bicifadine (DOV-220075) / XTL Biopharma - LARVOL DELTA

Nickel-catalyzed highly diastereo- and enantioselective hydroaminocarbonylation and hydrocarboxylation of cyclopropenes. (PubMed, Nat Commun) - "These reactions feature mild reaction conditions, exceptional levels of enantioselectivities and diastereoselectivities while also exhibiting remarkable tolerance towards diverse functional groups. Moreover, our methodology proves to be highly efficient for the synthesis of pharmaceutical compounds such as Levomilnacipran and Bicifadine."

Journal

Neuroprotective Activities of Sertraline, Tiagabine, and Bicifadine with Autophagy-Inducing Potentials in a 6-Hydroxidopamine-Treated Parkinson's Disease Cell Model. (PubMed, Neurochem Res) - "Furthermore, the analysis of neurochemical changes suggested that the ability of those compounds to restore the quantity of cellular neurotransmitters such as betaine, 5-hydroxyindoleacetic acid and kynurenine might be linked to their neuroprotective function. In conclusion, compounds like sertraline, tiagabine, and bicifadine that have the ability to induce autophagy and inhibit mTOR might be repurposed as PD treatment to protect the neuronal cells."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease