MDNA413 / Medicenna - LARVOL DELTA

Medicenna Reports Fiscal Year 2022 Financial Results and Operational Highlights (Bloomberg) - "...Medicenna announced the formation of a Clinical Advisory Board (CAB) comprised of leading experts in immunotherapy and drug development. Members of the CAB include...Hussein Tawbi."

Characterization of a long-acting IL-13 super-antagonist engineered to target tumor associated macrophages and myeloid cells (AACR 2022) - "Fc-MDNA413 is a long-acting IL-4/IL-13 super-antagonist that inhibits IL-4 and IL-13 induced signaling and M2 skewing of macrophages, resulting in tumor growth inhibition in vivo. Ongoing studies include testing in additional syngeneic tumor models, deciphering in vivo mechanism of action and investigating potential synergy with other therapies. Next generation multifunctional superkines that incorporate IL-4/IL-13 antagonism are under development to target immunologically challenging tumors."

Breast Cancer • Ewing Sarcoma • Lung Cancer • Oncology • Solid Tumor • IL13 • IL4R • STAT6

Medicenna Presents Preclinical Data Demonstrating Potent Immune Modulating Effects of an IL-2/IL-13 Dual Specific Cytokine at the 2021 AACR Annual Meeting (GlobeNewswire) - “Key data and conclusions from the AACR poster include: MDNA19-MDNA413 showed enhanced signaling in cancer killing effector T cells and NK cells and reduced activation of pro-tumor Treg cells corresponding to a 209-fold and 90-fold enhancement in CD8/Treg and NK/Treg ratios, respectively, when compared to native IL-2. MDNA19-MDNA413 selectively binds and inhibits both, IL-4 and IL-13 signaling, via the alpha 1 subunit (IL13Rα1) of the Type II IL-4 receptor, which is normally associated with pro-tumoral effects due to stimulation of Myeloid Derived Suppressor Cells (MDSCs) and M2a polarization of Tumor Associated Macrophages (TAMs), while showing reduced affinity for the IL13Rα2 decoy receptor…MDNA19-MDNA413 potently inhibited both IL-4 and IL-13 mediated pSTAT6 activity with an IC50 of 8.0 and 12.3 nM, respectively.”

Preclinical • Oncology

Medicenna Announces Preclinical Data on MDNA11 with Anti-PD-1 Therapy and Unveils Novel Bifunctional Superkines at the Cytokine-Based Cancer Immunotherapies Summit (GlobeNewswire) - "Medicenna Therapeutics Corp...announced an upcoming oral presentation of preclinical data on the Company’s Superkine platform programs. The presentation will take place today, March 25, 2021 at 2:25 pm ET at the virtual Cytokine-Based Cancer Immunotherapies Summit. The presentation will feature preclinical data on MDNA11, a long-acting IL-2 Superkine that preferentially binds the IL-2 beta receptor (IL-2Rβ) on immune cells, as well as an overview of Medicenna’s Bi-functional SuperKine ImmunoTherapies (BiSKITsTM) program, which includes engineered interleukins designed to target immunologically 'cold” tumors.'"

Preclinical • Oncology