verapamil modified release / Generic mfg. - LARVOL DELTA

Verapamil Effect in Cystic Fibrosis-related Dysglycemia (clinicaltrials.gov) - P2 | N=30 | Not yet recruiting | Sponsor: Rhode Island Hospital | Phase classification: P4 ➔ P2

Phase classification • Cystic Fibrosis • Diabetes • Genetic Disorders • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

Verapamil Effect in Cystic Fibrosis-related Dysglycemia (clinicaltrials.gov) - P4 | N=30 | Not yet recruiting | Sponsor: Rhode Island Hospital

New P2 trial • New P4 trial • Cystic Fibrosis • Diabetes • Genetic Disorders • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM) (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Stanford University

New P4 trial • CNS Disorders • Migraine • Otorhinolaryngology • Vertigo

Safety and Efficacy of HB-1 for Post-Traumatic Stress Disorder (clinicaltrials.gov) - P2 | N=200 | Recruiting | Sponsor: HB BioTech, LLC | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Ver-A-T1D: Verapamil SR in Adults With Type 1 Diabetes (clinicaltrials.gov) - P2 | N=136 | Completed | Sponsor: Medical University of Graz | Active, not recruiting ➔ Completed

Trial completion • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Safety and Efficacy of HB-1 for PTSD: A Multi-center, Randomized, Double-Blind, Placebo-Controlled Study (clinicaltrials.gov) - P2 | N=200 | Not yet recruiting | Sponsor: Honeybrains Biotech LLC

New P2 trial • CNS Disorders • Post-traumatic Stress Disorder

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=120 | Recruiting | Sponsor: City of Hope Medical Center | Not yet recruiting ➔ Recruiting

Enrollment open • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Ver-A-T1D: Verapamil SR in Adults With Type 1 Diabetes (clinicaltrials.gov) - P2 | N=138 | Active, not recruiting | Sponsor: Medical University of Graz | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=120 | Not yet recruiting | Sponsor: City of Hope Medical Center | Initiation date: Dec 2025 ➔ Mar 2026

Trial initiation date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=0 | Withdrawn | Sponsor: City of Hope Medical Center | Not yet recruiting ➔ Withdrawn | N=120 ➔ 0

Enrollment change • Trial withdrawal • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=120 | Not yet recruiting | Sponsor: City of Hope Medical Center | Initiation date: Dec 2026 ➔ Dec 2025

Trial initiation date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Precision Administration of Anti-thymocyte Globulin With or Without Verapamil (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: University of Florida | Not yet recruiting ➔ Recruiting

Enrollment open • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=120 | Not yet recruiting | Sponsor: City of Hope Medical Center | Initiation date: Jan 2026 ➔ Dec 2026

Trial initiation date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=120 | Not yet recruiting | Sponsor: City of Hope Medical Center | Initiation date: Oct 2025 ➔ Jan 2026

Trial initiation date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Construction and in vitro/ in vivo evaluations of pulse sustained release of verapamil hydrochloride delivery system. (PubMed, Pak J Pharm Sci) - "The findings showed that a verapamil hydrochloride pulsatile release suspension prepared with custom-made porous cation exchange resin achieved controlled and sustained release, potentially improving adherence in cardiovascular therapy by better aligning with disease progression. It is also likely to reduce dosing frequency and plasma concentration fluctuations, offering significant clinical value in the personalized management of conditions such as hypertension and angina."

Journal • Preclinical • Cardiovascular • Hypertension

AN INTERESTING CASE OF SEVERE CALCIUM CHANNEL BLOCKER OVERDOSE (CHEST 2025) - "CASE PRESENTATION: A 23-year-old male with a history of hypertension and morbid obesity presented to the emergency department after an intentional overdose on verapamil extended-release... This case highlights the critical management strategies for a life-threatening verapamil overdose. Early intervention with resuscitation and antidote therapy, along with continuous monitoring and multi-disciplinary care, is essential for improving patient outcomes in such severe cases. This report underscores the need for prompt recognition and aggressive treatment in the management of CCB toxicity."

Clinical • Acute Kidney Injury • Acute Respiratory Distress Syndrome • Addiction (Opioid and Alcohol) • Cardiovascular • Genetic Disorders • Hypertension • Hypotension • Nephrology • Obesity • Renal Disease • Respiratory Diseases

Management of Acute Tinnitus With Migraine Medications (clinicaltrials.gov) - P4 | N=100 | Active, not recruiting | Sponsor: University of California, Irvine | Recruiting ➔ Active, not recruiting | Trial completion date: Sep 2026 ➔ Dec 2026 | Trial primary completion date: May 2026 ➔ Dec 2026

Enrollment closed • Trial completion date • Trial primary completion date • CNS Disorders • Migraine • Otorhinolaryngology • Pain

Precision Administration of Anti-thymocyte Globulin With or Without Verapamil (clinicaltrials.gov) - P2 | N=60 | Not yet recruiting | Sponsor: University of Florida | Trial primary completion date: Jul 2028 ➔ Oct 2028

Trial primary completion date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

WAVE T1D: A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (clinicaltrials.gov) - P1/2 | N=120 | Not yet recruiting | Sponsor: City of Hope Medical Center

New P1/2 trial • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Precision Administration of Anti-thymocyte Globulin With or Without Verapamil (clinicaltrials.gov) - P2 | N=60 | Not yet recruiting | Sponsor: University of Florida | Trial completion date: Apr 2030 ➔ Jul 2030 | Initiation date: Apr 2025 ➔ Jul 2025 | Trial primary completion date: Apr 2028 ➔ Jul 2028

Trial completion date • Trial initiation date • Trial primary completion date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Management of Acute Tinnitus With Migraine Medications (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: University of California, Irvine | Initiation date: Mar 2025 ➔ Jun 2025

Trial initiation date • CNS Disorders • Migraine • Otorhinolaryngology • Pain

TEMPO II: Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Morten Steen Kvistholm Jensen | Trial completion date: Jun 2027 ➔ Dec 2027 | Trial primary completion date: Jun 2025 ➔ Apr 2027

Trial completion date • Trial primary completion date • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Hypertrophic Cardiomyopathy • Non-obstructive Hypertrophic Cardiomyopathy

Management of Acute Tinnitus with Migraine Medications (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: University of California, Irvine

New P4 trial • CNS Disorders • Migraine • Otorhinolaryngology • Pain

Ver-A-T1D: Verapamil SR in Adults With Type 1 Diabetes (clinicaltrials.gov) - P2 | N=138 | Active, not recruiting | Sponsor: Medical University of Graz | Recruiting ➔ Active, not recruiting

Enrollment closed • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

DON'T BE BRASH: A FATAL CASE OF VERAPAMIL OVERDOSE (CHEST 2024) - "CASE PRESENTATION: A 68-year-old female with a history of hypertension (on lisinopril and verapamil) and severe depression with persistent suicidal ideation presented to the emergency department after being found unresponsive at home...A thorough medication reconciliation revealed a missing verapamil SR 240 mg bottle despite a recent refill...Interventions are comprised by fluid resuscitation, IV glucagon, high-dose insulin infusion, bradycardia management (atropine, epinephrine infusion, ventricular pacing), and more advanced therapies, including IV lipid emulsion and extracorporeal membrane oxygenation (ECMO). Calcium channel overdose and BRASH syndrome both carry a high mortality rate. Early recognition and management are crucial to improve patient survival."

Clinical • Cardiovascular • CNS Disorders • Depression • Epilepsy • Gastrointestinal Disorder • Hypertension • Hypotension • Infectious Disease • Migraine • Nephrology • Pain • Pneumonia • Psychiatry • Renal Disease • Respiratory Diseases • Septic Shock • Suicidal Ideation