9MW1411 / Mabwell (Shanghai) Biosci - LARVOL DELTA

A New Model for the Transmembrane Heterocomplex of Hemagglutinin HA and Ionic Channel M2 Proteins in Influenza A Virus. (PubMed, Dokl Biochem Biophys) - "The third transmembrane protein, M2 (MW 14 kDa), forms tetramers of ion channels in quantities of about 10-20 per virion...The resulting HA0-M2 heterocomplex possessed a high structural complementarity of the macromolecular interfaces (ipTM = 0.65), had no structural clashes of atoms in the molecular interfaces (clash score = 0.0), and exhibited stable and reliable intermolecular topology with a high ranking score of 0.79. The constructed model allows to explain the phenomenon of blocking the function of M2 ion channels by the rigid conformation of the uncleaved HA0 protein and, in contrast, the activation of M2 channels after (i) specific point proteolysis of HA0 into HA1 (55 kDa) and HA2 (25 kDa) subunits and (ii) exposure to acidic pH of 4.0-5.5, leading to the disclosure of the 3D structure of the HA1/2 molecule and the opening of the M2 channel."

Journal • Infectious Disease • Influenza • Respiratory Diseases • Targeted Protein Degradation

Paenidepsins are a Family of Lipopeptides from Paenibacillus. (PubMed, J Nat Prod) - "A new 12-membered cyclic lipopeptide with antifungal activity, paenidepsin A (1), was isolated from the common-wheat-associated bacterial strain Paenibacillus apiarius MW-14...Detailed NRPS domain-level analyses provided bioinformatic evidence for recombination-driven diversification of this BGC. Our findings illustrate the utility of integrating mass spectrometric and genomic tools to discover diverse natural products, and highlight the significant biosynthetic capacity of Paenibacillus species."

Journal

A randomised, double-blind, placebo-controlled, first-in-human phase I study to characterize the safety, pharmacokinetics, and immunogenicity of 9MW1411 in healthy Chinese subjects. (PubMed, Int J Antimicrob Agents) - "9MW1411 has shown a good safety profile in healthy Chinese subjects after single dose up to 5000 mg. Single dose of 3000 mg 9MW1411 is appropriate for use in subsequent studies."

Journal • P1 data • PK/PD data

Glycosaminoglycans from the Starfish Lethasterias fusca: Structures and Influence on Hematopoiesis. (PubMed, Mar Drugs) - "The main fraction LF, having MW 14.5 kDa and dispersity 1.28 (data of gel-permeation chromatography), was solvolytically desulfated and giving rise to preparation LF-deS with a structure of dermatan core [→3)-β-d-GalNAc-(1→4)-α-l-IdoA-(1→], which was identified according to NMR spectroscopy data...Preparations LF and LF-deS were studied as stimulators of hematopoiesis in vitro. Surprisingly, it was found that both preparations were active in these tests, and hence, the high level of sulfation is not necessary for hematopoiesis stimulation in this particular case."

Journal • Hematological Disorders

A Clinical Study in Health Subjects to Evaluate 9MW1411 Injection (clinicaltrials.gov) - P1 | N=42 | Completed | Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd. | Active, not recruiting ➔ Completed | Trial completion date: Feb 2022 ➔ Aug 2021 | Trial primary completion date: Dec 2021 ➔ Aug 2021

Trial completion • Trial completion date • Trial primary completion date • Infectious Disease

A Phase Ⅱ Clinical Study of 9MW1411 Injection in Acute Bacterial Skin and Skin Structure Infections (clinicaltrials.gov) - P2 | N=90 | Recruiting | Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

New P2 trial • Dermatology • Infectious Disease