FML, FML Forte (fluorometholone ophthalmic suspension) / AbbVie - LARVOL DELTA

A case of primary meningococcal conjunctivitis in an older patient. (PubMed, J Infect Chemother) - "Levofloxacin 1.5% eye drops and fluorometholone 0.1% eye drops, each four times daily, were initiated before the results of conjunctival culture were available...Cefmenoxime hydrochloride 0.5% eye drops eight times daily were added and a single dose of oral levofloxacin 500 mg was administered to prevent IMD...All ST-11026 isolates have been found to lack the ability to synthesize capsular polysaccharide, which is one of the meningococcal pathogenicity. If a patient presents with conjunctivitis with copious ocular purulent discharge, conjunctival culture should be performed promptly for early diagnosis of PMC regardless of the patient's age."

Journal • Achromatopsia • Conjunctivitis • Infectious Disease • Meningococcal Infections • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain

Efficacy and safety of ROH-101 (0.15% ganciclovir gel) for cytomegalovirus corneal endotheliitis: an open-label, uncontrolled, phase 3 study in Japan. (PubMed, Jpn J Ophthalmol) - "ROH-101 was a safe and efficacious treatment in Japanese patients diagnosed with CMV corneal endotheliitis."

Journal • P3 data • Cytomegalovirus Infection • Inflammation

Adjunct Topical Human Immunoglobulin IgG Therapy in Dry Eye Disease. (PubMed, Indian J Ophthalmol) - "Topical immunoglobulin IgG 0.4% as adjunct therapy seems to have a definitive role in reducing topical steroid and lubricant dependency in moderate to severe chronic DED compared to conventional therapy."

Journal • Dry Eye Disease • Ophthalmology

Primary Results of the FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial (ARVO 2025) - "The trial found the treatment to be ineffective in avoiding relapses (same risk of recurrence as with placebo). The results suggest that fluorometholone eyedrops would be safe for indications in which they were more useful."

Surgery • Cataract • Ophthalmology

Once-daily Fluorometholone Vs Twice-daily Cyclosporine in Dry Eye Disease (clinicaltrials.gov) - P4 | N=32 | Completed | Sponsor: Korea University Anam Hospital

New P4 trial • Dry Eye Disease • Ophthalmology

Clinical Efficacy of Tobramycin Dexamethasone+Pranoprofen Eye Drops on Endophthalmitis in Cataract Patients Complicated with Diabetes Mellitus after Intraocular Lens Implantation. (PubMed, Niger J Clin Pract) - "Tobramycin dexamethasone+pranoprofen eye drops can inhibit inflammation better, recover vision faster, and make the incidence of adverse reactions lower in treating cataract patients complicated with DM developing endophthalmitis induced."

Clinical • Journal • Cataract • Diabetes • Inflammation • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

A case of immune checkpoint inhibitor-related conjunctivitis controlled by tacrolimus eye drops. (PubMed, Am J Ophthalmol Case Rep) - "We report a case where tacrolimus eye drops may have alleviated immune checkpoint inhibitor (ICI)-related conjunctivitis attributed to nivolumab...Initially, the patient was diagnosed with allergic conjunctivitis, managed with 0.1 % fluorometholone eye drops, 4 times daily in both eyes, but the symptoms did not improve despite 27 weeks of treatment, ICI-related conjunctivitis was considered, and the patient was prescribed with, 0.1 % tacrolimus eye drops twice daily in both eyes...The condition remains in remission with 0.1 % tacrolimus eye drops applied once daily in both eyes. Tacrolimus eye drops may have played a role to suppress ICI-related conjunctivitis."

Checkpoint inhibition • Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Observation on the effect of Zhangyanming tablets combined with fluorometholone eye drops (0.02%) and human epidermal growth factor eye drops in the treatment of moderate and severe dry eye disease (ChiCTR) - P4 | N=122 | Completed | Sponsor: Shenzhen Eye Hospital (SZEH); Shenzhen Eye Hospital(SZEH) | Recruiting ➔ Completed

Trial completion • Dry Eye Disease • Ophthalmology

Efficacy of moisture chamber goggles combined with fluorometholone eye drops on visual function and oxidative stress in patients with dry eye disease. (PubMed, Am J Transl Res) - "The combination of Moisture Chamber Goggles and Fluorometholone eye drops significantly improves subjective visual quality, promotes tear secretion, stabilizes the tear film, and reduces inflammatory and oxidative stress markers in patients with dry eye disease, while maintaining a favorable safety profile."

Journal • Dry Eye Disease • Ocular Inflammation • Oncology • Ophthalmology • TNFA

Comparison of the Effect of and Compliance With Cyclosporine 0.1% After Various Pretreatments in Dry Eye Disease. (PubMed, J Ophthalmol) - "Thirty patients (Group 1, 60 eyes) were not pretreated, while 68 patients (Group 2, 136 eyes) were pretreated with fluorometholone 0.1%, and 39 patients (Group 3, 78 eyes) were pretreated with cyclosporine 0.05% before treatment with cyclosporine 0.1%... Pretreatment with cyclosporine 0.05% can augment the anti-inflammatory effect of cyclosporine 0.1%. Pretreatment with a steroid or a lower concentration of cyclosporine can increase compliance in patients using a cyclosporine 0.1% eye drop."

Compliance • Journal • Dry Eye Disease • Immunology • Ocular Inflammation • Ophthalmology • Sjogren's Syndrome • MMP9

The FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial: Study Design. (PubMed, Ophthalmic Epidemiol) - P3 | "The FLAME Trial is designed to provide evidence of the efficacy, safety, and cost-effectiveness of adjunctive topical peri-/postoperative fluorometholone 0.1% therapy with trichiasis surgery, which is hypothesized to reduce the risk of recurrent trichiasis while being acceptably safe. https://www.clinicaltrials.gov/study/NCT04149210."

Clinical • Journal • Surgery • Cataract • Ophthalmology

Comparison of therapeutic effects of 0.05% Cyclosporine A versus 0.1% Fluorometholone in Chinese patients with mild dry eye unresponsive to artificial tears: a randomized control study. (PubMed, BMC Ophthalmol) - P=N/A | "The administration of 0.05% CsA proved effective in managing mild DED, offering a supplementary advantage in improving Schirmer scores, restoring CGC density and reducing corneal DC density compared to 0.1% FML eyedrops. Consequently, 0.05% CsA eyedrops are recommended as a safe and efficacious therapeutic alternative for patients with mild DED who fail to respond to conventional tear substitutes therapy."

Clinical • Journal • Dry Eye Disease • Ophthalmology

Resolution Of A Pterygium-Associated Dellen Combined With Ciprofloxacin Deposits In The Cornea (ESCRS 2024) - "Fluorometholone 0.1% (3 times/per day) and preservative- free artificial tears were added... Management and follow-up of corneal dellen can be challenging due to a high risk of corneal perforation. As presented in our case report, topical lubricants, and bandage contact lenses were proved to be an appropriate therapy. This case is unique because according to our knowledge, there is not any previously documented report of corneal dellen associated with ciprofloxacin deposits in literature so far."

Ophthalmology • Retinal Disorders

Ocular Infection By Monkeypox Virus: A Case Report. (ESCRS 2024) - "After starting systemic treatment with oral Tecovirimat (Tpoxx®) and topical Ganciclovir 0.15% (Virgan®), a significant improvement was observed, to which the use of 20% Autologous Serum eye drops for the treatment of residual corneal lesions also contributed. Finally, the patient was treated with Fluorometholone eye drops, showing a favourable evolution... Ocular involvement by Monkeypox virus is often mild and self-limiting. It usually manifests non-specific symptoms and signs such as preseptal cellulitis, conjunctival hyperemia, photosensitivity and secretions, without significantly affecting vision. In more severe cases, such as those with treatment-resistant corneal damage, multidisciplinary management can be of great help in administering systemic therapy, as well as monitoring with photographs of the anterior segment to determine the best treatment for each case."

Case report • Clinical • Conjunctivitis • Corneal Abrasion • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

The FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial: Study Design. (PubMed, medRxiv) - P3 | "The FLAME Trial is designed to provide evidence of the efficacy, safety, and cost-effectiveness of adjunctive topical peri-/postoperative fluorometholone 0.1% therapy with trichiasis surgery, which is hypothesized to reduce the risk of recurrent trichiasis while being acceptably safe. Trial Registration: ClinicalTrials.gov # NCT04149210."

Clinical • Journal • Surgery • Cataract • Ophthalmology

CES-NSLT: Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT (clinicaltrials.gov) - P4 | N=126 | Not yet recruiting | Sponsor: St. Joseph's Healthcare Hamilton

New P4 trial • Cardiovascular • Glaucoma • Inflammation • Ophthalmology

Topical tacrolimus for high-risk corneal transplantation: a randomized, clinical trial. (PubMed, BMC Ophthalmol) - "Our results demonstrated that good tolerability of 0.1% TAC ophthalmic suspension. However, we failed to demonstrate its efficacy in preventing immunological rejection in high-risk patients undergoing PKP."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Ophthalmology • Transplant Rejection • Transplantation

Impact of Topical 0.05% Cyclosporine A Eye Drops on Post-Femtosecond-Assisted Laser In Situ Keratomileusis Ocular Surface Recovery: A Randomized Clinical Trial. (PubMed, Eye Contact Lens) - "In conclusion, 0.05% CsA eye drops is a useful adjunct to conventional treatment for restoring the ocular surface stability after corneal refractive surgery and is more potent in sustaining anti-inflammatory effects."

Clinical • Journal • Ocular Inflammation • IL6

Autologous Cultivated Limbal Epithelial Cell Sheet Transplantation: A Report of Five Cases (ARVO 2024) - "The remaining patient, who experienced prolonged epithelial defects, switched from betamethasone phosphate eye drops to fluorometholone and used a soft contact lens for an extended period, resulting in re-epithelialization at five months... Autologous cultivated corneal epithelial transplantation (Nepic®) for LSCD seems to have promising results in the short and medium term."

Clinical • Ophthalmology

Changes in Ocular Surface Blood Flow by Measuring Laser Speckle Flowgraphy (LSFG): Case Series of Phlyctenular Keratitis (ARVO 2024) - "Treatment with Cefmenoxime and Fluorometholone eye drops, and oral Clarithromycin, led to regression of vascular invasion and improvement in nodular congestion within 3 weeks... In all cases, ocular surface blood flow (MBR) and OST decreased as the invading vessel to the cornea disappointed and inflammation decreased. Measuring blood flow and temperature pre- and post-treatment in phlyctenular keratitis with abnormal vascular invasion suggests these parameters may be useful for the quantitative assessment of anterior segment inflammation and abnormal vascular invasion in the cornea."

Clinical • Keratitis • Ocular Inflammation • Ophthalmology

Scleritis following intravitreal brolucizumab injection: a case series. (PubMed, J Med Case Rep) - "Intraocular inflammation following IVBr injection may progress to the posterior segment. Scleritis can occur after IVBr injection, and topical eye drops alone may not be sufficient for initial treatment. Clinicians should consider the possibility of scleritis in patients with worsening inflammation after IVBr injection."

Journal • Achromatopsia • Conjunctivitis • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Scleritis • Vasculitis

Use of nonsteroidal anti-inflammatory drugs in corneal epithelial ingrowth due to traumatic flap dislocation after LASIK: Case report. (PubMed, Medicine (Baltimore)) - "Nonsteroidal anti-inflammatory drugs may be broadly applied in the treatment of epithelial ingrowth after laser in situ keratomileusis."

Journal • Ophthalmology

Dual-Polymer Hydroxypropyl Guar-and Hyaluronic Acid Containing in Rheumatoid Arthritis (clinicaltrials.gov) - P4 | N=40 | Recruiting | Sponsor: Chang Gung Memorial Hospital

New P4 trial • Dry Eye Disease • Immunology • Inflammatory Arthritis • Ophthalmology • Rheumatoid Arthritis • Rheumatology

SEE CLEARLY ABOUT BELANTAMAB MAFODOTIN IN MYELOMA PATIENTS WITH BASELINE KERATHOPATY: A CASE REPORT (SIE 2023) - "At first relapse, in 2016, patient started lenalidomide-dex which was stopped in 2019 for H1N1 pneumonia complicated by Aspergillosis...In november 2021, at third relapse, patient underwent local radiotherapy for a huge right homeral osteolysis and started Pomalidomide-Vd...Due to the corneal transplant, our ophtalmologist advised against belamaf but patient refused carfilzomib based strategies...A mild keratopathy was described before cycle 3 and fluorometholone drops were prescribed achieving an improvement during subsequent eye controls...Close collaboration with ophtalomologists revealed to be precious to allow treatment. Although a limited experience, it suggests to deepen the role of pre-existent keratopathy and corneal transplant too in order to ensure therapeutic chances to all advanced RRMM patients, regardless comorbidities."

Clinical • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Oncology • Ophthalmology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Transplantation

Preoperative Treatment For Ocular Surface Disease In A Cataract Surgery Patient Requiring Premium Multifocal Toric Intraocular Lenses (Iol's) (ESCRS 2023) - "The patient was given preoperative treatment with AEON Protect Plus artificial tears and Fluorometholone (FML) eye drops...By treating the ocular surface pre-surgery it reduces post-surgical symptoms and therefore further increases patient satisfaction. The use of artificial tears not only provides comfort but also helps to maintain a stable tear film for optimal clarity of vision."

Clinical • Surgery • Astigmatism • Cataract • Ophthalmology