lomefloxacin / Generic mfg. - LARVOL DELTA

Efficient 2D HOF@Au SERS Substrates Synergized with the G-quadruplex Network-Based Catalytic Amplification Strategy for Low-Background Trimode Detection of Lomefloxacin. (PubMed, Anal Chem) - "This approach enabled the simultaneous SERS, colorimetric, and visual detection of lomefloxacin (LOM) with detection limits as low as 6.54 × 10-14 mol/L, 3.27 × 10-11 mol/L, and 5.31 × 10-11 mol/L, respectively. This method has been successfully applied to the analysis of real-world samples, demonstrating its promising potential for practical applications."

Journal

How do hydrodynamic conditions and land use drive antibiotic fate in estuarine and bay ecosystems? (PubMed, J Environ Sci (China)) - "The findings indicated that estuaries were more heavily polluted with antibiotics than the bays (P < 0.05), with tetracyclines and fluoroquinolones as the primary antibiotics...The concentrations of lomefloxacin and ofloxacin were positively correlated with build-up land...A comparative analysis of global estuaries and bays revealed that specific land-use types and hydrodynamic conditions produced similar trends in antibiotic fate. These insights offered new perspectives to safeguard the health of estuarine and bay ecosystems, such as altering landscape patterns and regulating aquaculture activities."

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Spatiotemporal Distribution Characteristics， Influencing Factors， and Ecological Risk Assessment of Antibiotics in a River of a Typical Northern City (PubMed, Huan Jing Ke Xue) - "Correlation analysis revealed no significant association between antibiotic distribution and water quality parameters， indicating that human activities and wastewater discharge practices in different regions were the primary influencing factors. Ecological risk assessments suggested that tetracycline （TCY） and sulfamethoxazole （SMX） posed higher ecological risks to fish， while ofloxacin （OFX）， lomefloxacin （LOM）， and erythromycin （ERY） exhibited certain ecological risks to algae."

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1H-NMR Spectroscopy Study of the Formation of Inclusion Complexes between Cucurbit[7]uril and Ciprofloxacin, Levofloxacin, and Lomefloxacin. (PubMed, Chem Pharm Bull (Tokyo)) - "Because the piperazine ring structure is commonly found in many drugs, CB[7] can be expected to capture other drugs apart from those evaluated in this study. Therefore, CB[7] is a promising candidate as a host molecule for use in drug removal in aquatic environments through host-guest chemistry."

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First Report on some N2O2-Donor Sets Tetradentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation. (PubMed, Chem Biodivers) - "The new Schiff base ligand N,N'-thiophene-(bis-1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid) (H2L) was synthesized via condensation of thiophene-2,5-diamine with lomefloxacin in ethanol using glacial acetic acid...The data revealed that Cr(III) complex as most effective against Escherichia coli and Staphylococcus aureus. Cytotoxicity tests on normal prostate epithelial cells (IC50 = 6.30-10.43 µM) indicated significant toxicity and limited selectivity, restricting anticancer applicability."

Journal • Oncology

Use of oral fluoroquinolones in France between 2014 and 2023: a nationwide drug utilization study. (PubMed, JAC Antimicrob Resist) - "From 2014 to 2023, ofloxacin, ciprofloxacin, levofloxacin and moxifloxacin use decreased by 40%, 22%, 5% and 72%, respectively. Norfloxacin and lomefloxacin use dropped by 86% and 79% from 2014 to 2019, the year their reimbursement ended. General practitioners were the primary prescribers, accounting for 82.9% of prescriptions in 2023, followed by urologists-nephrologists (6.1%), ophthalmologists (1.6%), otolaryngologists (1.2%) and gynaecologists (1.1%). FQ use in France has declined significantly over the past decade, driven by awareness efforts and guideline changes, but remains high compared with other European countries, highlighting the need for ongoing stewardship."

Journal • Ophthalmology • Otorhinolaryngology

Selective production of singlet oxygen for enhanced photocatalytic degradation performance of organic pollutants by C60/COF coupled with persulfate. (PubMed, Environ Res) - "The degradation efficiencies of lomefloxacin (LOMH) and trichloromethane (TCM) achieved 80.4% and 74% by the proposed system...DFT calculation results showed that the composite of C60/COF has enhanced adsorption strength of both target pollutant and O2, leading to a better photocatalytic oxidation effect. This work provided an efficient, economical and environmentally friendly way to remove organic pollutants driven by clean light energy, which shows practical application potential and is compatible with the "cost reduction and efficiency increase" strategy."

Journal

Topical antibiotics for treating bacterial keratitis: a network meta-analysis. (PubMed, Cochrane Database Syst Rev) - "In our NMA, mostly moderate- to very low-certainty evidence suggests that vancomycin + ceftazidime combination therapy, moxifloxacin monotherapy, and cefazolin + tobramycin combination therapy may be the most effective treatments for BK in terms of corneal healing time, whereas ciprofloxacin monotherapy is the least effective. Given that most evidence was not of high certainty, the results of this NMA should be interpreted with caution, and future research could potentially alter these findings."

Journal • Retrospective data • Review • Conjunctivitis • Corneal Abrasion • Glaucoma • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism. (PubMed, Chirality) - "In this work, the silica gel bonded amylose[(S)-α-methylbenzyl carbamate] (CHIRALPAK IH) was chosen as the chiral stationary phase (CSP) for the separation of five quinolone enantiomers by high-performance liquid chromatography (HPLC), namely, ofloxacin, flumequine, nadifloxacin, lomefloxacin, and clinafloxacin...The differences in these interaction forces between the quinolone enantiomers, particularly the greater contribution of hydrogen bonding in one enantiomer compared to the other, led to a significant difference in binding energy. This differential binding energy ultimately governed the elution order and enabled chiral recognition of the five quinolone enantiomers."

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Distribution Characteristics and Ecological Risk Assessment of Antibiotics in Water and Sediment of Yongjiang River Basin (PubMed, Huan Jing Ke Xue) - "Based on the ecological risk entropy assessment， ofloxacin， enoxacin， and norfloxacin in YRB exhibited higher risk to algae. Lomefloxacin posed a high risk to aquatic invertebrates. The presence of antibiotics in YRB posed a certain extent ecological risk."

Journal

Chitosan derivative-doped carboxymethyl cellulose-based films with robust mechanical properties and short dissolution time: preparation and physicochemical properties. (PubMed, Int J Biol Macromol) - "Lomefloxacin hydrochloride was used as a model drug to evaluate the drug-releasing behavior of the films. The results showed a very rapid release rate within 10 min, including an anomalous transport-controlled process. The results indicated that CMC/HTCC2%/LA-CMCh10% film was a promising ODF candidate, offering improved mechanical properties and rapid disintegration, which could enhance patient compliance and drug delivery efficiency."

Journal

Design of S-O "highway" at Z-scheme heterojunction interface for efficient degradation treatment of lomefloxacin and actual pharmaceutical wastewater. (PubMed, J Environ Manage) - "Notably, with the optimal Bi2Sn2O7/MoS2 sample, the COD of actual pharmaceutical wastewater decreased from 8327 mg/L to 1899 mg/L, achieving a removal rate of 77.2 %. The rapid transfer of charge transfer rates at the interfaces of heterojunction materials promoted the improvement of photocatalytic efficiency, thereby offering certain guidance for the practical treatment of antibiotic pollution."

Journal

Deep eutectic solvent-based extraction approach for separation of fluoroquinolones from soil and sediment followed by their chromatographic determination. (PubMed, Talanta) - "Various hydrophilic deep eutectic solvents were investigated for separation of fluoroquinolone antibiotics (ciprofloxacin, fleroxacin, gatifloxacin, lomefloxacin, and ofloxacin) from soil and sediment. The proposed approach eliminates the need for additional tedious and time-consuming purification by solid-phase extraction. It was successfully applied to real soil and sediment samples, showing no significant matrix interference."

Journal

Occurrence of pharmaceuticals, illicit drugs and PFAS in global surface waters: A meta-analysis-based review. (PubMed, Environ Pollut) - "Global PID concentrations ranged from 0.02 ng/L to 82,188 ng/L, with metformin (MFN) having the highest meta-analyzed median concentration of 729.4 ng/L. Meta-analysis revealed that perflurohexanoic acid (PFHxA) had the highest meta-synthesized median concentration of 3.6 ng/L in surface waters. Environmental risk assessment revealed high risk (HQ ≥ 1) for the following: MFN, acetaminophen (APAP), ibuprofen (IBU), sulfacetamide (SAM) and lomefloxacin (LFX) and moderate risk (HQ ≥ 0.1) for perfluorododecanoic acid (PFDoA), perfluorotetradecanoic acid (PFTeDA) and perfluoroundecanoic acid (PFUnDA)."

