tigecycline / Generic mfg. - LARVOL DELTA

In vitro activity of eravacycline compared to other antibiotics commonly used for treatment of infections involving anaerobic bacteria: a review of the literature and our own data. (PubMed, Diagn Microbiol Infect Dis) - "Eravacycline is a third-generation tetracycline, a fluorocycline agent with two modifications that distinguish it from tigecycline. So far, only the injectable eravacycline administration for complicated intraabdominal infections has been approved. However, more studies in more countries are needed to assess its usefulness for combination treatment and still not labeled indications."

Journal • Preclinical • Review • Infectious Disease

PERSISTING FEVER AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A CASE REPORT OF A RARE INFECTION WITH LOMENTOSPORA PROLIFICANS (EBMT 2026) - "Cytoreductive therapy with hydroxyurea was initiated immediately after diagnosis, with no other prior antineoplastic treatment administered. Conditioning with fludarabine, thiotepa, and melphalan was started 7 months after the initial diagnosis...The patient received an HLA-identical unrelated male donor peripheral blood stem cell graft, with graft-versus-host disease prophylaxis comprising cyclosporine, mycophenolate mofetil, and anti-thymocyte globulin (ATG)...On day −3, the patient developed febrile neutropenia and broad-spectrum antibiotic treatment (piperacillin/tazobactam) was initiated. Recurrent fever on day +1 led to escalation to meropenem and a switch from fluconazole to posaconazole; blood cultures remained negative.Under these measures, the fever persisted...On day +11, increasing somnolence, pathological breathing pattern, and new oxygen requirement prompted sampling of peripheral and central blood cultures and empiric addition of linezolid and..."

Case report • Clinical • Bone Marrow Transplantation • Chronic Myelomonocytic Leukemia • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Respiratory Diseases • Septic Shock • Transplantation • ASXL1 • NRAS • RUNX1 • SETBP1 • SRSF2

MYCOBACTERIUM ABSCESSUS AS A COMPLICATION OF IMMUNOSUPPRESSION AFTER ALLOGENEIC STEM CELL TRANSPLANTATION FOR CONGENITAL NEUTROPENIA (EBMT 2026) - "Despite treatment with systemic corticosteroids, ruxolitinib, ibrutinib, antiviral agents, and antifungal therapy for a probable invasive pulmonary aspergillosis infection, respiratory status continued to decline.By day +190, the patient presented with septic shock, for which invasive mechanical ventilation (IMV), fluid expansion and vasopressor therapy were required...BAL and blood cultures were positive for M. abscessus massiliense, confirming invasive pulmonary disease with bacteremia.Treatment consisted of intravenous amikacin, tigecycline, imipenem, and TDM guided azithromycin and clofazimine, in addition to ongoing antifungal therapy... This case illustrates how Mabs can emerge insidiously in pediatric alloSCT recipients, mimicking more common post-transplant complications and progressing rapidly to severe invasive infection. The patient's gradual recovery underscores the importance of early recognition, aggressive multidrug therapy, and careful reassessment of..."

Graft versus Host Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Neutropenia • Nontuberculous Mycobacterial Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Transplantation • CSF3R

Impact of eravacycline on fibrinogen. (PubMed, J Antimicrob Chemother) - "A majority of eravacycline-treated patients experienced at least a 25% decrease in fibrinogen levels. Although the decreased fibrinogen levels did not result in major clinically significant bleeding, fibrinogen levels should be monitored at baseline and at least weekly. Patients should also be monitored for any signs and symptoms of bleeding."

Journal • Retrospective data • Infectious Disease • Respiratory Diseases • Solid Organ Transplantation • Transplantation • Tuberculosis

Molecular characterization & risk factors associated with carbapenemase-producing enterobacterales acquisition in hospitalised patients in a tertiary care setting. (PubMed, Indian J Med Res) - "CP-CRE isolates exhibited high resistance (70-90%) to fluoroquinolones, aztreonam, aminoglycosides, and tetracyclines, moderate resistance to tigecycline, and the lowest to colistin (2/58, 3.5%). Interpretation & conclusions This study revealed a high prevalence of CP-CRE, predominantly blaNDM-producing K. pneumoniae. CP-CRE infections were associated with multidrug resistance, increased mortality, and risk factors like prolonged hospitalisation, surgical procedures, and previous carbapenem exposure."

Journal • Infectious Disease • Pneumonia

Multidrug-Resistant Acinetobacter baumannii: Resistance Mechanisms, Emerging Therapies, and Prevention-A Narrative Review. (PubMed, Antibiotics (Basel)) - "Resistance is driven by OXA-type carbapenemases (notably OXA-23/24/58), efflux systems (AdeABC/IJK/FGH), porin alterations (CarO, Omp33-36), and lipopolysaccharide (LPS) modifications conferring colistin resistance. Management options include polymyxins, optimized tigecycline dosing, β-lactam/β-lactamase inhibitors, and newer agents such as cefiderocol and sulbactam-durlobactam, though mortality and safety outcomes vary across trials. A comparative table is included, summarizing antimicrobial mechanism coverage, PK/PD parameters, and adverse effects to support regimen selection in ventilator-associated pneumonia (VAP) and bacteremia. Optimized, multimodal approaches integrating timely diagnostics, targeted combination therapies, infection prevention, and antimicrobial stewardship are essential to improve outcomes and limit the spread of MDR and XDR A. baumannii."

Journal • Review • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Drug-resistant genes, virulence characteristics, and molecular typing of clindamycin-resistant Streptococcus agalactiae in late pregnancy. (PubMed, Front Cell Infect Microbiol) - "All strains were susceptible to penicillin, ampicillin, linezolid, vancomycin, and tigecycline. In contrast, resistance rates to erythromycin, levofloxacin, and tetracycline were 95.5%, 60.1%, and 56.7%, respectively...Clindamycin-resistant S. agalactiae in late-pregnancy women in Shandong Province, China exhibits a broad resistance spectrum, diverse molecular types, and significant regional heterogeneity. These findings underscore the need for continued surveillance and region-specific strategies for preventing neonatal S. agalactiae infections."

Journal • Infectious Disease

Chitosan-dextran sulfate nanocapsules for enhanced tigecycline efficacy against non-typhoidal Salmonella enterica. (PubMed, Sci Rep) - No abstract available

Journal • Infectious Disease

Phosphorus-Nitrogen Co-doped Carbon Dots for Fluorescence Detection of Tigecycline: Mechanistic Exploration. (PubMed, J Fluoresc) - No abstract available

Journal

Resistome, virulome and mobilome of clinical carbapenemase-producing Acinetobacter baumannii strains isolated in Togo. (PubMed, Int J Med Microbiol) - "All isolates exhibited resistance to imipenem, ticarcillin, clavulanic acid, cefotaxime, and ciprofloxacin, but remained susceptible to colistin, tigecycline, and rifampicin. Furthermore, several multidrug resistance plasmids and one virulence and AMR hybrid plasmid (accession number JBFMWK020002174.1) were identified. This study provides valuable insights into clinical A. baumannii in Togo, underscoring the need for more frequent genomic studies in sub-Saharan countries to effectively monitor and combat AMR in Africa."

Journal

Incidence and characteristics of eravacycline-associated increase in serum bilirubin levels: a retrospective study. (PubMed, Front Pharmacol) - "To compare the effects of eravacycline and tigecycline on serum bilirubin levels and investigate the incidence and clinical characteristics of total bilirubin increase associated with eravacycline. Eravacycline has been identified as an independent risk factor for the increase in total bilirubin. Monitoring serum bilirubin levels should be considered in patients receiving eravacycline, particularly in critically ill patients."

Journal • Retrospective data

Intraventricular tigecycline for post-neurosurgery ventriculitis due to XDR Acinetobacter baumannii (ESCMID Global 2026) - No abstract available

Surgery

Emergence of plasmid-mediated tigecycline, colistin and carbapenem resistance genes in E. coli isolated from minks in China (ESCMID Global 2026) - No abstract available

Standard- vs high-dose tigecycline in pneumonia due to carbapenem-resistant Acinetobacter baumannii: a propensity score-matched retrospective study (ESCMID Global 2026) - No abstract available

Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Colistin/sulbactam vs colistin/sulbactam plus high-dose tigecycline for the treatment of carbapenem-resistant Acinetobacter baumannii pneumonia: a multi-centre randomised controlled trial (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Pneumonia • Respiratory Diseases

Genomic decoding of tigecycline resistance and daptomycin non-susceptibility in Enterococcus faecium (ESCMID Global 2026) - No abstract available

In vivo evolution of tigecycline resistance in carbapenem-resistant Acinetobacter baumannii during tigecycline treatment (ESCMID Global 2026) - No abstract available

Preclinical

Co-emergence of plasmid-borne tigecycline resistance genes tet(X4) and tmexCD1-toprJ1 in Raoultella ornithinolytica isolated from retail pork in Jiangsu province, China (ESCMID Global 2026) - No abstract available

A multi-centre cohort study of tigecycline effectiveness and safety in patients with carbapenem-resistant Klebsiella pneumoniae and carbapenem-resistant Acinetobacter baumannii co-infection (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Pneumonia

Comparative effectiveness of polymyxin B combined with sulbactam vs polymyxin B combined with tigecycline in treatment of carbapenem-resistant Acinetobacter baumannii pneumonia: a retrospective observational study (ESCMID Global 2026) - No abstract available

HEOR • Observational data • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Mitoxantrone restores tigecycline activity by inhibiting tet(X4) and disrupting resistance mechanisms in Escherichia coli (ESCMID Global 2026) - No abstract available

Tigecycline-selected tyrosine kinase mutation in Klebsiella pneumoniae triggers metabolic rewiring and increased phage susceptibility without affecting virulence (ESCMID Global 2026) - No abstract available

Infectious Disease • Pneumonia

Mycobacterium abscessus lumbar osteomyelitis: A rare and challenging case with review of literature. (PubMed, IDCases) - "He was initially treated with IV amikacin, IV meropenem, IV tigecycline, and oral linezolid...He was discharged on IV tigecycline, imipenem, amikacin, and oral linezolid, later transitioning to oral omadacycline, azithromycin, and linezolid (Table 1). This case illustrates the challenges of managing Mycobacterium abscessus (MAB) infections, which require a multi-drug approach due to intrinsic and acquired antibiotic resistance. Therapy should begin with in-vitro guided IV antibiotics and transition to oral drugs for the continuation phase, optimizing therapeutic efficacy and overcoming resistance mechanisms."

Journal • Back Pain • Infectious Disease • Inflammation • Musculoskeletal Pain • Nontuberculous Mycobacterial Disease • Pain

Prevalence of Carbapenem-Resistant Enterobacteriaceae in Intensive Care Units in Saudi Arabia: A 10-Year Systematic Review. (PubMed, Saudi Med J) - "The high and rising prevalence of CRE in Saudi Arabian ICUs underscores the urgent need for standardized molecular diagnostics, comprehensive surveillance systems, and targeted antimicrobial stewardship programs. Implementing these strategies is crucial to reducing CRE transmission, overcoming resistance challenges, and improving patient outcomes in critical care environments."

Journal • Review • Chronic Kidney Disease • Critical care • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Renal Disease

Antibiotic resistance genes against "last-resort" antibiotics within the One Health framework: Dissemination, mechanisms, and AI-driven opportunities. (PubMed, J Hazard Mater) - "Last-resort antibiotic resistance genes (LARGs), resistance determinants that compromise last-line antibiotics, including blaNDM, mcr and tet(X), are emerging environmental contaminants that undermine the efficacy of carbapenems, polymyxins and tigecycline...Emerging approaches such as advanced oxidation processes, photocatalytic technologies, enhanced composting and biochar-based interventions offer improved but still incomplete removal, underscoring the need for more integrated and effective control frameworks. This study synthesizes mechanistic and ecological insights into LARGs and emphasizes artificial intelligence-enabled advances for precise detection, environmental surveillance, dissemination prediction, and optimization of mitigation strategies, providing a foundation for developing sustainable, integrative, and intelligent frameworks for resistance monitoring and control within the One Health context."

Journal • Review