fluocinolone acetonide / Generic mfg. - LARVOL DELTA

CD09 Complexities of contact dermatitis: lessons from a case of concomitant budesonide and propylene glycol sensitivity. (PubMed, Br J Dermatol) - "Positive reactions on day 4 included propylene glycol 20%, colophony 20%, jasmine absolute Egyptian, tixocortol-21-pivalate 1% in petrolatum, budesonide 0.01% in petrolatum and mometasone furoate ointment...Safe alternatives were recommended, while propylene glycol-containing products such as Dermovate, Metosyn and Synalar were to be avoided...Contact Dermatitis 2019; 81: 280-7). Vigilant allergen avoidance, individualized treatment plans and education are paramount for optimal management to prevent exposure to such allergens in future treatments."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Impact of baseline visual acuity, time-in-range and early treatment on functional outcomes in DMO: insights from the IRISS outcomes. (PubMed, Eye (Lond)) - "Eyes with better initial VA maintained functionally better visual acuity for longer following FAc implant treatment. TIR emerged as a potentially clinically relevant endpoint for evaluating long-term treatment outcomes in DMO, offering a broader perspective than traditional VA measures."

Journal • Diabetic Macular Edema • Macular Edema • Ophthalmology

Real-World Clinical Outcomes After Sustained Delivery of the 0.19 mg Fluocinolone Acetonide Implant for Treatment of Diabetic Macular Edema. (PubMed, J Vitreoretin Dis) - "The fluocinolone acetonide implant demonstrated sustained visual stability, significant anatomical improvement, reduced treatment burden, and a manageable safety profile. These findings support its role as an effective long-term therapeutic option for DME, including in vitrectomized eyes."

Clinical data • Journal • Real-world evidence • Diabetes • Diabetic Macular Edema • Diabetic Retinopathy • Metabolic Disorders • Ophthalmology • Retinal Disorders • Type 2 Diabetes Mellitus

Citrobacter koseri Endophthalmitis Following Intravitreal Fluocinolone Acetonide Implant Injection. (PubMed, Ophthalmic Surg Lasers Imaging Retina) - "A vitreous biopsy and intravitreal injection of vancomycin and ceftazidime were performed upon presentation. The vitreous sample culture was positive for C. koseri. The patient responded well with ultimate resolution of the infection and return of pre-infection visual acuity without a vitrectomy."

Journal • Diabetic Macular Edema • Infectious Disease • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

The Combination of Fluocinolone Acetonide and Ketocaine Hydrochloride in the Conservative Management of Symptomatic Hemorrhoidal Disease: An Overview of Preclinical and Clinical Data. (PubMed, J Gastrointestin Liver Dis) - "Furthermore, its combination with flavonoid-based supplements, which improve venous tone and reduce capillary permeability, may aid in preventing recurrence. This combined approach leverages the rapid symptom relief provided by topical agents and the long-term benefits of systemic therapies, promoting comprehensive HD management and reducing the risk of recurrence."

Clinical data • Journal • Preclinical • Review • Anesthesia • Gastroenterology • Inflammation • Pain • Venous Ulcer

Shedding Light on Effective Management of Acne Keloidalis Nuchae: The Utility of Excimer Pulsed Light Therapy (EADV 2025) - "Previous treatments included three intralesional triamcinolone injections at two-month intervals (10–40 mg/mL), a four-month course of topical fluocinolone acetonide gel, and oral lymecycline (408 mg daily), all of which had minimal impact. To our knowledge, this is the first reported use of EPL for AKN. While other UV wavelengths have demonstrated efficacy in previous studies, evidence supporting the use of UVB for this condition remains limited. This case highlights EPL as a safe and effective treatment for AKN."

Acne Vulgaris • Alopecia • Atopic Dermatitis • Fibrosis • Genetic Disorders • Pruritus • Psoriasis • Skin Cancer • Thermal Injury

Safety and efficacy profile of the fluocinolone acetonide implant in non-infectious uveitic macular edema: 5-year follow-up. (PubMed, Arch Soc Esp Oftalmol (Engl Ed)) - "The fluocinolone acetonide implant (FAI), in our series of cases, turned out to be an effective and safe therapy for non-infectious uveitic macular edema, providing sustained and long-lasting effects, in some cases up to 60 months post-implantation. Sub-Tenon triamcinolone proves to be a valuable adjunctive therapy."

Journal • Cardiovascular • Cataract • Glaucoma • Macular Edema • Ocular Inflammation • Ophthalmology • Uveitis

Efficacy of fluocinolone acetonide implant in diabetic macular edema patients previously treated with dexamethasone implant: A systematic review and meta-analysis. (PubMed, Pak J Med Sci) - "The use of FACI seems safe without significant change in IOP. Registration: PROSPERO CRD42025635691."

Journal • Retrospective data • Diabetic Macular Edema • Diabetic Retinopathy • Macular Edema • Ophthalmology • Retinal Disorders

Radiation-induced maculopathy and fluocinolone acetonide implant. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "FAc implant improved BCVA and significantly reduced the therapeutic burden in patients with radiation maculopathy. However, careful IOP monitoring is required to effectively manage intraocular hypertension."

Journal • Cardiovascular • Eye Cancer • Glaucoma • Macular Degeneration • Macular Edema • Melanoma • Ocular Melanoma • Oncology • Ophthalmology • Retinal Disorders • Solid Tumor • Uveal Melanoma

Identification and validation of ANXA3 and SOCS3 as biomarkers for acute myocardial infarction related to sphingolipid metabolism. (PubMed, Hereditas) - "ANXA3 and SOCS3 were identified as SM-related biomarkers in AMI, providing insights for clinical diagnosis."

Biomarker • IO biomarker • Journal • Cardiovascular • Metabolic Disorders • Myocardial Infarction • ANXA3 • CD4 • SOCS3

Efficacy of Botulinum Toxin A for the Management of Melasma: A Split-Face, Randomized Control Study. (PubMed, J Cosmet Dermatol) - "Intradermal incoBoNT-A injection combined with TCC demonstrated superior efficacy in melasma treatment and recurrence prevention compared to TCC monotherapy."

Clinical • Journal • Dermatology • Dermatopathology

Efficacy and safety of multiple fluocinolone acetonide implants in diabetic macular oedema: comparison between first and second intravitreal injections. (PubMed, Eye (Lond)) - "Multiple FAc-I injections are a safe and effective treatment option for chronic DMO in real life. The second injection maintained similar functional and anatomical outcomes to the first, supporting the sustainability and repeatability of the treatment."

Journal • Diabetic Macular Edema • Macular Edema • Ophthalmology

Pars plana suturing of intravitreal fluocinolone acetonide in noninfectious uveitis. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "In patients with aphakia, compromised zonules/posterior lens capsule, and anterior or scleral-fixated intraocular lenses, all of which are contraindications to injection of posterior segment implants, scleral fixation of the 0.18 mg fluocinolone acetonide implant may be useful for treatment of noninfectious uveitis."

Journal • Inflammation • Macular Edema • Ocular Inflammation • Ophthalmology • Uveitis

Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique. (PubMed, Pharmaceuticals (Basel)) - "Although scleral fixation of the FAc implant has been described in small series of patients with successful results, this approach remains off-label. Although off-label, ITC of the FAc implant may offer a promising treatment option for patients who would otherwise remain untreated."

Journal • Cardiovascular • Glaucoma • Macular Edema • Ophthalmology

The effect of fluocinolone acetonide, ProRoot MTA and their combination on inflammation and odontogenic differentiation of inflamed human dental pulp cells. (PubMed, Clin Oral Investig) - "Under the simulated inflammatory condition of HDPCs, this in vitro study suggests the potential benefit of FA for anti-inflammatory and mineralisation enhancing properties."

Journal • Inflammation • IL1B • IL6

When Normal Flora Turns Pathogenic: A Pediatric Case of Infectious Eczematoid Dermatitis. (PubMed, Cureus) - "The lesions were initially treated with topical fluocinolone acetonide prescribed by an otolaryngologist, without clinical improvement...The patient was treated with ciprofloxacin, selected based on antibiotic sensitivity, along with mometasone furoate 0.1% cream to address both infectious and inflammatory components. On follow-up, the lesions showed improvement; however, the patient was later lost to follow-up. This case highlights the need to consider IED in children with refractory eczematous eruptions."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Otorhinolaryngology • Pediatrics

Handshake technique for removal of fluocinolone acetonide implant from the vitreous cavity. (PubMed, BMJ Case Rep) - "Fluocinolone implant could be safely removed through 25 G cannula in toto, and removal resulted in good control of intraocular pressure at 3-month and 9-month follow-up. This innovative bimanual handshake technique to transfer and realign the implant coaxially is a quicker and safer way to remove FAc implant, which avoids removing the cannula and thereby retains all advantages of 25G cannula, including better sclerotomy closure."

