OPC-108459 / Otsuka, Ligand - LARVOL DELTA

Discontinued Drugs for the Treatment of Cardiovascular Disease from 2016 to 2018. (PubMed, Int J Mol Sci) - "Of these, six candidates (MDCO-216, TRV027, ubenimex, sodium nitrite, losmapimod, and bococizumab) were dropped for lack of clinical efficacy, the other six for strategic or unspecified reasons...Four candidate developments (OPC-108459, ONO-4232, GSK-2798745, and TAK-536TCH) were run without biomarkers, which could be used as surrogate endpoints in the 12 cardiovascular drugs discontinued from 2016 to 2018. This review will be useful for those involved in the field of drug discovery and development, and for those interested in the treatment of cardiovascular disease."

Biomarker • Journal • Review