RP03707 / Risen (Suzhou) Biosci - LARVOL DELTA

Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC. (PubMed, J Med Chem) - "RP03707 effectively inhibits tumor cell growth in multiple KRASG12D cell lines. It also exhibits prolonged PK/PD effects and excellent efficacy in mouse CDX models bearing KRASG12D tumors, highlighting its potential for the treatment of KRASG12D-driven tumors in clinical settings."

Journal • Oncology • Targeted Protein Degradation • CRBN • KRAS

Targeting KRAS G12D mutant tumors with the PROTAC degrader RP03707 (AACR 2024) - "Moreover, RP03707 exhibits high selectivity for degrading the KRAS G12D protein and possesses favorable drug-like properties. RP03707, therefore, meets the criteria for advancing into drug development and represents a valuable therapeutic option for treating KRAS G12D-associated tumors."

Oncology • KRAS