Journal • Glaucoma • Ophthalmology

Predictive value of short-term steroid intraocular pressure elevation testing for long-term steroid intraocular pressure elevation in diabetic macular edema treatment. (PubMed, Int Ophthalmol) - "It is crucial to evaluate the necessity of a prior short-acting steroid challenge, which carries the risk of multiple disease relapses, given the potential for a prolonged and stable steroid to provide superior control. The predictive value of the test with TA was not evident in our sample, suggesting some usefulness in delaying treatment with the FAc implant."

Journal • Observational data • Retrospective data • Diabetic Macular Edema • Ophthalmology

REDD1/DDIT4 knockout prevents skin atrophy in aged mice (SID 2025) - "We observed that chronic fluocinolone acetonide (FA) treatment in 20-month-old REDD1 KO mice induced epidermal hyperplasia, in contrast to significant epidermal thinning in WT isogenic controls...Gene set enrichment analysis (GSEA) identified a significant number of histone genes, including targets of Polycomb Repressive Complex 2 (PRC2) methylation, only in aged REDD1 KO mice. These findings suggest that the absence of REDD1 gene may reverse the phenotypic skin changes associated with GC-induced atrophy in aged mice, possibly through modulation of epigenetic pathways altered during intrinsic aging."

Preclinical • Dermatology • Inflammation • DDIT4

Nontargeted Analysis Reveals Organofluorine Pharmaceutical Compounds Responsible for Formation of Toxic Disinfection Byproducts in a Drinking Water Treatment Plant in China. (PubMed, Environ Sci Technol) - "These findings were validated using chemical standards, including fluoroquinolone antibiotics (e.g., enrofloxacin and difloxacin) and fluorosteroids (e.g., fluocinolone acetonide and triamcinolone)...Fluorosteroids showed smaller toxicity increases (1.3-1.5 times), but their conversion rates in real water were 1.7-2.3 times higher than in laboratory conditions. This study highlights the role of organofluorine precursors in DBP formation and provides an innovative method to identify unknown DBPs, elucidate their formation pathways, and trace their sources, advancing water treatment safety."

Journal

The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Chulalongkorn University

New trial • Dermatology • Dermatopathology • Lichen Planus

Occlusive Retinal Vasculitis After Aflibercept 8mg Injection for Wet Macular Degeneration. (PubMed, Retin Cases Brief Rep) - "ORV is a rare complication of some intravitreal anti-VEGF medications and infectious causes of endophthalmitis. It can be managed with aggressive steroid treatment for an excellent visual outcome in some cases, although the disease may be chronic or recurrent."

Journal • Age-related Macular Degeneration • Inflammation • Macular Degeneration • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis • Vasculitis • Wet Age-related Macular Degeneration

Electroretinography of disease activity and treatment response in birdshot chorioretinopathy. (PubMed, Eye (Lond)) - "Timing of 30 Hz flicker, bright scotopic a-wave, and photopic b-wave may be useful biomarkers for disease activity in BSCR. Moreover, both SI and IVFAI were effective in preserving retinal function to varying degrees."

Journal • Immunology • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Dexamethasone and fluocinolone acetonide implants side by side. (PubMed, J Fr Ophtalmol) - No abstract available

Journal

Long-Term Treatment Outcomes with a Single 0.19 Mg Fluocinolone Acetonide Implant in Non-Infectious Uveitis - A Real-World Study. (PubMed, Ocul Immunol Inflamm) - "Within 48 months, ocular hypertension (≥25 mmHg) occurred in 22.2% of eyes (8/36), with 19.4% (7/36) requiring new-onset IOP-lowering drops. FAc demonstrated efficacy in managing low-grade NIU-PS, reducing the need for additional treatments and controlling intraocular inflammation for an average of 32 months."

Journal • Real-world evidence • Cardiovascular • Glaucoma • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis