tigecycline / Generic mfg. - LARVOL DELTA

Real-world Pharmacovigilance Study of Drug-induced Diabetes Insipidus from the FAERS Database. (PubMed, Endocr Connect) - "Lithium (n = 114, Information Component at the 95% lower credibility interval [IC025] = 6.12) and dexmedetomidine (n = 105, IC025 = 6.79) were identified as the most frequently reported drugs and showed the strongest association with DI. Several drugs, such as aripiprazole, letrozole, tigecycline, and dapagliflozin, were found to have unexpected potential associations with DI. This study provides a comprehensive overview of drug-induced DI based on real-world data. It highlights the importance of monitoring patients for DI when using certain medications, particularly high-risk nervous system drugs and antineoplastic agents."

Adverse events • Journal • Real-world evidence • Metabolic Disorders • Oncology

GD04 (P064) A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

P064 A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

Factors Associated with Candidemia After Living Donor Liver Transplantation: A Case-Control Study. (PubMed, J Clin Med) - " Univariate analysis revealed significant associations with prolonged intubation (p < 0.001), bile leaks (p < 0.001), relaparotomy (p < 0.001), chronic renal disease (p = 0.011), hepatocellular carcinoma (p = 0.011), and the use of antimicrobials including meropenem (p = 0.048), linezolid (p = 0.005), tigecycline (p = 0.045), third-generation cephalosporins (p = 0.003), anidulafungin (p < 0.001), fluconazole (p = 0.006), mycophenolate (p = 0.011), and total parenteral nutrition (TPN) (p = 0.049). Prolonged intubation, bile leaks, antifungal exposure, and lack of CMV prophylaxis are independently associated with higher odds of candidemia after LDLT. Targeted prophylaxis, prudent antimicrobial stewardship, and timely biliary intervention may reduce fungal morbidity and mortality in post-transplant patients."

Journal • Chronic Kidney Disease • Hepatocellular Cancer • Infectious Disease • Nephrology • Oncology • Renal Disease • Solid Tumor • Transplantation

Prevalence and Antimicrobial Resistance Patterns of Salmonella in Asymptomatic Horses in Eastern Spain: A One Health Perspective. (PubMed, Animals (Basel)) - "The highest resistance rates were against sulfamethoxazole and gentamicin, followed by ciprofloxacin and tigecycline. (4) Healthy horses can act as silent carriers of multidrug-resistant Salmonella, highlighting the need for surveillance, strengthened biosecurity, and prudent antimicrobial use within a One Health framework."

Journal

Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales. (PubMed, Antimicrob Agents Chemother) - "Tigecycline and colistin inhibited 94.1% and 76.6% of the isolates (FDA and EUCAST breakpoints, respectively). MBL-producing organisms are still considered an unmet medical need. Aztreonam-avibactam was active against this large collection of MBL-producing isolates that had elevated MIC values for many comparator agents."

Journal

Eravacycline pharmacokinetics/pharmacodynamics in the hollow fiber system model of Mycobacterium abscessus lung disease. (PubMed, Microbiol Spectr) - "The treatment guidelines include tetracyclines as part of the combination. While eravacycline MICs and static concentrations suggest great potential and even activity better than omadacycline and tigecycline, the drug only killed 0.56 log10 CFU/mL below stasis in the HFS-MAB. Monte Carlo simulation experiments suggested that optimal doses for MAB pulmonary disease are likely in the range that would not be tolerated by patients."

Journal • PK/PD data • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Analysis of Carbapenem-Resistant Enterobacterales Resistance in a Hospital in Kunming Over the Past Two Years. (PubMed, Infect Drug Resist) - "Conversely, the resistance rates to tigecycline, ceftazidime/avibactam, and polymyxin B were 1.26%, 24.24%, and 5.43%, respectively. CRE infections are difficult to treat and have a high mortality rate. Therefore, to meet the needs of Infection Prevention and Control, it is necessary to strengthen the monitoring of CRE resistance in this institution, contributing to the prevention, control, and clinical management capabilities for infections."

Journal • Critical care • Infectious Disease • Pneumonia

Carbapenem-resistant Klebsiella pneumoniae from clinical infections: a multifactorial analysis of resistance, virulence, and biofilm potential. (PubMed, Front Cell Infect Microbiol) - "MIC testing showed high resistance to meropenem (71%), colistin (61%), and tigecycline (43%). These findings highlight the convergence of antimicrobial resistance, virulence factors, and biofilm-forming capacity in K. pneumoniae. The coexistence of these traits promotes persistence, increases pathogenic potential, and complicates therapeutic interventions, emphasizing the urgent need for strengthened infection control and alternative treatment strategies."

Journal • Infectious Disease • Pneumonia

Global epidemiological and genetic characteristics of carbapenem-resistant Escherichia coli carrying blaIMP. (PubMed, Microbiol Spectr) - "The nine isolates were multidrug-resistant but susceptible to colistin, tigecycline, and amikacin. Additionally, the study elucidated the global epidemiological status, transmission features, and potential threats of blaIMP-positive CRECs through a large-scale analysis of publicly available genomic data. These findings not only facilitate a better understanding of the genetic dynamics and transmission pathways of blaIMP but also help develop effective regulatory measures and antibiotic stewardship programs to alleviate the increasingly severe burden of antimicrobial resistance."

Journal

Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes. (PubMed, FEMS Microbiol Ecol) - "While most isolates were susceptible to amoxicillin-clavulanic acid, imipenem, and metronidazole, resistance to tetracycline (12%), clindamycin (35%), and cefotaxime (35%) was observed. Distinct species-specific resistance included linezolid (Clostridium argentinense), chloramphenicol (Clostridium innocuum), and tigecycline (Paeniclostridium sordellii), and a one Robinsonella peoriensis isolate displayed vancomycin resistance. The detection of tet and erm genes corresponded with phenotypic resistance, while β-lactamase activity was uncommon. Although colonizing at low levels, these findings highlight the ecological significance of rarely studied commensal Clostridia and their contribution to the neonatal resistome, acting as underappreciated reservoirs of AMR genes during a critical window of microbiome assembly."

Journal

Predicting tigecycline-related adverse events in infected patients: a machine learning approach with clinical interpretability. (PubMed, Front Pharmacol) - "Notably, co-administration of meloxicillin and higher baseline red blood cell (RBC) levels appeared to be protective. This study constructed an online dynamic nomogram with good discrimination and calibration, which can help to identify high-risk patients and assist clinicians in early risk stratification and individualized treatment planning."

Adverse events • Journal • Hematological Disorders • Hepatitis B • Hepatology • Infectious Disease • Inflammation • Liver Failure • Septic Shock

Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae ST15-KL19 isolates from ICU patients in a Chinese tertiary hospital. (PubMed, Front Microbiol) - "The isolates exhibited complete resistance to β-lactams and carbapenems but remained susceptible to tigecycline and amikacin. Clinically, infections were associated with prolonged ICU stays and poor outcomes, with only 17.6% of patients achieving full recovery and 5.9% experiencing in-hospital mortality. These findings indicate that ST15-KL19 CRKP constitutes a regionally endemic clone with high resistance and virulence potential, underscoring the urgent need for strengthened molecular surveillance and stringent infection control measures."

Journal • Critical care • Infectious Disease • Pneumonia

Clinical Effectiveness of a Once-daily Regimen of Tigecycline Compared to the Standard Regimen (clinicaltrials.gov) - P4 | N=86 | Active, not recruiting | Sponsor: Air Force Specialized Hospital, Cairo, Egypt

New P4 trial • Infectious Disease

Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro. (PubMed, BMC Microbiol) - "This study provides valuable insights and theoretical support for the clinical therapy of relevant heteroresistance."

Journal • Preclinical • Infectious Disease • Pneumonia

Sphingobacterium spp. as intrinsic producers of SPI Ambler class B metallo-β-lactamases. (PubMed, J Antimicrob Chemother) - "S. spiritivorum was the most prevalent species of Sphingobacterium identified in clinical samples. All S. spiritivorum-like species produced a chromosomally encoded SPI-like MBL that might be challenging for the treatment of infections caused by this bacterial species."

Journal • Infectious Disease

Formation of a novel multiresistance plasmid co-carrying tigecycline, carbapenem and other resistance genes by recombination during conjugative transfer in Klebsiella pneumoniae. (PubMed, Int J Antimicrob Agents) - "Conjugative transfer experiments confirmed the transferability of different resistance genes, and surprisingly, recombination and co-transfer of the tet(A)v and blaNDM-1 genes were detected within the conjugative plasmid. These findings further reveal the crucial role of transposases in the formation of complex multidrug-resistant bacterial strains, providing a new perspective and key evidence for understanding the resistance mechanisms and dissemination pathways of multidrug-resistant K. pneumoniae."

Journal • Infectious Disease • Pneumonia

Genomic and Phenotypic Characterization of Extensively Drug-Resistant Clinical Klebsiella quasipneumoniae subsp. similipneumoniae ST1929 Isolates. (PubMed, Infect Drug Resist) - "All four isolates belonged to the novel ST1929-KL159 clonotype and exhibited an extensively drug-resistant phenotype, with resistance to β-lactams, carbapenems, fluoroquinolones, tigecycline, and trimethoprim-sulfamethoxazole. Amikacin was the only consistently active agent; one isolate showed high-level resistance to polymyxin B due to a premature stop mutation in mgrB (Gln30*)...similipneumoniae ST1929, an extensively drug-resistant lineage harboring bla NDM-1 and the tigecycline resistance cluster tmexC2D2-toprJ2 on a transferable IncU plasmid. The findings underscore the need for accurate detection and surveillance of this rare lineage."

Journal • Infectious Disease • Pneumonia

Incidence and Antibiotic Susceptibility of Gram-Negative Bacteria Associated With Chest Infections in Intensive Care Unit Patients From a Selected Hospital in the Kingdom of Saudi Arabia. (PubMed, Biomed Res Int) - "exhibited high resistance to third-generation cephalosporins (86%-93%) and carbapenems (70%-77%) while maintaining moderate susceptibility to amikacin (45%) and tigecycline (36%). These findings demonstrate a substantial burden of MDR among ICU GNB isolates, with colistin emerging as the only consistently effective therapeutic option. ICU cohort is dominated by a limited number of highly resistant GNB led by K. pneumoniae, P. aeruginosa, and A. baumannii. The cohort predominantly affects older adults (> 60 years), and the breadth of MDR/XDR/PDR underscores the urgency of rigorous antimicrobial stewardship, infection prevention, and rapid diagnostics to optimize empiric therapy."

Journal • Retrospective data • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Molecular Characterization of KPC-2 and CMY AmpC Beta Lactamases in Ceftazidime-Avibactam Resistant Klebsiella pneumoniae in a Tertiary Care Hospital. (PubMed, Cureus) - "Introduction Multidrug-resistant (MDR) Klebsiella pneumoniae poses significant treatment challenges, particularly in intensive care settings. Sanger sequencing confirmed 99.3% similarity with bla CMY-2. Conclusion CMY AmpC β-lactamase emerged as the predominant mechanism of CZA resistance in K. pneumoniae, highlighting the need for routine AmpC screening, prudent use of alternatives such as cefiderocol, tigecycline, or fosfomycin, and sustained genomic surveillance to guide therapy and infection control."

Journal • Critical care • Infectious Disease • Pneumonia

Antimicrobial Resistance of Acinetobacter Species and Pseudomonas Species in a Tertiary Care Center in Gandaki Province, Nepal. (PubMed, J Nepal Health Res Counc) - "The study underscores alarming levels of antimicrobial resistance in Acinetobacter species and Pseudomonas species. Acinetobacter species demonstrated higher resistance to most antibiotics compared to Pseudomonas species. The variation in resistance patterns across sample types highlights the need of infection site and pathogen-specific antibiotic stewardship strategies."

Journal • Retrospective data • Infectious Disease

Carbapenemase Producing Multi Drug Resistant Klebsiella pneumoniae from a Referral Hospital in Nepal. (PubMed, J Nepal Health Res Counc) - "The study underscores alarming levels of antimicrobial resistance in Acinetobacter species and Pseudomonas species. Acinetobacter species demonstrated higher resistance to most antibiotics compared to Pseudomonas species. The variation in resistance patterns across sample types highlights the need of infection site and pathogen-specific antibiotic stewardship strategies."

Journal • Retrospective data • Infectious Disease • Pneumonia

Staphylococcus aureus bloodstream infection at a referral children's hospital in Cape Town, South Africa, 2018-2022. (PubMed, BMC Infect Dis) - "S. aureus BSI remains a major cause of morbidity and mortality in children. Admission to ICU during a BSI episode was significantly associated with 28-day mortality. Furthermore, over time changes to the epidemiology of S. aureus BSI have occurred at RCWMCH."

Journal • Critical care • Human Immunodeficiency Virus • Infectious Disease • Septic Shock

An observational study on multidrug resistance in pediatric patients with urinary tract infections. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Escherichia coli demonstrated high resistance to nalidixic acid (84.4%), ampicillin (78.1%), and ciprofloxacin (78.1%), while maintaining high susceptibility to fosfomycin (90.6%), ertapenem (81.3%), gentamicin (71.9%), and nitrofurantoin (71.9%)...exhibited high resistance to tetracycline (64.3%), and levofloxacin (63%). but remained sensitive to linezolid (93.27%), vancomycin (85.71%), teicoplanin (78.57%), and tigecycline (71.4%)...Fosfomycin, nitrofurantoin, and carbapenems retain efficacy, though over-reliance may accelerate resistance. Regular, pediatric-specific AMR surveillance and antimicrobial stewardship programs are essential to preserve treatment efficacy and improve outcomes in this vulnerable population."

Journal • Observational data • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Management of non-tuberculous mycobacterial pulmonary disease (NTM-PD): a European wide NTM-NET survey (BTS WM 2025) - "The most frequently used were amikacin (100%), tigecycline (61%) and imipenem (50%). Second-line agents including nebulised amikacin, linezolid and clofazimine were used by 68%(n=23), 74%(n=25) and 76%(n=26) respondents, respectively...Ten (29%) centres prescribed Bedaquiline for NTM-PD...Use of injectable and second-line therapy is increasing with limited international/national guidance available. Ensuring access to evidence-based guidelines incorporating these anti-microbials and expert advisory groups is essential to ensure consistent, high-quality NTM-PD care."

Nontuberculous mycobacteria • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases