sulpiride / Generic mfg. - LARVOL DELTA

Targeting dopamine D2 receptors to alter fear extinction in adolescent rats. (PubMed, Behav Neurosci) - "Further, in contrast to what has been reported in past studies with adults, we did not observe any effect of sulpiride on adult female and male extinction recall (Experiment 4). Overall, these findings suggest that sulpiride may have sex-specific effects on extinction recall in adolescence, as has been reported in adults, though these effects appear to not be robust."

Journal • Preclinical • CNS Disorders • Mood Disorders • Psychiatry • DRD2

Pharmaco-EEG-Based Classification of Psychotropic Activity of a Novel Chromone-Containing Allylmorpholine in Rats. (PubMed, Adv Pharm Bull) - "Amplitude-spectral analysis using PCA resulted in 6 new principal components that accounted for 83.57% of the variance...CCAM 33a at doses of 100 and 300 mg/kg shows similar effects to hydroxyzine and sulpiride...The data obtained confirm the effectiveness of the combined use of NBC and PCA for classification tasks. The effects of the different doses of compound 33a on ECoG, as well as the abolition of the effects of apomorphine and 5-HTP in mice and rats, suggest a dopamine- and 5-HT2-blocking action of the molecule under study."

Journal • Preclinical • CNS Disorders

Involvement of D1- and D2-like dopamine receptors in the hippocampal CA1 region in mediating the restraint stress-induced analgesia in the rats. (PubMed, IBRO Neurosci Rep) - "This study's findings indicated that the administration of SCH23390 and sulpiride into the CA1 area of the hippocampus at the maximal doses (4 µg/0.5 µl; P < 0.001) markedly diminished the analgesic benefits of RS in the acute pain paradigm. The magnitude of estimated ED50s in the effect of these antagonists on reducing the RS-induced analgesia was 1.64 µg for SCH23390 and 2.79 µg for sulpiride, suggesting that both dopamine D1-like and D2-like receptors in the CA1 region of the hippocampus likely contribute to the analgesic effects of RS in the rats."

Journal • Preclinical • Pain

Correction of Psychoemotional Disorders in Perimenopausal Women with Uterine Fibroids: Clinical Efficacy of Sulpiride Therapy (ISGE 2026) - "Sulpiride (Prosulpin, 200 mg/day) demonstrates high efficacy and good tolerability for the correction of psychoemotional disorders in perimenopausal women with uterine fibroids. The drug contributes to rapid improvement in emotional well-being and reduction of vasomotor symptoms. Its use may be considered a non-hormonal therapeutic option in managing climacteric syndrome in patients with contraindications to hormonal therapy."

Clinical • Cardiovascular • CNS Disorders • Depression • Gynecology • Mood Disorders • Sleep Disorder • Solid Tumor • Uterine Leiomyoma • Women's Health

Consensus Molecules Associated with Parkinson's Disease. (PubMed, Neurol Int) - "Drugs include L-dopa (49%), carbidopa (63%), benserazide (50%), entacapone (74%), tolcapone (56%), rasagiline (76%), selegiline (46%), pargyline (4%), ropinirole (61%), pramipexole (56%), lisuride (27%), cabergoline (16%), bromocriptine (12%), and zonisamide (9%). Adjunctive therapies include droxidopa (33%), trihexyphenidyl (28%), biperiden (17%), amantadine (24%), memantine (7%), rivastigmine (13%), donepezil (6%), galantamine (4%), domperidone (6%), clonazepam (4%), tetrabenazine (16%), mazindol (13%), quetiapine (6%), and clozapine (4%). Contraindicated drugs include haloperidol (4%), sulpiride (3%), and methyldopa (6%)...Chemical inducers of PD include 6-hydroxydopamine (40%), N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 78%), tetrahydropyridine (77%), probenecid (4%), quinolinic acid (4%), 1,2,3,4-tetrahydroisoquinoline (TIQ, 16%), salsolinol (32%), rotenone (25%), and β-Methylamino-L-alanine (BMAA, 29%). Notably, our study highlights conditional essential..."

Journal • Review • CNS Disorders • Movement Disorders • Parkinson's Disease

Exploring Sulpiride as an Alternative to Testosterone Propionate for Inducing Benign Prostatic Hyperplasia in Rodent Models. (PubMed, Toxics) - "We also highlight the strengths and limitations of TP and sulpiride in replicating clinical symptoms and examine the toxicological effects of sulpiride on the kidney, testis, liver, and brain. We recommend the sulpiride model for the induction and studying of BPH, as it is readily accessible and closely mimics the pathogenesis of BPH in humans, unlike the TP model, which requires castration."

Journal • Preclinical • Review • Benign Prostatic Hyperplasia • ER

Linking Structural Features of Amisulpride and Sulpiride to Their Photoreactivity and Environmental Fate: The Role of NH2 Substitution in Photodegradation Behavior. (PubMed, Environ Sci Technol) - "Toxicity predictions showed that SUL photodegradation leads to detoxification, whereas AMI produces multiple transformation products with higher predicted toxicity. These findings demonstrate that -NH2 positional isomerism governs photoexcitation, indirect photoreactivity, and environmental risk."

Journal • CNS Disorders

Trait Neuroticism and the Nocebo Effect: The Mediating Role of Side-Effect Expectations. (PubMed, J Pers) - "These results suggest that negative expectations associated with neuroticism contribute to nocebo responses, potentially creating a feedback loop whereby negative expectations heighten side effects, reinforcing negative expectations in future treatments."

Adverse events • Journal

OBSESSIVE-COMPULSIVE DISORDER: A CASE REPORT ABOUT CULTURAL AND RELIGIOUS BARRIERS TO TREATMENT (WRMC 2026) - "We report the case of a 31-year-old Hispanic man with no prior psychiatric history, though with a past psilocybin, methamphetamine, and cannabis use, who was referred for intrusive violent and sexual thoughts, including images of harming others...In Japan, he was prescribed Sulpiride 50 mg and Estazolam 2 mg once daily, with minimal relief...He was started on Clonazepam 1 mg nightly, Fluoxetine 40 mg daily, and Risperidone 0.5 mg twice daily...Fluvoxamine 50 mg daily was initiated but self-discontinued due to palpitations...A sensitive, multidisciplinary approach that respected the patient's worldview while maintaining therapeutic alliance proved essential for adherence and improvement. Awareness of these barriers may guide clinicians in tailoring interventions that address both psychiatric symptoms and the patient's cultural context."

Case report • Clinical • Depression • Mood Disorders • Obsessive-Compulsive Disorder • Suicidal Ideation

Caffeine potentiates the dependence induced by central nervous system depressants contained in over-the-counter medications in mice. (PubMed, J Toxicol Sci) - "The period required for dextromethorphan, diphenhydramine, bromovalerylurea, and morphine to acquire place preference was shortened by co-administration with caffeine, demonstrating that CNS stimulation enhances the preference of these sedatives in mice. Moreover, the preference for these drugs was suppressed by the dopamine D1 receptor antagonist SCH23390, and by the dopamine D2 receptor antagonist sulpiride, suggesting that dopamine is involved in the enhancing effect. These findings underscore the need to reconsider the active ingredients and distribution practices of OTC products, as the prolonged or inappropriate use of OTC medications and polypharmacy increases the risk of dependence."

Journal • Preclinical • CNS Disorders • Psychiatry • DRD2

Mechanism of Antinociceptive Effect of Vanillin in Formalin Test. (PubMed, Int J Prev Med) - "Different groups of mice were pretreated with prazocin (2 mg/kg), yohimbine (5 mg/kg), propranolol (2 mg/kg), cyproheptadine (2 mg/kg), ondansetron (2 mg/kg), naloxone (5 mg/kg), sulpiride (20 mg/kg), arginine (100 mg/kg), L-NAME (20 mg/kg), methylene blue (5 mg/kg), or glibenclamide (10 mg/kg) to evaluate the role of pertinent receptors or pathways on vanillin-induced antinociception. Pretreatment with ondansetron, sulpiride, L-NAME, methylene blue, or glibenclamide prevented vanillin antinociceptive effect. Vanillin showed antinociceptive effect in formalin test, and according to the results, the NO/cGMP/KATP pathway and serotonin 5HT3 and dopamine D2 receptors have an important contribution to its antinociceptive effect, but opioid and adrenergic receptors are not involved in this effect."

Journal • DRD2

Single administration of vitamin C produces rapid antidepressant-like effects in female mice: A possible role of dopamine D2 receptor signalling. (PubMed, Brain Res) - "Our findings suggest that vitamin C may serve as an ideal candidate for the treatment of depression in females, potentially through the restoration of the D2R-BDNF pathway."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Psychiatry • BDNF • DRD2

Overall and Sex-Based Risk Factors for Hyperprolactinemia in Patients With Schizophrenia: A Retrospective Cohort Study. (PubMed, Curr Neuropharmacol) - "Multiple pharmacological and non-pharmacological factors contribute to HPRL in patients with schizophrenia, with notable sex-specific differences. The potential role of HPRL in breast cancer development among female patients requires further investigation."

Journal • Retrospective data • Breast Cancer • CNS Disorders • Oncology • Psychiatry • Schizophrenia • Solid Tumor

Evaluation of safety and efficacy of the combination of mebeverine and sulpiride in treatment of patients with functional gastrointestinal disorders: A prospective cohort. (PubMed, J Int Med Res) - "Among 253 patients, 227 patients (89.72%, 95% confidence interval: 85.96%-93.49%) demonstrated ≥50% improvement in the tailored gastrointestinal symptoms rating scale total score, whereas 26 (10.28%) did not report any improvement. In terms of safety, 2 (0.79%) patients reported diarrhea, 1 (0.4%) had mild dyspepsia, and 1 (0.4%) had galactorrhea.ConclusionOur results suggest that the combination of mebeverine and sulpiride may represent a safe and effective treatment option for patients with functional gastrointestinal disorders."

Clinical • Journal • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Pain

Fate, chlorination kinetics, and comprehensive risk assessment of pharmaceuticals and personal care products in drinking water distribution systems. (PubMed, J Contam Hydrol) - "Four compounds (atenolol, sulpiride, paroxetine, and nadolol) exhibited pseudo-first-order kinetics with residual chlorine, while the others exhibited significant resistance to chlorination...Ecological risk assessment revealed ibuprofen posed a moderate ecological risk, a risk quotient (RQ) of 0.335, while triclocarban presented a high ecological risk (RQ = 4.6031)...Among the detected PPCPs, meclofenamic acid was identified as the compound of highest concern, with average relative risk indices exceeding >10-4. These findings provide critical insights into the fate and transformation of PPCPs in drinking water systems and offer scientific guidance for optimizing treatment processes and risk management strategies."

Journal

Enhancing Identification Confidence in Non-Targeted Screening of Emerging Contaminants via an Ensemble Retention Time Prediction Model: Applications in Screening and Ecological Risk Assessment. (PubMed, Environ Pollut) - "Ecological risk assessment via toxicological priority index identified personal care products and pharmaceuticals as primarily high-risk ECs, with fipronil, ensulizole, lidocaine, amantadine, and sulpiride posing greatest risks. This ensemble framework provided precise RT prediction for NTS, improving EC detection efficiency and supporting risk management."

Journal

Exploration of neural mechanisms underlying antidepressant-like property of Ziziphora clinopodioides Lam. essential oil using mouse forced swimming test: Involvement of the monoaminergic systems. (PubMed, Curr Res Physiol) - "Moreover, naloxone (non-selective antagonist for opioid receptor subtypes, 1 mg/kg), prazosin (α1-adrenergic receptor antagonist, 1 mg/kg), yohimbine (α2-adrenergic receptor antagonist, 1 mg/kg), propranolol (β-adrenergic receptor antagonist, 2 mg/kg), WAY100635 (selective 5-HT1A receptor antagonist, 0.1 mg/kg), ondansetron (5-HT3 receptor antagonist, 1 mg/kg), haloperidol (non-selective dopamine receptor blocker, 0.2 mg/kg), SCH23390 (selective dopamine D1 receptor blocker, 0.05 mg/kg), sulpiride (selective dopamine D2 receptor blocker, 50 mg/kg) and flumazenil (GABAA/BDZ receptor antagonist, 10 mg/kg) were used to ascertain the neural pathways implicated in the antidepressant-like response of EOZC. However, this effect remained unaffected by naloxone, propranolol and flumazenil. These findings indicate that EOZC elicits antidepressant-like response, which relies on its interaction with noradrenergic, serotonergic and..."

Journal • Preclinical • Addiction (Opioid and Alcohol) • DRD2

ECHINATIN AS A MULTIMODAL MODULATOR OF MONOAMINERGIC SYSTEM: PRECLINICAL EVIDENCE FOR ANTIDEPRESSANT-LIKE ACTIVITY. (PubMed, Eur J Pharmacol) - "Male BALB/c mice received echinatin (20 or 30 mg/kg), fluoxetine (10 mg/kg) or reboxetine (20 mg/kg). The anti-immobility effect was abolished by serotonergic (PCPA, WAY-100635), noradrenergic (AMPT, phentolamine, propranolol) and dopaminergic (SCH-23390, sulpiride) interventions, but was not altered by ketanserin. These findings provide the first pharmacological evidence that echinatin elicits antidepressant-like effects through broad monoaminergic modulation and support its further evaluation as a potential lead compound for antidepressant drug development."

Journal • Preclinical • CNS Disorders • Mood Disorders • Psychiatry

Administration of the dopamine D2 auto-receptor agonist quinpirole in the nucleus accumbens decreases the effects of the nicotinic acetylcholine receptor agonist cytisine on oral ethanol self-administration in rats (Neuroscience 2025) - "The rats then received intra-accumbal injections of cytisine (0.0, 0.8, 1.6, 3.2 μg) or combinations of QUIN (0.0, 1.0, 2.0 μg) with cytisine (3.2 μg), or the DA D2 receptor antagonist sulpiride (0.0, 1.0, 2.0 μg) with QUIN (2.0 μg) and cytisine (3.2 μg)... The data indicated that intra-accumbal injections of cytisine significantly increased operant oral EtOH self-administration, while QUIN reduced the oral self-administration of EtOH induced by cytisine. Furthermore, the effects of QUIN were diminished with the administration of SULP. These findings suggest that the DA D2 auto-receptor agonist modulates the increases in oral EtOH self-administration caused by cytisine."

Preclinical • CNS Disorders

Sex-specific impact of prenatal methamphetamine exposure on the development of the juvenile dopaminergic system (Neuroscience 2025) - "Slice recordings of dynamic dLight activity were conducted following bath perfusion of METH at a low (1uM) or high (10uM) concentration in the presence or absence of DA transporter (DAT) blockade (10uM nomifensine) or D2R antagonism (10uM sulpiride). Future studies will focus on the age-specific developmental impact, assessing whether these effects persist through adolescence and adulthood and influence the sensitivity to the addictive potential of psychostimulants in later life. Ultimately, we hope this work will uncover the molecular implications of prenatal METH exposure on offspring DAergic pathway maturation and how disruptions in development of these circuits confer increased susceptibility to neuropsychiatric disease."

CNS Disorders • Mental Retardation • Psychiatry • DRD2

The cannabinoid CB1 receptor inverse agonist/antagonist activates adenylate cyclase/PKA signaling pathway among other well-recognized intracellular emetic signals to evoke vomiting in least shrews (Cryptotis parva) (Neuroscience 2025) - "SR141716A (20 mg/kg, i.p.)-induced vomiting occurred via both central and peripheral mechanisms as it was accompanied by robust emesis-associated increases in: i) c-fos- and phospho-glycogen synthase kinase-3α/β (p-GSK-3αβ)- expression in the shrew brainstem dorsal vagal complex (DVC), ii) phospho-extracellular signal-regulated kinase1/2 (p-ERK1/2) expression in both the DVC and jejunal enteric nervous system (ENS), iii) time-dependent upregulation of cAMP levels and phosphorylation of several protein kinases [protein kinase A (PKA; Ser338), protein kinase B (Akt; Ser473), GSK-3α/β (Ser21/9), ERK1/2 (Thr202/204), and protein kinase C αβII (PKCαβII; Thr638/641)] in the brainstem emetic loci, and iv) SR141716A-evoked emetic parameters were attenuated by diverse inhibitors/antagonists of: PKA (H-89), ERK1/2 (U0126 and PD98059), GSK-3 (AR-A014418 and SB216763), phosphatidylinositol 3-kinase (PI3K)-Akt pathway (LY294002), phospholipase C (PLC; U73122), PKC (GF109203X),..."

CNS Disorders • ARVA • FOS • PRKCB

Cerebellar Dopamine Signaling Shapes Network Activity: Receptor-Specific Mechanisms and Antipshychotic Modulation (Neuroscience 2025) - "Conversely, sulpiride (10 µM) did not affect basal PC activity but partially reversed the effect of clozapine (N=2, n=104), implicating D2 receptors in clozapine modulation of PC firing. Ongoing work is examining how the DA system influences plasticity. Moreover, these observations are being incorporated into computational models to predict the impact of DA and DAergic drugs on network dynamics in schizophrenia."

CNS Disorders • Psychiatry • Schizophrenia

In-vivo characterization of cerebellar modulation of prefrontal cortex activity in anesthetized mice (Neuroscience 2025) - "To investigate the nature of PrL responses, we locally superfused the PrL with antagonists of GABA-A receptors (gabazine), D1-like and D2-like dopamine receptors (SCH23390 and Sulpiride, respectively), and NMDA and AMPA glutamate receptors (NBQX, D-APV and 7Cl-kynurenate)...In vivo calcium imaging of multiple neurons is undergoing to obtain further insights on the nature of these electrophysiological results. Overall, these findings provide evidence for a complex cerebellar modulation of PrL activity."

Preclinical • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: potential repurposing for epilepsy treatment (Neuroscience 2025) - "These effects were blocked by the Kv7 inhibitor XE-991 and were not replicated by the D2 receptor antagonist (-)-sulpiride, confirming that the observed effects of JNJ-37822681 were specifically mediated via Kv7 channel activation. In vivo, JNJ-37822681 significantly reduced the severity and frequency of pentylenetetrazole-induced seizures in C57BL mice and sound-induced seizures in genetically epilepsy-prone DBA/2 mice, with a potency comparable to retigabine. Pretreatment with XE-991 attenuated the antiseizure effects of JNJ-37822681 in both models, further supporting a Kv7-dependent mechanism of action. Given its favorable safety profile in humans and lack of the chemical liabilities associated with retigabine, JNJ-37822681 represents a compelling candidate for further development of novel ASMs."

CNS Disorders • Epilepsy • DRD2 • KCNQ1OT1

The D2-like dopamine and opioidergic receptors have interactions in the CA1 region of the hippocampus in modulating the formalin-induced inflammatory pain. (PubMed, Brain Res Bull) - "Naloxone blocked the pain-relieving effects of Quinpirole, while Sulpiride reduced Morphine's analgesic responses in the CA1 region. These results suggest that understanding these interactions can help develop new medications to improve pain management and reduce risks associated with current opioid treatments."

Journal • Pain