sulpiride / Generic mfg. - LARVOL DELTA

Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats. (PubMed, Methods Protoc) - "The training set, relative to which the effects of the pharmacological agents from the test set were classified, were the matrices of effects of 12 pharmacological agents: the NMDA antagonist dizocilpine, the D2/D3 antagonists haloperidol and sulpiride, the M-anticholinergic tropicamide, the H1/5HT2A receptor blocker hydroxyzine, the acetylcholinesterase inhibitor galantamine, the alpha-2 adrenergic agonist dexmedetomidine, the alpha-2 adrenergic antagonist atipamezole, the adenosine receptor blocker caffeine and the GABA-mimetics aminophenylbutyric acid (phenibut), bromdihydrochlorophenylbenzodiazepine (phenazepam) and 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione. The test set included various drugs with tropism for the targets of the training set drugs: dopamine receptor antagonists chlorpromazine, droperidol, tiapride and raclopride, H1-histamine blockers diphenhydramine and promethazine, 5-HT2-receptor blockers ritanserin and glemenserin, acetylcholinesterase..."

Journal • Preclinical • Pain

Risk of hyperprolactinemia and extrapyramidal symptoms in antipsychotic-treated schizophrenia: a retrospective single-center real-world study. (PubMed, Front Pharmacol) - "Risperidone, paliperidone and sulpiride showed an increasing trend with elevated PRL levels, whereas quetiapine and aripiprazole were more frequently prescribed in the low-risk HPRL group. Based on homogeneous clinical real-world data, this study comprehensively evaluated multiple antipsychotic medications simultaneously. It provides empirical clinical evidence for individualized medication strategies in patients with comorbid HPRL and EPS, and offers real-world evidence for the clinical early risk recognition, and long-term medication decision-making among patients with multiple adverse reactions concurrently."

Journal • Real-world evidence • Retrospective data • CNS Disorders • Mental Retardation • Psychiatry • Schizophrenia • PRL

Visualizing synaptic disruptions in the release and regulation of dopamine hotspots in Huntington's Disease. (PubMed, J Neurosci) - "Compellingly, we found that D2-receptor (D2R) antagonist sulpiride drives increased fidelity of dopamine hotspot activity in wild type striatum but not in late-disease HD striatum, suggesting that D2R regulation of dopamine release is compromised in late HD...Furthermore, we demonstrate that D2-receptor signaling may be altered in late disease R6/2 HD mice, and that these disruptions are likely to drive decreased dopamine release fidelity over multiple stimulations. These findings suggest dopaminergic neurons projecting to the striatum as a potential therapeutic target for HD treatment to complement more commonly targeted medium spiny neurons."

Journal • CNS Disorders • Huntington's Disease • Movement Disorders • Psychiatry

Dopamine modulates striatal activity when controlling the output of working memory. (PubMed, J Neurosci) - "We fill this gap by directly testing the role of dopamine for both WM input-and output-gating in a double-blind, placebo-controlled within-subject fMRI study (N = 34; 23 female, 11 male human subjects), using a 400 mg oral dose of the dopamine D2 receptor antagonist sulpiride...It also made the brain's visual areas represent this information less clearly, and this change affected people's behaviour. Therefore, we conclude that dopamine in the striatum plays a role when our brain controls which information in working memory is sent to other parts of the brain to guide actions."

Journal • DRD2

A nicotinic-dopaminergic hybrid probe enhances D2-like autoreceptor-mediated inhibition of dopamine release. (PubMed, Biomed Pharmacother) - "Structure-guided modeling supports a plausible bitopic binding mode at D2R, in which the dopaminergic fragment is predicted to engage the orthosteric site while the nicotinic fragment may contact a secondary binding region, providing a working structural rationale for the observed inhibitory phenotype. Together, these data identify NiCh8 as a hybrid probe that functionally enhances sulpiride-sensitive D2-like autoreceptor-mediated inhibition of DA release and provides a basis for future studies testing the role of D2R secondary-pocket engagement."

