ALN-4324
/ Alnylam
- LARVOL DELTA
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December 10, 2025
Uncovering the Structural Logic of Grb7: From Domain Mutagenesis to Therapeutic Implications in Cancer Signaling.
(PubMed, J Mol Recognit)
- "Grb7 is a member of the Grb7 protein family, which also includes Grb10 and Grb14...Truncating the distorted poly-proline region of Grb7 improved its model quality. Collectively, the results provide additional insight into the regulatory mechanisms of Grb7 and may aid in the development of Grb7-signaling dependent cancer therapeutics."
Journal • Oncology • GRB7
October 03, 2025
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
(clinicaltrials.gov)
- P1/2 | N=144 | Recruiting | Sponsor: Alnylam Pharmaceuticals | Phase classification: P1 ➔ P1/2 | N=84 ➔ 144 | Trial completion date: Jun 2026 ➔ Aug 2027 | Trial primary completion date: Jun 2026 ➔ Aug 2027
Enrollment change • Phase classification • Trial completion date • Trial primary completion date • Diabetes • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus
April 02, 2025
A Phase 1 Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=84 | Recruiting | Sponsor: Alnylam Pharmaceuticals | Not yet recruiting ➔ Recruiting
Enrollment open • Obesity
February 26, 2025
A Phase 1 Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=84 | Not yet recruiting | Sponsor: Alnylam Pharmaceuticals
New P1 trial • Obesity
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