hydralazine hydrochloride / Generic mfg. - LARVOL DELTA

NAT2 Pharmacogenomics: Applying CPIC Guidelines with CDC GeT-RM Reference Materials (AMP 2026) - "N-acetyltransferase 2 (NAT2) genotype predicts acetylator status, informing dosing for isoniazid, hydralazine, and other NAT2 substrates...Particular attention is given to characterized reference materials from the CDC's Genetic Testing Reference Material Coordination Program (GeT-RM), which support assay validation and inter-laboratory concordance for NAT2 testing. Attendees will leave with practical guidance for implementing NAT2 genotyping in clinical or research laboratory workflows, including panel design considerations and quality assurance best practices using GeT-RM consensus genotypes."

Biomarker • NAT2

The Phantom Pigment: Iron-Negative Pseudomelanosis Duodeni Unmasked in a Patient With Prior Malignancy (ACG 2026) - "It is important to note that she was on hydralazine 50 mg three times daily, a drug that is known to cause periodontal disease, but had no iron intake by mouth...Duodenal biopsy demonstrating preserved villous architecture with clusters of pigment-laden macrophages at the villous apices, containing coarse brown-black cytoplasmic granules consistent with pseudomelanosis duodeni. Villous morphology is intact with no acute or chronic inflammation, cytologic atypia, or infectious organisms identified."

Clinical • Celiac Disease • Chronic Kidney Disease • Dental Disorders • Diabetes • Diabetic Nephropathy • Dyslipidemia • Gastric Cancer • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Metabolic Disorders • Nephrology • Oncology • Periodontitis • Renal Disease • Solid Tumor

Harmless or Harmful? A Case Report on Pseudomelanosis Duodeni (ACG 2026) - "She reported adherence with her medications including carvedilol, hydralazine, torsemide, semaglutide, and ferrous sulfate...PD appears to occur predominantly in middle-age females and have a strong association with hypertension and diabetes mellitus and the use of certain medications such as hydralazine, ferrous sulfate, and sulfur-containing loop diuretics such as furosemide or torsemide...Therefore, the purpose of this case report is to bring awareness about PD and highlight the importance of distinguishing it from duodenal melanoma to avoid unnecessary work-up as it is benign and requires no further work-up or treatment. Figure: Abnormal mucosa in the duodenum"

Case report • Clinical • Cardiovascular • Congestive Heart Failure • Constipation • Diabetes • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hypertension • Melanoma • Metabolic Disorders • Solid Tumor

Preeclampsia-Induced Pancreatitis Four Weeks Postpartum: A Case Report (ACG 2026) - "She was prescribed hydralazine for her gestational hypertension, but she did not take the medication...She was started on intravenous fluids, intravenous magnesium, and nifedipine...This case portrays a unique case of preeclampsia developing four weeks postpartum that induced acute pancreatitis. We believe that this case report will raise awareness of this topic, leading to more prompt diagnosis and timely treatment in future clinical cases."

Case report • Clinical • Cardiovascular • Gastroenterology • Genetic Disorders • Gynecology • Hypertension • Obesity • Pancreatitis • Renal Disease

Beyond Iodine Exposure: The Role of Hydralazine, Renal Dysfunction, and ANCA Positivity in Iododerma (EADV 2026) - No abstract available

Nephrology • Renal Disease

FROM HYPERTENSION TO HEMOPTYSIS: A CASE OF HYDRALAZINE-INDUCED ANCA VASCULITIS CAUSING DIFFUSE ALVEOLAR HEMORRHAGE (CHEST 2026) - No abstract available

Clinical • ANCA Vasculitis • Cardiovascular • Hematological Disorders • Hypertension • Vasculitis

A MASS APPEAL: HYDRALAZINE-INDUCED AFOP MIMICKING MALIGNANCY (CHEST 2026) - No abstract available

Oncology

DELAYED SEVERE PULMONARY-RENAL SYNDROME AFTER INITIAL RENAL IMPROVEMENT IN HYDRALAZINE-INDUCED ANCA VASCULITIS (CHEST 2026) - No abstract available

ANCA Vasculitis • Nephrology • Renal Disease • Vasculitis

HYDRALAZINE-ASSOCIATED MPO-ANCA VASCULITIS WITH DIFFUSE PULMONARY INVOLVEMENT AND CRESCENTIC GLOMERULONEPHRITIS (CHEST 2026) - No abstract available

ANCA Vasculitis • Glomerulonephritis • Lupus Nephritis • Nephrology • Vasculitis

RECURRENT EXUDATIVE PLEURAL EFFUSION REQUIRING TUNNELED PLEURAL CATHETER AS A MANIFESTATION OF HYDRALAZINE ASSOCIATED AUTOIMMUNE POLYSEROSITIS (CHEST 2026) - No abstract available

Pleural effusion • Immunology • Respiratory Diseases

WHEN ANCA MEETS LUPUS: HYDRALAZINE-INDUCED PULMONARY-RENAL SYNDROME PRESENTING WITH DIFFUSE ALVEOLAR HEMORRHAGE AND RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS (CHEST 2026) - No abstract available

Glomerulonephritis • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease

HEMOPTYSIS AS THE PRESENTING FEATURE OF HYDRALAZINE-INDUCED ANCA-ASSOCIATED VASCULITIS (CHEST 2026) - No abstract available

ANCA Vasculitis • Vasculitis

UNDER PRESSURE: HYDRALAZINE-INDUCED LUPUS PRESENTING WITH TAMPONADE AND ILD (CHEST 2026) - No abstract available

Immunology • Inflammatory Arthritis • Interstitial Lung Disease • Lupus

WHEN ANTIHYPERTENSIVE THERAPY TURNS NEPHROTOXIC : HYDRALAZINE INDUCED ANCA VASCULITIS (CHEST 2026) - No abstract available

ANCA Vasculitis • Vasculitis

Transplanted but Not Cured: IL-1-Dependent Relapsing Pericarditis in Hydralazine-Induced Lupus (AHA 2026) - "Abstract is embargoed at this time."

Cardiovascular • Immunology • Inflammatory Arthritis • Lupus • Transplantation

Hydralazine-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Presenting with Diffuse Alveolar Hemorrhage and Thrombotic Vasculopathy: A Case Report (AHA 2026) - "Abstract is embargoed at this time."

Case report • Clinical • ANCA Vasculitis • Hematological Disorders • Vasculitis

Association between up-titration of guideline-directed medical therapy and clinical outcomes in patients with chronic heart failure with reduced ejection fraction (ESC 2026) - "The GDMT score was calculated based on the use and dose of the quadruple therapy, ivabradine, vericiguat, and hydralazine/nitrates (Figure 1).1 Patients were classified into an up-titration group or a no up-titration group according to the change in GDMT score from baseline to 9 months after enrolment. In patients with HFrEF, up-titration of GDMT was independently associated with favourable clinical outcomes and LVRR. The GDMT score could facilitate optimisation of GDMT even in patients with chronic HFrEF."

Clinical • Clinical data • Cardiovascular • Congestive Heart Failure • Heart Failure

Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue. (PubMed, Hypertension) - "SHRs were treated with vehicle, follistatin, or hydralazine for 8 weeks...Proteomic analysis revealed a shift in proteome towards a normal state, upregulating processes associated with adipose browning. Follistatin restores PVAT-mediated vascular relaxation via ROS reduction, activin neutralization, and AMPK-dependent browning, positioning the potential for PVAT as a therapeutic target for vascular dysfunction in essential hypertension."

Journal • Cardiovascular • Hypertension • AMPK

EHSAN: Effect of Hydralazine on Alzheimer's Disease (clinicaltrials.gov) - P3 | N=228 | Completed | Sponsor: Shahid Sadoughi University of Medical Sciences and Health Services | Recruiting ➔ Completed | N=424 ➔ 228 | Trial completion date: Dec 2023 ➔ Mar 2026 | Trial primary completion date: Jun 2023 ➔ Mar 2026

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Alzheimer's Disease • CNS Disorders

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

Exploring cellular consequences of hydroxylamine derived covalent adducts at apurinic/apyrimidinic sites in DNA (ACS-Fall 2026) - "Our previous work demonstrated that medicinally relevant concentrations of the antihypertensive drug hydralazine efficiently generate covalent adducts with AP sites in duplex DNA (Islam et al., Chem. The compounds exhibited synergistic cytotoxicity when cotreated with radiotherapy or chemotherapeutics such as temozolomide. Notably, enhanced sensitivity in PTEN deficient cells suggests a synthetic lethal relationship, highlighting the therapeutic potential of AP targeting hydroxylamines as BER disruptive chemo enhancing agents."

PTEN

Perioperative Management of a patient with Baroreceptor Reflex Failure Undergoing a Total Knee Replacement (ASA 2026) - "She had episodes of tachycardia and hypertension (SBP up to 250 mmHg), managed with six antihypertensives and PRN hydralazine, pending renal denervation...She was discharged the same day. This case highlights the need for vigilant monitoring and preparedness in a patient with baroreceptor dysfunction."

Clinical • Reflex • Cardiovascular • Hypertension • Musculoskeletal Diseases • Orthopedics

Drug mule, body packer transit time versus obstruction- Does the substance matter? (ASA 2026) - "He remained hypertensive throughout his stay despite nicardipine, clonidine, hydralazine, and hydrochlorothiazide. it was removed with paralysis. It was confirmed to be marijuana wrapped in electrical tape."

Large Pericardial Effusion as a Manifestation of Overlapping Hydralazine-Induced Lupus and ANCA Vasculitis. (PubMed, JACC Case Rep) - "Hydralazine at doses >200 mg qd can cause severe overlapping autoimmune syndromes. Clinicians should maintain a high suspicion for drug-induced disease in patients with pericardial effusions and multiorgan failure in the setting of chronic hydralazine use."

Journal • ANCA Vasculitis • Cardiovascular • Chronic Myelomonocytic Leukemia • Hematological Malignancies • Hypertension • Immunology • Inflammatory Arthritis • Leukemia • Lupus • Oncology • Renal Disease • Respiratory Diseases • Rheumatology • Vasculitis

Cardiovascular Outcomes in Middle-Aged Adults on Antihypertensive Medications and No Prior Cardiovascular Disease. (PubMed, Clin Ther) - "Among middle-aged adults with hypertension and no prior cardiovascular disease, ARB users had the lowest observed cardiovascular event rates in this cohort. The higher event rates observed with beta-blockers and diuretics likely reflect confounding by indication. These hypothesis-generating findings require confirmation in prospective studies."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Myocardial Infarction