chlorpromazine injection / Generic mfg. - LARVOL DELTA

Establishing a Mouse Model of Chlorpromazine-Induced Corneal Trigeminal Denervation. (PubMed, Transl Vis Sci Technol) - "Retrobulbar chlorpromazine injections were administered to 6- to 8-week-old C57BL/6j mice to induce corneal denervation. The CCTD model is a user-friendly mouse model for studying corneal trigeminal denervation that offers a less invasive alternative to existing models. The CCTD model serves as a valuable tool for investigating the functional mechanisms of corneal trigeminal nerves and their interactions with corneal cells."

Journal • Preclinical

Neuropsychology performance and antipsychotic load in severe mental disorder (ECNP 2023) - "Afterward, we scrutinized the medical records of the chosen patients to determine the antipsychotic dosage that was administered to them (both oral or long-acting injections) in chlorpromazine-equivalent units (Eq-CPZ) for statistical purposes [5]. Clinicians should maintain a vigilant awareness and thorough understanding of the conceivable and significant neuropsychological impairment that may be linked to the administration and prolonged use of antipsychotic medication in individuals who have been accurately diagnosed with severe mental disorders, as this knowledge is pivotal for ensuring comprehensive and holistic care, enhancing treatment outcomes, and minimizing potential cognitive and functional deficits that could arise as a consequence of such pharmacological interventions."

Alzheimer's Disease • Bipolar Disorder • CNS Disorders • Cognitive Disorders • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

SEVERE CASE OF RHABDOMYOLYSIS WITHOUT NEUROLEPTIC MALIGNANT SYNDROME REQUIRING HEMODIALYSIS FOLLOWING INTRAMUSCULAR CHLORPROMAZINE ADMINISTRATION (CHEST 2023) - "Our patient did not meet criteria for NMS and there have been previous case reports of antipsychotics causing rhabdomyolysis without NMS, but they have mostly been with haloperidol [4]...Therefore, we suspect that a combination of injury from the IM injections and chlorpromazine induced dopaminergic blockade led to this unique presentation of rhabdomyolysis without NMS. Our case highlights that IM antipsychotic use can lead to rhabdomyolysis without the rest of clinical findings associated with NMS. Early recognition of this adverse effect is crucial to improve patient outcomes."

Clinical • CNS Disorders • Developmental Disorders • Epilepsy • Infectious Disease • Mental Retardation • Pneumonia • Prader–Willi syndrome • Renal Disease • Respiratory Diseases

Use of Intramuscular Chlorpromazine Versus Intramuscular Olanzapine for the Management of Acute Agitation and Aggression in Youth. (PubMed, J Pediatr Pharmacol Ther) - "Management of acute agitation with IM olanzapine resulted in a greater change in BARS score, despite more youth requiring coadministration with diphenhydramine. In comparison, IM chlorpromazine demonstrated a higher likelihood of returning patients to baseline. Study results suggest tolerability of IM chlorpromazine and olanzapine."

Journal • CNS Disorders • Psychiatry

In vivo synaptic activity-independent co-uptakes of amyloid β and Zn into dentate granule cells in the normal brain. (PubMed, Sci Rep) - "In vivo rapid uptake of Aβ was not modified in the dentate granule cell layer after co-injection of Aβ and tetrodotoxin, a Na channel blocker, into the dentate gyrus. Both the rapid uptake of Aβ and Zn into the dentate granule cell layer was not modified after co-injection of CNQX, an AMPA receptor antagonist, which blocks extracellular Zn influx, Both the rapid uptake of Aβ and Zn into the dentate granule cell layer was not also modified after either co-injection of chlorpromazine or genistein, an endocytic repressor. The present study suggests that Aβ and Zn are synaptic activity-independently co-taken up into dentate granule cells in the normal brain and the co-uptake is preferential in dentate granule cells in the hippocampus. We propose a hypothesis that Zn-Aβ oligomers formed in the extracellular compartment are directly incorporated into neuronal plasma membranes and form Zn-permeable ion channels."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders

Retrobulbar chlorpromazine injection in a child with gliosarcoma invasion into the orbits. (PubMed, BMJ Case Rep) - "In spite of treatment, the tumour progressed and eventually invaded into the right orbit. He subsequently developed a proptotic, blind, painful eye and was treated with retrobulbar chlorpromazine injection, which provided immediate symptomatic relief."

Clinical • Journal • Brain Cancer • Glioblastoma • Gliosarcoma • Oncology • Pain • Pediatrics • Solid Tumor