pallidum isolates carrying amino acid polymorphisms at positions 506, 625, and 708 of the penicillin-binding protein (PBP) Tp0705 are equally susceptible to penicillin G and ceftriaxone."

Journal • Infectious Disease

Visualizing and profiling de novo protein synthesis in Drosophila with cell-type specificity. (PubMed, Methods Cell Biol) - "Targeted expression of Penicillin G acylase (PGA) in a cell population of interest removes an enzyme-labile blocking group on PhAc-OPP, thus permitting OPP-dependent labeling of nascent proteins in that cell population. This method, which we call POPPi (PGA-dependent OPP incorporation), provides a versatile approach to visualize or identify proteins synthesized in cell populations of interest in vivo. Here, we provide detailed protocols for labeling newly-synthesized protein in Drosophila brain cell populations by POPPi followed by detection via immunofluorescence or by capture and protein identification."

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Activity of cloxacillin against Cutibacterium acnes: MIC evaluation and utility of gradient test. (PubMed, Infect Dis (Lond)) - "We aimed to compare MIC distributions of C.acnes to benzylpenicillin and cloxacillin. Gradient test results for cloxacillin showed high agreement with agar dilution (essential agreement 0.87), supporting its use as a practical alternative to agar dilution cloxacillin MIC determination if susceptibility testing is necessary. Our findings indicate that intravenous cloxacillin is an effective treatment of C. acnes infections, and that cloxacillin gradient testing is a convenient and reliable alternative for MIC determination for clinical laboratories."

Journal • Infectious Disease • Orthopedics

Comparing Basophil Activation Test and Specific IgE Assay in the Diagnosis of Allergy to Penicillin G and Ibuprofen. (PubMed, Iran J Allergy Asthma Immunol) - "Despite a lack of agreement between the positive results of the BAT and sIgE assay, five patients were identified by one of these methods. Despite positive BAT and sIgE results in two and three patients, respectively, the risks, high cost, and time-consuming nature of drug challenges render these tests valuable for reducing the number of patients who are candidates for a drug challenge."

Clinical • Journal • Allergy • Cardiovascular • Dermatology • Immunology • Urticaria

Clinical manifestations and treatment prognosis of patients with co-infection of ocular syphilis and HIV. (PubMed, BMC Ophthalmol) - "Co-infection of ocular syphilis and HIV predominantly affects the posterior segment, with optic neuritis exhibiting a distinct clinical profile. A comprehensive ocular and serological evaluations in high-risk populations is recommended."

Journal • Retrospective data • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Optic Neuritis • Retinal Disorders • Uveitis • Vasculitis