Journal • Retrospective data • Review

Cobalt-Modification on UiO-bpydc MOF Facilitates Ligand-to-Metal Charge Transfer for Superior Visible-Light Photocatalytic Degradation of Refractory Fluoroquinolone Antibiotics. (PubMed, Environ Res) - "The UiO-bpydc(Co) achieved 95.8% degradation of lomefloxacin (LOM) within 30 minutes in the presence of PMS, attributing to narrowed bandgap (i.e., 2.82 eV), improved charge transfer via Co centers, and increased pollutant affinity due to electron-rich ligand...Theoretical calculations indicated a reduced HOMO-LUMO gap upon the formation of a -Co-OOSO3 bridge, which promotes carrier separation and improves pollutant-catalyst interactions. The degradation pathways and toxicity evolution of intermediates were clarified, while the exceptional stability, recyclability, and broad pollutant applicability of UiO-bpydc(Co) demonstrate its potential for utilization in oxidative environments This work highlights the potential of transition metal doping to alter the electronic structure of MOFs for target-specific catalytic reactions, offering new opportunities for advanced environmental remediation technologies."

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Oxygen vacancy-mediated BiVO4/Bi3O4Br S-scheme heterojunction for enhanced photocatalytic degradation of antibiotics. (PubMed, J Colloid Interface Sci) - "A novel S-scheme heterojunction nanocomposite, BiVO4/Bi3O4Br, was designed and successfully synthesized in this work, which exhibits superior performance in degrading fluoroquinolone antibiotics (gatifloxacin hydrochloride (GAT) and lomefloxacin hydrochloride (LOM)) and tetracycline antibiotics (tetracycline hydrochloride (TCH)). Furthermore, the possible degradation routes of GAT were thoroughly explored, and the photocatalytic degradation mechanism of BiVO4/Bi3O4Br was comprehensively elucidated. This study highlights the combined action of S-scheme heterojunctions and OVs in boosting photocatalytic performance, thus providing a fresh perspective for developing OVs-rich S-scheme heterojunction photocatalysts for wastewater treatment."

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Comprehensive assessment of 45 antibiotics in ten urban wastewater treatment plants in Northeastern China: Terminal treatment is not a reliable guard. (PubMed, J Hazard Mater) - "The results showed that the total influent concentrations ranged from 9351.63 to 50126.08 ng/L, with the primary contributors being Norfloxacin (NOR), Ofloxacin (OFX) and Ciprofloxacin (CIP), accounting for 57.63, 18.09 and 9.01 %, respectively...Certain antibiotics, such as Clindamycin hydrochloride (CLH), Roxithromycin (ROX) and Lomefloxacin (LOF), exhibited significant fluctuations...Antibiotic emissions from different WWTPs ranged from 20.75 to 284.66 g/day, with Clarithromycin (CLA), Erythromycin (ERY) and OFX being the primary contributors...More importantly, the study highlighted the current lack of predictive methods for such fluctuations. Correlation analysis between operational parameters and removal rates revealed weak relationships."

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Integrating State-Space Modeling, Parameter Estimation, Deep Learning, and Docking Techniques in Drug Repurposing: A Case Study on COVID-19 Cytokine Storm. (PubMed, J Am Med Inform Assoc) - "This framework provides an efficient method for identifying critical regulatory proteins and advancing drug repurposing, contributing to the rapid development of therapeutic strategies for COVID-19 and future global pandemics."

Journal • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases

Efficient SERS Substrate HOF@Au in Conjunction with DNAzyme-Mediated DNA Walker as a Signal Amplifier for the Ultrasensitive Detection of Lomefloxacin. (PubMed, Anal Chem) - "Using this principle, this sensor achieved the ultrasensitive detection of LOM through the "signal on" strategy, with a detection limit as low as 4.62 × 10-14 mol/L. This strategy explored a meaningful innovative path for the design of a novel SERS biosensor for the sensitive and selective detection of antibiotics in food."

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Deciphering spread of quinolone resistance in mariculture ponds: Cross-species and cross-environment transmission of resistome. (PubMed, J Hazard Mater) - "Residues of both veterinary-specific (enrofloxacin and sarafloxacin) and prohibited quinolones (ofloxacin, ciprofloxacin, pefloxacin, norfloxacin, and lomefloxacin) were detected. Our findings suggest a potential for ARG transmission across various bacterial species and environments in mariculture. This study emphasized the risk of resistance spread within the mariculture ecosystem."

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Hepatotoxicity, developmental toxicity, and neurotoxicity risks associated with co-exposure of zebrafish to fluoroquinolone antibiotics and tire microplastics: An in silico study. (PubMed, J Hazard Mater) - "Factorial analysis and the mixture toxicity index revealed that the synergistic effects of lomefloxacin × moxifloxacin and ciprofloxacin × lomefloxacin × enrofloxacin interactions significantly contributed to hepatotoxicity in zebrafish exposed to SBR TMP. This study provides new insights regarding the toxicological risks to aquatic organisms from co-exposure to SBR TMPs and FQs from a microscopic perspective. Future studies should include a broader range of antibiotics and tire microplastics and consider their long-term adverse effects on aquatic life."

Journal • Hepatology • ACOX1

Non-targeted Screening and Ecological Risk Assessment of Emerging Contaminants in Beijiang Drinking Water Source of the Pearl River Delta (PubMed, Huan Jing Ke Xue) - "The concentrations of ATZ, PPS, roxithromycin （ROX）, and ibuprofen （IBU） were significantly higher in the spring season compared to those in other seasons （P<0.05）. Elevated ecological risk levels （RQ>1） were observed at sampling point 1 （S1） and sampling point 3 （S3） for ATZ and Lomefloxacin （LOM）, while for 4-NP, it was determined to be high only at sampling site 2 （S2）...The concentration level of ATZ exhibited significant seasonal variation due to its agricultural origin, so it is recommended to strengthen control during spring. Overall, this research provides critical insights into a comprehensive understanding of the presence and impact of ECs in this specific region."

Journal

Strategy of Constructing Ratio-Dependent Coordination Polymer probes and Their Film Application with a Smart Phone for Detection of Lomefloxacin Hydrochloride and Sodium Salicylate. (PubMed, Inorg Chem) - "Furthermore, a strategy for constructing ratio-based fluorescent probes by exploiting the luminescence of analytes and Ln3+ ions in host coordination polymers is proposed. This work provides a new insight by combining luminescence probes, portable devices, and a smart-phone app for real-time detection of drugs and food additives."

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A chitosan-α-naphthaldehyde hydrogel film containing pineapple leaf fibers for wound dressing applications. (PubMed, J Mater Chem B) - "The prepared hydrogel film exhibited high encapsulation efficiency for antibacterial drugs such as ciprofloxacin and lomefloxacin, with the ability to release the antibiotics in a controlled manner over an extended period and prevent long-term bacterial infections. In addition to its mechanical strength, significant cell viability against human embryonic kidney (HEK-293) cells was observed from in vitro cell culture experiments for this PLF-hydrogel film. As a result, the prepared therapeutic agent-loaded hydrogel film under study meets the requirements to be considered for use as a wound dressing material."

Journal • Infectious Disease

Aldose reductase with quinolone antibiotics interaction: In vitro and in silico approach of its relationship with diabetic complications. (PubMed, Arch Biochem Biophys) - "In this study, we evaluated the inhibitory potential of five quinolone antibiotics-gatifloxacin, lomefloxacin, nalidixic acid, norfloxacin, and sparfloxacin-as ARIs relevant to various physiological and pathological conditions...Our findings reveal that these quinolones moderately inhibit AR at micromolar concentrations, with inhibition constants (KIs) ranging from 1.03 ± 0.13 μM to 4.12 ± 0.51 μM, compared to the reference drug epalrestat (KI of 0.85 ± 0.06 μM). The combined in vitro and in silico results underscore significant interactions between these drugs and AR, suggesting their potential as therapeutic agents against the aforementioned pathological conditions. Furthermore, these insights will aid in optimizing clinical dosing regimens and mitigating unexpected drug-drug interactions when these antibiotics are co-administered with other treatments."

Journal • Preclinical • Cardiovascular • Diabetes • Metabolic Disorders • Oncology • Pain • Renal Disease • Retinal Disorders • AKR1B1