Journal • CNS Disorders • Nicotine Addiction • Psychiatry • DRD2

Dopaminergic fronto-striatal connectivity underlies schema-dependent learning. (PubMed, J Psychopharmacol) - "Our findings give novel insights by showing that schema-dependent learning is modulated by dopamine, and they suggest that this relates to fronto-striatal connectivity."

Journal

Occurrence, temporal variation and environmental fate of psychoactive substances in wastewater treatment plant and receiving river | Poster Board #1509 (ACS-Fall 2026) - "Among antidepressants, venlafaxine, desvenlafaxine and amisulpride were the dominant compounds, with mean concentrations 575.98, 532.03 and 490.85 ng/L. Sulpiride and amisulpride were the main antipsychotic drugs...The consumption pattern of methamphetamine, MDA, ketamine and codeine shows a significant weekend effect. In the downstream receiving river, the concentrations of most PSs showed a decreasing trend with increasing distance from the WWTP effluent, whereas the concentrations of norketamine, benzoylecgonine and desvenlafaxinesome increased, indicating that bio-transformation and abiotic transformation processes occurred during the transport of pollutants in the aquatic environment."

CNS Disorders

Real-world antipsychotic prescribing patterns and mortality in schizophrenia: a registry cohort study from China. (PubMed, Epidemiol Psychiatr Sci) - "Antipsychotic treatment is associated with significantly reduced mortality among patients with schizophrenia in China, with effects varying by patient characteristics and drug regimen."

Journal • Real-world evidence • CNS Disorders • Mental Retardation • Psychiatry • Schizophrenia

Seizures associated with clozapine augmentation by other antipsychotics: a pharmacovigilance-pharmacodynamic analysis using VigiBase. (PubMed, Ther Adv Psychopharmacol) - "Among antipsychotics classified under ATC code N05A, DDIs with clozapine were detected for amisulpride, chlorpromazine, haloperidol, lurasidone, olanzapine, penfluridol, risperidone, sulpiride, zotepine, and zuclopenthixol. These findings suggest a potential role of dopamine D4 receptor occupancy in seizures associated with clozapine augmentation by other antipsychotics. Further large-scale epidemiological studies are needed to validate these findings."

Adverse events • Journal • PK/PD data • CNS Disorders • Epilepsy • Psychiatry • Schizophrenia

Real-World Antidepressant Treatment Persistence in Children and Adolescents with Major Depressive Disorder in Japan: A Retrospective Nationwide Claims-Based Study. (PubMed, Neuropsychiatr Dis Treat) - "The most frequently prescribed initial antidepressant was sulpiride (30.0%)...Relatively high persistence was observed among those prescribed SSRIs or SNRIs as their initial antidepressant treatment and those who received clinical interventions provided by mental health specialists. Given the claims data and no clinical severity measures, these findings should be interpreted with caution."

Journal • Real-world evidence • Retrospective data • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pediatrics • Psychiatry

Sulpiride-Induced Severe Hyperprolactinemia in an IBS Patient: A Case Report From Saudi Arabia. (PubMed, AACE Endocrinol Diabetes) - "Monitoring hyperprolactinemia is critical in patients receiving Sulpiride, especially when prescribed for nonpsychiatric cases like irritable bowel syndrome. Regular checks and cautious off-label prescribing are crucial for prompt identification and discontinuation of the medication to prevent long-term endocrine issues."

Journal • Endocrine Disorders • Gastrointestinal Disorder • Gynecology • Oncology • Pituitary Gland Carcinoma • Psychiatry • PRL

Dopamine D2-like receptors differentially shape GABAergic plasticity in distinct subtypes of hippocampal VIP interneurons. (PubMed, Sci Rep) - "We show that D2Rs activation with quinpirole upregulated the amplitude of miniature inhibitory postsynaptic currents (mIPSCs) in IS, while analogous result was observed in non-IS VIP INs upon D2Rs blockade with sulpiride and these effects were accompanied by prolongation of mIPSC decay. Notably, D2R agonism, but not antagonism, impaired NMDA-evoked iLTP in IS VIP INs, consistent with occlusion. Collectively, these findings reveal cell-specific and D2R-dependent GABAergic plasticity phenomena in IS and non-IS VIP INs."

Journal

L-Carnitine Improves Visceral Hypersensitivity and Colonic Hyperpermeability in a Rat Model of Irritable Bowel Syndrome. (PubMed, Neurogastroenterol Motil) - "L-Carnitine prevents visceral hypersensitivity and colonic hyperpermeability in IBS models via mechanisms involving brain orexin, as well as central muscarinic, dopamine D2, nitric oxide, AMPK, and PPAR-γ signaling. These findings suggest that L-carnitine may represent a promising therapeutic option for IBS."

Journal • Preclinical • Gastrointestinal Disorder • Immunology • Pain • DRD2

Galactagogue activity of shalukam (Nelumbium speciosum Willd rhizome) compared to domperidone in Wistar albino rats. (PubMed, Front Pharmacol) - "Commonly used galactagogues include domperidone, metoclopramide, chlorpromazine, and sulpiride. The results suggest that the trial drug double-dose group demonstrated better galactagogue activity than the standard drug domperidone group in parameters serum prolactin and cortisol levels and trial drug single dose group demonstrated better galactagogue activity than the standard drug domperidone group in parameters serum prolactin and milk yield of 10 days. The findings suggests that the double dose group demonstrates stronger galactagogue potential."

Journal • Preclinical • Anesthesia • Cardiovascular • Dental Disorders • Gastroenterology • Gastrointestinal Disorder • Hypertension • Mood Disorders • Pain • Psychiatry • Xerostomia • PRL

Dopaminergic Effects on Schema-Dependent Memory Revealed by Aperiodic EEG Dynamics (OHBM 2026) - "In our recent fMRI study using the same pharmacological manipulation, administration of the dopamine D2 receptor agonist bromocriptine and the D2 receptor antagonist sulpiride, we observed behavioral and functional effects consistent with dopaminergic modulation of semantic memory benefits under placebo conditions (Yousuf et al., 2025). During the encoding phase, responses were faster for congruent than for incongruent trials (F(1,83)=53.12, p 0.1). During the recognition phase, corrected high-confidence hit rates were higher for congruent than for incongruent words (F(1,83)=452.133 , p 0.1)."

CNS Disorders • DRD2

Dopaminergic modulation of large-scale brain activity in reversal learning (OHBM 2026) - "In a cross-over, placebo controlled design, 100 healthy participants completed three fMRI sessions in which they performed a reversal learning task following a single dose of 220 mg methylphenidate, 400 mg sulpiride, and placebo. Ongoing analyses will apply dimensionality reduction techniques to the BOLD timeseries to establish low-dimensional, dynamic neural signatures associated with contextual prediction errors. Together these findings suggest that dopamine plays a critical role in updating learning rates and highlights distinct neural substrates underlying enhanced versus impaired reversal learning under pharmacological modulation."

CNS Disorders

Investigating Immune Microenvironment of Inflammatory Bowel Disease and the Mitochondrial Metabolism-Related Molecular Mechanisms: Combining a Multiomics Approach and Experimental Validation. (PubMed, OMICS) - "Additionally, therapeutic drugs targeting key genes were predicted, including cimetidine, eugenol, chlortetracycline, vincristine, irinotecan, bisacodyl, and sulpiride, with molecular docking validating high affinity between these drugs and key targets. This study constructed a multiomics integrated analysis strategy and identified MRPL35 and MRPL39 as potential markers and therapeutic targets, providing new insights for the diagnosis and treatment of IBD."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • CD4 • CD74 • CXCR4 • ITGB2 • SDC1 • XIST

MORDOR: REALITY MONITORING AND DOPAMINE (clinicaltrials.gov) - P=N/A | N=39 | Recruiting | Sponsor: Hôpital le Vinatier | Trial primary completion date: Jun 2026 ➔ Jan 2027

Trial primary completion date

Antipsychotic selection in combination with electroconvulsive therapy for acute schizophrenia: differential efficacy and safety profiles from a real world study. (PubMed, BMC Psychiatry) - P=N/A | "In this observational study of patients with acute phase schizophrenia, the comparative effectiveness and tolerability of antipsychotic medications combined with ECT appeared to differ depending on the specific agent used. These preliminary observations require confirmation in randomized controlled trials before guiding individualized treatment selection."

Journal • Real-world evidence • CNS Disorders • Psychiatry • Schizophrenia

Effect of aripiprazole on cytokine production by T cells in schizophrenia (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "Aripiprazole may exert anti-inflammatory effects in schizophrenia by inhibiting the secretion of pro-inflammatory cytokines by T cells. This effect is likely mediated through D2DR activation."

Journal • CNS Disorders • Psychiatry • Schizophrenia • DRD2 • IFNG • IL17A

Case report: Could hikikomori be a specific presentation of psychotic decompensation in people with autism spectrum disorder? (PubMed, Psychiatr Pol) - "In the case of a 10-year-old boy with ASD, sulpiride brought an improvement in social withdrawal, which, together with the symptoms presented by him, may indicate the possibility of psychotic decompensation in the form of hikikomori. Due to the lack of therapeutic guidelines for the management of people with hikikomori, this may be a valuable guideline for the implementation of appropriate pharmacotherapy by clinicians, in which attention should also be paid to frequently occurring other psychiatric disorders."

Journal • Autism Spectrum Disorder • CNS Disorders • Genetic Disorders • Mental Retardation • Mood Disorders • Personality Disorder • Psychiatry

Repurposing Cimetidine as a Therapeutic Candidate for Irritable Bowel Syndrome in a Rat Model. (PubMed, Fundam Clin Pharmacol) - "These findings suggest that cimetidine prevents visceral hypersensitivity and colonic hyperpermeability in IBS models through mechanisms involving central orexin signaling possibly triggered by NHE inhibition, NO, and central muscarinic and dopamine D2 receptor pathways. These findings may provide a basis for future therapeutic approaches targeting IBS."

Journal • Preclinical • Gastrointestinal Disorder • Immunology • Pain • DRD2 • TLR4

Identification of Dopamine D2 Receptor as a Direct Target of Salidroside and Tyrosol by Integrated Transcriptomic and Biophysical Approaches. (PubMed, Pharmaceuticals (Basel)) - "DRD2 antagonist sulpiride pre-intervention and small interfering RNA (siRNA)-mediated DRD2 knockdown were conducted to verify the receptor dependence of the compounds' effects... These findings identify DRD2 as a direct molecular target of salidroside and tyrosol and provide mechanistic insight into their dopaminergic regulatory effects. This study highlights the utility of CMap-guided target discovery combined with rigorous experimental validation for elucidating the molecular mechanisms of natural products."

Journal • DRD2

The activity of D2 dopamine receptors of the ventral tegmental area changed the induced- cognitive responses of the lateral hypothalamic cholinergic stimulation following neuropathic pain. (PubMed, Brain Res) - "The present study suggest that the analgesic and memory enhancer effects which produced by LH cholinergic stimulation is mediated by D2-like dopamine receptors of VTA in neuropathic pain. Additionally, the cholinergic stimulation of LH via citicoline can increase firing rate of VTA neurons during neuropathic pain and intra-VTA injection of sulpiride effectively reversed the effects of citicoline on firing rate of VTA neurons."

Journal • Cognitive Disorders • Neuralgia • Pain • DRD2

NL6220204217: HAMLETT. Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment. A study comparing continuation versus discontinuation/dose reduction of antipsychotic medication in patients remitted after a first episode of psychosis (clinicaltrialsregister.eu) - P4 | N=444 | Active, not recruiting | Sponsor: Universitair Medisch Centrum Groningen | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • CNS Disorders • Psychiatry