benzylpenicillin / Generic mfg. - LARVOL DELTA

Ocular Syphilis in Individuals with and Without HIV: A Single-Center University Hospital Experience. (PubMed, Pathogens) - "All patients received intravenous penicillin G or ceftriaxone, and systemic corticosteroids were administered in half of the cases. Clinical improvement was observed in all patients. Our findings highlight that ocular syphilis in PLWH is associated with more severe inflammation and higher neurosyphilis risk, underscoring the importance of routine cerebrospinal fluid examination and neurosyphilis-based treatment strategies in this group."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Uveitis

Clinical characteristics and diagnostic challenges of otosyphilis in patients with HIV coinfection: a retrospective analysis. (PubMed, AIDS Res Ther) - "Otosyphilis should be considered in individuals with HIV infection presenting with auditory symptoms, and syphilis testing should be performed in unexplained SNHL. Early recognition and appropriate treatment are critical to preventing irreversible hearing loss."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease • Otorhinolaryngology

Genomic Features and Antimicrobial Susceptibility of Listeria innocua Isolated from Raw Drinking Milk in Poland. (PubMed, Foods) - "All isolates were phenotypically susceptible to benzylpenicillin, ampicillin, meropenem, erythromycin, and trimethoprim-sulfamethoxazole. These findings underscore the importance of ongoing genomic surveillance of L. innocua in food environments and highlight the need to assess the potential risk posed by specific lineages, such as ST492, to food safety."

Journal • Immune Modulation • Immunology

A natural probioenzyme strategy as an effective alternative to antibiotics against multidrug-resistant Klebsiella pneumoniae in broilers: Benefits for growth, immunity, and organ health. (PubMed, PLoS One) - "Antimicrobial susceptibility testing showed bacterial resistance to penicillin G (100%) but complete sensitivity to colistin sulphate (100%). These findings demonstrate that dietary probioenzyme is a viable alternative to antibiotics, effectively mitigating K. pneumoniae infection while improving growth, organ health, and immune competence without contributing to antimicrobial resistance. This strategy supports sustainable poultry production and aligns with global efforts to reduce antibiotic reliance."

Journal • Infectious Disease • Pneumonia • CAT

Antimicrobial Susceptibility Patterns and Outcomes of Neonatal Early-Onset Sepsis over a Decade: Implications for Empirical Therapy in a Tertiary NICU. (PubMed, J Clin Med) - "All GBS isolates (n = 7) were susceptible to benzylpenicillin and vancomycin. Although 90% of E. coli were ampicillin-resistant, 90-95% remained susceptible to third-generation cephalosporins, piperacillin-tazobactam, and aminoglycosides...However, the widespread ampicillin resistance, particularly among E. coli strains, supports consideration of cephalosporin-aminoglycoside combinations or meropenem monotherapy when rapid beta-lactam bactericidal activity is clinically essential. Mortality was higher in E. coli EOS, though not statistically significant, and unrelated to ampicillin resistance."

Journal • Critical care • Infectious Disease • Septic Shock

Antibiotic Prophylaxis and Treatment of Neonatal Group B Streptococcus Disease in the Era of Antimicrobial Resistance. (PubMed, Antibiotics (Basel)) - "β-lactam antibiotics, including penicillin G and ampicillin, remain the cornerstone of both GBS prophylaxis and neonatal treatment, supported by sustained susceptibility, favorable pharmacokinetics, and extensive clinical experience. However, increasing global resistance to macrolides and lincosamides has markedly reduced the reliability of clindamycin and erythromycin, which are commonly used as second-line agents in women with severe penicillin allergy...Available surveillance data demonstrate substantial geographic variability in resistance but consistently low resistance to β-lactams and vancomycin...Alternative agents such as linezolid and teicoplanin exhibit activity against GBS, but their use remains limited by sparse neonatal data and pharmacokinetic variability. Ongoing antimicrobial surveillance, susceptibility-guided therapy, and stewardship initiatives are essential to preserve effective GBS prevention and treatment strategies."

Journal • Review • Allergy • Immunology • Infectious Disease • Septic Shock

Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort. (PubMed, Environ Health (Wash)) - "In couple-based analyses, sulfaclozine, roxithromycin, sulfamonomethoxine, erythromycin, and penicillin V were positively related to several early IVF reproductive outcomes, while sulfamethoxazole, penicillin G, chlorotetracycline, norfloxacin, florfenicol amine (FFA), sulfadiazine, cyadox, and sulfachloropyridazine were negatively related to early IVF outcomes. The association between parental antibiotic exposure and IVF outcomes requires further validation in a larger cohort of couples. Additionally, the extrapolation of our results to the general childbearing-aged couples requires caution as infertile couples may be more susceptible to antibiotics."

Journal • Preclinical • Gynecology • Infertility

Analysis of Pharmacist Interventions to Reduce Medication-Related Problems in a Neonatal Clinical Care Unit. (PubMed, Pharmacy (Basel)) - "343/873, 39.3% of interventions documented were from the Neonatal Intensive Care Unit, involving medications such as gentamicin (n = 46/343, 13.4%), benzylpenicillin (n = 37/343, 10.8%), caffeine (n = 34/343, 9.9%), parenteral nutrition (n = 23/343, 6.7%), and morphine (n = 16/343, 4.7%) and meropenem (n = 16/343, 4.7%)). (4) Regular analysis of pharmacist interventions provides valuable insights into local MRP trends and highlights opportunities for quality improvement and education."

Journal • Critical care

Pus-Forming Infections in an Advanced Care Hospital in Morocco: Enterobacterales Dominance With High Burden of Extended-Spectrum β-Lactamase Producers and Carbapenem Resistance. (PubMed, Cureus) - "The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in S. aureus was 14.75%; resistance to penicillin G among staphylococci was very high, whereas all staphylococcal and enterococcal isolates remained susceptible to vancomycin and linezolid...In P. aeruginosa, resistance to ceftazidime and/or carbapenems was modest (7.69%), and all isolates were susceptible to amikacin and colistin, whereas 75.0% of Acinetobacter spp...Fine-needle aspirates outperformed superficial swabs for pathogen detection. These findings support the use of deep sampling whenever feasible, regular updating of local antibiograms, and rational use of antimicrobial agents, particularly regarding third-generation cephalosporins and carbapenems, to optimize empirical therapy for pus-forming infections in this setting."

Journal • Infectious Disease • Pneumonia

Benzylpenicillin as a re-emerging therapeutic option for MSSA bacteraemia: results from a national surveillance study, Belgium, 2025 (ESCMID Global 2026) - No abstract available

Late-breaking abstract

Prevalence and phenotypic expression of blaZ-mediated penicillin G resistance in invasive methicillin-susceptible Staphylococcus aureus in Belgium national hospital surveillance (2022–2023) (ESCMID Global 2026) - No abstract available

Clinical

A population pharmacokinetic model of benzylpenicillin in patients with infective endocarditis to support individualised dosing strategies (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Cardiovascular

CUTIBACTERIUM INDUCED-PERICARDIAL EFFUSION IN A DIALYSIS PATIENT: A CASE REPORT (ACC 2026) - "This guided targeted therapy with penicillin G for six weeks and close follow-up imaging to monitor resolution. Cutibacterium acnes is a rare but significant cause of pericardial effusion. Accurate interpretation of cultures, prompt administration of antibiotics, and follow-up imaging are essential for achieving favorable outcomes."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Diabetic Nephropathy • Dyslipidemia • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Pulmonary Disease • Renal Disease

WHEN 'GOOD BACTERIA' GO BAD: LACTOBACILLUS ENDOCARDITIS IN COMPLEX CONGENITAL HEART DISEASE (ACC 2026) - "He was treated with 6 weeks of IV penicillin G with clearance of bacteremia and clinical improvement... This case underscores the potential for invasive infection in congenital heart disease and highlights probiotic exposure and GLP-1 therapy as possible contributors to bacterial translocation. Clinicians should maintain vigilance for unusual pathogens in high-risk patients and consider underlying immunodeficiency when evaluating recurrent or atypical infections."

Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hematological Disorders • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus • CD4

A case of refractory meningovascular syphilis followed up by vessel wall imaging (PubMed, Rinsho Shinkeigaku) - "The patient was treated with intravenous penicillin G for 14 days...This case highlights the utility of VWI in evaluating and monitoring cerebral vasculitis associated with MVS. However, VWI improvement did not correlate with clinical recovery, suggesting the need for further investigation into treatment strategies and prognostic indicators."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Infectious Disease • Pain • Subarachnoid Hemorrhage • Vasculitis

Cefazolin and benzylpenicillin cause less acute kidney injury than flucloxacillin in a global trial of Staphylococcus aureus bloodstream infection. (UKKW 2026) - "Introduction Staphylococcus aureus (S. Discussion Rates of AKI were found to be higher with (flu)cloxacillin than cefazolin or (benzyl)penicillin. These finding suggest that cefazolin and (benzyl) penicillin have clinical benefits over (flu)cloxacillin, with equivalent efficacy."

Clinical • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Pneumococcal serotype epidemiology and resistance after PCV13 replacement with PCV10, Sweden. (PubMed, J Infect) - "Serotypes 19A and 3 re-emerged as predominant, indicating the need for continued surveillance. Our study emphasises the risk of rapid serotype resurgence when lower-valency vaccines are reintroduced."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Isolation, Antibiogram and Factors Associated With Staphylococcus aureus From Fish at the Landing Site and Selected Restaurants in Central Gondar, Ethiopia: One Health Approach. (PubMed, Vet Med Sci) - "Over one-fourth of samples were contaminated with S. aureus, mainly due to poor hygiene and bare-hand handling, with high resistance to penicillin and tetracycline observed. Strengthened hygiene practices, routine resistance monitoring and continuous food safety training are recommended."

Journal • Infectious Disease

Distribution and Antibiotic Resistance Trends of Staphylococcus aureus: A 10-Year Retrospective Study. (PubMed, Microb Drug Resist) - "In conclusion, the prevalence of S. aureus infections within our hospital remains a significant concern. It is imperative to closely monitor the epidemiological distribution and ABR patterns of this pathogen to facilitate early intervention and guide appropriate therapeutic strategies."

Journal • Retrospective data • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pediatrics

Iberian Registry of Ocular Syphilis (IBERSOS) report 1: epidemiology, clinical spectrum and treatment outcomes of ocular syphilis in the Iberian Peninsula. (PubMed, Br J Ophthalmol) - "Ocular syphilis in the Iberian Peninsula shows a wide clinical spectrum and frequent posterior segment involvement. Most patients achieved favourable serological and visual outcomes. These findings support the effectiveness of standard therapies and highlight the need for early diagnosis, especially in high-risk populations."

Journal • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

Nisin and lysozyme as antibiotic alternatives in an extender for chilled canine semen. (PubMed, Anim Reprod Sci) - "One ejaculate from each of fifteen animals was diluted in Tris-citrate-fructose-egg yolk (TCF-EY) extender, and each ejaculate was divided into three groups: control-Antb (0.06 g/100 mL benzylpenicillin + 0.1 g/100 mL streptomycin), Nis (50 µg/mL nisin + 1.25 µg/mL EDTA), and Lys (500 µg/mL lysozyme)...Forty percent of the fresh samples had no bacterial growth, whereas some isolates were antibiotic-resistant. These results indicate that both nisin with EDTA and lysozyme exhibit promising bacteriostatic activity in chilled canine semen without compromising sperm characteristics."

Journal

Investigation of the cefazolin inoculum effect in blood culture-isolated methicillin-susceptible Staphylococcus aureus strains: A Japanese multicenter study. (PubMed, Diagn Microbiol Infect Dis) - "This study highlighted the low prevalence of CInE-presenting MSSA isolates in Japan. When the cefazolin MIC is ≥1 μg/mL or the penicillin G MIC is ≥0.25 μg/mL, the rapid nitrocefin test may be useful for considering the CInE in patients with high bacterial volume MSSA infections."

Clinical • Journal • Infectious Disease

Neurosyphilis Presenting With Syringomyelia: An Unusual Reversible Myelopathy (AAN 2026) - "Following a 14-day course of intravenous aqueous crystalline penicillin G, he showed significant motor recovery, improved bladder control, and a partial reduction of the syrinx on one month follow-up MRI... This case illustrates syringomyelia as a rare and reversible manifestation of neurosyphilis. Clinicians should consider syphilis in the differential diagnosis of unexplained syrinx formation or longitudinal spinal cord lesions. Early serologic testing and prompt antimicrobial therapy can lead to favorable neurological and radiologic outcomes."

CNS Disorders • Genetic Disorders • Infectious Disease • Inflammation

The Great Imitator Strikes Again: Neurosyphilis Mimicking Demyelinating and Vascular Disease (AAN 2026) - "Ophthalmology noted anterior/intermediate uveitis.He was treated with IV penicillin G for 14 days followed by benzathine penicillin. For vasculitis and myelitis, he received 3 days of IV methylprednisolone followed by oral prednisone taper... Neurosyphilis can present with a rare triad of transverse myelitis, vasculitic stroke, and uveitis. The differential included multiple sclerosis, neuromyelitis optica, infectious meningomyelitis, and systemic vasculitis, but diagnosis was confirmed with reactive CSF VDRL. This case emphasizes the importance of obtaining a thorough sexual history, recognizing CSF VDRL as the diagnostic gold standard, and initiating timely penicillin therapy, with adjunctive corticosteroids considered in cases of vasculitis or myelitis."

Cardiovascular • CNS Disorders • Infectious Disease • Multiple Sclerosis • Neuromyelitis Optica Spectrum Disorder • Ocular Inflammation • Ophthalmology • Rare Diseases • Urology • Uveitis • Vasculitis

Meningovascular Neurosyphilis Causing Multifocal Cerebral Infarcts in a Young Adult with Newly Diagnosed HIV/AIDS (AAN 2026) - "Empiric treatment was initiated with intravenous penicillin G on day 5; ART (bictegravir, emtricitabine, tenofovir alafenamide) started on day 8. This case highlights meningovascular neurosyphilis as a rare but important etiology of multifocal bilateral cerebral infarcts in young adults with HIV/AIDS. Clinicians should maintain high suspicion for neurosyphilis in patients with unexplained strokes, especially with atypical imaging and HIV risk factors. Early CSF analysis, serologic testing, and prompt antimicrobial therapy are essential to limit neurological morbidity."

Clinical • Cardiovascular • Human Immunodeficiency Virus • Infectious Disease • Ischemic stroke • Substance Abuse • Vasculitis • CD4