tigecycline / Generic mfg. - LARVOL DELTA

Antimicrobial Susceptibility Pattern of Ceftriaxone-Sulbactam-EDTA Against Multidrug-Resistant Gram-Negative Bacilli From ICU Clinical Isolates. (PubMed, Cureus) - "High resistance was observed against meropenem (94.57%), netilmicin (93.48%), and ciprofloxacin (90.22%). Nitrofurantoin showed good activity among urinary isolates, with 35 (89.74%) susceptible. Co-trimoxazole showed susceptibility in 6 (14.63%) of 41 tested isolates, while tigecycline showed susceptibility in 5 (12.20%) of 41 tested isolates...CSE showed promising in vitro activity against MDR-GNB isolates and may be considered when guided by susceptibility testing. Strict infection control practices, routine resistance screening, and antimicrobial stewardship are essential in ICU settings."

Journal • Critical care • Infectious Disease • Pneumonia

Microbiological Profile of Pathogens Among Patients at a Tertiary Care Hospital in Mumbai, India. (PubMed, Cureus) - "Gram-negative bacteria were the predominant pathogens isolated with a substantial burden of MDROs. The observed antimicrobial resistance patterns emphasize the need for continuous microbiological surveillance, regular updating of institutional antibiograms, and implementation of robust antimicrobial stewardship programs to optimize empirical antimicrobial therapy and improve patient outcomes."

Journal • Critical care • Infectious Disease • Pneumonia

Trends in pathogens and antimicrobial resistance in culture-proven neonatal sepsis over a decade (2015-2024): the impact of COVID-19 pandemic. (PubMed, Front Cell Infect Microbiol) - "coli) showed a numerical increase in ceftazidime resistance...faecium) remained susceptible to vancomycin and linezolid...coli maintained favorable susceptibility to carbapenems and piperacillin-tazobactam, whereas K. pneumoniae showed a fluctuating carbapenem resistance trend that initially increased then declined, though it remained susceptible to tigecycline...Enhanced hand hygiene and contact isolation are consistent with a sustained decline in CoNS, but show limited association with changes in Gram-negative bacilli. Routine surveillance and optimized empirical therapy remain crucial for improving neonatal sepsis outcomes."

Journal • Observational data • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Septic Shock

Epidemiology and predictors of multidrug-resistant Enterobacteriaceae in intensive care units of a tertiary hospital in Somalia: a five-year retrospective study (2019-2024). (PubMed, Front Antibiot) - "Tigecycline was tested in only 20.4% of isolates, among which resistance was 17.4%. Multidrug-resistant Enterobacteriaceae are escalating alarmingly in Somali ICUs, with ciprofloxacin resistance of 95.4% among tested MDR isolates, which severely constrains empiric therapeutic options. The urgent implementation of antimicrobial stewardship programs, restricted-use protocols for carbapenems and colistins, and strengthened infection prevention measures are essential. National engagement with the WHO GLASS surveillance is critical."

Journal • Retrospective data • Critical care • Infectious Disease

Molecular epidemiology of antimicrobial-resistant Klebsiella pneumoniae in intensive care unit patients, southwestern Saudi Arabia. (PubMed, Cell Mol Biol (Noisy-le-grand)) - "The highest resistance rates were observed against piperacillin‑tazobactam (55.1%), cefotaxime (55.1%), imipenem (53.0%), and meropenem (53.0%), while tigecycline (100% susceptibility) and amikacin (93.9% susceptibility) remained the most effective agents. Notably, susceptibility to trimethoprim‑sulfamethoxazole was 83.7% (corrected figure)...The alarmingly high prevalence of ESBL and carbapenemase phenotypes, coupled with significant multidrug resistance, underscores the urgent need for routine molecular surveillance and targeted antibiotic stewardship in this region. Rapid phenotypic screening combined with genotypic confirmation is essential to guide empirical therapy and curb the spread of these high‑risk clones in critically ill populations."

Journal • Retrospective data • Critical care • Infectious Disease • Pneumonia

Risk Factors for Extended-Spectrum β-lactamase, Carbapenem, and Colistin Resistance Among Enterobacterales Bloodstream Infections in Intensive Care Units. (PubMed, Microb Drug Resist) - "Admission-to-blood-culture interval, malignancy, and purulent endotracheal secretions were independently associated with ESBL positivity; respiratory failure and tigecycline use within the previous 3 months were independently associated with colistin resistance; and central nervous system disease and hemodialysis were independently associated with carbapenem resistance. ICU-associated E-BSI exhibited substantial antimicrobial resistance, with distinct phenotype-specific risk profiles supporting early risk stratification and targeted antimicrobial stewardship interventions."

Journal • Critical care • Infectious Disease • Oncology • Respiratory Diseases

Gain and loss of acquired doxycycline resistance in Lactiplantibacillus plantarum: an adaptive laboratory evolution study. (PubMed, Microbiol Spectr) - "This gene has been previously reported to harbor mutations associated with tetracycline-class resistance, including DOX and tigecycline. DNA sequencing identified variants in the rpsJ gene, which encodes a protein important for translation. As doxycycline interferes with this process, the rpsJ variants may underlie the emergence of the modest resistance we observe."

Journal

A retrospective study assessing clinical outcome of carbapenem resistant infections treated with Ceftriaxone+Sulbactum+EDTA versus other carbapenem sparing therapy. (ERS 2026) - "Increasing resistance to last-resort agents are colistin and tigecycline includes effective carbapenem-sparing strategies. CSE is an effective carbapenem-sparing option for CRE infections, offering superior clinical response to alternative regimens."

Clinical data • Retrospective data • Infectious Disease • Pneumonia • Septic Shock

SPARK: Exploring the Combination of Intracalvariosseous and Intravenous Antibiotics for Moderate to Severe Bacterial Meningitis (clinicaltrials.gov) - P=N/A | N=9 | Not yet recruiting | Sponsor: yilong Wang

New trial • CNS Disorders • Infectious Disease

Silent carriage of tigecycline- and carbapenem-resistant Klebsiella quasipneumoniae co-harbouring tetX(4) and blaNDM-1 in healthy individuals in China. (PubMed, Int J Antimicrob Agents) - "To our knowledge, this is the first report of K. quasipneumoniae co-harbouring tet(X4) and blaNDM-1 in healthy individuals in China. The findings indicate that healthy community populations may serve as a hidden reservoir for last-resort antimicrobial resistance genes and underscore the importance of community-based surveillance within a One Health framework."

Journal • Infectious Disease • Pneumonia

Tigecycline versus doxycycline for scrub typhus: a preliminary randomized trial. (PubMed, Trop Med Health) - P=N/A | "In this preliminary randomized trial, intravenous tigecycline was associated with faster defervescence than oral doxycycline in clinically stable hospitalized adults with scrub typhus. These findings support further evaluation of tigecycline as an intravenous option in selected patients. Trial registration ClinicalTrials.gov, NCT07513103."

Journal

Evolution, Mechanisms, and Therapeutic Implications of Mobile Tetracycline Destructases. (PubMed, Bioessays) - "Tetracycline destructases (TDases) pose an emerging global threat by enzymatically inactivating all generations of tetracycline (Tet) antibiotics, including last-resort agents such as tigecycline. Key gaps remain in understanding ancestral reservoirs, evolutionary trajectories, and effective surveillance strategies. Addressing these areas through integrative evolutionary, biochemical, and ecological studies is critical for mitigating the clinical spread and therapeutic impact of TDases globally."

Journal • Review

Evolution of Staphylococcus aureus during chronic infection in people with cystic fibrosis (NACFC 2026) - "Mutations linked to rifampin ( rpoB ) and tigecycline ( rpsJ ) resistance and small colony variant phenotypes were observed. This study provides a high-resolution genomic characterization of S. aureus population structure, persistence, and adaptation in CF airways. Findings demonstrate frequent chronic infection by single strains, interpatient transmission, and ongoing within-host evolution driven by antibiotic and host selective pressures. The dominance of CC5 and high antimicrobial resistance burden highlight therapeutic challenges."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Respiratory Diseases

Exploring the impact of polymyxin B combined with tigecycline on clinical efficacy in ICU-CRAB infected patients with immunosuppression: a multicenter retrospective cohort study (ChiCTR) - P=N/A | N=200 | Not yet recruiting | Sponsor: Southern Medical University Southern Hospital; Southern Medical University Southern Hospital

New trial • Infectious Disease

Epidemiology, antimicrobial resistance trends, and predictors of mortality among vancomycin-resistant enterococci: a six-year retrospective cohort study from Oman. (PubMed, Infection) - "Enterococcal vancomycin resistance increased substantially at this centre and is concentrated in E. faecium, with preserved last-line susceptibility. However, much of the apparent rise after 2023 is attributable to the introduction of active rectal screening and to intrinsically resistant vanC species, and half of VRE-positive patients were colonised rather than infected. Prognostic models built on routine admission biomarkers were insufficiently discriminating and calibrated for clinical use and should be regarded as hypothesis-generating."

Journal • Retrospective data • Critical care • Infectious Disease

Effect of an antibiotic stewardship program on antimicrobial use and resistance in a high prescribing, high resistance setting: A single-center, interrupted time series analysis. (PubMed, Eur J Clin Microbiol Infect Dis) - P=N/A | "The implementation of PAF intervention in a setting with high antimicrobial consumption and resistance led to a significant reduction in the use of targeted antimicrobials, although total antimicrobial consumption showed an increasing trend. The effect of the AMS program on resistance rates was minimal."

Journal • Infectious Disease

Molecular epidemiology and genomic characteristics of clinical Acinetobacter baumannii isolates from patients with hospital-acquired pneumonia in China, 2019-2020: a multicentre retrospective study. (PubMed, EBioMedicine) - "This study demonstrates the extremely high prevalence and clonal dominance of CRAB in Chinese patients with HAP, providing critical evidence for clinical treatment, antimicrobial stewardship, and targeted infection control."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Various antibiotics susceptibility of acute hematogenous osteomyelitis caused by Staphylococcus aureus in children: A retrospective study. (PubMed, Medicine (Baltimore)) - "The MRSA group showed significantly higher resistance rates to levofloxacin, moxifloxacin, gentamicin, erythromycin, clindamycin, tigecycline, and sulfamethoxazole/trimethoprim compared with the MSSA group (P < .05). Currently, children with acute hematogenous osteomyelitis infected with MRSA show resistance to multiple antibiotics. MRSA infection is associated with more severe inflammatory responses, higher fever, longer hospital stays, higher medical costs, and a greater risk of complications."

Journal • Retrospective data • Anesthesia • Infectious Disease • Inflammation • Pediatrics • Septic Shock • CRP

Tigecycline Plus β-Lactam Versus Tigecycline Monotherapy in Complicated Intra-abdominal Infections: A Propensity-Matched Analysis (IDWeek 2026) - No abstract available

Monotherapy • Infectious Disease

Comparative Effectiveness and Safety of Eravacycline- versus Tigecycline-Based Therapy in Critically Ill Patients with Carbapenem-Resistant Acinetobacter baumannii Infection: A Multicenter Retrospective Cohort Study (IDWeek 2026) - No abstract available

HEOR • Retrospective data • Infectious Disease

An O-glycosylation-based prognostic signature for biochemical recurrence in prostate cancer identifies GALNTL6 as a potential promoter of malignant phenotypes. (PubMed, Transl Androl Urol) - "Drug-sensitivity analysis suggested that patients with different OGs scores may show distinct predicted responses to candidate agents, including AZD7762, a checkpoint kinase inhibitor, and tigecycline, a glycylcycline antibiotic with reported antitumor activity. This study establishes an O-glycosylation-related prognostic model for BCR risk stratification in PCa and identifies GALNTL6 as a potential promoter of malignant phenotypes. These findings suggest that GALNTL6 may be associated with AKT pathway activity and oxidative-stress-related transcriptional programs, although further mechanistic validation is required."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Genomic Characterization of Antimicrobial Resistance and Virulence in ST11 Carbapenem-Resistant Klebsiella Pneumoniae Colonizing the Intestinal Tract of Elderly Inpatients. (PubMed, Infect Drug Resist) - "All isolates carried the carbapenemase gene bla KPC-2 and exhibited extensive drug resistance, with tigecycline retaining the highest susceptibility (64.7%)...This clone universally carries the bla KPC-2 gene conferring carbapenem resistance and exhibits a unique virulence gene profile characterized by a low carriage rate of classical hypervirulence markers and an incomplete rmpA2 regulator gene. This finding clarifies the local epidemic status of this clone and underscores the importance of implementing active surveillance and targeted prevention strategies for high-risk populations."

Journal • Infectious Disease • Pneumonia

Analysis of the Etiology and Antibiotic Resistance of Bacterial Infections in Newborns in a Chinese Tertiary Hospital: From 2019 to 2024. (PubMed, Infect Drug Resist) - "It demonstrated the highest resistance to penicillin (86.1%) and a relatively high resistance to erythromycin (52.6%), while remaining 100% sensitive to vancomycin, linezolid, and tigecycline. Staphylococcus epidermidis exhibited significant resistance to benzathine penicillin (75.3%) and erythromycin (62.3%), with a positive rate of 77.9% in the cefotaxime screening test...Among the Gram-negative pathogens, Escherichia coli showed high resistance (80.0-86.1%) to cefoperazone-sulbactam and other β-lactams but only 0.9% resistance to carbapenems and full sensitivity to amikacin...Additionally, multidrug-resistant strains have been identified. Temporal trend analysis revealed significant increasing trends for S. aureus (P=0.027) and S. epidermidis (P=0.038), and significant decreasing trends for E. coli (P=0.016)."

Journal • Critical care • Infectious Disease • Pneumonia

Efficacy and safety of ceftazidime-avibactam versus tigecycline in the treatment of pneumonia caused by carbapenem-resistant Klebsiella pneumoniae. (PubMed, Front Med (Lausanne)) - "In this exploratory retrospective cohort, CAZ-AVI-based regimens were associated with a higher bacterial clearance rate and a lower incidence of coagulation and platelet abnormalities, while no statistically significant differences were observed in clinical efficacy or survival outcomes between the two regimens. Advanced age and comorbid diabetes mellitus showed exploratory associations with increased all-cause mortality, which warrant attention in clinical practice."

Journal • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Pneumonia • Respiratory Diseases • Thrombocytopenia

Molecular Characterization and Resistance Gene Co-occurrence in Carbapenem-Resistant Klebsiella peumoniae from a Bangkok Tertiary Hospital, Thailand. (PubMed, J Infect Dev Ctries) - "This study reveals a high prevalence of blaOXA-48-like and blaNDM-1 genes among CRKP isolates in a tertiary hospital in Bangkok. The diversity of resistance profiles and the clustering of complex gene combinations, particularly in medical and ICU wards, underscore the need for continuous molecular surveillance and stringent infection control measures to manage the spread of CRKP in healthcare setting."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases