naproxen ER / Generic mfg. - LARVOL DELTA

Pharmacological Interventions for the Prevention of Esophagitis in Lung Radiation: Systematic Review and Meta-Analysis (IASLC-WCLC 2026) - "Eight trials reported survival or treatment response outcomes, all of which showed no difference between trial arms Conclusions : Previous clinical trials have investigated the role of amofostine, epoetin-alpha, indomethacin, naproxen, glutamine and sodium alginate in preventing radiation-induced esophagitis in lung cancer. Pooled analysis demonstrates promising results for amfostine."

Retrospective data • Review • Gastrointestinal Disorder • Lung Cancer • Solid Tumor

Analgesic Effectiveness of a New Fixed-Dose Combination Acetaminophen/Naproxen Sodium: A Phase 3 Placebo-controlled, Randomized, Double-blind, Factorial Trial in Post-operative Dental Pain (PAINWeek 2026) - "Among 447 factorial trial participants, 59.5% reported severe pain and 93.7% had 4 third molars extracted. Among 279 POC trial participants, 65.5% reported severe pain and 90.3% had 4 third molars extracted. FDC Acet650/NPX220 participants in the factorial trial reported superior pain control compared to Acet650, NPX220, and PBO participants throughout 12 hours (mean SPID 0-12: 49.3, 24.0, 40.7, 4.1, respectively, each p≤0.003) and during the initial 6 hours (mean SPID 0-6: 27.1, 15.6, 20.3, 1.8, respectively, each p≤0.003)."

Clinical • P3 data • CNS Disorders • Pain

Pharmacokinetic and Mechanistic Rationale for Combining Acetaminophen with Naproxen Sodium: A Systematic Analysis of Temporal and Mechanistic Complementarity (PAINWeek 2026) - "A total of 576 publications were identified for acetaminophen, 351 for aspirin, 294 for ibuprofen, and 75 for naproxen sodium - of which 35 studies for acetaminophen,14 studies for aspirin, 26 studies for ibuprofen, and 4 for naproxen sodium were selected for evaluation based on the inclusion/exclusion criteria. Naproxen sodium was associated with fewer qualifying publications possibly due to limited available formulations and doses compared to multiple APAP and ibuprofen doses/formulations. Sample sizes ranged from 5 to 50 subjects."

PK/PD data • CNS Disorders • Migraine • TRPV1

A Phase 3 Multiple-dose Efficacy and Safety Trial of a Novel Fixed Dose Combination of Acetaminophen and Naproxen Sodium in a Post-surgical Bunionectomy Pain Model (PAINWeek 2026) - "Postsurgical bunionectomy pain is a well-established and reliable pain model that has been used to assess moderate- and high-potency analgesics and support regulatory agency review and approval of many prescription analgesics, including, suzetrigine and hydrocodone bitartrate/acetaminophen... Among 143 randomized participants, mean baseline pain intensity score was 7.6 on PI-NRS with 86 (60.1%) reporting moderate and 57 (39.9%) severe pain. FDC Acet650/NPX220 participants reported greater reductions in pain intensity compared with placebo throughout the trial (SPID 0-12, 15.2 and 2.6, respectively; SPID 0-24 [primary endpoint], 48.4 and 14.2, respectively; SPID 0-48, 151.5 and 68.3, respectively; each p< 0.001). FDC Acet650/NPX220 participants reported significantly greater PID compared with placebo from 3-48 hours (p< 0.05 across timepoints)."

Clinical • P3 data • CNS Disorders • Pain

National Survey of Pharmacists' Practices in OTC Pain Management (PAINWeek 2026) - "[Carrasco-Labra 2024, Qaseem 2020, Dowell 2022] In a population-based online survey of U.S. adults, over-the-counter (OTC) medications were among the most prevalent medications used, with acetaminophen, ibuprofen, aspirin, and naproxen sodium as the most utilized pharmacologic agents... 201 U.S. retail pharmacists who currently counsel patients on OTC pain medications completed the online survey. Most of the respondents practice in chain community pharmacy settings (53%, n=106) and suburban locations (51%, n=102). Over half reported more than 10 years of practice (58%, n=117) and 51% (n=103) counseled more than 50 patients weekly on OTC medications."

Back Pain • CNS Disorders • Musculoskeletal Pain • Pain

Safety of Acute Naproxen Use: A Systematic Review of Secondary Analyses (PAINWeek 2026) - "Of the nine reviews that met the inclusion criteria, four were Cochrane reviews, two were academic meta-analyses, and three were large industry-sponsored pooled analyses. AMSTAR-2 ratings ranged from low to high. An estimated 14,000 patients were included across indications, including postoperative pain, migraine, dysmenorrhea, osteoarthritis, sore muscle, and ankle sprain, with trial overlap across reviews."

Clinical • Review • Addiction (Opioid and Alcohol) • CNS Disorders • Migraine

2026 Taiwan guidelines for the acute pharmacologic treatment of migraine in adults. (PubMed, J Chin Med Assoc) - "Non-specific agents include acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs: diclofenac, ibuprofen, naproxen). Injectable prochlorperazine is also strongly recommended. Ergotamine/caffeine combinations are less effective and are second-line agents, while high-dose aspirin is limited by gastrointestinal risk. Considering the potential risk of dependency, tramadol or tramadol/paracetamol combinations should be reserved until all other agents fail, and should be limited to oral forms. Other opioids, such as morphine, butorphanol, etc., lack evidence and are not recommended...Acetaminophen remains first-line for children and pregnant women. To prevent medication-overuse headache, acute treatments, including NSAIDs, acetaminophen, triptans, ergot derivatives, and combination analgesics, should not exceed two days per week, probably with the exception of rimegepant."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Migraine • Pain

Opioid Therapy vs. Multimodal Analgesia in Head and Neck Cancer (OPTIMAL-HN): Results of a Randomized Clinical Trial (ASTRO 2024) - P2 | "HNC patients receiving curative-intent RT/CRT and experiencing moderate 4/10 RIM pain were randomized 1:1, stratified by RT vs. CRT, to opioids alone per institutional standard or MMA (Pregabalin, Acetaminophen, Naproxen, and opioids if required)...Median weekly opioid use was numerically higher in the opioid arm (99.2 mg oral morphine equivalent dose [OMED], IQR: 16.3-173.1) compared to the MMA arm (50.5 mg OMED; IQR: 8.4-126.3), although nonsignificant (p=0.435)... MMA demonstrates non-inferiority to opioid analgesia alone in managing RIM pain during the last week of RT and superiority when analyzing the post-RT time period. MMA is therefore an effective analgesic regimen and should be considered for use in HNC patients."

Clinical • Acute Kidney Injury • Head and Neck Cancer • Mucositis • Nephrology • Oncology • Pain • Renal Disease • Solid Tumor

Effect of Multimodal Pre-emptive Analgesia with Pregabalin Versus Naproxen on Post-Thoracotomy Pain and Opioid Consumption: A Randomized Clinical Trial. (PubMed, Turk J Anaesthesiol Reanim) - "Pregabalin reduced opioid requirement: fewer patients required rescue analgesia (46.2% vs. 69.2%; P=0.042), time to first rescue was longer (7.6±3.1 vs. 5.4±2.8 h; P=0.001), and 24-hour opioid consumption was lower (6.2±3.0 vs. 8.6±3.4 mg morphine equivalents; P=0.001). Dynamic pain during deep breathing and coughing was lower with pregabalin at early time points; sedation was slightly higher at 2 hours, without significant adverse neurocognitive events. Pre-emptive pregabalin improved functional analgesia and produced an opioid-sparing effect compared with naproxen after thoracotomy, with acceptable short-term safety, thereby supporting enhanced recovery pathways."

Clinical • Journal • Anesthesia • Pain

Effectiveness and safety of sumatriptan 85 mg/naproxen sodium 500 mg combination for acute migraine: prospective real-world evidence from the GRASP Study Group. (PubMed, Front Neurol) - "Fixed-dose sumatriptan/naproxen sodium was associated with modest 2-h pain freedom but clinically meaningful pain relief, functional recovery, and low rescue medication use. Tolerability was consistent with the known profiles of triptans and non-steroidal anti-inflammatory drugs."

HEOR • Journal • Real-world evidence • CNS Disorders • Fatigue • Migraine • Pain

Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-Endodontic Treatment Pain: A Randomised Controlled Trial. (PubMed, J Coll Physicians Surg Pak) - "The efficacy of trypsin-chymotrypsin was comparable to that of naproxen sodium in reducing post-endodontic pain in teeth with symptomatic irreversible pulpitis."

Clinical • Journal • Dental Disorders • Pain

In vivo Predictive Dissolution Test Using Biorelevant Bicarbonate Buffer for High-dose Free Acid Drug. (PubMed, AAPS J) - "Valsartan and naproxen were selected as model compounds exhibiting solubility-limited absorption at high doses...In contrast, when using USP or the compendial Dose/FV, the pHbulk, 4 h and Cdissolv, 4 h were less reduced, leading to an overestimation of Fa. Overall, the use of BCB or PPB and a clinical Dose/FV improved the in vivo predictability for high-dose free acid drugs."

Journal • Preclinical

Efficacy of Switching from Prior Nonsteroidal Anti-inflammatory Drugs to Transdermal Diclofenac in Cancer Pain Management. (PubMed, In Vivo) - "Switching to transdermal diclofenac effectively reduced pain in patients with cancer and may serve as a useful alternative when oral or prior NSAID therapy is difficult to continue."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Dermatology • Oncology • Pain • Palliative care • Pruritus

Expression of circulating GRP78 and gp96, endoplasmic reticulum stress-related proteins, in menstrual and bladder pain sensitivity. (PubMed, Sci Rep) - "After correcting for Menstrual phase, naproxen exposure, and oral contraceptive use, GRP78 was higher in DYSB than in DYS (ratio 1.33; p = .028), while gp96 was lower in both DYS (ratio 0.62; p = .019) and DYSB (ratio 0.59; p = .031) compared to controls...The inverse pattern of higher GRP78 and lower gp96 levels points to selective, rather than global, ER chaperone dysregulation as a candidate mechanism. However, future mechanistic and longitudinal investigations will be required to establish whether GRP78 and gp96 carry predictive or pathophysiological relevance."

Journal • CNS Disorders • Depression • Inflammation • Mood Disorders • Pain • Psychiatry • Sleep Disorder • Women's Health • HSPA5

Etoricoxib-Induced Fixed Drug Eruption: A Case Series and Assessment of Tolerance to Alternative NSAIDs (EAACI 2026) - "Provocations were carried out with aspirin in 4 patients (50%), ibuprofen in 2 (25%), naproxen in 1 (12.5%), and meloxicam in 1 (12.5%)...Notably, most patients exhibited a multifocal pattern. OP testing with alternative NSAIDs was well tolerated in all evaluated cases."

Clinical • Allergy • Immunology

Tolperisone Hypersensitivity: An Underrecognized Drug Allergy in the Context of Widespread Off-Label Use (EAACI 2026) - "Oral provocation testing remains essential for diagnostic confirmation. Increased awareness is warranted to avoid misattribution of reactions to co-administered drugs."

Late-breaking abstract • Allergy • Immunology

Etoricoxib-Induced Fixed Drug Eruption: A Case Series and Assessment of Tolerance to Alternative NSAIDs (EAACI 2026) - "Provocations were carried out with aspirin in 4 patients (50%), ibuprofen in 2 (25%), naproxen in 1 (12.5%), and meloxicam in 1 (12.5%)...Notably, most patients exhibited a multifocal pattern. OP testing with alternative NSAIDs was well tolerated in all evaluated cases."

Clinical • Allergy • Immunology

Severe Drug-Induced Anaphylaxis After Naproxen Sodium Administration: A Case Report (EAACI 2026) - "Conclusion This case highlights the importance of early recognition and prompt treatment of drug-induced anaphylaxis. NSAID-related hypersensitivity reactions may occur even in patients without prior known drug allergies, emphasizing the need for careful drug history assessment and appropriate patient education upon discharge."

Case report • Clinical • Immunology • CRP

Tofacitinib in early active axial spondyloarthritis: results from the randomised, double-blind, placebo-controlled, multicentre Phase IV study, FASTLANE (EULAR 2026) - P4 | "Conclusions In patients with early active axSpA, tofacitinib was superior to placebo in achieving remission (ASDAS inactive disease) at Week 16 on a background of naproxen. The safety of tofacitinib was consistent with the established safety profile and was similar to that observed in clinical trials in AS."

Clinical • P4 data • Ankylosing Spondylitis • Back Pain • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • Seronegative Spondyloarthropathies • Spondylarthritis • CRP

Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen. (PubMed, J Pharm Pharm Sci) - "The use of a PC membrane resulted in higher permeability, compared to the PVDF membrane. Adequately improved, this methodology could be transferred for the ex vivo membrane dissolution-permeability testing."

Journal

Cellulose and Its Derivatives in Drug Delivery: Recent Advances and Applications. (PubMed, Pharmaceutics) - "Recent advances include pH-responsive bacterial nanocellulose/carboxymethyl cellulose hydrogels for oral ibuprofen delivery, carboxylated nanocellulose/polyethylene glycol/β-cyclodextrin composite aerogels for gastric-selective release of imatinib, and hydroxypropyl methyl cellulose-based microneedle patches for transdermal co-delivery of sumatriptan succinate and naproxen sodium. These examples highlight how cellulose-based systems can be engineered for site-selective delivery, sustained release, and multi-stimuli responsiveness. In this review, we summarize the structural features of cellulose derivatives and nanocellulose, discuss the design principles and release mechanisms of representative delivery platforms, and outline current challenges in manufacturability, safety evaluation, and clinical translation."

Journal • Review

Silk Sericin Functionalized with Carboxy Drugs for Dermocosmetic Applications. (PubMed, ACS Appl Bio Mater) - "In this paper, we report the preparation of sericin conjugates with carboxy drugs of dermatological interest, i.e., naproxen, retinoic acid, and azelaic acid...Ex vivo tests on defatted pig skin demonstrated effective passage of the free drug through the skin (5% w/w of the applied dose) from a NAP@SER glycerol suspension and a significant retention of the drug (33% w/w) within the dermal or epidermal tissues. These results hint at the potential of sericin conjugates as prodrugs for dermal administration."

Journal

Fatty Acid Binding Protein 5 Inhibitors art26.12 Provides Immediate and Lasting Analgesia for Osteoarthritic Pain (ASRA-SPRING 2026) - "Eight weeks post-surgery, five rat groups (N=10) received acute dosing (PO BID) of vehicle, 8 mg/kg naproxen, and three concentrations of ART26.12 (10, 25, and 50 mg/kg)...•Use of only female rats in a single DMM osteoarthritis model limits generalizability to males and human OA. •Pain assessment relied on behavioral surrogate measures without histologic, mechanistic, or long-term safety data."

Gastrointestinal Disorder • Immunology • Osteoarthritis • Pain • FABP5

An empirical relationship between physicochemical properties and sublingual absorption of the model drugs. (PubMed, Int J Pharm) - "Orally disintegrating tablets and oral tablets of five model drugs atenolol, caffeine, naproxen, propranolol, and verapamil were administered to healthy human subjects via both sublingual and oral routes...Drugs with lower lipophilicity and molecular flexibility exhibited faster sublingual absorption. These findings help to highlight the important physicochemical properties that may influence sublingual absorption."

Journal

Randomized controlled trial of intravenous dexamethasone to prevent relapse in the treatment of migraine in a pediatric emergency department. (PubMed, Headache) - "In this small clinical trial of children and adolescents with acute migraine attack treated in the ED, adjunctive dexamethasone did not reduce relapse rates nor improve functional outcomes compared with placebo. Although limited by low statistical power, these findings raise questions about the routine use of dexamethasone in migraine management of children and adolescents."

Journal • CNS Disorders • Migraine • Pain • Pediatrics