hydralazine hydrochloride / Generic mfg. - LARVOL DELTA

Kölliker-Fuse/Parabrachial Complex PACAP-Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension. (PubMed, Int J Mol Sci) - "In rats given hydralazine (10 mg/kg, i.p.), we quantified Fos protein during an early phase (60 min) and a late phase (120 min)...Together, these data suggest that a KF PACAP+/VGluT1+ projection forms calyceal terminals around PKCδ+/GluD1+ EA neurons, providing a high-fidelity route for rapid autonomic rebound to falling blood pressure, while slower endocrine support is subsequently recruited via neurohormone-magnocellular activation. This work links multimodal parabrachial output to temporally layered autonomic-neuroendocrine control."

Journal • Hypotension • ADCYAP1 • SLC2A1

Autoimmune-like hepatitis induced by drugs: Still many unanswered questions. (PubMed, World J Hepatol) - "Several drugs, including nitrofurantoin, minocycline, hydralazine, methyldopa and infliximab, have a well-documented capacity to induce DI-ALH. International collaborative studies are needed to further characterize DI-ALH. In this review, we update current controversies, present emerging concepts, and outline future challenges in the diagnosis and management of this complex condition learned so far."

Journal • Review • Autoimmune Hepatitis • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure

A Case of Postpartum Preeclampsia With an Unusual Presentation. (PubMed, Cureus) - "Management included oxygen and antihypertensive therapy with hydralazine...Careful evaluation, timely treatment, and appropriate monitoring led to a favorable outcome. This highlights the importance of considering preeclampsia in postpartum patients with atypical presentations."

Journal • Cardiomyopathy • Cardiovascular • Gynecology • Hypertension • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Women's Health

Integrated Bioinformatics Identifies NLRP3 Inflammasome Hub Genes and Therapeutic Targets in Schizophrenia. (PubMed, Neuropsychiatr Dis Treat) - "Molecular docking revealed strong binding affinities of ellagic acid to FLNA (-4.70 kcal mol- 1), and of hydralazine to HSPA8 (-4.27), TRAF2 (-4.84), and SCAP (-4.98)...Additionally, SZ patients exhibited increased naive B cells and neutrophils, along with reduced resting NK cells and M2 macrophages. Five genes (HSPA8, SCAP, FLNA, TRAF2, PINK1-AS) were identified as potential novel biomarkers and therapeutic targets for SZ, providing a theoretical foundation for elucidating disease mechanisms and advancing precision medicine in SZ."

Journal • CNS Disorders • Inflammation • Psychiatry • Schizophrenia • HSPA8 • NLRP3

Association of hydralazine use with risk of hematologic neoplasms in patients with hypertension: A nationwide population-based cohort study in Taiwan. (PubMed, PLoS Med) - "In this study, we observed that long-term hydralazine use in patients with hypertension was associated with a lower, duration-dependent risk of hematologic neoplasms. These findings warrant prospective studies to confirm this association and its potential clinical implications."

Journal • Cardiovascular • Hematological Disorders • Hematological Malignancies • Hypertension • Leukemia • Multiple Myeloma • Oncology • Solid Tumor

Prevalence, associated factors, and pharmacotherapy of hypertensive disorders among parturients in Bono Region of Ghana: An analytical cross-sectional study. (PubMed, Afr J Reprod Health) - "Oral nifedipine and intravenous hydralazine were the primary antihypertensive therapies. Magnesium sulfate was universally administered using the Pritchard regimen, though product concentrations for intramuscular use varied slightly. Findings highlight the need to standardize magnesium sulfate formulations to optimize intramuscular dosing and enhance treatment consistency in lower-level facilities managing HDPs."

Journal • Observational data • Cardiovascular • Gynecology • Hypertension

Expanding Metabolome Coverage in LC-MS/MS Analysis through Hydralazine-Based Multifunctional Derivatization. (PubMed, Anal Chem) - "The sensitivities of HZN-derivatized metabolites improved significantly, ranging from 10 to 5000-fold, and the limits of quantitation for derivatized metabolites varied from 5 pM to 100 nM, depending on their structures. Furthermore, alterations of various gut microbiota-derived metabolites in mice fed with a high-fat diet were unraveled using the HZN-based derivatization method, indicating its promising applications in the investigation of disease-related changes in the metabolome."

Journal

Not All That Glitters Is Systemic Lupus Erythematosus (SLE): Hydralazine-Induced Lupus with a Twist of Hydroxychloroquine Toxicity (KIDNEY WEEK 2025) - "Sputum grew P. aeruginosa ; cefepime was started. Diagnostic complexity arose from overlapping drug effects, CKD & systemic symptoms. This case highlights the importance of detailed medication history & histologic evaluation in differentiating primary autoimmune disease from drug-induced pathology."

Chronic Kidney Disease • Cough • Fabry Disease • Genetic Disorders • Glomerulonephritis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • Systemic Lupus Erythematosus

Real-world evidence for repurposing hydralazine as a potential epigenetic modulator for psoriasis: a 16-year retrospective nationwide cohort study. (PubMed, J Transl Med) - No abstract available

HEOR • Journal • Real-world evidence • Retrospective data • Dermatology • Immunology • Psoriasis

Effectiveness of Short-Acting Oral Antihypertensives in Asymptomatic Markedly Elevated Blood Pressure: An Inverse Probability Treatment Weighted Study. (PubMed, J Clin Med Res) - "Although urgent BP reduction is not routinely recommended in the ED, oral captopril appears to be a reasonable first-line option when clinically necessary, while hydralazine may be a suitable alternative. Combination of these two drugs should be used with caution due to the risk of excessive MAP reduction."

Journal • Cardiovascular • Hypertension

Reducing the Nonindicated Use of IV Hydralazine in the Inpatient Setting. (PubMed, JACC Case Rep) - "Nonindicated IV hydralazine use decreased from 69% to 25%. Order set modifications had a greater impact than education alone. Embedding decision support with targeted education offers a scalable, reproducible model for safer inpatient prescribing."

Journal • Acute Kidney Injury • Cardiovascular • Critical care • Hypertension • Hypotension • Nephrology • Renal Disease

Copper Intrauterine Device-Associated ANCA Vasculitis: Rare Entity or a Coincidence? (KIDNEY WEEK 2025) - "Case Description A 50-year-old-female with a past medical history of hyperlipidemia, asthma, migraine, mild obesity, and pre- diabetes on metformin and empagliflozin presented to the clinic for evaluation of albuminuria of 139 mg/gm of creatinine (90 ml/min/1.73m2)...She was prescribed topical tacrolimus and clindamycin, along with oral doxycycline...Cutaneous small vessel vasculitis has been documented in association with chronic hepatitis A or C, oral contraception, hydralazine, propylthiouracil, allopurinol, β-lactams, streptokinase, tamoxifen, influenza vaccines, and environmental risk factors (silica exposure, farming, and chronic colonization with Staphylococcus aureus). One other case report has proposed a possible link between a copper-IUD and ANCA-associated retinal vasculitis, which was resolved following IUD removal. One caveat is the lack of a kidney or skin biopsy, as our patient declined."

ANCA Vasculitis • Asthma • CNS Disorders • Dermatitis • Dermatology • Diabetes • Dyslipidemia • Genetic Disorders • Hepatology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Influenza • Long-acting Reversible Contraceptives • Metabolic Disorders • Migraine • Obesity • Ocular Inflammation • Psoriasis • Renal Disease • Respiratory Diseases • Vasculitis

Primary Hyperaldosteronism Presenting Clinically as Classic Pheochromocytoma (KIDNEY WEEK 2025) - "Therapy at the time included irbesartan 300mg daily, nebivolol 20mg daily, amlodipine 10mg daily and hydralazine 10mg three times daily. Symptoms of profuse sweating, palpitations and impending sense of doom are often associated with pheochromocytomas which can also result in hypertension. This case demonstrates how variability can exist in symptomatic burden."

Clinical • Cardiovascular • Endocrine Disorders • Hypertension • Solid Tumor

ANCA Alert: A Curious Case of Amikacin-Induced Vasculitis (KIDNEY WEEK 2025) - "Introduction Drug induced-antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is commonly caused by medications such as hydralazine, propylthiouracil, methimazole, and minocycline, but to date, amikacin has not been reported in the literature.We present the first case of AAV with renal involvement with amikacin as the unusual culprit...Empiric piperacillin-tazobactam and intravenous fluids were started...The patient was discharged on prednisone with plans for outpatient rituximab and avacopan...Plasma exchange and steroids resulted in significant improvement in renal function shortly after initiation which can be associated with return of renal function and creatinine apheresis. As we learn more about renal involvement in AAV, the list of causative agents expands."

Clinical • ANCA Vasculitis • Benign Prostatic Hyperplasia • Chronic Kidney Disease • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis • MPO

Complement-Mediated Thrombotic Microangiography Presenting as Hypertensive Emergency and Kidney Failure (KIDNEY WEEK 2025) - "He was discharged on Carvedilol, Hydralazine, Nifedipine and Spironolactone...He was started on ravulizumab-cwvz with improvement in his Cr and BP...CM-TMA tends to fall lower on the differential, however early diagnosis and treatment is essential for treatment and prevention of worsening renal failure. This case also highlights the importance of access to care and the financial burdens that may limit or delay treatment."

Acute Kidney Injury • Anemia • Atypical Hemolytic Uremic Syndrome • Cardiovascular • Complement-mediated Rare Disorders • Hematological Disorders • Hypertension • Immunology • Nephrology • Renal Disease • Thrombocytopenia • Thrombocytopenic Purpura

Dark Web Steroids Cause Kidney Failure? A Case of Proteinuria and CKD in a Young Bodybuilder (KIDNEY WEEK 2025) - "Had previously been admitted with same symptoms at different hospital 1 week and found to be significantly hypertensive, diagnosed with HTN emergency and started on amlodipine, hydralazine at discharge, but symptoms did not resolve, and he returned for re-evaluation...This case also shows some of the confounding factors such as high-protein intake which can cause elevated serum Cr. Patient’s such as this may benefit from early genetic testing, renal biopsies which may improve long-term outcome."

Clinical • IO biomarker • Anemia • Chronic Kidney Disease • Eosinophilia • Hematological Disorders • Nephrology • Pulmonary Disease • Renal Disease • CST3

Diabetic and Hypertensive Nephropathy Masquerading as Ifosfamide Nephrotoxicity in a Young Patient: A Case Report (KIDNEY WEEK 2025) - "His treatment included surgical resection followed by chemotherapy with the VAI regimen (vincristine, doxorubicin, and ifosfamide)...Losartan was discontinued due to worsening renal function and the AKI was attributed to ifosfamide-induced nephrotoxicity...His antihypertensive regimen was optimized with hydralazine and amlodipine...Kidney biopsy was crucial in distinguishing true chemotherapy-induced toxicity from preexisting pathology. Early tissue diagnosis can guide chemotherapy planning and dosing to prevent further renal injury."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetic Nephropathy • Fibrosis • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hypertension • Immunology • Metabolic Disorders • Nephrology • Renal Disease • Sarcoma • Solid Tumor

Resistant Hypertension in ANCA-Associated Vasculitis: Role for Aliskiren? (KIDNEY WEEK 2025) - "Despite receiving cyclophosphamide and methylprednisolone, he remained dialysis-dependent and was referred for renal transplant. He had multiple hypertensive emergency admissions despite a multi-drug regimen with nifedipine, telmisartan, carvedilol, eplerenone, clonidine, and hydralazine, and dry weight optimization...Studies are warranted to compare DRI efficacy against standard antihypertensives in similar clinical scenarios. The views expressed in this abstract are those of the author(s) and do not necessarily reflect the official policy of the Department of Defense or the U.S. Government."

ANCA Vasculitis • Cardiovascular • Glomerulonephritis • Hypertension • Inflammation • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis • MPO

Overlapping IgM Mesangioproliferative Glomerulonephritis (GN) and ANCA-Associated Crescentic GN Associated with Hydralazine (KIDNEY WEEK 2025) - "Hydralazine was discontinued, and she was started on rituximab infusions and high dose steroids. Given the widespread use of hydralazine, hydralazine-induced glomerulonephritis (GN) should remain a consideration in the differential diagnosis. Management typically involves immunosuppressive therapy and discontinuation of hydralazine, with clinical outcomes comparable to those observed in primary ANCA-associated GN."

Acute Kidney Injury • ANCA Vasculitis • Asthma • Cardiovascular • Dyslipidemia • Fatigue • Glomerulonephritis • Hypertension • Immunology • Lupus Nephritis • Nephrology • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Calculi • Renal Disease • Respiratory Diseases • Vasculitis • MPO

The Silent Killer: Recurrent Severe Paroxysmal Hypertension Causing Kidney Failure in a Patient with Pseudopheochromocytoma (KIDNEY WEEK 2025) - "He was re-admitted a week later for HTN emergency, AKI (SCr 3.5 mg/dL) and non-ST elevation myocardial infarction, managed with IV hydralazine, nicardipine and heparin drips...Despite a six-drug regimen including clonidine and phenoxybenzamine, renal function deteriorated requiring dialysis in one year. Discussion This case highlights recurrent symptomatic paroxysmal HTN as a presenting sign for pseudopheochromocytoma, importance in identifying and treating psychosocial factors that cause sympathetic nervous system activation. Plasma metanephrine (MN) and normetanephrine (NM) levels Left adrenal adenoma on MRI with gadolinium and 123-I MIBG scan."

Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Dyslipidemia • Endocrine Disorders • Genito-urinary Cancer • Hypertension • Myocardial Infarction • Nephrology • Peripheral Arterial Disease • Prostate Cancer • Renal Disease • Solid Tumor

A Balancing Act: Prostate Cancer, Antiandrogen Therapy, and Cardiovascular Disease (KIDNEY WEEK 2025) - "Case Description A 70-year-old male with no comorbidities and high risk, localized PCa was initially treated with Bicalutamide followed by radiation. Three years later due to recurrence abiraterone and prednisone was initiated...BP was refractory to five anti-HTN medications (amlodipine, hydralazine, eplerenone, clonidine, indapamide), which were added over time at tolerated doses...Mineralocorticoid receptor antagonists may interfere with Abiraterone's mechanism of action, limiting their role in treating HTN. Thus Timely recognition of PCa therapy-related side effects is essential to minimize cardiovascular mortality and prevent treatment disruption."

Congestive Heart Failure • Genito-urinary Cancer • Heart Failure • Hypertension • Oncology • Prostate Cancer • Solid Tumor

Drug- and vaccine induced ANCA-associated vasculitis: An overview. (PubMed, Autoimmun Rev) - "Whereas causality is difficult to prove and rechallenges are considered unethical, pathophysiological mechanisms suggesting causality have been demonstrated for drugs such as hydralazine, propylthiouracil, levamisole, and immune checkpoint inhibitors. In general, however, the long-term prognosis of drug-induced ANCA-associated vasculitis is more favorable compared to the prognosis of idiopathic ANCA-associated vasculitis. Physicians that are treating patients with vasculitis should be aware of the possible role of drugs and vaccines in the development ANCA-associated vasculitis."

Journal • Review • ANCA Vasculitis • Oncology • Vasculitis

A Case of Abrupt Cessation of Intrathecal Clonidine (ASRA-FALL 2025) - "Case Presentation: A 70-year-old man with refractory neuropathic pain secondary to bilateral lower-extremity complex regional pain syndrome was managed with an intrathecal drug delivery system infusing fentanyl (350 mcg/day), ziconotide (6.56 mcg/day), and clonidine (450 mcg/day)...The 3 FDA approved intrathecal medications include morphine, baclofen, and ziconotide...Once stabilized after 72 hours, he was transitioned to the medical floor with as-needed oral hydralazine and continuation of oral and transdermal clonidine...In this case, the patient’s opioid withdrawal was effectively managed with oral methadone 5 mg TID...Outcome: The patient's infection resolved with targeted antibiotics. Clonidine withdrawal was successfully managed with combination of oral and transdermal clonidine followed by taper schedule on hospital discharge (tapered off oral clonidine first then transdermal clonidine)."

Clinical • Late-breaking abstract • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Dermatology • Gastrointestinal Disorder • Hypertension • Infectious Disease • Musculoskeletal Pain • Neuralgia • Psychiatry

A Rare Manifestation of Drug-Induced Lupus: Hydralazine-Induced ANCA Vasculitis and Persistent Pericarditis (AHA 2025) - "Hydralazine was discontinued and colchicine with prednisone was started. He was then treated outpatient for HIL with associated vasculitis on long-term prednisone taper and rituximab...Persistent pericarditis despite normalized inflammatory markers in autoimmune conditions usually resolves within weeks to months although rarely may evolve into chronic autoimmune pericarditis. While no definitive management guidelines exist, treatment generally involves discontinuation of hydralazine although long-term immunosuppressive therapy may be needed."

ANCA Vasculitis • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Depression • Fibrosis • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Musculoskeletal Pain • Nephrology • Psychiatry • Renal Disease • Systemic Lupus Erythematosus • Vasculitis

Efficacy and Safety of Nifedipine Compared to Intravenous Hydralazine for Severe Hypertension in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (AHA 2025) - "Nifedipine and intravenous hydralazine showed comparable efficacy in achieving optimal blood pressure control and similar maternal and neonatal outcomes. However, nifedipine was associated with significantly fewer maternal adverse effects, indicating superior tolerability."

Retrospective data • Review • Cardiovascular • Gynecology • Hypertension