lomefloxacin / Generic mfg. - LARVOL DELTA

Development of a monospecific monoclonal antibody and a homogeneous chemiluminescence immunoassay for selective detection of "stopped" lomefloxacin. (PubMed, Anal Chim Acta) - "This study offers a viable solution for the selective detection of a target analyte among structurally similar drugs by providing a broadly applicable strategy for generating monospecific antibodies. The established HCLIA provides a robust tool for monitoring LOM residues in animal-derived foods, enhancing surveillance efficiency and strengthening food safety assurance."

Journal

Pipette-tip micro solid-phase extraction coupled with HPLC-UV using a zwitterionic cyclodextrin-based copolymer for the determination of fluoroquinolones in food. (PubMed, J Chromatogr A) - "Under the optimized conditions, the method exhibited good linearity over the range of 1.0 to 500 μg L⁻¹, limits of detection of 0.07 and 0.24 μg L⁻¹, and limits of quantification of 0.23 and 0.72 μg L⁻¹ for lomefloxacin and gatifloxacin, respectively. Recoveries in spiked milk and honey ranged from 74.8% to 110.3%, and norfloxacin and enrofloxacin were also effectively enriched. The proposed miniaturized method provides a simple, economical, and practical approach for FQs enrichment and screening in complex food matrices."

Journal

A Label-Free Bioluminescent scFv-NLuc Fusion Probe Enabling a Smartphone-Based Sensitive Immunoassay Platform Using Lomefloxacin as a Model Analyte. (PubMed, Small) - "Recovery rates ranged from 79.0% to 113.0%, with coefficients of variation (CVs) between 2.3% and 10.9%, indicating high accuracy and reproducibility. This system offers a novel rapid detection platform for monitoring hazardous residues in food safety."

Journal

An artificial model of ATP-binding cassette mediated transport. (PubMed, Colloids Surf B Biointerfaces) - "Using real-time electrochemical impedance spectroscopy, adsorption and intercalation of six antibiotics-doxorubicin, daunorubicin, epirubicin, moxifloxacin, lomefloxacin, and vancomycin-were detected in E. coli bilayers with and without reconstituted BmrA, each producing a characteristic decrease in membrane admittance...Inhibition studies revealed that verapamil suppressed ATP-dependent transport for all tested drugs except epirubicin. These results establish the microcavity-supported lipid bilayer (MSLB) platform as a robust, biomimetic, and label-free system capable of resolving active versus passive drug transport across biomembranes. The approach offers a powerful tool for mechanistic interrogation of ABC transporters and may accelerate the discovery of antibiotics and efflux pump inhibitors."

Journal • CNS Disorders • Infectious Disease • Oncology

Lomefloxacin-induced stress on groundwater denitrification and its recovery potential. (PubMed, J Contam Hydrol) - "Despite the subsequent growth of fluoroquinolone (FQ) resistant bacteria and carbon source supplementation, the sustained inhibition of the cell cycle by LOM resulted in a slow and limited recovery of denitrification. This emphasized the challenges in recovering from occasional high antibiotic pollution events and highlighted the secondary risks linked to prolonged antibiotic exposure, such as the dissemination of FQ- and multidrug-resistant genes."

Journal

MXene-bridged S-scheme C₃N₅/SrTiO₃ heterojunction integrating photothermal effect and interfacial charge transfer for lomefloxacin mineralization. (PubMed, J Colloid Interface Sci) - "Density Functional Theory (DFT) calculations combined with liquid chromatography-mass spectrometry (LC-MS) analysis clarified preferential bond cleavage, multi-pathway degradation routes, and progressive toxicity reduction. This study provides new insights into MXene-mediated S-scheme photocatalysts for efficient antibiotic remediation and environmental risk mitigation."

Journal

High-performance molecularly imprinted electrochemical sensor based on 3D Ti3C2Tx/Ni(OH)2 for trace detection of lomefloxacin. (PubMed, Biosens Bioelectron) - "The sensor also delivered consistent recovery rates in real sample analyses-such as milk and lake water-validated by comparative studies with liquid chromatography. The use of 3D Ti3C2Tx-based MIECS in ultrasensitive antibiotic monitoring is made possible by this work."

Journal

Preparation and applications of sulfonated hyper-crosslinked polymers for capture and enrichment of fluoroquinolones. (PubMed, J Chromatogr A) - "The material, rich in sulfonic acid groups, exhibited rapid, high-capacity, and selective adsorption towards FQs, with maximum adsorption capacities of 924, 958, 889, and 848 mg·g-1 for ofloxacin, lomefloxacin hydrochloride, enrofloxacin, and difloxacin hydrochloride, respectively, ranking among the top-tier of previously reported results for FQ adsorption...In complex matrices such as eggs and milk, the established analytical method exhibited recoveries of 89.3-116.6% for FQs, with intra-day and inter-day relative standard deviations (RSD) below 15%, and the detection limits ranging from 0.33 to 1.67 ng·mL-1, which underscores its applicability and reliability. This work offers a novel material and reliable methodology for the analysis of trace FQs in environmental and food safety monitoring."

Journal

Comprehensive Review of Analytical Methods for the Determination of Lomefloxacin Across Multiple Matrices. (PubMed, Crit Rev Anal Chem) - "LC-MS/MS achieves the lowest detection limits (∼0.1 ng mL⁻¹), followed by HPLC (0.5-10 ng mL⁻¹), electrochemical sensors (low ng mL⁻¹), and spectrophotometric methods (µg mL⁻¹). Future directions include greener methodologies, improved sample preparation, miniaturized sensors, and AI-driven optimization."

Journal • Review

Co-selection of heavy metal and antibiotic resistance in Enterobacteriaceae members from Mula-Mutha River (Pune, India). (PubMed, Environ Monit Assess) - "Pearson correlation analysis revealed strong associations between HMR and ABR, including arsenic-lomefloxacin (r = 0.43), copper-cefotaxime (r = 0.46), and lead-piperacillin tazobactam (r = 0.365), suggesting co-selection via shared resistance mechanisms. These findings hold significance and highlight the convergence of chemical and biological pollution in shaping resistant microbial communities and emphasize the urgent need for integrated river basin monitoring and pollution control strategies."

Journal

Whole-genome sequencing and genomic characterization of Riemerella anatipestifer strain RA-NM from China. (PubMed, Microb Pathog) - "It was resistant to kanamycin, amikacin, gentamicin, streptomycin, lomefloxacin, and polymyxin B, consistent with six detected resistance genes (tet(X4), erm(F), aadS, blaOXA-209, ranA, ranB). No soft-core genes were detected, highlighting clear separation between conserved and variable genes and extensive genomic plasticity. Overall, this study provides a comprehensive phenotypic and genomic characterization of RA-NM, offering insights into its antimicrobial resistance, virulence, pangenome structure, and evolutionary background, serving as a foundation for future studies on R. anatipestifer pathogenicity."

Journal • Infectious Disease

Unraveling the activity of phage-carrying antibiotic resistance genes in constructed wetlands. (PubMed, Front Cell Infect Microbiol) - "In addition, sediment acts as a high-risk reservoir where redox and ionic gradients, together with residual lomefloxacin and other antibiotics, enhance phage infectious activity and the accumulation of ARGs. Through cross-compartment transmission along the sediment-water interface, these phage-associated and PARB populations continuously seed the overlying water. It is recommended that ARG risk assessment shift from static abundance to an activity-aware, carrier- and host-resolved approach, prioritizing sediment-targeted transcript monitoring and phage transduction early warning to support risk mitigation in CW."

Journal • Gene Therapies

In-situ silver-bridged interfaces drive Z-scheme coupling on iron-doped NH2-UiO-66(Zr)/silver iodide for efficient aqueous antibiotic degradation. (PubMed, J Colloid Interface Sci) - "Fluoroquinolone antibiotics like ciprofloxacin (CIP) pose environmental risks when released into water...It also showed high removal efficiencies for tetracycline, lomefloxacin, and Rhodamine B...This Z-scheme mechanism efficiently separated carriers, facilitated generation of ROS, and enabled thorough mineralization of CIP; toxicity predictions showed most products were less mutagenic than CIP, confirming reduced ecological risk. The findings demonstrate that the Fe-doped NH2-UiO-66(Zr)@AgI heterostructure is a promising photocatalyst for antibiotic-contaminated wastewater remediation."

Journal

Machine learning-enhanced colorimetric and surface-enhanced Raman scattering-based bimodal lateral flow immunoassay for sensitive and simultaneous detection of the residues of lomefloxacin, ofloxacin, and pefloxacin. (PubMed, Food Chem) - "ML-based multi-peak analysis reduced quantification error from 21-fold to 13-fold overestimation, compared to single-peak calibration. Overall, this ML-integrated SERS-LFIA delivers unprecedented sensitivity, accuracy, and field-deployability for quinolone residue monitoring in dairy products."

Journal

Chiral separation of fluoroquinolones by capillary electrophoresis using glucosamine-functionalized carbon quantum dots as a Pseudostationary phase. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Compared to the CE system using free glucosamine solely as the chiral selector, the CE system employing GA-CQDs as a pseudostationary phase demonstrated a substantial improvement in chiral resolution (Rs) for all six model analytes (Ofloxacin: 1.56 → 9.21; Pazufloxacin: 0 → 8.53; Prulifloxacin: 1.38 → 7.58; Lomefloxacin: 1.01 → 2.84; Gemifloxacin: 0 → 1.25; Balofloxacin: 0 → 0.88). This study represents the first report on employing GA-CQDs as a chiral selective medium to construct a capillary electrophoresis system, which achieved satisfactory enantioselectivity. Furthermore, the chiral recognition mechanism of glucosamine was preliminarily investigated through molecular modeling simulations, with the binding energy providing insights into the separation process."

Journal

Experimental Study and Molecular Modeling of Antibody Interactions with Different Fluoroquinolones. (PubMed, Int J Mol Sci) - "The most pronounced CRs were observed for lomefloxacin, sarafloxacin, and ciprofloxacin. It was shown by the dynamical network analysis that the sum of betweenness centrality between a node corresponding to the quinolone ring and nodes representing MAb amino acids is higher for cross-reactive haptens. The found regularities can be transferred to other analyte-antibody systems as a binary classifier that discriminates cross-reactive and non-cross-reactive compounds."

Journal

Efficient 2D HOF@Au SERS Substrates Synergized with the G-quadruplex Network-Based Catalytic Amplification Strategy for Low-Background Trimode Detection of Lomefloxacin. (PubMed, Anal Chem) - "This approach enabled the simultaneous SERS, colorimetric, and visual detection of lomefloxacin (LOM) with detection limits as low as 6.54 × 10-14 mol/L, 3.27 × 10-11 mol/L, and 5.31 × 10-11 mol/L, respectively. This method has been successfully applied to the analysis of real-world samples, demonstrating its promising potential for practical applications."

Journal

How do hydrodynamic conditions and land use drive antibiotic fate in estuarine and bay ecosystems? (PubMed, J Environ Sci (China)) - "The findings indicated that estuaries were more heavily polluted with antibiotics than the bays (P < 0.05), with tetracyclines and fluoroquinolones as the primary antibiotics...The concentrations of lomefloxacin and ofloxacin were positively correlated with build-up land...A comparative analysis of global estuaries and bays revealed that specific land-use types and hydrodynamic conditions produced similar trends in antibiotic fate. These insights offered new perspectives to safeguard the health of estuarine and bay ecosystems, such as altering landscape patterns and regulating aquaculture activities."

Journal

Spatiotemporal Distribution Characteristics， Influencing Factors， and Ecological Risk Assessment of Antibiotics in a River of a Typical Northern City (PubMed, Huan Jing Ke Xue) - "Correlation analysis revealed no significant association between antibiotic distribution and water quality parameters， indicating that human activities and wastewater discharge practices in different regions were the primary influencing factors. Ecological risk assessments suggested that tetracycline （TCY） and sulfamethoxazole （SMX） posed higher ecological risks to fish， while ofloxacin （OFX）， lomefloxacin （LOM）， and erythromycin （ERY） exhibited certain ecological risks to algae."

Journal

1H-NMR Spectroscopy Study of the Formation of Inclusion Complexes between Cucurbit[7]uril and Ciprofloxacin, Levofloxacin, and Lomefloxacin. (PubMed, Chem Pharm Bull (Tokyo)) - "Because the piperazine ring structure is commonly found in many drugs, CB[7] can be expected to capture other drugs apart from those evaluated in this study. Therefore, CB[7] is a promising candidate as a host molecule for use in drug removal in aquatic environments through host-guest chemistry."

Journal

First Report on some N2O2-Donor Sets Tetradentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation. (PubMed, Chem Biodivers) - "The new Schiff base ligand N,N'-thiophene-(bis-1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid) (H2L) was synthesized via condensation of thiophene-2,5-diamine with lomefloxacin in ethanol using glacial acetic acid...The data revealed that Cr(III) complex as most effective against Escherichia coli and Staphylococcus aureus. Cytotoxicity tests on normal prostate epithelial cells (IC50 = 6.30-10.43 µM) indicated significant toxicity and limited selectivity, restricting anticancer applicability."

Journal • Oncology

Use of oral fluoroquinolones in France between 2014 and 2023: a nationwide drug utilization study. (PubMed, JAC Antimicrob Resist) - "From 2014 to 2023, ofloxacin, ciprofloxacin, levofloxacin and moxifloxacin use decreased by 40%, 22%, 5% and 72%, respectively. Norfloxacin and lomefloxacin use dropped by 86% and 79% from 2014 to 2019, the year their reimbursement ended. General practitioners were the primary prescribers, accounting for 82.9% of prescriptions in 2023, followed by urologists-nephrologists (6.1%), ophthalmologists (1.6%), otolaryngologists (1.2%) and gynaecologists (1.1%). FQ use in France has declined significantly over the past decade, driven by awareness efforts and guideline changes, but remains high compared with other European countries, highlighting the need for ongoing stewardship."

Journal • Ophthalmology • Otorhinolaryngology

Selective production of singlet oxygen for enhanced photocatalytic degradation performance of organic pollutants by C60/COF coupled with persulfate. (PubMed, Environ Res) - "The degradation efficiencies of lomefloxacin (LOMH) and trichloromethane (TCM) achieved 80.4% and 74% by the proposed system...DFT calculation results showed that the composite of C60/COF has enhanced adsorption strength of both target pollutant and O2, leading to a better photocatalytic oxidation effect. This work provided an efficient, economical and environmentally friendly way to remove organic pollutants driven by clean light energy, which shows practical application potential and is compatible with the "cost reduction and efficiency increase" strategy."

Journal

Topical antibiotics for treating bacterial keratitis: a network meta-analysis. (PubMed, Cochrane Database Syst Rev) - "In our NMA, mostly moderate- to very low-certainty evidence suggests that vancomycin + ceftazidime combination therapy, moxifloxacin monotherapy, and cefazolin + tobramycin combination therapy may be the most effective treatments for BK in terms of corneal healing time, whereas ciprofloxacin monotherapy is the least effective. Given that most evidence was not of high certainty, the results of this NMA should be interpreted with caution, and future research could potentially alter these findings."

Journal • Retrospective data • Review • Conjunctivitis • Corneal Abrasion • Glaucoma • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism. (PubMed, Chirality) - "In this work, the silica gel bonded amylose[(S)-α-methylbenzyl carbamate] (CHIRALPAK IH) was chosen as the chiral stationary phase (CSP) for the separation of five quinolone enantiomers by high-performance liquid chromatography (HPLC), namely, ofloxacin, flumequine, nadifloxacin, lomefloxacin, and clinafloxacin...The differences in these interaction forces between the quinolone enantiomers, particularly the greater contribution of hydrogen bonding in one enantiomer compared to the other, led to a significant difference in binding energy. This differential binding energy ultimately governed the elution order and enabled chiral recognition of the five quinolone enantiomers."

Journal