hydralazine hydrochloride / Generic mfg. - LARVOL DELTA

Clinical Findings in Cryptococcoid Neutrophilic Dermatosis: A Review of Literature and Single-Center Retrospective Study (AAD 2026) - "Our findings suggest that cases of CND may fall within the same syndrome. Iodine exposure in a patient with CKD, coupled with hydralazine, may potentiate a profound neutrophilic response resulting in p-ANCA positivity and CND."

Retrospective data • Review • Chronic Kidney Disease • Dermatology • Hematological Disorders • Nephrology • Renal Disease • Vasculitis

Beyond the Blister: Bullous Pyoderma Gangrenosum Unmasking B-cell Lymphoma with Drug-Induced Lupus Nephritis (AAD 2026) - "Rheumatology was consulted and diagnosed the patient with drug-induced lupus nephritis due to hydralazine...The patient was treated with high-dose intravenous methylprednisolone but ultimately elected for hospice care...It is associated with various hematologic malignancies, most commonly leukemia, in up to 70% of cases. 2 As BPG is a diagnosis of exclusion with nonspecific histology, our case underscores the importance of a thorough clinical workup prior to establishing the final diagnosis, especially in patients with multiple ongoing processes (2,3)."

B Cell Lymphoma • Glomerulonephritis • Hematological Malignancies • Hypertension • Immunology • Inflammatory Arthritis • Leukemia • Lupus • Lupus Nephritis • Lymphoma • Nephrology • Non-Hodgkin’s Lymphoma • Pyoderma Gangrenosum • Vasculitis • MPO

Current Management of Resistant Hypertension in Patients with Intracerebral Hemorrhage. (PubMed, Int J Mol Sci) - "After initiating oral antihypertensives with a calcium channel blocker, an ACEi or ARB beta-blocker, and a mineralocorticoid receptor antagonist to maximally tolerated doses, the next line of antihypertensive treatment should be tailored to the patient's co-morbidities, and may include a beta-blocker, central alpha agonist, hydralazine, and minoxidil. We present novel mechanisms implicated in hypertensive ICH, including ferroptosis, neuroinflammation, the CNS-gut microbiome axis, and novel therapeutics. We also propose a simple algorithm for the optimal pharmacological management of resistant hypertension in ICH."

Journal • Review • Cardiovascular • Cerebral Hemorrhage • Heart Failure • Hematological Disorders • Hypertension • Inflammation

DISTINCT TRANSCRIPTOMIC RESPONSES REVEAL A REGULATORY ROLE OF PIEZO1 IN PODOCYTE ADAPTATION TO MECHANICAL STRESS (ISN-WCN 2026) - "Podocyte injury in AII/HS-treated pPiezo1 KO mice was prevented by losartan and hydralazine, and partially ameliorated by the Rho kinase inhibitor fasudil.Conclusion Piezo1 is dispensable for podocyte maintenance under basal conditions but is essential for adaptation to mechanical stress. Its absence leads to severe podocyte injury, albuminuria, and glomerulosclerosis under both short- and long-term hypertensive stress. These findings highlight Piezo1 as a key mechanosensor in podocytes, with both insufficient and excessive activity potentially driving injury through distinct signaling pathways."

Cardiovascular • Chronic Kidney Disease • Glomerulonephritis • Hypertension

UNDERSTANDING READINESS WITH COM-B: BARRIERS AND ENABLERS FOR HYPERTENSION AND DIABETES SCREENING IN PRIMARY HEALTH CARE IN ADDIS ABABA, ETHIOPIA (ISN-WCN 2026) - "Eight centers had all antihypertensive medications available, while Hydralazine and Enalapril were missing in two.A total of 814 staff were reported across all facilities, including 549 key clinical staff (39 physicians, 319 nurses, 191 health officers). Improving hypertension and diabetes screening and management in Ethiopia requires strengthening workforce capacity, ensuring consistent diagnostic and medication supplies, and implementing supportive staff policies.Given that uncontrolled hypertension and diabetes are the leading precursors of chronic kidney disease, enhancing PHC readiness for early detection and management directly contributes to CKD prevention and better kidney health outcomes. Integrating kidney health indicators within existing NCD programs, expanding access to renal function testing, and fostering interlinkages between hypertension, diabetes, and CKD care at the primary level could significantly reduce the long-term burden of kidney disease in..."

Cardiovascular • Chronic Kidney Disease • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease

MPO ANCA-ASSOCIATED VASCULITIS RELAPSE IN A LIVING KIDNEY DONOR PRECIPITATED BY HYDRALAZINE RE-INTRODUCTION (ISN-WCN 2026) - "She was diagnosed with ANCA-associated vasculitis and was successfully treated with high-dose steroids and rituximab with an improvement in her eGFR and seroconversion. Given its side effect profile, and the multiplicity of other anti-hypertensive agents, use of hydralazine should be reserved for patients without alternatives. If used, clinicians should have a high index of suspicion for autoimmune disease and hydralazine should be promptly and permanently discontinued where an association is suspected."

ANCA Vasculitis • Cardiovascular • Congestive Heart Failure • Glomerulonephritis • Heart Failure • Hypertension • Inflammatory Arthritis • Lupus • Lupus Nephritis • Musculoskeletal Diseases • Musculoskeletal Pain • Nephrology • Orthopedics • Renal Disease • Vasculitis

Hydralazine-Induced Lupus: A Rare Culprit Behind Lymphocyte-Predominant Pleural Effusion (SCCM 2026) - "This case stresses considering medication causes in unexplained effusions, especially with high-dose hydralazine. AI has been used to effectively summarize this paper."

Pleural effusion • Colon Cancer • Colorectal Cancer • Gastroenterology • Hodgkin Lymphoma • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Respiratory Diseases • Solid Tumor • Tuberculosis

Hydralazine-Associated Pericardial Effusion Causing Cardiac Tamponade Without Hypotension. (PubMed, JACC Case Rep) - "Medication-induced autoimmunity should be considered in unexplained pericardial effusions. Early recognition and drug withdrawal can prevent life-threatening complications."

Journal • ANCA Vasculitis • Cardiovascular • Hypotension • Immunology • Inflammation • Pulmonary Disease • Vasculitis • MPO

Hydralazine Use and Risk of Vasculitis. (PubMed, JAMA Netw Open) - "In this cohort study of adults who were newly prescribed hydralazine, vasculitis associated with hydralazine was rare, despite multiple reported cases. Use of hydralazine is unlikely to be associated with a clinically meaningful increased risk of vasculitis."

Journal • Retrospective data • ANCA Vasculitis • Cardiovascular • Vasculitis

HEMODYNAMIC RESPONSIVENESS TO VASODILATOR CHALLENGE IN HEREDITARY ATTR CARDIOMYOPATHY: EXPANDING THE ROLE OF GUIDELINE-DIRECTED MEDICAL THERAPY (ACC 2026) - "During nitroprusside challenge, he showed striking improvement: mean pulmonary artery pressure fell from 34 to 20 mmHg, PVR from 5.1 to 1.3 WU, and CI rose to 2.0 L/min/m². Oral hydralazine was initiated and titrated, sustaining improvement (CI 2.65)... This case shows that select ATTR-CM patients with systolic dysfunction may benefit from vasodilators and selective GDMT. Endothelial dysfunction and microvascular ischemia, rather than purely restrictive physiology, may drive progression in a subset of CA. These findings shed light on hemodynamic and phenotypic heterogeneity in CA, suggesting not all patients share the same substrate or therapeutic responsiveness."

Amyloidosis • Cardiac Amyloidosis • Cardiomyopathy • Cardiovascular

UNMASKING HYDRALAZINE-INDUCED LUPUS: ISOLATED SEROSITIS LEADING TO PERICARDIAL WINDOW (ACC 2026) - "Hydralazine was discontinued, and prednisone, colchicine, and hydroxychloroquine were initiated, leading to clinical improvement and reduced drain output. Hydralazine-induced lupus should be considered in patients with unexplained serositis, especially those with comorbidities such as CKD and long-term drug exposure. Prompt diagnosis, drug withdrawal, and targeted therapy are crucial to preventing life-threatening complications such as pericardial tamponade."

Acute Kidney Injury • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Heart Failure • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders • Musculoskeletal Diseases • Renal Disease • Respiratory Diseases • Systemic Lupus Erythematosus • Type 2 Diabetes Mellitus

TAMPONADE TURNAROUND: STEROIDS OBVIATE PERICARDIOCENTESIS IN HYDRALAZINE-INDUCED LUPUS (ACC 2026) - "Although tamponade physiology developed, early recognition of HIL and initiation of steroids led to rapid resolution without drainage. HIL should be considered in patients on chronic therapy presenting with new pericardial effusion, as timely drug withdrawal and steroid therapy may obviate invasive intervention."

Cardiovascular • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Respiratory Diseases

WHEN HYDRALAZINE STRIKES THE HEART: DRUG-INDUCED PERICARDIAL EFFUSION (ACC 2026) - "Hydralazine was discontinued, and he was treated with colchicine, resulting in marked clinical improvement and no recurrence of effusion on follow-up imaging. This case highlights tamponade as a rare but life-threatening presentation of HILS. After excluding more common etiologies of hemorrhagic pericardial effusion, clinicians should maintain suspicion for drug-induced lupus, as prompt recognition and drug withdrawal are crucial for recovery."

Cardiovascular • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus

HYDRALAZINE-ASSOCIATED MASSIVE PERICARDIAL EFFUSION CAUSING TAMPONADE WITHOUT HYPOTENSION (ACC 2026) - "This case demonstrates hydralazine as an underrecognized cause of massive pericardial effusion and tamponade. It highlights that tamponade can occur without hypotension, reinforcing the importance of echocardiographic vigilance and careful medication review in unexplained effusions."

Cardiovascular • Hypertension • Hypotension • Immunology • Pulmonary Disease • Respiratory Diseases • Vasculitis

LARGE PERICARDIAL EFFUSION AS A MANIFESTATION OF OVERLAPPING HYDRALAZINE-INDUCED LUPUS AND ANCA VASCULITIS (ACC 2026) - "A large pericardial effusion may be the initial manifestation of a severe drug-induced autoimmune syndrome. Diagnostic overlap between DILE and AAV may complicate diagnosis. Early recognition and cessation of hydralazine is critical to avoid shock and unresolving serositis."

ANCA Vasculitis • Cardiovascular • Chronic Myelomonocytic Leukemia • Hematological Malignancies • Hypertension • Immunology • Inflammatory Arthritis • Leukemia • Lupus • Renal Disease • Respiratory Diseases • Vasculitis • MPO

Rituximab-Associated Posterior Reversible Encephalopathy Syndrome in Severe Hydralazine-Induced Antineutrophil Cytoplasmic Antibody Vasculitis: An Unexpected Complication. (PubMed, Cureus) - "Although PRES remains uncommon in vasculitis cohorts, it has been reported in association with several therapeutic agents, including rituximab, high-dose glucocorticoids, and cyclophosphamide.  We present a case of hydralazine-induced dual-positive ANCA-associated vasculitis complicated by respiratory failure requiring mechanical ventilation. Vigilant monitoring is recommended in those with severe inflammation or unstable blood pressure. Any new focal neurologic deficits, seizures, visual changes, or altered mental status after rituximab infusion should raise concern for PRES and warrant immediate cessation of therapy and urgent diagnostic evaluation, highlighting the need for heightened vigilance for neurologic complications during immunosuppressive treatment of severe vasculitis."

Journal • ANCA Vasculitis • Cardiovascular • CNS Disorders • Epilepsy • Hypertension • Inflammation • Nephrology • Renal Disease • Respiratory Diseases • Vasculitis

Acute bullous iododerma with cryptococcoid neutrophilic dermatosis: A case series. (PubMed, JAAD Case Rep) - No abstract available

Journal • Chronic Kidney Disease • Dermatology • Nephrology • Renal Disease • Vasculitis

Hydralazine-induced antineutrophil cytoplasmic antibody vasculitis with significant dermatologic manifestations. (PubMed, JAAD Case Rep) - No abstract available

Journal • ANCA Vasculitis • Vasculitis

IgM-Dominant Mesangioproliferative Immune Complex Glomerulonephritis with Full House Pattern in a Kidney Transplant Recipient (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 63-year-old male with a history of membranoproliferative GN underwent a second kidney transplant in December 2020.The patient was maintained on tacrolimus, mycophenolate mofetile, and prednisone...Hydralazine was discontinued, proteinuria treated conservatively with valsartan and dapagliflozin; proteinuria improved marginally...Similarly, malignancy-associated GN is well recognized, but there is no established link between SqCC of the skin and IgM-dominant GN. The coexistence of previous MPGN history, IgM-dominant deposition and full house pattern on IF currently, hydralazine exposure, and recurrent squamous cell carcinoma raises questions about overlapping pathogenic mechanisms, highlighting theimportance of comprehensive evaluation for such cases"

Clinical • ANCA Vasculitis • Chronic Kidney Disease • Diabetic Nephropathy • Glomerulonephritis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Squamous Cell Carcinoma • Transplantation • Vasculitis • CFHR3

DNAJB9-positive crescentic fibrillary glomerulonephritis with full-house IF: dialysis- dependent AKI and patient-directed deferral of cyclophosphamide (NKF-SCM 2026) - "Crescentic cases with full-house IF can mimic lupus or hydralazine-associated GN, complicating early immunosuppression...Therapy included IV methylprednisolone followed by prednisone 20 mg daily with atovaquone prophylaxis...Respiratory failure improved with hemodialysis. CONCLUSION DNAJB9-positive crescentic FGN can present with dialysis-dependent AKI and full-house IF despite lupus-like serology."

Clinical • Chronic Obstructive Pulmonary Disease • Fibrosis • Glomerulonephritis • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Sarcoidosis

Oral Immediate-Release Nifedipine Versus Intravenous Hydralazine for Controlling Severe Hypertension in Pregnancy: A Double-Blind Randomised Controlled Trial. (PubMed, Int J Med Sci Dent Health) - "The mean dose used before target blood pressure was reached, the proportion of participants that crossed over to another treatment allocation, and the proportion that required a rescue antihypertensive (labetalol) to achieve the target blood pressure were similar between the two groups (P >0.05). More robust studies are encouraged to increase the evidence for its use as first line antihypertensives, especially in low and middle-income countries. Pan African Clinical Trial registry, PACTR201906662822573, registration date: 19th June, 2019."

Journal • Cardiovascular • Hypertension

Hydralazine Induced Autoimmunity: A Case of ANCA Vasculitis and Lupus Overlap (ATS 2026) - No abstract available

Clinical • ANCA Vasculitis • Immunology • Inflammatory Arthritis • Lupus • Vasculitis

From Hypertension to Hypersensitivity: A Case of Hydralazine-induced Lupus (ATS 2026) - No abstract available

Clinical • Cardiovascular • Hypertension • Immunology • Inflammatory Arthritis • Lupus

A Case of Hydralazine-induced Lupus Leading to Irreversible Vocal Cord Paralysis (ATS 2026) - No abstract available

Clinical • Immunology • Inflammatory Arthritis • Lupus

Hydralazine-associated Diffuse Alveolar Hemorrhage in a Renal-transplant Recipient: A Case Report (ATS 2026) - No abstract available

Case report • Clinical • Hematological Disorders • Transplantation