naproxen ER / Generic mfg. - LARVOL DELTA

Chronic nonbacterial osteomyelitis: a typical case and review. (PubMed, Front Pediatr) - "Treatment included NSAIDs, intravenous antibiotics, and oral medications such as diclofenac sodium, naproxen, methotrexate, and calcitriol...After escalation to intravenous pamidronate and subcutaneous adalimumab, the patient achieved sustained clinical remission...This case underscores the complexity of diagnosing and managing CNO, highlighting the need for a multidisciplinary approach. Further research is essential to establish standardized diagnostic criteria and optimize treatment strategies for this rare condition."

Journal • Review • Infectious Disease • Inflammation • Oncology • Orthopedics • Pain

CARDIORENAL SAFETY OF NSAIDS IN PATIENTS WITH ARTHRITIS: A NETWORK METANALYSIS (ACC 2026) - " We included 23 studies (19 RCTs, 4 cohort) with 1245,108 patients,NSAIDs evaluated were Naproxen (n=69,209),Ibuprofen(n=535,651), Celecoxib(n=107,493),oral Diclofenac (n=335,154),Rofecoxib (n=105,102), Nabumetone (n=507),Valdecoxib (n=5,075), Meloxicam (n=27,713),Piroxicam (n=14,585),Mefenamic acid (n=13,856),Indomethacin (n=26,254),placebo (n=4192), Acetaminophen (n=287),and Amtolmetin guacil (n=30).Compared to placebo, Valdecoxib had highest odds of MACE [OR: 2.96 (95%CI:1.80-4.85)] and Rofecoxib highest odds of renal AEs [OR: 5.11 (95%CI: 2.58-10.10)].League tables showed no differences between different NSAIDs, SUCRA rankings identified Celecoxib with highest MACE and Rofecoxib with highest renal risk (Figure). Valdecoxib and Rofecoxib confer the highest cardiorenal risks. SUCRA rankings ranked Celecoxib as highest for MACE risk and Rofecoxib for renal risk, underscoring the importance of NSAID-specific safety profiles to guide arthritis treatment decisions."

Clinical • Cardiovascular • Immunology • Rheumatology

Comparing the Effect of Drug, Sodium Carboxymethyl Cellulose and Other Excipients on Shape, Size and Drug Release from the Matrices. (PubMed, Int J Pharm Compd) - "The swelling rate of the different matrices was constrained only by NaCMC. The ratio of anionic NaCMC primarily controlled the release rate of drugs. The shape and size of the matrices, according to the solubility and charge of these drugs. Other excipients, such as surfactants, lactose, and magnesium stearate, affected the release rate of the drugs, shape and size of the matrices but did not influence their swelling rate."

Clinical • Journal

Cryogenic auriculotherapy reduces pain and opioid use in patients undergoing endoscopic carpal tunnel release surgery: a retrospective analysis. (PubMed, Front Pain Res (Lausanne)) - "The primary end points were overall consumption-expressed as the area under the curve (AUC) for oral morphine equivalent (OME) in mg-and pain scores between POD1 and POD3...Naproxen consumption was not significantly different...Our study suggests that cryogenic AT is an effective complementary alternative to opioids to control postoperative pain following CTR. Further investigations are required to confirm these findings."

Journal • Retrospective data • Anesthesia • Pain

Synthetic Tetrahydrocannabinol (THC) is a Safe Adjunct to the Treatment of Postoperative Pain after Arthroscopic Knee Surgery: A Pilot Randomized Safety Trial (AAOS 2026) - "Exclusion criteria included patients under the age of 18, patients unable to provide consent, patients who are pregnant, breastfeeding, or trying to become pregnant, patients with an allergy to any of the study drugs, patients undergoing revision surgery or open surgery, patients with a history of mania, depression, or schizophrenia, patients currently diagnosed with alcohol or drug abuse, patients who cannot or will not abide by the medication regimen, or patients taking any of the following drugs: anticholinergic agents, benzodiazepines, central nervous system depressants, droperidol, hydroxyzine, levomepromazine, methotrimeprazine, monoamine oxidase inhibitors, ritonavir, selective serotonin reuptake inhibitors, sympathomimetics, St...Primary outcome for this pilot study was safety of the test drug with the secondary outcome being pain control and number of opioid tablets (hydrocodone-acetaminophen 5-325mg) consumed at 3 different time intervals: 24 hours, 48 hours,..."

Clinical • Surgery • Addiction (Opioid and Alcohol) • Bipolar Disorder • Depression • Immunology • Orthopedics • Pain • Schizophrenia • Xerostomia

Novel optimization of multi-mechanistic approaches for the acute treatment of a migraine attack: A review. (PubMed, Headache) - "Combination treatments with different mechanisms of action targeting key distinct pathophysiological processes of migraine may be more effective than monotherapies, particularly if their pharmacokinetic profiles are optimized to target those processes at the right time. Further research in this area is warranted."

Journal • Review • CNS Disorders • Migraine • Pain

CAN IT BE DONE IN ONE DAY? PEDIATRIC PATIENTS WITH MULTIPLE DRUG ALLERGY LABELS: A RETROSPECTIVE ANALYSIS (AAAAI 2026) - "One patient developed coughing/wheezing during a naproxen challenge, which improved with antihistamines; this was the only symptomatic event on a multi-challenge day. No patients required epinephrine. Conclusions Our data demonstrates that patients can safely complete multiple oral challenges within a singular visit. This would result in decreased financial and time burden for patients, families, providers, clinic staff, and the healthcare system."

Retrospective data • Allergy • Immunology • Pediatrics

A multi-compartment pulsatile drug delivery system for sequential release: in vitro and in vivo evaluation. (PubMed, Drug Deliv Transl Res) - "The in vitro dissolution displayed immediate release of esomeprazole and delayed release of naproxen with Tlag of 11.33 ± 1.37 h...The time to maximum plasma concentration (Tmax) of esomeprazole was 0.67 ± 0.67 h, whereas the Tmax of naproxen was 9.83 ± 2.40 h with a Tlag of 4.75 ± 1.17 h. These findings demonstrate that this modular 3D-printed platform, combined with conventional tablets, provides controlled and sequential drug delivery, thereby supporting patient-tailored therapeutic regimens."

Journal • Preclinical

Host-Guest Doping Room-Temperature Phosphorescence Sensing Strategy for the Detection of Related Substances in Naproxen APls and in the Production of Dosage Forms. (PubMed, Anal Chem) - "Furthermore, both spectral analysis and real-time visualization inspection were successfully achieved for the limit test of MANAP in naproxen granules and tablets. This work introduces a novel RTP-based PAT approach for impurity testing in pharmaceutical manufacturing."

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Opioid Therapy vs. Multimodal Analgesia in Head and Neck Cancer (OPTIMAL-HN): Results of a Randomized Clinical Trial (ASTRO 2024) - P2 | "HNC patients receiving curative-intent RT/CRT and experiencing moderate 4/10 RIM pain were randomized 1:1, stratified by RT vs. CRT, to opioids alone per institutional standard or MMA (Pregabalin, Acetaminophen, Naproxen, and opioids if required)...Median weekly opioid use was numerically higher in the opioid arm (99.2 mg oral morphine equivalent dose [OMED], IQR: 16.3-173.1) compared to the MMA arm (50.5 mg OMED; IQR: 8.4-126.3), although nonsignificant (p=0.435)... MMA demonstrates non-inferiority to opioid analgesia alone in managing RIM pain during the last week of RT and superiority when analyzing the post-RT time period. MMA is therefore an effective analgesic regimen and should be considered for use in HNC patients."

Clinical • Acute Kidney Injury • Head and Neck Cancer • Mucositis • Nephrology • Oncology • Pain • Renal Disease • Solid Tumor

Vitamin C Conjugates in Biomedicine: A Comprehensive Exploration with Drugs, Polymers, Proteins, and Peptides. (PubMed, Mini Rev Med Chem) - "Vitamin C-drug conjugates, including derivatives of diclofenac, aspirin, and naproxen, have demonstrated improved transport across the blood-brain barrier via SVCT-mediated uptake, offering potential for the treatment of neurodegenerative disorders. Similarly, conjugation with antivirals such as saquinavir improves oral absorption and systemic bioavailability by bypassing efflux mechanisms...Protein conjugates, utilizing carriers such as HSA, BSA, and β-lactoglobulin, facilitate systemic transport, while peptide conjugates leverage the antioxidant activity of vitamin C in conjunction with peptide-based targeting, providing synergistic benefits in cosmetics and dermatology. Collectively, these studies highlight vitamin C conjugation as a versatile platform for precision medicine and targeted therapy."

Journal • CNS Disorders • Dermatology • Oncology

Efficacy of JOINS Tablet for Lumbar Spinal Stenosis: Prospective, Randomized, Open-Label Clinical Trial. (PubMed, Medicina (Kaunas)) - "The control group was prescribed the usual spinal stenosis medications (Naproxen, Limaprost, and Pregabalin), while the test group was prescribed JOINS tablets in addition to the usual medications...At all follow-up periods, the functional outcomes did not show statistically significant differences between the test and control groups. The significant reduction in pain suggests that JOINS tablets may be an effective adjunct for pain relief, particularly in patients at high risk of adverse effects from long-term NSAID use."

Clinical • Journal • Back Pain • Inflammation • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

REB methodology application on topical and oral NSAIDS' therapeutic benefit evaluation on acute pain related to musculoskeletal injuries (PubMed, Therapie) - "According to REB methodology, topical NSAIDs, unlike oral formulations, have demonstrated efficacy in managing acute pain related to musculoskeletal injuries. These results reinforce recent meta-analyses favoring topical NSAIDs and recommending to limit the use of oral NSAIDs due to a lack of proof in this indication. Finally, NSAIDs impact on tissue healing has not been objectively studied by RCTs in humans, so further research is warranted. The use of NSAIDs in trauma care may potentially evolve as new data and knowledge emerge."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Kidney Safety of Nonsteroidal Anti-Inflammatory Drugs in Patients with Arthritis: A Network Meta-Analysis (KIDNEY WEEK 2025) - "NSAIDs evaluated were naproxen (n=17,185), ibuprofen (n=28,531), celecoxib (n=37,843), oral diclofenac (n=6,060), rofecoxib (n=804), nabumetone (n=15), valdecoxib (n=544), and amtolmetin guacil (n=30)...Conclusion Rofecoxib, naproxen, and diclofenac are associated with a higher incidence of renal AEs, edema, and HTN compared with placebo, respectively. Physicians should weigh renal safety when prescribing NSAIDs for arthritis."

Retrospective data • Immunology • Osteoarthritis • Rheumatoid Arthritis • Rheumatology

Population Pharmacokinetics of Atogepant for the Prevention of Migraine. (PubMed, Clin Pharmacokinet) - P3 | "The pharmacokinetics of atogepant are similar in healthy participants and patients with CM or EM. Dose adjustments owing to intrinsic factors of age, sex, race, and body weight, or owing to concomitant medications consisting of P-glycoprotein (P-gp) inhibitors, BCRP inhibitors, oral contraceptive components (ethinyl estradiol and levonorgestrel), famotidine, esomeprazole, sumatriptan, acetaminophen, and naproxen are not necessary. Atogepant's popPK model provides a valuable tool for evaluating specific questions for patients, healthcare providers, and regulatory agencies. Integration into other modeling approaches has also aided in model-informed drug development decisions."

Journal • PK/PD data • Breast Cancer • CNS Disorders • Hepatology • Migraine • Oncology • Pain • Renal Disease • Solid Tumor

Patient-Reported Use of Concomitant Treatments for Crohn's Disease Among Adults Treated With Risankizumab in Clinical Practice: Initial Results From the ASPIRE-CD Study (ACG 2025) - "aCorticosteroids include oral prednisone, oral budesonide, and topical steroids.bOTC treatments include methylcellulose, loperamide, acetaminophen, ibuprofen, naproxen, vitamins, and mineral supplementation.cDietary adjustments include oral nutritional supplements and diet restriction (low fiber diet and low residual diet).Figure: Figure 2... Of the 286 patients who received the first induction RZB dose, 212 (76.0%) completed the wk20 survey. Most patients had prior biologic or Janus kinase inhibitor (JAKi) experience (75.2%) at baseline, with 45.5% having ≥ 2 prior biologics or JAKis. Patient-reported corticosteroid use reduced from 33.9% at baseline to 14.6% at wk20 (P < .001; Fig."

Clinical • Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease • IL23A

Gel-Phase Microextraction Using Microfluidic-Directed Ultrashort Peptide Assemblies for the Determination of Drugs in Oral Fluids. (PubMed, Int J Mol Sci) - "The peptide fibers co-assembled successfully with 5-fluorouracil (5-FU) and naproxen (39.8 ± 1.4 nmol of 5-FU and 27.4 ± 6.6 nmol of naproxen per 112 nmol of peptide used to prepare the fiber), resulting in a molar ratio drug/peptide ratio of approximately 1:3 and 1:4, respectively, demonstrating versatility in drug entrapment...The extension of the methodology to simulated saliva samples allowed extraction of 36% of 5-FU by the fiber, as determined by 19F NMR spectroscopy on microcoils, which enabled us to work with the small volume of fluid extracted from the microfluidic device and provided clean spectra and quantitative results. These findings highlight the potential of this tripeptide hydrogel as a sorbent material for therapeutic drug monitoring and toxicological analysis via a simple, non-invasive and rapid approach for drug detection in oral fluids."

Journal

A case of cutaneous vasculitis triggered by naproxen. (PubMed, Br J Nurs) - "Following assessment and investigations, naproxen was discontinued and oral prednisolone 40mg was prescribed...Nurses are central to recognising early skin changes, educating patients about potential adverse effects, and co-ordinating follow-up care. Effective communication and collaboration within the multidisciplinary team were crucial in achieving a positive outcome."

Journal • Musculoskeletal Pain • Pain • Vasculitis

SyrSpend® SF PH 4 as a Safe Vehicle for Extemporaneous Oral Suspensions: Microbiological Stability of Seven APIs. (PubMed, Int J Pharm Compd) - "This study aimed to evaluate the microbiological stability of oral suspensions containing dapsone, griseofulvin, levofloxacin, terbinafine, indometacin, naproxen, and paracetamol in SyrSpend® SF PH4, under both room temperature and refrigerated conditions...SyrSpend® SF PH4 effectively preserved the microbiological integrity of all tested formulations without added preservatives. These findings complement existing chemical stability data and support the use of SyrSpend® SF PH4 as a safe and effective vehicle for extemporaneous oral suspensions, particularly in populations requiring preservative-free formulations."

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Stable Analgesia, Reduced Hepatic Burden: Pharmacokinetic and Pharmacodynamic Advantages of Transdermal Diclofenac Tape(ZICTHORU® Tape) in Personalized Oncology Care (ASA 2025) - "Oral NSAIDs such as naproxen and diclofenac undergo significant hepatic metabolism during the first-pass effect, potentially exacerbating existing liver dysfunction, particularly in patients receiving hepatotoxic anticancer therapies such as tyrosine kinase inhibitors and immunotherapy agents...G represents the period, including nighttime, during which the concentration remains above the dashed-line threshold when 225mg ZICTHORU® Tapes is applied once a day. These pharmacokinetic characteristics suggest that ZICTHORU®Tapes provides a more stable and sustained plasma concentration, potentially enhancing pain management while minimizing peak-related side effects."

PK/PD data • Hepatology • Liver Failure • Musculoskeletal Pain • Pain

Post-Thyroidectomy Complications Associated with NSAID Use (AAO-HNSF 2025) - "Two cohorts were created: those receiving opioid analgesics alone (OA) and those receiving opioid analgesics in combination with NSAIDs including ibuprofen, ketorolac, acetylsalicylic acid, naproxen, or celecoxib (ON), within two weeks post-thyroidectomy... NSAIDs are associated with slightly increased complications post-thyroidectomy. Further research is needed to explore the underlying mechanisms of this association."

Endocrine Disorders • Hematological Disorders • Infectious Disease • Otorhinolaryngology

Synthesis and biological evaluation of novel naproxen-phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability. (PubMed, Bioorg Chem) - "Compounds 46 (IC₅₀ = 0.16 μM, SI = 2.36), 55 (0.19 μM, SI = 2.27), and 59 (0.21 μM, SI = 1.65) demonstrated potency comparable to celecoxib...Orally administered compounds 55 and 64 (20 mg/kg) reduced paw oedema by 61 % and 52 %, respectively, similar to indomethacin (52 %), without causing visible gastric lesions (lesion score ∼ 2 vs. 5 for indomethacin)...Overall, the 1,2,4-triazole-thione-naproxen/phenacetin hybrids represent promising lead candidates for the development of GI-safer NSAIDs. Compounds 55 and 64, in particular, merit further optimization and long-term safety evaluation."

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Comparative effects of cyclooxygenase-2 selective and nonselective nonsteroidal anti-inflammatory drugs and acetaminophen on rotator cuff tendon-bone healing in a rat model. (PubMed, Acta Orthop Traumatol Turc) - "Objective: This study aimed to investigate and compare the e!ects of naproxen (a nonselective nonsteroidal anti-inflammatory drug [NSAID]), celecoxib (a cyclooxygenase (COX)-2 selective NSAID), and acetaminophen (an analgesic with minimal anti-inflammatory activity) on tendon and tendon-bone healing following surgically induced supraspinatus tendon repair in a rat model...Although biomechanical di!erences were not statistically significant at 28 days, histological findings underscore the potential impact of analgesic selection on early postoperative tendon healing. Level of Evidence: N/A."

Clinical • Journal • Preclinical • Pain

The efficacy and safety of XG005, a novel non-opioid chemical entity concurrently inhibiting both nociceptive and neuropathic signals, in managing post-operative pain: a randomized, placebo-controlled phase 2b trial (PAINWeek 2025) - P2/3 | "XG005 is a single molecule conjugating naproxen and pregabalin, which is not active in gastrointestinal tract and thus minimizes naproxen side effects compared with administering naproxen directly...Qualified subjects were randomized (1:1:1) to receive either 1250 mg or 750 mg of XG005 tablets, or placebo...Tramadol consumption in the placebo group was 4.1- or 3.0-fold more than in the 1250 mg or 750 mg groups over 72 hours, and those were 3- or 2.5-fold in acetaminophen consumption...In comparison with other analgesics to treat acute pain using the same bunionectomy model with the same efficacy endpoint (SPI48) or Summed Pain Intensity Difference at 48 hours (SPID48), the pooled mean effect sizes are: 0.59 with various NSAIDs, 0.52 with various opioids combination with either acetaminophen or NSAIDs, 0.88 with tapentadol (an opioid) and 0.36 with a Nav1.8 antagonist... This trial randomized 450 participants (median age, 48 years; 80% female) with comparable..."

Clinical • P2b data • Addiction (Opioid and Alcohol) • CNS Disorders • Neuralgia • Pain • Psychiatry • Sleep Disorder • NAV1

Effect of Mixing Technology on Homogeneity and Quality of Sodium Naproxen Tablets: Technological and Analytical Evaluation Using HPLC Method. (PubMed, Molecules) - "The analytical method proved fast and robust, allowing for reliable API quantification without full chromatographic separation. These findings underscore the need to balance mechanical blending energy with formulation properties and support the use of streamlined analytical strategies in pharmaceutical development."

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