MyMiR (HC2101) / Zhejiang Haichang Bio-Tech - LARVOL DELTA

Strength training and sarcopenia-a mandatory link: focus on MicroRNAs. (PubMed, Front Aging) - "Some of them are expressed differently by subjects affected by sarcopenia (as happens in various forms of cancer or other diseases). Therefore, monitoring a specific signature of microRNAs can better clarify the etiopathology of sarcopenia, providing an early biomarker for sarcopenia (currently, there are some hypotheses, but none is well recognized), and even serve as the basis for the development of drugs."

Journal • Review • Oncology • Sarcopenia

MyomiR-133b suppresses colorectal cancer cell proliferation and modulates expression of multiple gene targets (EACR 2025) - "This study provides evidence that myomiR-133b suppresses CRC proliferation, which may be mediated through the regulation of transcription factors (SRF), deacetylases (Sirtuin1, HDAC4) and genes related to cancer cell proliferation and apoptosis (P53, LIF). The mechanisms of tumour-suppressing effect of exercise-conditioned human plasma will require further research. Grant support: VEGA-2/0144/23, Sedlárová-Rabanová scholarship, APVV 19-0411, APVV 23-0604"

Colorectal Cancer • Genetic Disorders • Obesity • Oncology • Solid Tumor • HDAC4 • MIR133B • SIRT1 • TIMP1

microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy. (PubMed, Mol Ther Nucleic Acids) - "miR-133a is a muscle-enriched non-coding RNA (myomiR) involved in muscle development and function and is implicated in the regulation of the XLMTM modifier gene DNM2...Moreover, we show that miR-133a expression in treated Mtm1 KO mice positively correlates with treatment response and was shown to have high discrimination accuracy for XLMTM by linear discriminant analysis (79%-90%) and receiver operating characteristic curve analysis (AUC >0.80). These results support miR-133a as a robust, circulating biomarker that reflects disease severity and treatment response in XLMTM."

Journal • CNS Disorders • Myositis • Pediatrics

Muscle-specific miRNAs in plasma and skeletal muscle of patients with idiopathic inflammatory myopathy are modulated by disease and training. (PubMed, Rheumatology (Oxford)) - "Lower myomiR levels in skeletal muscle of IIM patients might indicate reduced muscle regenerative potential in IIM, which could be linked to inflammation, metabolic dysfunction, and immunosuppressive therapy. Training-induced changes of muscle and plasma myomiRs indicate an increase in myomiRs release, which could contribute to the adaptive response underlying the positive systemic effects of exercise in IIM."

Journal • Inflammation • Metabolic Disorders • Myositis • MIR133B • MIR206

Extracellular vesicle miR-206 improves chronic binge alcohol mediated decreased myoblast differentiation in SIV-infected female macaques. (PubMed, Am J Physiol Cell Physiol) - "Myotube and myotube derived EV myomiR expression, including miR-206, was lower in the CBA/SIV group...Similarly, EV-mediated delivery of miR-206 increased both fusion index and myotube density of CBA/SIV-derived myoblasts. These results support the potential therapeutic utility of EVs in delivering myomiRs to improve SKM stem cell differentiation."

Journal • Human Immunodeficiency Virus • Infectious Disease • HDAC4 • MIR206 • PAX7

Increased Expression of MiRNA-1 Contributes to Hypobaric Hypoxia-Induced Skeletal Muscle Loss. (PubMed, Adv Biol (Weinh)) - "Studies found the potential role of miR-1 (myomiR) as a biomarker under different atrophic conditions...This study indicates the increased expressions of miR-1 and reduced expression of PAX3 and HSP70 lead to impaired myogenesis in skeletal muscle under HH. Further, enhanced expression of muscle degradation genes such as FOXO3, MSTN, and ATROGIN under HH exposure causes skeletal muscle protein loss."

Journal • Muscular Atrophy • FOXO3 • PAX3

EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method. (PubMed, Mol Ther Nucleic Acids) - "Furthermore, we observed pro-myogenic effects with undifferentiated myoblast-derived EVs, in which myomiR concentrations are even lower, suggestive of a myomiR-independent mechanism underlying the observed pro-myogenic effects...Specifically, co-purification of insulin (a component of Opti-MEM) in non-EV LC fractions and polymer precipitated EV preparations. These findings provide further evidence that polymer-based precipitation techniques should be avoided in EV research."

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