Micetal (flutrimazole) / Uriach Pharma - LARVOL DELTA

Enhancing NMR Signals in Liquids by Fluorine-19 Overhauser Dynamic Nuclear Polarization (DNP) and Hyperpolarization Transfer to Carbon-13. (PubMed, Angew Chem Int Ed Engl) - "We demonstrate this with 19F→13C INEPT (insensitive nuclei enhanced by polarization transfer) spectra of the drug flutrimazole at 13C natural abundance, where quaternary carbons become readily detectable, opening perspectives for accelerated NMR on fluorinated drugs or small molecules. The results are corroborated by a theoretical analysis of 19F OE-DNP coupling factors."

Journal

Cutaneous lesion caused by Filobasidium uniguttulatum in the suprapubic region: an unusual case in an immunocompetent patient (EADV 2025) - "After repeated isolations of this species, our department prescribed miconazole combined with hydrocortisone for two weeks without achieving resolution...In immunocompromised hosts, it is an infrequent cause of ventriculitis and meningitis, usually resistant to first-line antifungals, with liposomal amphotericin B being the most effective treatment for systemic infections... Based on the available evidence, this report describes the first documented case of a cutaneous infection clearly attributed to F. uniguttulatum as the sole pathogen responsible for the lesion. Our case highlights resistance to topical azoles (clotrimazole, flutrimazole, miconazole), underscoring potential azole cross-resistance and* being this case the first to describe the resolution of a skin lesion with topical ciclopiroxolamine, circumventing the risk of systemic treatments."

Clinical • CNS Disorders • Dermatology • Diabetes • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Tuberculosis

First Confirmed Description of Acremonium egyptiacum from Greece and Molecular Identification of Acremonium and Acremonium-like Clinical Isolates. (PubMed, J Fungi (Basel)) - "Flutrimazole, lanoconazole, and luliconazole presented the lower minimum inhibitory concentration (MIC) values against A. egyptiacum, with a geometric mean (GM) MIC of 2.50, 1.92, and 1.57 μg/mL, respectively. Amphotericin B, itraconazole, posaconazole, voriconazole, terbinafine, amorolfine, and griseofulvin MICs were overall high (GM 12.79-29.49 μg/mL)...Antifungal susceptibility of the three different A. egyptiacum genotypes was homogeneous. Overall, the high MICs recorded for all systemically administered drugs, and for some topical antifungals against the tested A. egyptiacum and other acremonium-like clinical isolates, justify the routine susceptibility testing of clinical isolates."

Journal • Brain Cancer • CNS Tumor • Infectious Disease • Oncology • Solid Tumor • Transplantation

Direct Amination of α-Triaryl Alcohols via Vanadium Catalysis. (PubMed, J Org Chem) - "This process is scalable, as demonstrated by a gram-scale synthesis, and the reaction still works at as low as a 0.01 mol % catalyst loading with the turnover number reaching 3900. Moreover, commercial pharmaceuticals including clotrimazole and flutrimazole have been successfully prepared rapidly and efficiently using this newly developed method."

Journal • Oncology