acenocoumarol / Generic mfg. - LARVOL DELTA

Incomplete Brown-Séquard syndrome secondary to acenocoumarol-induced hematomyelia: A case report. (PubMed, World J Crit Care Med) - "In some cases, the cause of hematomyelia remains idiopathic. Vitamin K antagonists are widely used for the long-term prevention of thromboembolic events; hence, prompt diagnosis of potential complications is important."

Journal • Cardiovascular • Hematological Disorders • Mood Disorders • Musculoskeletal Pain • Oncology • Pain

Life-Threatening Spontaneous Retroperitoneal Hemorrhage Associated with Acenocoumarol Anticoagulation in a Young Patient with a Mechanical Aortic Valve: A Case Report. (PubMed, Int Med Case Rep J) - "Spontaneous retroperitoneal hemorrhage should be considered in anticoagulated patients with abdominal or flank pain, syncope, unexplained anemia, hypotension, or acute kidney injury. Prompt diagnosis, urgent reversal, and individualized anticoagulation resumption are essential."

Journal • Acute Kidney Injury • Cardiovascular • Hematological Disorders • Hypotension • Nephrology • Pain • Renal Disease • Thrombosis

Prosthetic valve endocarditis due to non-toxigenic Corynebacterium diphtheriae: A case report. (PubMed, Acta Microbiol Immunol Hung) - "In March 2026, a 61-year-old woman with a mechanical mitral valve receiving chronic acenocoumarol therapy was admitted with fever, malaise, and abdominal pain...Antimicrobial susceptibility testing showed resistance to penicillin G and trimethoprim-sulfamethoxazole, with susceptibility to meropenem, erythromycin, clindamycin, tetracycline, linezolid, vancomycin and rifampicin, and susceptibility with increased exposure to cefotaxime and ciprofloxacin...Intravenous vancomycin and bisoprolol were initiated...This case highlights the severe invasive potential of non-toxigenic C. diphtheriae in PVE and the risk of devastating thromboembolic and hemorrhagic neurological complications. It also emphasizes the necessity of rapid microbiological identification, integration of genomic data, and multidisciplinary management, particularly regarding anticoagulation strategies in patients with mechanical prosthetic valves."

Journal • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Infectious Disease • Pain • Respiratory Diseases

ABDOMINAL AORTIC OCCLUSION AS A PRESENTATION OF ANTIPHOSPHOLIPID SYNDROME (APS) (ISTH 2026) - "The patient was discharged on acenocoumarol...Table or Figure Upload (1) Abdominal aortic angio-MRI Page 2 Table or Figure Upload (2) Histopathological findings of abdominal aortic thrombosis. DOI*10.1016/j.rpth.2026.106531 Page 3"

Atherosclerosis • Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Peripheral Arterial Disease • Thrombosis • Vasculitis

Comparison of INR results obtained with POC devices based on different measurement principles (ISTH 2026) - "Eighty patients were receiving acenocoumarol and 41 warfarin. These findings support the interchangeable use of both devices for patient follow-up, facilitating therapeutic management in different clinical settings. Table or Figure Upload (1) Page 2 DOI*10.1016/j.rpth.2026.105510"

Atrial Fibrillation • Cardiovascular • Genetic Disorders • Hematological Disorders • Pulmonary Embolism • Respiratory Diseases

Risk of Haematuria Following the Initiation of Oral Anticoagulant Therapy: A Systematic Review (ISTH 2026) - "Among VKA-treated patients, haematuria occurred in 185/15087 (1.2%), with incidence ranging from 0.1% (9/8102) in a large acenocoumarol cohort to 3.5% (20/565) in a small single-centre warfarin cohort enriched for urologic intervention. In DOAC-treated patients, haematuria occurred in 2.5% (190/7,468), with incidence ranging from 0.3% with edoxaban (6/1,732) to 3.1% with dabigatran (78/2527)...These findings underscore the importance of sustained clinical vigilance, highlighting the need for prospective studies to use the ISTH standardised bleeding definitions to inform risk stratification and clinical decision-making. Table or Figure Upload (1) Page 2 DOI*10.1016/j.rpth.2026.105396"

Review • Cardiovascular

Early Post-CPB Hyperfibrinolysis in a Pediatric Patient: Diagnostic Challenge Highlighted by ROTEM (ISTH 2026) - "ROTEM EXTEM showed A5 14 mm, A10 22 mm, MCF 26 mm, and ML 97%, consistent with catastrophic hyperfibrinolysis (tracing "waterdrop"/"fish-like" pattern).ROTEM-guided hemostatic management was promptly initiated and included transfusion of one unit of packed red blood cells, fresh frozen plasma, four platelet concentrates,, recombinant factor VIIa, and tranexamic acid...Given the Fontan physiology, anticoagulation was subsequently initiated with acenocoumarol (Sintrom®) at a dose of 1/8 tablet every other day, achieving a therapeutic INR of 2...The tracing demonstrates severely impaired clot firmness with early and almost complete clot lysis (maximum lysis 97%) Page 2 Table or Figure Upload (2) ROTEM after treatment. The tracing demonstrates restoration of clot formation and stability DOI*10.1016/j.rpth.2026.105076"

Clinical • Cardiovascular • Hematological Disorders • Pediatrics • Respiratory Diseases • Thrombocytopenia

Drivers of Paediatric Thrombosis: a 10-Year Evaluation of Comorbidities and Genetic Risk (ISTH 2026) - "Therapeutic management included enoxaparin (50.42%), followed by acenocoumarol (26.89%). A combination of acetylsalicylic acid and anticoagulants was required for 10.08% of patients. Conclusions Pediatric thromboembolism is a multifactorial disease primarily driven by CVCs and infections, but genetic profiles provide deeper insight into individual susceptibility, particularly in high-risk groups such as those with cancer or severe sepsis. DOI*10.1016/j.rpth.2026.105066"

Cardiovascular • Infectious Disease • Pediatrics • Respiratory Diseases • Septic Shock • Thrombosis • Venous Thromboembolism • MTHFR

AN UNUSUAL CARDIAC MANIFESTATION OF ANTIPHOSPHOLIPID SYNDROME (ISTH 2026) - "The patient was discharged on acenocoumarol...Table or Figure Upload (1) Echocardiography: a mass involving the tricuspid valve. Page 2 Table or Figure Upload (2) Histopathological findings DOI*10.1016/j.rpth.2026.103928 Page 3"

Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Obstetrics • Thrombocytopenia • Thrombosis

Clinical-genetic characterization and management of antithrombin deficiency: A registry for 5 years in a single center experience. (ISTH 2026) - "Currently, over half of the patients (54%) receive anticoagulant therapy, using agents such as Acenocoumarol, Warfarin, Dabigatran, and Apixaban. This detailed profiling is essential for optimizing anticoagulant management and preventing life-threatening thrombotic events in clinical practice. Table or Figure Upload (1) Page 2 Table or Figure Upload (2) Page 3 DOI*10.1016/j.rpth.2026.103986"

Clinical • Cardiovascular • Genetic Disorders • Gynecology • Hematological Disorders • Obesity • Rare Diseases • Respiratory Diseases • Venous Thromboembolism

[Translated article] Healthcare impact of increased use of direct oral anticoagulants in patients with hip fractures. A retrospective study. (PubMed, Rev Esp Cir Ortop Traumatol) - "The analysis of anticoagulant use from 2018 to 2023 revealed a significant shift in prescription patterns, both in the general population and in patients with hip fractures. DOAC use was associated with increased surgical delay and longer hospital stays in patients with proximal femur. The use of acenocoumarol is associated with an increase in mortality in patients who have undergone hip fracture surgery compared to users of DOACs."

Journal • Retrospective data • Musculoskeletal Diseases • Orthopedics

When a Bulbar Ulcer Hides a Darker Reality: The Unusual Diagnosis of a Portal Cavernoma in a 69-Year-Old Adult. (PubMed, Clin Case Rep) - "Treatment consisted of 40 mg of injectable omeprazole every 12 h, 40 mg of propranolol per day, and one sachet of Gaviscon every 8 h. Anticoagulation was initiated with enoxaparin and then continued with 4 mg of acenocoumarol per day. The patient responded well to treatment, with regression of abdominal pain and gastrointestinal hemorrhage, and was discharged home after 10 days following two stable INR readings. Although most commonly described in pediatrics, this clinical case sheds light on adult forms of the disease."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Pain • Pediatrics • Thrombosis

Anticoagulant medicines for Balloon Pulmonary Angioplasty (clinicaltrialsregister.eu) - P4 | N=84 | Active, not recruiting | Sponsor: St. Antonius Ziekenhuis | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

MULTIPLE-HIT PROTHROMBOTIC PHENOTYPE: PERSISTENT IGM ANTIPHOSPHOLIPID SYNDROME COMBINED WITH INHERITED PROTEIN S/C DEFICIENCY AND CHRONIC INTESTINAL INFLAMMATION LEADING TO RECURRENT VENOUS THROMBOSIS (EHA 2026) - "Antiphospholipid syndrome (APS) with persistent IgM positivity, when combined with inherited deficiencies of natural anticoagulants and chronic inflammatory triggers, represents a high-risk phenotype that challenges conventional management Aims To illustrate a rare, complex multi-hit thrombotic phenotype integrating persistent IgM APS, inherited protein S/C deficiency, and chronic intestinal inflammation, highlighting its clinical and therapeutic implications Methods We describe a 51-year-old female, active smoker (BMI 31.9 kg/m²) with prior gastric bypass (2011) and collagenous colitis refractory to budesonide, presenting with recurrent unprovoked VTE (three DVTs 2016–2017, one superficial venous thrombosis 2019) and labile INR on acenocoumarol. Recognition of such overlapping mechanisms is critical for individualized anticoagulation strategies and multidisciplinary management. The case emphasizes that persistent IgM APS is clinically relevant when coupled with..."

Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Thrombosis • Venous Thromboembolism • PROS1

SPONTANEOUS LOBAR INTRACEREBRAL HEMORRHAGE REVEALING COMBINED INHERITED THROMBOPHILIA AND INCIDENTAL PULMONARY EMBOLISM: A THERAPEUTIC PARADOX (EHA 2026) - "After incidental detection of bilateral PE, prophylactic-dose low-molecular-weight heparin (enoxaparin) was started, although was contraindicated due to acute ICH...She Currently anticoagulated with acenocoumarol (Sintrom®), INR: 2-2.8 Individualized risk assessment is essential to balance thrombotic and hemorrhagic risks in complex cases such as this. Right Image: intracerebral hemorrhage. Left image: bilateral PE"

Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Infectious Disease • Metabolic Disorders • Pulmonary Embolism • Respiratory Diseases • Venous Thromboembolism

CLINICAL AND SEROLOGICAL CHARACTERIZATION OF ANTIPHOSPHOLIPID SYNDROME IN MEN: A SINGLE-CENTER STUDY (EHA 2026) - "Management: 83.3% (5/6) of patients are managed with Vitamin K Antagonists (acenocoumarol). Our study highlights that while thrombosis is common, a significant subset of male patients presents with cytopenias (pancytopenia or isolated thrombocytopenia) without thrombotic events. Early integration of immunosuppression (azathioprine or prednisone) alongside or instead of anticoagulation— depending on the phenotype—is crucial to manage hematological manifestations and improve long-term outcomes in this diverse male cohort."

Clinical • Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Systemic Lupus Erythematosus • Thrombocytopenia • Thrombosis • Vasculitis

HEMATOLOGIC AND HEMOLYSIS-RELATED LABORATORY PROFILE IN PATIENTS WITH MECHANICAL HEART VALVES RECEIVING CHRONIC VITAMIN K ANTAGONIST THERAPY (EHA 2026) - "Methods We conducted a retrospective observational study including 53 adult patients with mechanical heart valves treated with acenocoumarol...Interpretation of potential low-grade hemolysis is limited by incomplete availability of dedicated hemolysis markers, particularly LDH and haptoglobin. Larger prospective studies incorporating standardized hemolysis panels and longitudinal assessment are warranted to better define the hematologic signature of mechanical valve carriers."

Clinical • Hematological Disorders • HP

Calciphylaxis – When You Ask Yourself: What More Can I Do? (ERA 2026) - "His history included hypertension, ischemic cardiomyopathy with reduced LVEF, cerebrovascular accident, abdominal aortic aneurysm, and atrial fibrillation anticoagulated with acenocoumarol...The case highlights the potential benefit of combining these modalities in refractory calciphylaxis and supports a multidisciplinary approach. Image"

Atrial Fibrillation • Calciphylaxis • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Hypertension • Infectious Disease • Nephrology • Rare Diseases • Renal Disease

TREAT-CAD 2: Antithrombotic Treatment Strategies in Cervical Artery Dissection (clinicaltrials.gov) - P=N/A | N=1100 | Not yet recruiting | Sponsor: University Department of Geriatric Medicine FELIX PLATTER

New trial

The safety of anticoagulant treatment in cirrhotic patients with portal vein thrombosis and severe thrombocytopenia (EASL 2026) - "The majority of the patients received apixaban or rivaroxaban (81 patients, 66.9%), 33 patients (29.7%) were treated with enoxaparin, and only 4 patients (3.4%) received acenocoumarol. Anticoagulant therapy in cirrhotic patients with PVT appears safe even in the presence of severe thrombocytopenia, with low rates of major bleeding and no increase in mortality. These findings warrant confirmation in prospective studies."

Clinical • Cardiovascular • Fibrosis • Hematological Disorders • Immunology • Liver Cirrhosis • Thrombocytopenia • Thrombosis

Challenging Anticoagulation With Warfarin and Heparin Following Mechanical Mitral Valve Replacement in a Patient With Infective Endocarditis: A Case Report Highlighting Diagnostic Difficulties. (PubMed, Clin Case Rep) - "Alternative vitamin K antagonists (e.g., acenocoumarol) may be considered in refractory cases, but direct oral anticoagulants are strictly contraindicated in mechanical valves based on the RE-ALIGN trial. Clinicians should maintain a high index of suspicion for challenging anticoagulant response resistance when INR remains subtherapeutic despite high doses and evaluate all possible etiologies systematically. This case expands current understanding of refractory anticoagulation following valve replacement and highlights the diagnostic limitations faced in resource-constrained settings."

Journal • Cardiovascular • CYP2C9

Device-detected and device-terminated supraventricular tachycardia with use remote monitoring of ICD in the emergency department (HEART FAILURE 2026) - "Anticoagulation consisted predominantly of apixaban, except for one patient on acenocoumarol (due to history of prosthetic heart valve). Device-guided electrical cardioversion proved feasible, well tolerated, and acutely effective in nearly all patients, with no periprocedural complications and short post-procedure observation time. Although arrhythmia recurrence during follow-up was common—reflecting the advanced structural heart disease burden—this approach supports the utility of ICD remote monitoring to streamline early rhythm control strategies, reduce unnecessary hospitalization, and facilitate timely intervention in appropriately selected patients."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

Antibiotic-Associated Overanticoagulation Unmasking Prosthetic Valve Endocarditis Diagnosed by Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (FDG-PET/CT). (PubMed, Cureus) - "We present the case of a 50-year-old man with a mechanical aortic valve prosthesis secondary to severe aortic stenosis, on anticoagulation therapy with acenocoumarol, who presented with severe over-anticoagulation, with multiple hemorrhagic complications, including hemothorax, chronic subdural hematoma, and extensive intramuscular hematomas involving the iliopsoas muscle and deep compartments of the thigh. The onset of these complications was temporally associated with the administration of an antibiotic regimen containing amoxicillin, secondary to an upper respiratory tract infection...This case highlights the vast clinical consequences of anticoagulation instability associated with VKAs, and especially the exponential increase in risk due to drug interactions, as in this case, linked to antibiotic therapy. Furthermore, it emphasizes the value of FDG-PET/CT in the diagnosis of prosthetic valve endocarditis, particularly when echocardiographic findings are..."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Infectious Disease • Respiratory Diseases

Laser-Assisted Management of Amlodipine-Induced Gingival Overgrowth in a Medically Complex Patient. (PubMed, Spec Care Dentist) - "This case highlights the usefulness of diode laser surgery as a safe and effective therapeutic option for the management of severe DIGO in patients requiring continuous antithrombotic therapy. Its excellent hemostatic properties and minimal invasiveness make it particularly valuable in special care dentistry and in interdisciplinary management of high-risk cardiovascular patients."

Journal • Cardiovascular • Dental Disorders • Fibrosis • Ischemic stroke • Periodontitis

Healthcare impact of increased use of direct oral anticoagulants in patients with hip fractures. A retrospective study. (PubMed, Rev Esp Cir Ortop Traumatol) - "The analysis of anticoagulant use from 2018 to 2023 revealed a significant shift in prescription patterns, both in the general population and in patients with hip fractures. DOAC use was associated with increased surgical delay and longer hospital stays in patients with proximal femur. The use of acenocoumarol is associated with an increase in mortality in patients who have undergone hip fracture surgery compared to users of DOACs."

Journal • Retrospective data • Musculoskeletal Diseases • Orthopedics