hyoscine butylbromide oral / Generic mfg. - LARVOL DELTA

Decoding the Neuroprotective Intervention of Angiotensin Receptor Blockers: A Multimodal Approach Using In Silico Network Pharmacology, Molecular Modeling, and In Vivo Validation of Key Markers. (PubMed, ACS Chem Neurosci) - "Building on these findings, this study sought to compare the activity of azilsartan with other commonly used ARBs, including telmisartan, olmesartan, valsartan, eprosartan, irbesartan, and candesartan, using an integrative network pharmacology approach. To experimentally validate these predictions, in vivo studies were conducted in a scopolamine-induced memory-impaired model, which demonstrated significant restoration of the levels of AKT1 and PIK3CA. These findings clearly demonstrate the PI3K/AKT modulating effects of azilsartan, reinforcing its repurposing potential in dementia and related disorders, thereby expanding novel therapeutic opportunities within this drug class."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Dementia • AKT1 • PIK3CA • PIK3CB

A Novel Probiotic Limosilactobacillus fermentum IOB802 and Its Postbiotic Alleviate Cognitive Impairment Induced by Scopolamine in Mice. (PubMed, Foods) - "These findings suggest that IOB802 and its postbiotic can improve cognitive function through enhancing cholinergic activity, reducing oxidative stress, providing neuroprotection, and restoring gut microbiota composition. Postbiotics, in particular, may represent a promising alternative to live probiotics for supporting cognitive health."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • BDNF • IL1B • IL6 • TNFA

Scopolamine induced learning deficit in marmosets. (PubMed, Res Sq) - "Although the averaged data revealed no impact of acute or chronic scopolamine injections on learning, modeling the choice data with trial-level analysis revealed both age- and sex-specific deficits. The results demonstrate the value of home-cage testing combined with trial-level analysis to reveal subtle behavioral changes, such as those brought about by scopolamine."

Journal • Cognitive Disorders

GC-MS/MS and LC-MS/MS Identification of Opium and Tropane Alkaloids in Pottery from Funnel Beaker Culture Sites in South-Eastern Poland. (PubMed, Materials (Basel)) - "Papaverine was identified in three artifacts (N1, N2, G2) using GC-MS/MS, and its presence was independently confirmed in two of these vessels (N1, N2) by LC-MS/MS. In one miniature vessel (D1), trace amounts of tropane alkaloids-scopolamine and presumptive atropine-were detected following derivatization...The analytical results indicate that psychoactive plant derivatives could have been intentionally used and stored in selected FBC vessels, supporting interpretations related to ritual or medicinal practices. The validated procedures developed in this work provide a robust framework for the detection of unstable biomolecular residues in prehistoric ceramics and can be applied to future archaeometric and materials-science research."

Journal

Death rattle : what is the appropriate management ? (PubMed, Rev Med Suisse) - "Anticholinergics should therefore be limited to situations in which the death rattle causes significant distress for relatives or discomfort for the patient. Among the available agents, scopolamine butylbromide and glycopyrronium show a more favorable tolerance profile."

Journal

Tropine alkaloid-driven panomic (transcriptome-metabolome) reprogramming delivers insights into cold stress tolerance in rapeseed (Brassica napus L.). (PubMed, Plant Physiol Biochem) - "In this study, we investigated the role of scopolamine (SCOP; a "tropine alkaloid" and close to "neurotransmitters") in mediating cold tolerance in rapeseed...Collectively, our results provide a deeper understanding of the TA-mediated cold response independent of the traditional CBF pathway, highlighting its role in carbon reallocation, cell wall reinforcement, and reactive oxygen species scavenging. In short, this study offers significant insights into the molecular mechanisms by which SCOP regulates cold tolerance in rapeseed, and identifies new targets for future engineering applications to fast-track stress-smart breeding for crop improvement."

Journal

A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of Hyoscine Butylbromide Capsules for Preoperative Preparation in Painless Gastrointestinal Endoscopy Procedures (clinicaltrials.gov) - P=N/A | N=74 | Not yet recruiting | Sponsor: Shanghai Jiao Tong University School of Medicine

New trial • Pain

Benzylpiperidine-pyridazin-3(2H)-one derivatives as potential multifunctional agents against Alzheimer's disease. (PubMed, Eur J Med Chem) - "In vivo evaluation demonstrated that 7a effectively ameliorated scopolamine-induced cognitive impairment in the Morris water maze, which was associated with restored cholinergic function and mitigated oxidative stress in mice. The synergistic multi-target efficacy combined with favorable pharmacokinetic properties underscores its potential as a disease-modifying therapeutic agent for AD."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • Pain

Yangxue Qingnao Wan ameliorates cognitive impairment in scopolamine-induced AD mice via modulating neuropeptide signaling pathways and suppressing neuroinflammation. (PubMed, Phytomedicine) - "YXQNW alleviates AD-like pathology by restoring cholinergic homeostasis, suppressing oxidative stress and neuroinflammation, and regulating neuropeptide signaling. And its active ingredient (Palmatine) can inhibit inflammatory response by regulating the expression of Gpr139 protein. This study supports YXQNW's clinical application and provides novel insights for AD drug discovery."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation

Scopolamine exerted antidepressant-like behavioral effects via restoring the synaptic plasticity in CRS-treated mice. (PubMed, Metab Brain Dis) - No abstract available

Journal • Preclinical

ASTRAL: Efficacy and Safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea (clinicaltrials.gov) - P3 | N=238 | Recruiting | Sponsor: EMS | Not yet recruiting ➔ Recruiting

Enrollment open • Pain • Women's Health

Pterostilbene mitigates scopolamine-induced cognitive impairment by modulating cholinergic pathway and reducing neuroinflammation. (PubMed, Phytomedicine) - "Our findings establish Pte as a novel dual-target therapeutic agent that simultaneously modulates cholinergic function and directly inhibits NLRP3-mediated pyroptosis. The MCC950 competition assay provides evidence of Pte's NLRP3-targeting specificity, offering a promising multi-target alternative to conventional single-pathway treatments for cognitive impairment."

Journal • Cognitive Disorders • Inflammation • NLRP3

Emerging of a new neuroprotective isoflavonoid with potent Keap1/Nrf2/ARE pathway activation and AChE inhibition. (PubMed, Bioorg Chem) - "Notably, it markedly upregulated vital antioxidant defense systems and efficiently inhibited the AChE (IC50 = 14.79 μM), surpassing the efficacy of the reference drug rivastigmine (IC50 = 24.5 μM). Furthermore, compound 32 significantly ameliorated memory impairment and the neuroinflammation associated with scopolamine-initiated cognitive dysfunction in a zebrafish model. Collectively, this study identifies compound 32 as a promising dual-acting neuroprotective lead, offering potential value for advancing therapeutic strategies in AD drug development."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • Pain

Motion Sickness: Multiple Linear Regression Identifies Behaviours Linked to Motion-Induced Emesis in Suncus murinus (House Musk Shrew). (PubMed, Eur J Pharmacol) - "Administration of two anti-MS drugs, diphenhydramine (30 mg/kg, s.c.) and scopolamine (10 mg/kg, s.c.), significantly reduced the MS symptom score from 14.25 ± 1.89 to 7.84 ± 0.85 and from 18.11 ± 2.28 to 11.91 ± 0.87 respectively, indicating the validity of the scoring system as a quantitative measure of motion-induced 'sickness', 'malaise', and even 'nausea' in this species. Shapley additive explanation (SHAP) analysis further indicated the contributions of two individual spontaneous behaviours, stationary duration and chin on the floor episode, to MS prediction. Our findings suggest that this behavioural scoring system provides a reliable and translationally relevant tool for studying MS and screening potential anti-emetic treatments for humans."

Journal

Protective effects of clinical anticholinergic and anticholinesterase agents against Bungarus multicinctus venom and neurotoxin-rich snake venoms. (PubMed, PLoS Negl Trop Dis) - "This study investigated the protective effects of clinically standard anticholinergic and anticholinesterase agents-scopolamine, neostigmine methylsulfate, bethanechol chloride, pilocarpine hydrochloride, and atropine sulfate-against different bungarotoxins and wide distribution neurotoxin-rich crude snake venoms (B. Upon confirming victims were bitten by B. multicinctus, administering atropine sulfate or neostigmine methylsulfate as emergency treatment might provide supplementary benefits for subsequent care. Importantly, the administration of clinic used drugs does not interfere with the efficacy of B. multicinctus antivenin in later treating stages."

Journal

Stability of expired tropane alkaloid ampoules using HPLC-UV/CAD. (PubMed, J Pharm Biomed Anal) - "The results indicated a high stability of atropine, with a determined content of 101.9 % and a small amount of degradation products. Scopolamine, however, showed higher degree of degradation with a remaining content of 68 %."

Journal

Scopolamine induced learning deficit in marmosets. (PubMed, bioRxiv) - "Although the averaged data revealed no impact of acute or chronic scopolamine injections on learning, modeling the choice data with trial-level analysis revealed both age- and sex-specific deficits. This deficit was hidden in session-averaged measures and only became evident in trial-level modeling of the choice data. Our findings demonstrate that cholinergic blockade impairs the dynamics of learning in marmosets and highlights the value of trial-level analysis for detecting nuanced pharmacological effects on primate cognition."

Journal • Cognitive Disorders

Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs. (PubMed, J Am Chem Soc) - "Hyoscyamine 6β-hydroxylase (H6H) is a mononuclear nonheme iron and 2-oxoglutrate dependent oxidase responsible for the biosynthesis of the tropane alkaloid scopolamine...The results suggest that additional factors, which include H-bonding interactions that stabilize intermediary hydroxy-ferric complexes against rebound, are likely at play in determining the fate of the individual substrate radicals. These effects are both important and expected to correlate with substrate-cofactor disposition."

Journal • Addiction (Opioid and Alcohol)

Using Subcutaneous Hyoscine Butylbromide in A Terminal Patient with Myasthenia Gravis: A Case Report. (PubMed, J Pain Palliat Care Pharmacother) - "A trial of hyoscine butylbromide was effective in treating the death rattle, while the myasthenic symptoms remained quiescent. To our knowledge, this has not been reported previously."

Journal • CNS Disorders • Immunology • Myasthenia Gravis

Inhibitory Effect of Lidocaine on Duodenal Peristalsis During Endoscopic Retrograde Cholangiopancreatography: A Multicenter, Randomized Controlled Trial (With Video). (PubMed, DEN Open) - "Conventional antispasmodics used during endoscopic retrograde cholangiopancreatography (ERCP), such as hyoscine butylbromide and glucagon, are often contraindicated in elderly patients with comorbidities...In our limited cohort, lidocaine inhibited duodenal peristalsis during ERCP without adverse events, suggesting its potential as a safe and practical option (jRCT No. 031190059)."

Journal • Video

In Vitro and In Silico Assessment of Datura stramonium Flower Alkaloids as Multi-Target Inhibitors of Biofilm Formation, Xanthine Oxidase, and Tyrosinase Enzymes. (PubMed, Chem Biodivers) - "In this study, three alkaloids, pyrrolezanthine 1, hyoscine 2, and atropine 3, were isolated from Datura stramonium flowers and evaluated for their inhibitory activities against bacterial biofilm formation, xanthine oxidase (XO), and tyrosinase enzymes using both in vitro and in silico studies...Network pharmacology studies of compounds 2 and 3 identified the inflammatory targets and the potential mechanisms underlying their therapeutic effects. These results suggest that tropane alkaloids isolated from D. stramonium hold promising activities as multi-target drug candidates for treating gout, hyperpigmentation, and resistant bacterial infections."

Journal • Preclinical • Gout • Infectious Disease • Inflammatory Arthritis • Rheumatology • Tyrosinase

Comparison of the Effects of Hyoscine-N-Butylbromide and Ondansetron on Postoperative Nausea-Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study. (PubMed, Niger J Clin Pract) - "The effects of hyoscine-n-butylbromide and ondansetron on PONV and pain are similar in laparoscopic cholecystectomy. In laparoscopic cholecystectomies, hyoscine-n-butylbromide is a good alternative for PONV prophylaxis in eligible patients."

Clinical • Journal • Pain

RETRACTED: Abo Mansour et al. The Potential Neuroprotective Effect of Thymoquinone on Scopolamine-Induced In Vivo Alzheimer's Disease-like Condition: Mechanistic Insights. Molecules 2023, 28, 6566. (PubMed, Molecules) - "The journal retracts the article "The Potential Neuroprotective Effect of Thymoquinone on Scopolamine-Induced In Vivo Alzheimer's Disease-like Condition: Mechanistic Insights" [...]."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders

Administration of Cilostazol Mitigates Learning and Memory Disturbance in a Rat Model of Amnesia by Modifying Cholinergic Function and Neuroinflammation. (PubMed, Mol Neurobiol) - "To investigate the neuroprotective mechanisms of Cil, oral treatment with Cil and donepezil (DNP, positive control) was administered over three weeks. Additionally, Cil and DNP elevated hippocampal levels of sulfhydryl groups (P = 0.01-P"

Journal • Preclinical • CNS Disorders • Cognitive Disorders • Inflammation • CHRM1 • IL1B • TNFA

Protective role of fucoidan against cognitive deficits and redox imbalance in a scopolamine-induced Alzheimer's disease model in rats. (PubMed, Sci Rep) - "Fucoidan (15-60 mg/kg) or donepezil (1 mg/kg) was administered prior to behavioral tests over three consecutive weeks...A significant decrease in the mean Q2 time was observed during the probe trial in the water maze task after scopolamine injection on the test day...Biochemical analysis demonstrated a decline in protein carbonyl and malondialdehyde levels, along with an elevation in reduced glutathione and total antioxidant capacity in the fucoidan-treated rats (15-60 mg/kg). It is supposed that cholinergic dysfunction and oxidative stress are key contributors to cognitive deficits, and fucoidan may protect the hippocampus and prefrontal cortex by mitigating oxidative damage biomarkers."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders