lomefloxacin / Generic mfg. - LARVOL DELTA

Co-selection of heavy metal and antibiotic resistance in Enterobacteriaceae members from Mula-Mutha River (Pune, India). (PubMed, Environ Monit Assess) - "Pearson correlation analysis revealed strong associations between HMR and ABR, including arsenic-lomefloxacin (r = 0.43), copper-cefotaxime (r = 0.46), and lead-piperacillin tazobactam (r = 0.365), suggesting co-selection via shared resistance mechanisms. These findings hold significance and highlight the convergence of chemical and biological pollution in shaping resistant microbial communities and emphasize the urgent need for integrated river basin monitoring and pollution control strategies."

Journal

Whole-genome sequencing and genomic characterization of Riemerella anatipestifer strain RA-NM from China. (PubMed, Microb Pathog) - "It was resistant to kanamycin, amikacin, gentamicin, streptomycin, lomefloxacin, and polymyxin B, consistent with six detected resistance genes (tet(X4), erm(F), aadS, blaOXA-209, ranA, ranB). No soft-core genes were detected, highlighting clear separation between conserved and variable genes and extensive genomic plasticity. Overall, this study provides a comprehensive phenotypic and genomic characterization of RA-NM, offering insights into its antimicrobial resistance, virulence, pangenome structure, and evolutionary background, serving as a foundation for future studies on R. anatipestifer pathogenicity."

Journal • Infectious Disease

Unraveling the activity of phage-carrying antibiotic resistance genes in constructed wetlands. (PubMed, Front Cell Infect Microbiol) - "In addition, sediment acts as a high-risk reservoir where redox and ionic gradients, together with residual lomefloxacin and other antibiotics, enhance phage infectious activity and the accumulation of ARGs. Through cross-compartment transmission along the sediment-water interface, these phage-associated and PARB populations continuously seed the overlying water. It is recommended that ARG risk assessment shift from static abundance to an activity-aware, carrier- and host-resolved approach, prioritizing sediment-targeted transcript monitoring and phage transduction early warning to support risk mitigation in CW."

Journal • Gene Therapies

In-situ silver-bridged interfaces drive Z-scheme coupling on iron-doped NH2-UiO-66(Zr)/silver iodide for efficient aqueous antibiotic degradation. (PubMed, J Colloid Interface Sci) - "Fluoroquinolone antibiotics like ciprofloxacin (CIP) pose environmental risks when released into water...It also showed high removal efficiencies for tetracycline, lomefloxacin, and Rhodamine B...This Z-scheme mechanism efficiently separated carriers, facilitated generation of ROS, and enabled thorough mineralization of CIP; toxicity predictions showed most products were less mutagenic than CIP, confirming reduced ecological risk. The findings demonstrate that the Fe-doped NH2-UiO-66(Zr)@AgI heterostructure is a promising photocatalyst for antibiotic-contaminated wastewater remediation."

Journal

Machine learning-enhanced colorimetric and surface-enhanced Raman scattering-based bimodal lateral flow immunoassay for sensitive and simultaneous detection of the residues of lomefloxacin, ofloxacin, and pefloxacin. (PubMed, Food Chem) - "ML-based multi-peak analysis reduced quantification error from 21-fold to 13-fold overestimation, compared to single-peak calibration. Overall, this ML-integrated SERS-LFIA delivers unprecedented sensitivity, accuracy, and field-deployability for quinolone residue monitoring in dairy products."

Journal

Chiral separation of fluoroquinolones by capillary electrophoresis using glucosamine-functionalized carbon quantum dots as a Pseudostationary phase. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Compared to the CE system using free glucosamine solely as the chiral selector, the CE system employing GA-CQDs as a pseudostationary phase demonstrated a substantial improvement in chiral resolution (Rs) for all six model analytes (Ofloxacin: 1.56 → 9.21; Pazufloxacin: 0 → 8.53; Prulifloxacin: 1.38 → 7.58; Lomefloxacin: 1.01 → 2.84; Gemifloxacin: 0 → 1.25; Balofloxacin: 0 → 0.88). This study represents the first report on employing GA-CQDs as a chiral selective medium to construct a capillary electrophoresis system, which achieved satisfactory enantioselectivity. Furthermore, the chiral recognition mechanism of glucosamine was preliminarily investigated through molecular modeling simulations, with the binding energy providing insights into the separation process."

