nevirapine / Generic mfg. - LARVOL DELTA

Comparative Analysis of Effectiveness of Dolutegravir-Based Regimen (TLD) vs. Efavirenz-Based Regimen (TLE) to Prevent Mother-to-Child Transmission of HIV. (PubMed, Cureus) - "The TLD regimen was associated with a trend towards lower MTCT of HIV compared to the TLE regimen. Thus, continued use of dolutegravir-based therapy is recommended to support national and global goals of eliminating new HIV infections among exposed infants."

Journal • Human Immunodeficiency Virus • Infectious Disease • CD4

HIV-1 drug resistance and genetic clustering among ART-treated individuals with virologic failure in Aksu, China. (PubMed, Front Microbiol) - "The most common DRMs were K103N/S (60.7%), M184V/I (27.3%), G190A/E/S (11.3%), and E138A/K/Q/G (10.8%), conferring high-level resistance mainly to lamivudine (3TC), efavirenz (EFV), and nevirapine (NVP)...The clustering of DRMs underscores the importance of molecular surveillance for guiding targeted interventions. These findings support accelerating access to effective second-line regimens, strengthening pretreatment resistance surveillance, and prioritizing adherence support among central individuals with high viral loads."

Journal • Human Immunodeficiency Virus • Infectious Disease

Retention in care of HIV-exposed infants and associated infant and maternal factors in Teso Sub Region, Eastern Uganda. (PubMed, AIDS Res Ther) - "Retention in care showed an early peak, followed by a gradual decline during mid-follow-up, and later stabilized toward the end of the observation period. The retention in care of HIV-exposed infants was significantly higher among infants residing in Kumi and Serere districts compared to Bukedea. Timely EID registration and timely initiation of Nevirapine prophylaxis significantly reduced retention in care. These findings underscore the importance of strengthening early infant diagnosis while addressing contextual barriers to enhance continuity of care with targeted support to lower-performing districts like Bukedea."

Journal • Human Immunodeficiency Virus • Infectious Disease

Predictors of HIV Vertical Transmission in Exposed Infants in Northwest, Ethiopia: A Retrospective Cohort Study. (PubMed, Health Sci Rep) - "Therefore, we recommend further PMTCT service expansion; focus on maternal HIV diagnosis in the preconception period; improve provision of infant Nevirapine prophylaxis and maternal ART help to minimize HIV vertical transmission. Reduce home delivery also helps to decrease HIV vertical transmission."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease • Pediatrics

Time to treatment failure and its predictors among children receiving first-line antiretroviral therapy in Tigray Region public general hospitals, North Ethiopia, 2024: Retrospective cohort study. (PubMed, PLoS One) - "The incidence of treatment failure among children receiving first-line ART was found to be high according to the UNAIDS virological suppression targets. Poor adherence, baseline CD4 count, and initial NVP-based regimen were predictors of time to treatment failure of ART. Hence, all children on ART should be closely monitored, mainly on these identified predictors."

Journal • Retrospective data • Human Immunodeficiency Virus • Infectious Disease • Pediatrics • CD4

Repurposing of FDA-Approved Antiviral Drugs Against Monkeypox Virus: Comparative In Vitro Screening and Structure Based In Silico Studies. (PubMed, Pharmaceuticals (Basel)) - "Twenty-three FDA-approved drugs, including Abacavir, Acyclovir, Amantadine, Chloroquine, Daclatasvir, Dolutegravir, Entecavir, Favipiravir, Hydroxychloroquine, Lamivudine, Molnupiravir, Nevirapine, Oseltamivir, Penciclovir, Remdesivir, Ribavirin, Sofosbuvir, Tenofovir, Valaciclovir, Valganciclovir, Velpatasvir, Zanamivir, and Zidovudine, were screened for potential anti-monkeypox activity in vitro...The employed computational methods indicate that remdesivir demonstrated superior binding patterns with elevated scores and stable complexes throughout the simulation. Our findings showed that Remdesivir therapeutic compound is potent against the tested strain of MPXV, and exhibited a robust binding affinity for Thymidylate Kinase, A42R Profilin-Like Protein, and VACV D13 enzymes, and thus may potentially be utilized as antiviral for the treatment of monkeypox virus."

FDA event • Journal • Preclinical • Infectious Disease

Postpartum maternal monitoring for renal safety related to tenofovir exposure during breastfeeding in the PROMISE 1077BF randomized trial. (PubMed, J Acquir Immune Defic Syndr) - "Although participants randomized to TDF-ART had larger decreases in CrCl from Entry compared with participants randomized to iNVP, differences attenuated overtime and were not clinically significant. TDF-containing ART had no observed safety concerns for maternal renal function during the postpartum period."

Journal • Human Immunodeficiency Virus • Infectious Disease • CD4

Structure-Guided Design of Novel Diarylpyrimidine-Based NNRTIs Through a Comprehensive In Silico Approach: 3D-QSAR, ADMET Evaluation, Molecular Docking, and Molecular Dynamics. (PubMed, Pharmaceuticals (Basel)) - "P14 and P43 showed higher binding affinities than nevirapine and favorable ADMET profiles...Drug-likeness profiles indicated optimal log P, strong hydrogen bonding, and acceptable bioavailability. P14 and P43 demonstrate strong potential as NNRTI leads, combining binding affinity, structural stability, and favorable pharmacokinetics, supporting further experimental development."

Journal • Human Immunodeficiency Virus • Infectious Disease

Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches. (PubMed, Front Pharmacol) - "Among them, FHW exhibited the strongest interaction with HIV-1 RT, with a binding energy of -63.50 kcal/mol using MM/GBSA, outperforming the reference drug Nevirapine...Molecular dynamics simulations confirmed the structural stability of the FHW-RT complex over a 100 ns trajectory. Collectively, these findings identify FHW as the most promising tripeptide-based RT inhibitor with potential for development into next-generation HIV therapeutics, with HFW and HHW as alternative candidates."

Journal • Human Immunodeficiency Virus • Infectious Disease

A Riboflavin-Derived Flavinium Salt Mediates Chemoselective Methylation Reactions. (PubMed, Chemistry) - "Methylation is accomplished with complex molecules, including venetoclax and nevirapine. We envision the flavin-mediated methodology to be adaptable to other alkylation reactions besides methylation. Within the realm of the latter, chemoselective modification of nucleobases stands out as a promising target."

Journal

Maternal and health worker preferences for paediatric antiretroviral formulations in neonates exposed to HIV. (PubMed, AIDS Care) - P1/2 | "Oral liquid formulations of zidovudine (ZDV) and nevirapine (NVP) are the main antiretrovirals (ARVs) for neonates born to mothers living with HIV, but they have limitations including poor palatability, short shelf-life, frequent dosing and supply challenges...Within the PETITE-DTG trial in South Africa (NCT05590325), evaluating the pharmacokinetics, safety and acceptability of novel dolutegravir (DTG) formulations in neonates, we explored ARV preferences among mothers (n = 28) and health workers (n = 6)...Transdermal patches were least favoured, with concerns regarding the comfort of neonates, impact of water exposure and effectiveness. These findings underscore strong support for innovative ARV options, emphasizing usability, ease of administration and reduced dosing frequency for the treatment of neonates."

Journal • Human Immunodeficiency Virus • Infectious Disease • Pediatrics

Drug Resistance Among Newly Diagnosed People Living with HIV-1 in Sichuan, China: A Large-Scale Population-Based Cross-Sectional Study. (PubMed, Infect Drug Resist) - "Within NNRTIs, efavirenz (EFV) and nevirapine (NVP) resistance rates were 6.26% and 6.50%, respectively. The prevalence of TDR in Sichuan had reached moderate epidemic levels, with certain cities already experiencing high epidemic rates. It is urgent that we urgently expand targeted genotypic drug resistance detection and implement interventions to improve medication adherence."

Journal • Observational data • Human Immunodeficiency Virus • Infectious Disease

Inhibitory potential of α-amyrin from Calotropis procera against HIV-1 reverse transcriptase: insights from in silico and in vitro assays. (PubMed, In Silico Pharmacol) - "An in vitro HIV-1 RT inhibition assay was conducted using a colorimetric ELISA kit, with nevirapine as the reference drug...Its strong binding affinity, significant enzymatic inhibition, and favorable pharmacokinetics suggest its potential for further development as a plant-based NNRTI, addressing drug resistance concerns and contributing to improved antiretroviral therapies. The online version contains supplementary material available at 10.1007/s40203-025-00498-z."

Journal • Preclinical • Human Immunodeficiency Virus • Infectious Disease

Inflammatory and redox reprogramming of macrophages by HIV cell-to-cell transmission inhibits bone resorption capacity. (PubMed, Front Immunol) - "Nevirapine partially restored osteoclastogenesis and revealed contact-associated drug insensitivity. The effects scaled with the proportion of infected T cells. HIV cell-to-cell spread induces inflammatory and redox reprogramming in macrophage precursors that blocks osteoclast differentiation and function, offering testable targets (inflammasome, adhesion, ROS) to protect bone in HIV."

Journal • Human Immunodeficiency Virus • Infectious Disease • Osteoporosis • ANXA5 • CD4 • CD63 • CD81 • CD9 • ICAM1 • IFNG • IL1B • TNFA

HIV vertical transmission linked to virological failure in pregnant women on ART. (PubMed, AIDS Res Ther) - "Maternal VF was strongly associated with increased risk of VT. These findings highlight the importance of early initiation of ART, consistent viral suppression, adherence support, and routine viral load monitoring as key strategies to reduce VT, particularly in high-burden settings. Strengthening these interventions may help target the small subset of mothers at highest risk and improve overall prevention outcomes."

Journal • Retrospective data • Review • Human Immunodeficiency Virus • Infectious Disease • CD4

Retroelements in thyroid cancer: epigenetic plasticity, dedifferentiation, and therapeutic opportunities. (PubMed, Rev Endocr Metab Disord) - "Emerging data also indicate that reverse transcriptase inhibitors (e.g., lamivudine, nevirapine) can partially suppress retroelement activity, induce transcriptional reprogramming and restore radioiodine uptake in refractory thyroid tumors, highlighting a potential therapeutic vulnerability. By integrating cancer epigenetics and mobilome biology, this review reframes thyroid tumor evolution as a process shaped not only by genetic alterations but also by retroelement-mediated disruption of genome regulation. Retroelements may serve as biomarkers of aggressive transformation and as actionable targets in translational oncology."

Journal • Review • Oncology • Solid Tumor • Thyroid Gland Anaplastic Carcinoma • Thyroid Gland Carcinoma • BRAF • TERT • TP53

In Vitro and In Vivo Specificity and Biodistribution of a Novel CD8-Targeted Fusosome (ASH 2023) - "Reverse transcriptase inhibitor nevirapine was used as control for the in vitro studies...Collectively, these studies demonstrate high on target specificity of SG299 fusosome to transduce CD8+ T cells in vitro and in vivo. Therefore, SG299 represents a novel therapeutic opportunity to generate CAR T cells in vivo and potentially overcome challenges associated with ex vivo CAR T therapies."

Preclinical • Gene Therapies • Hematological Malignancies • Oncology • CD4 • CD8

Drug-Induced Vanishing Bile Duct Syndrome: A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS) Database (ACG 2025) - "A total of 899 cases of VBDS were reported to the FAERS from 2003-2024. 893 were characterized as severe, including 166 deaths (18.6%). The most common reported drugs were – Ibuprofen (11.12%; ROR: 32.35 [26.28, 39.83]; p< 0.05), Sulfamethoxazole/Trimethoprim (9.12%; ROR: 63.23 [50.38, 79.37]; p< 0.05), Ciprofloxacin (7.00%; ROR: 37.87 [29.31, 48.92]; p< 0.05), Lamivudine with and without Zidovudine (6.1%; ROR: 59.38 [45.2, 78.02]; p< 0.05), Azithromycin (5.5%; ROR: 59.21 [44.51, 78.78]; p< 0.05), Temozolomide (5.12%; ROR: 66.57 [49.47, 89.59]; p< 0.05), Nevirapine (4.89%; ROR: 117.62 [86.83, 159.33]; p< 0.05), Levofloxacin (4.67%; ROR: 25.06 [18.39, 34.17]; p< 0.05), Acetaminophen (4.67%; ROR: 9.14 [6.7, 12.46]; p< 0.05), Levetiracetam (4.67%; ROR: 19.02 [13.95, 25.93]; p< 0.05), Lamotrigine (4.00%; ROR: 15.64 [11.2, 21.82]; p< 0.05), and Prednisone (3.78%; ROR: 6.72 [4.77, 9.47]; p< 0.05). Ibuprofen was the most reported drug as a..."

Adverse events • Cholestasis • Hepatology

Insights from systematic reviews (2019-2024) and drug interaction database analysis in people with HIV and comorbidities. (PubMed, Int J STD AIDS) - "Severe adverse drug reactions associated with ARTs, including efavirenz, darunavir, nevirapine, and atazanavir-ritonavir, especially when combined with treatments for TB and malaria. Key interactions included reduced drug levels from rifampicin and QT prolongation from artemether-lumefantrine...Database discrepancies were noted, especially for riociguat interactions and ritonavir through inhibition of P-gp or OATP1B1 functions.ConclusionsDDIs in PWH receiving ART with comorbidities have highlighted the crucial need for personalized treatment. Incorporating pharmacokinetic, pharmacodynamic, and pharmacogenomic factors is essential for optimizing therapy outcomes."

Journal • Cardiovascular • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Malaria • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Seasonal analysis and environmental risk assessment of selected emerging pollutants in the Vaal River catchment area of South Africa. (PubMed, Environ Monit Assess) - "This study investigates the presence of four selected antibiotics and an antiretroviral drug (nevirapine) in the Vaal River in South Africa. Amongst the studied pharmaceuticals, ciprofloxacin exhibited the highest ecological risk, with its risk quotient evaluated to be 11.67. These results call for action to ascertain the sources and stop their release into the river across the catchment area."

Journal

ABCB1 Polymorphism in HIV-Infected Individuals Taking Antiretroviral Drugs. (PubMed, AIDS Res Treat) - "The ABCB1 1236TT genotype along with nevirapine (NVP) usage exhibited a risk for hepatotoxicity severity (OR = 2.11, p = 0.55)...Protective effects were observed for CC and TT haplotypes. Larger studies are warranted to confirm these findings and assess clinical relevance."

Journal • Human Immunodeficiency Virus • Infectious Disease • ABCB1

Investigating the pharmacogenetic basis of Nevirapine-induced cutaneous reactions among selected HIV patients in Ghana. (ASTMH 2025) - "The study emphasizes the need for advanced HLA typing techniques such as next-generation sequencing (NGS), broader sequence coverage, and combined typing strategies to enhance pharmacogenetic screening. A larger, prospective NGS-based study is recommended to validate findings and inform the implementation of genetic screening in HIV treatment in African settings."

Biomarker • Clinical • Dermatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • HLA-B

Decline in estimated glomerular filtration rate following substitution of Nevirapine-based regimen with Tenofovir-based regimen in Indonesia. (PubMed, BMC Infect Dis) - No abstract available

Journal • Human Immunodeficiency Virus • Infectious Disease

HIV-1 genetic diversity and pretreatment drug resistance survey prior to dolutegravir introduction in Senegal. (PubMed, IJID Reg) - "Among NRTIs, the most frequent mutation was M184V (3/6), conferring high-level resistance to lamivudine and emtricitabine, and K103N (11/12) among NNRTIs, conferring resistance to efavirenz and nevirapine. Through a quasi-national survey, an intermediate level of NNRTI resistance was observed, with regional disparities in Senegal. These findings highlight the limitations of NNRTI-based first-line regimens in Senegal and support the transition to other antiretroviral therapy regimens, such as dolutegravir-based therapy in newly infected individuals as well as in treated patients."

Journal • Human Immunodeficiency Virus • Infectious Disease • Inflammation

IMPACT OF PREEXISTING K103N ON THE EFFECTIVINES OF LA-CAB+RPV: REAL-LIFE RELATIVITY COHORT (EACS 2025) - "Purpose : K103N is a nonpolymorphic NNRTI resistance-associated mutation (RAM) selected in people with HIV (PWH) treated with nevirapine (NVP) or efavirenz (EFV). It reduces susceptibility to NVP and EFV by approximately 50-fold and 20-fold, respectively, but does not affect susceptibility to rilpivirine (RPV), etravirine (ETR), or doravirine (DOR)...BASELINE CHARACTERISTICS REGARDING THE PRESENCE OF K103N Conclusions : The presence of the K103N mutation was not associated with an increased risk of virological failure in PWH treated with LA-CAB+RPV. These findings suggest that a history of K103N should not preclude the use of this regimen."

Clinical • Human Immunodeficiency Virus • Infectious Disease