foscarnet / Generic mfg. - LARVOL DELTA

Managing refractory herpes simplex keratitis. (PubMed, Br J Ophthalmol) - "The emergence of acyclovir-resistant HSV-1 strains, particularly in immunocompromised or long-term treated patients, represents an increasing concern. In these situations, alternative agents such as trifluridine, foscarnet or more recently, helicase-primase inhibitors, including amenamevir, have demonstrated clinical efficacy. The new strategies outlined here will all provide benefit in treating the drivers of refractory HSK, to quickly resolve and reduce risk of recurrence, providing new opportunities to prevent vision loss in refractory and antiviral-resistant cases."

Journal • Review • Dry Eye Disease • Herpes Simplex • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Bilateral cytomegalovirus retinitis in the setting of acquired lymphopenia following administration of bendamustine. (PubMed, Retin Cases Brief Rep) - "Bendamustine can cause profound lymphopenia with reduced CD4 T-cell levels; risk of herpes virus retinitis is elevated in the setting of such immunosuppression. In HIV-negative patients, there is no specific treatment to raise the CD4 count. Prompt initiation and continued administration of systemic and local antiviral treatment can lead to disease control and preservation of vision while awaiting immune reconstitution."

Journal • Cytomegalovirus Infection • Follicular Lymphoma • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Human Immunodeficiency Virus • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Ocular Inflammation • Oncology • Ophthalmology • Retinal Disorders • CD4

Foscarnet-associated Hypercalcemia in an Infant With Cytomegalovirus Myocarditis and Severe Combined Immunodeficiency: An Unusual Therapeutic Challenge. (PubMed, J Pediatr Hematol Oncol) - No abstract available

Journal • Cardiovascular • Cytomegalovirus Infection • Endocrine Disorders • Genetic Disorders • Immunology • Inflammation • Metabolic Disorders • Primary Immunodeficiency

Efficacy and Safety of Pritelivir vs Foscarnet for the Treatment of Acyclovir-Refractory Herpes Simplex Virus Infection in Immunocompromised Adults: A Randomized, Open-Label Phase 2 Trial. (PubMed, Open Forum Infect Dis) - "In Part B, the median time to healing was 19.0 days, with a 63% healing rate. Pritelivir demonstrated encouraging efficacy and favorable safety in immunocompromised adults with limited treatment options, supporting Phase 3 evaluation for the treatment of refractory HSV infection in this population."

Clinical • Journal • P2 data • Herpes Simplex • Infectious Disease

CMV transplant nephritis and graft failure: A cautionary tale (TTS 2026) - "The patient received induction immunosuppression with alemtuzumab...The patient was treated initially with intravenous ganciclovir, briefly switched to foscarnet, and ultimately discharged on oral valganciclovir... CMV nephritis is a rare but serious complication of kidney transplantation associated with high rates of graft failure. This case highlights the importance of maintaining high clinical suspicion for CMV end-organ disease in patients with risk factors such as lymphocyte-depleting induction therapy, even in CMV-seropositive recipients. Early recognition through kidney biopsy and aggressive antiviral treatment are essential, though outcomes remain poor."

Chronic Kidney Disease • Cytomegalovirus Infection • Fibrosis • Focal Segmental Glomerulosclerosis • Gastrointestinal Disorder • Glomerulonephritis • Immunology • Infectious Disease • Nephrology • Transplantation • Vasculitis

New Strategies for the Management of Hospitalized AIDS Patients with Concurrent High CMV Viremia (ChiCTR) - P=N/A | N=440 | Not yet recruiting | Sponsor: The Second Hospital of Nanjing; The Second Hospital of Nanjing

New trial • Human Immunodeficiency Virus • Infectious Disease • CD4

Real world efficacy of maribavir when used as pre-emptive therapy for cytomegalovirus reactivation in alloHCT patients who are intolerant, refractory or resistant (TTS 2026) - "Existing antivirals (val)ganciclovir and foscarnet have significant toxicities (myelosuppression and renal dysfunction) and often necessitate inpatient admissions. This real-world study demonstrates that MBV is an effective, well-tolerated antiviral when used as PET. It is beneficial in cases of bone marrow dysfunction and reduces inpatient hospitalisation days in patients who require foscarnet."

Clinical • Real-world • Real-world effectiveness • Real-world evidence • Cytomegalovirus Infection • Infectious Disease • Nephrology • Renal Disease

Pritelivir for treatment of resistant/refractory HSV in stem cell transplant patients: Real-world experience from a single centre tertiary hospital (TTS 2026) - "Salvage therapies including foscarnet and cidofovir, are limited by nephrotoxicity, cytopenias, and the need for intravenous administration...Pritelivir, a novel first-in-class helicase-primase inhibitor that blocks viral DNA synthesis, offers activity against aciclovir- and foscarnet-resistant HSV...Case 1: A 68-year-old female allogeneic HSCT recipient for pre-B acute lymphoblastic leukaemia developed refractory perianal HSV-2 ulcers despite high-dose valaciclovir, IV foscarnet, and topical imiquimod... In a phase 3 trial, pritelivir demonstrated superior healing of refractory/ resistant HSV lesions compared to standard therapies. Although optimal durations of pritelivir could not be completed in our cases due to transplant related morbidity, there was evidence of initial clinical improvement. Early consideration of pritelivir may help mitigate significant morbidity associated with refractory or resistant HSV ulceration."

Clinical • Real-world • Real-world evidence • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Herpes Simplex • Immunology • Infectious Disease • Leukemia • Myelodysplastic Syndrome • Septic Shock • Transplantation

Post transplant parvovirus infection: Strategic management of a double edged sword (TTS 2026) - "15 (57.3%) patients were changed from Mycophenolic acid to Azathioprine...8 (33.3%) patients were changed from Tacrolimus to Cyclosporine...One patient treated with foscarnet and IVIg... An early diagnosis, prompt isolation from the rest of the transplant recipient population, regular teleopd follow-ups with laboratory reports (CBC/Reticount/RFT/Tac level/Parvo PCR), timely tapering or hiking of immunosuppressants and IV Immunoglobulin therapy in a strategic way had led to the control of spread and manage parvo with minimal graft loss or dysfunction and increased graft survival and patient survival."

Post-transplantation • Infectious Disease • Solid Organ Transplantation • Transplantation

Early Access Program (EAP) Experience of Pritelivir in the Treatment of Acyclovir- and Foscarnet-Refractory Herpes Simplex Virus (HSV) Infection in Immunocompromised (IC) Patients (IDWeek 2026) - No abstract available

Clinical • Herpes Simplex • Infectious Disease

The Hidden Burden on OPAT Programs of Managing Patients Receiving Foscarnet in The Outpatient Setting (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand. (PubMed, Intern Med J) - "Institutional preferences and medicine funding drives variability in ANZ practice. This leaves potential for healthcare inequity since newer antiviral agents are inconsistently used, contrasting with international guidelines."

Journal • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Pediatrics • Transplantation

Treatment of Herpes simplex encephalitis with the helicase-primase inhibitor pritelivir in an immunocompromised patient. (PubMed, NPJ Antimicrob Resist) - "After 1.5 months, while still on valacyclovir prophylaxis, HSE relapsed, confirmed by Magnetic Resonance Imaging (MRI) and HSV1 DNA detection in cerebrospinal fluid (CSF). Following transient response to acyclovir and foscarnet, combined pritelivir/acyclovir treatment was initiated in this comatose patient with cerebral edema and necrosis...Pritelivir plasma and CSF concentrations exceeded the 50% effective concentration for HSV1. This case highlights the potential of pritelivir for treating HSE."

Journal • Bone Marrow Transplantation • CNS Disorders • Herpes Simplex • Infectious Disease • Transplantation

Multi-Criteria Decision Analysis using Physician Preferences from a Global Discrete Choice Experiment to Investigate the Selection of Preemptive Antiviral Treatments for Post-Hematopoietic Cell Transplant Cytomegalovirus Infection. (PubMed, Open Forum Infect Dis) - "Maribavir had a higher overall benefit-risk score than ganciclovir and foscarnet in both ANC cohorts. Within this MCDA framework, maribavir was preferred over valganciclovir, ganciclovir, and foscarnet for preemptive treatment of CMV after HCT."

Journal • Cytomegalovirus Infection • Hematological Disorders • Infectious Disease • Neutropenia • Transplantation

Multinational Retrospective Chart Review of Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization in Solid Organ Transplant Recipients With Refractory/Resistant Cytomegalovirus Infection or Intolerance to Anti-Cytomegalovirus Therapy. (PubMed, Transplant Proc) - "In this multinational real-world study of SOT recipients with RRI CMV infection, 21.1% did not achieve viremia clearance and 21.6% experienced recurrence, and a notable portion had unfavorable outcomes, such as adverse events, mortality, and hospitalizations. Results suggest that therapies that achieve and maintain CMV clearance without treatment-limiting toxicities are needed."

Clinical data • HEOR • Journal • Retrospective data • Cytomegalovirus Infection • Infectious Disease • Solid Organ Transplantation • Transplantation

Varicella zoster virus infection. (PubMed, Nat Rev Dis Primers) - "VZV infection is treated with antiviral drugs including oral valacyclovir (drug of choice), famciclovir, acyclovir or amenamevir; for severe or disseminated disease, intravenous acyclovir or foscarnet (when other drugs fail) are used. Critical challenges remain in recognizing and diagnosing atypical presentations, developing novel therapeutics, establishing the causal role of VZV in vascular and neurodegenerative disease, and achieving broader vaccine implementation worldwide."

Journal • Review • Cardiovascular • CNS Disorders • Herpes Zoster • Infectious Disease • Neuralgia • Pain • Varicella Zoster

Chasing Cytomegalovirus: A Rare Case of Foscarnet-induced Hypercalcemia in an Infant With SCID. (PubMed, Pediatr Infect Dis J) - No abstract available

Journal • Cytomegalovirus Infection • Endocrine Disorders • Metabolic Disorders

Clinical Challenges in Managing Ganciclovir-Resistant CMV Ileitis (ACG 2026) - "Case Description/ A 63-year-old male with type 1 diabetes mellitus and end-stage renal disease status post deceased donor renal transplantation (CMV D+/Râ) two months prior, on mycophenolate 720 mg twice daily and Belatacept 5mg/kg every 28 days presented to the emergency department with seven episodes of non-bloody diarrhea...Diarrhea improved after treatment with Maribavir and immunosuppression was resumed...UL54 encodes the catalytic subunit of viral DNA polymerase conferring resistance to ganciclovir as well as foscarnet and cidofovir...This case highlights the clinical course of a patient with CMV in a notably uncommon location, the terminal ileum. Figure: A. Endoscopic images of terminal ileum showing ulcers due to CMV Ileitis."

Clinical • Cytomegalovirus Infection • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus

Severe CMV Esophagitis and Major GI Hemorrhage as the Index Manifestation of HIV: A Case Report (ACG 2026) - "Hemostasis was successfully achieved using epinephrine injection and bipolar cautery...The patient was started on IV ganciclovir induction (250 mg BID) and also had a diagnosis of CMV retinitis requiring intravitreal foscarnet and ganciclovir injections...Gastrointestinal bleeding from CMV esophagitis typically presents as occult blood loss or melena; massive hematochezia and acute blood loss anemia is a rare, high-morbidity complication. Figure: A. Upper third esophageal ulcer B. Lower third esophageal ulcer C. Lower esophageal Mallory-Weiss tear Figure: Histopathology showing enlarged cells with characteristic intranuclear "owls eye" inclusion suggestive of CMV."

Case report • Clinical • Acute Kidney Injury • Back Pain • CNS Disorders • Cytomegalovirus Infection • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Musculoskeletal Pain • Nephrology • Ocular Inflammation • Ophthalmology • Renal Disease • Retinal Disorders • CD4

CMV Ileitis Causing Small Bowel Perforation With Disseminated CMV Disease in Common Variable Immunodeficiency (CVID) (ACG 2026) - "Empirical IV piperacillin-tazobactam and fluconazole were commenced...Ophthalmological assessment confirmed concurrent CMV retinitis, necessitating escalation to IV ganciclovir with intravitreal foscarnet twice weekly for three weeks. The patient was discharged on oral valganciclovir with weekly CMV DNA surveillance...A high index of suspicion and multidisciplinary management are paramount in immunocompromised patients presenting with gastrointestinal emergencies. Figure: Disseminated CMV Disease in Common Variable Immunodeficiency ( CVID )"

Crohn's disease • Endocrine Disorders • Gastroenterology • Genetic Disorders • Hematological Disorders • Hypotension • Immunology • Infectious Disease • Nephrology • Ocular Inflammation • Ophthalmology • Primary Immunodeficiency • Renal Disease • Retinal Disorders

HHV-6-Positive Meningitis in an Immunocompetent Adult: Diagnostic Challenges in Distinguishing Active Infection From Chromosomal Integration: A Case Report. (PubMed, Clin Case Rep) - "Qualitative CSF PCR requires cautious interpretation because it cannot exclude chromosomally integrated HHV-6. Serial CSF improvement and rapid clinical recovery may support probable self-limited infection and help avoid unnecessary ganciclovir or foscarnet therapy."

Journal • CNS Disorders • Epstein-Barr Virus Infections • Infectious Disease

Real-World Effectiveness and Renal Safety of Foscarnet for CMV Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation. (PubMed, J Clin Med) - "Letermovir is used to prevent infections, but it is not available in many countries. Ganciclovir and valganciclovir carry a risk of bone marrow suppression...These findings suggest that close renal and electrolyte monitoring may be warranted. However, given the retrospective, single-center design, small sample size, and absence of a comparator group, the findings should be interpreted cautiously and confirmed in larger prospective comparative studies."

Journal • Real-world evidence • Acute Kidney Injury • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Nephrology • Renal Disease • Transplantation

LETERMOVIR FOR SECONDARY PROPHYLAXIS OF CYTOMEGALOVIRUS INFECTION AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A SINGLE CENTER EXPERIENCE (EHA 2024) - "LMV was administered at a dose of 480 mg once daily, with a reduction to 240 mg once daily when co-administered with cyclosporine owing to a drug-drug interaction...By definition, all patients had previously received treatment for CMV reactivation (36 with valganciclovir; 6 withganciclovir; 2 with foscarnet)... LMV used as SP is effective and well tolerated in this high-risk patient population. Prospective studies on alarger cohort should be performed to validate these findings."

Clinical • Acute Graft versus Host Disease • Bone Marrow Transplantation • Cytomegalovirus Infection • Graft versus Host Disease • Immunology • Infectious Disease • Oncology • Transplantation

Now you see me, now you don't: A vanishing papillomatous CMV pseudotumor in an immunocompetent host. (PubMed, IDCases) - "The patient was treated with IV ganciclovir and later completed PO valganciclovir for three weeks...Treatment includes antivirals such as ganciclovir, foscarnet, and cidofovir. Previous studies have demonstrated that CMV-induced inflammatory tissue, which appears as tumor-like masses, has completely resolved with antiviral therapy. In our patient, bleeding stopped after initiation of therapy, and her follow-up colonoscopy to evaluate the resolution of her pseudotumor confirmed regression of the tumor."

Journal • Acute Kidney Injury • Cardiovascular • Colorectal Cancer • Cytomegalovirus Infection • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Nephrology • Oncology • Renal Disease • Septic Shock • Thrombosis • Transplantation • Vasculitis

Disseminated Ganciclovir-Resistant Cytomegalovirus in a Nontransplant Pediatric ALL Patient: A Case Report. (PubMed, J Pediatr Hematol Oncol) - "This case underscores the potential severity of CMV in nontransplant pediatric ALL with prolonged lymphopenia, challenges of antiviral resistance, and limited treatment options for central nervous system involvement. The progression from asymptomatic viremia to clinically significant CMV disease remains poorly understood. Enhanced CMV surveillance protocols and resistance-guided treatment strategies may be warranted in selected high-risk populations."

Journal • Acute Lymphocytic Leukemia • Cytomegalovirus Infection • Genetic Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Ocular Inflammation • Oncology • Ophthalmology • Pediatrics • Retinal Disorders • T Acute Lymphoblastic Leukemia • Transplantation