Journal

Experimental Study and Molecular Modeling of Antibody Interactions with Different Fluoroquinolones. (PubMed, Int J Mol Sci) - "The most pronounced CRs were observed for lomefloxacin, sarafloxacin, and ciprofloxacin. It was shown by the dynamical network analysis that the sum of betweenness centrality between a node corresponding to the quinolone ring and nodes representing MAb amino acids is higher for cross-reactive haptens. The found regularities can be transferred to other analyte-antibody systems as a binary classifier that discriminates cross-reactive and non-cross-reactive compounds."

Journal

Efficient 2D HOF@Au SERS Substrates Synergized with the G-quadruplex Network-Based Catalytic Amplification Strategy for Low-Background Trimode Detection of Lomefloxacin. (PubMed, Anal Chem) - "This approach enabled the simultaneous SERS, colorimetric, and visual detection of lomefloxacin (LOM) with detection limits as low as 6.54 × 10-14 mol/L, 3.27 × 10-11 mol/L, and 5.31 × 10-11 mol/L, respectively. This method has been successfully applied to the analysis of real-world samples, demonstrating its promising potential for practical applications."

Journal

How do hydrodynamic conditions and land use drive antibiotic fate in estuarine and bay ecosystems? (PubMed, J Environ Sci (China)) - "The findings indicated that estuaries were more heavily polluted with antibiotics than the bays (P < 0.05), with tetracyclines and fluoroquinolones as the primary antibiotics...The concentrations of lomefloxacin and ofloxacin were positively correlated with build-up land...A comparative analysis of global estuaries and bays revealed that specific land-use types and hydrodynamic conditions produced similar trends in antibiotic fate. These insights offered new perspectives to safeguard the health of estuarine and bay ecosystems, such as altering landscape patterns and regulating aquaculture activities."

Journal

Spatiotemporal Distribution Characteristics， Influencing Factors， and Ecological Risk Assessment of Antibiotics in a River of a Typical Northern City (PubMed, Huan Jing Ke Xue) - "Correlation analysis revealed no significant association between antibiotic distribution and water quality parameters， indicating that human activities and wastewater discharge practices in different regions were the primary influencing factors. Ecological risk assessments suggested that tetracycline （TCY） and sulfamethoxazole （SMX） posed higher ecological risks to fish， while ofloxacin （OFX）， lomefloxacin （LOM）， and erythromycin （ERY） exhibited certain ecological risks to algae."

Journal

1H-NMR Spectroscopy Study of the Formation of Inclusion Complexes between Cucurbit[7]uril and Ciprofloxacin, Levofloxacin, and Lomefloxacin. (PubMed, Chem Pharm Bull (Tokyo)) - "Because the piperazine ring structure is commonly found in many drugs, CB[7] can be expected to capture other drugs apart from those evaluated in this study. Therefore, CB[7] is a promising candidate as a host molecule for use in drug removal in aquatic environments through host-guest chemistry."

Journal

First Report on some N2O2-Donor Sets Tetradentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation. (PubMed, Chem Biodivers) - "The new Schiff base ligand N,N'-thiophene-(bis-1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid) (H2L) was synthesized via condensation of thiophene-2,5-diamine with lomefloxacin in ethanol using glacial acetic acid...The data revealed that Cr(III) complex as most effective against Escherichia coli and Staphylococcus aureus. Cytotoxicity tests on normal prostate epithelial cells (IC50 = 6.30-10.43 µM) indicated significant toxicity and limited selectivity, restricting anticancer applicability."

Journal • Oncology

Use of oral fluoroquinolones in France between 2014 and 2023: a nationwide drug utilization study. (PubMed, JAC Antimicrob Resist) - "From 2014 to 2023, ofloxacin, ciprofloxacin, levofloxacin and moxifloxacin use decreased by 40%, 22%, 5% and 72%, respectively. Norfloxacin and lomefloxacin use dropped by 86% and 79% from 2014 to 2019, the year their reimbursement ended. General practitioners were the primary prescribers, accounting for 82.9% of prescriptions in 2023, followed by urologists-nephrologists (6.1%), ophthalmologists (1.6%), otolaryngologists (1.2%) and gynaecologists (1.1%). FQ use in France has declined significantly over the past decade, driven by awareness efforts and guideline changes, but remains high compared with other European countries, highlighting the need for ongoing stewardship."

Journal • Ophthalmology • Otorhinolaryngology

Selective production of singlet oxygen for enhanced photocatalytic degradation performance of organic pollutants by C60/COF coupled with persulfate. (PubMed, Environ Res) - "The degradation efficiencies of lomefloxacin (LOMH) and trichloromethane (TCM) achieved 80.4% and 74% by the proposed system...DFT calculation results showed that the composite of C60/COF has enhanced adsorption strength of both target pollutant and O2, leading to a better photocatalytic oxidation effect. This work provided an efficient, economical and environmentally friendly way to remove organic pollutants driven by clean light energy, which shows practical application potential and is compatible with the "cost reduction and efficiency increase" strategy."

Journal

Topical antibiotics for treating bacterial keratitis: a network meta-analysis. (PubMed, Cochrane Database Syst Rev) - "In our NMA, mostly moderate- to very low-certainty evidence suggests that vancomycin + ceftazidime combination therapy, moxifloxacin monotherapy, and cefazolin + tobramycin combination therapy may be the most effective treatments for BK in terms of corneal healing time, whereas ciprofloxacin monotherapy is the least effective. Given that most evidence was not of high certainty, the results of this NMA should be interpreted with caution, and future research could potentially alter these findings."

Journal • Retrospective data • Review • Conjunctivitis • Corneal Abrasion • Glaucoma • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism. (PubMed, Chirality) - "In this work, the silica gel bonded amylose[(S)-α-methylbenzyl carbamate] (CHIRALPAK IH) was chosen as the chiral stationary phase (CSP) for the separation of five quinolone enantiomers by high-performance liquid chromatography (HPLC), namely, ofloxacin, flumequine, nadifloxacin, lomefloxacin, and clinafloxacin...The differences in these interaction forces between the quinolone enantiomers, particularly the greater contribution of hydrogen bonding in one enantiomer compared to the other, led to a significant difference in binding energy. This differential binding energy ultimately governed the elution order and enabled chiral recognition of the five quinolone enantiomers."

Journal

Distribution Characteristics and Ecological Risk Assessment of Antibiotics in Water and Sediment of Yongjiang River Basin (PubMed, Huan Jing Ke Xue) - "Based on the ecological risk entropy assessment， ofloxacin， enoxacin， and norfloxacin in YRB exhibited higher risk to algae. Lomefloxacin posed a high risk to aquatic invertebrates. The presence of antibiotics in YRB posed a certain extent ecological risk."

Journal

Chitosan derivative-doped carboxymethyl cellulose-based films with robust mechanical properties and short dissolution time: preparation and physicochemical properties. (PubMed, Int J Biol Macromol) - "Lomefloxacin hydrochloride was used as a model drug to evaluate the drug-releasing behavior of the films. The results showed a very rapid release rate within 10 min, including an anomalous transport-controlled process. The results indicated that CMC/HTCC2%/LA-CMCh10% film was a promising ODF candidate, offering improved mechanical properties and rapid disintegration, which could enhance patient compliance and drug delivery efficiency."

Journal

Design of S-O "highway" at Z-scheme heterojunction interface for efficient degradation treatment of lomefloxacin and actual pharmaceutical wastewater. (PubMed, J Environ Manage) - "Notably, with the optimal Bi2Sn2O7/MoS2 sample, the COD of actual pharmaceutical wastewater decreased from 8327 mg/L to 1899 mg/L, achieving a removal rate of 77.2 %. The rapid transfer of charge transfer rates at the interfaces of heterojunction materials promoted the improvement of photocatalytic efficiency, thereby offering certain guidance for the practical treatment of antibiotic pollution."

Journal

Deep eutectic solvent-based extraction approach for separation of fluoroquinolones from soil and sediment followed by their chromatographic determination. (PubMed, Talanta) - "Various hydrophilic deep eutectic solvents were investigated for separation of fluoroquinolone antibiotics (ciprofloxacin, fleroxacin, gatifloxacin, lomefloxacin, and ofloxacin) from soil and sediment. The proposed approach eliminates the need for additional tedious and time-consuming purification by solid-phase extraction. It was successfully applied to real soil and sediment samples, showing no significant matrix interference."

Journal

Occurrence of pharmaceuticals, illicit drugs and PFAS in global surface waters: A meta-analysis-based review. (PubMed, Environ Pollut) - "Global PID concentrations ranged from 0.02 ng/L to 82,188 ng/L, with metformin (MFN) having the highest meta-analyzed median concentration of 729.4 ng/L. Meta-analysis revealed that perflurohexanoic acid (PFHxA) had the highest meta-synthesized median concentration of 3.6 ng/L in surface waters. Environmental risk assessment revealed high risk (HQ ≥ 1) for the following: MFN, acetaminophen (APAP), ibuprofen (IBU), sulfacetamide (SAM) and lomefloxacin (LFX) and moderate risk (HQ ≥ 0.1) for perfluorododecanoic acid (PFDoA), perfluorotetradecanoic acid (PFTeDA) and perfluoroundecanoic acid (PFUnDA)."

Journal • Retrospective data • Review

Cobalt-Modification on UiO-bpydc MOF Facilitates Ligand-to-Metal Charge Transfer for Superior Visible-Light Photocatalytic Degradation of Refractory Fluoroquinolone Antibiotics. (PubMed, Environ Res) - "The UiO-bpydc(Co) achieved 95.8% degradation of lomefloxacin (LOM) within 30 minutes in the presence of PMS, attributing to narrowed bandgap (i.e., 2.82 eV), improved charge transfer via Co centers, and increased pollutant affinity due to electron-rich ligand...Theoretical calculations indicated a reduced HOMO-LUMO gap upon the formation of a -Co-OOSO3 bridge, which promotes carrier separation and improves pollutant-catalyst interactions. The degradation pathways and toxicity evolution of intermediates were clarified, while the exceptional stability, recyclability, and broad pollutant applicability of UiO-bpydc(Co) demonstrate its potential for utilization in oxidative environments This work highlights the potential of transition metal doping to alter the electronic structure of MOFs for target-specific catalytic reactions, offering new opportunities for advanced environmental remediation technologies."

Journal

Oxygen vacancy-mediated BiVO4/Bi3O4Br S-scheme heterojunction for enhanced photocatalytic degradation of antibiotics. (PubMed, J Colloid Interface Sci) - "A novel S-scheme heterojunction nanocomposite, BiVO4/Bi3O4Br, was designed and successfully synthesized in this work, which exhibits superior performance in degrading fluoroquinolone antibiotics (gatifloxacin hydrochloride (GAT) and lomefloxacin hydrochloride (LOM)) and tetracycline antibiotics (tetracycline hydrochloride (TCH)). Furthermore, the possible degradation routes of GAT were thoroughly explored, and the photocatalytic degradation mechanism of BiVO4/Bi3O4Br was comprehensively elucidated. This study highlights the combined action of S-scheme heterojunctions and OVs in boosting photocatalytic performance, thus providing a fresh perspective for developing OVs-rich S-scheme heterojunction photocatalysts for wastewater treatment."

Journal

Comprehensive assessment of 45 antibiotics in ten urban wastewater treatment plants in Northeastern China: Terminal treatment is not a reliable guard. (PubMed, J Hazard Mater) - "The results showed that the total influent concentrations ranged from 9351.63 to 50126.08 ng/L, with the primary contributors being Norfloxacin (NOR), Ofloxacin (OFX) and Ciprofloxacin (CIP), accounting for 57.63, 18.09 and 9.01 %, respectively...Certain antibiotics, such as Clindamycin hydrochloride (CLH), Roxithromycin (ROX) and Lomefloxacin (LOF), exhibited significant fluctuations...Antibiotic emissions from different WWTPs ranged from 20.75 to 284.66 g/day, with Clarithromycin (CLA), Erythromycin (ERY) and OFX being the primary contributors...More importantly, the study highlighted the current lack of predictive methods for such fluctuations. Correlation analysis between operational parameters and removal rates revealed weak relationships."

Journal

Integrating State-Space Modeling, Parameter Estimation, Deep Learning, and Docking Techniques in Drug Repurposing: A Case Study on COVID-19 Cytokine Storm. (PubMed, J Am Med Inform Assoc) - "This framework provides an efficient method for identifying critical regulatory proteins and advancing drug repurposing, contributing to the rapid development of therapeutic strategies for COVID-19 and future global pandemics."

Journal • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases