sodium valproate / Generic mfg. - LARVOL DELTA

Presentation of an individual with a 3.3 Mb duplication in 3q13.2q13.31 (ACMG 2026) - "He had moderate intellectual disability and epilepsy, for which he was taking a pediatric dose of carbamazepine with decreasing efficacy...At age 26, his epilepsy medication was switched to levetiracetam 2000 mg/day with breakthrough seizures, and increased to 3000 mg/day after three weeks. His epilepsy remains uncontrolled and sodium valproate is being considered...Conclusion The individual we present expands the phenotype of the (3q13.2q13.31) duplication syndrome, and the creatine findings we describe suggests a possible metabolic component to this condition. Future considerations include a brain MRI and repeat ES since the initial genomic investigation was done in 2017."

Clinical • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Mental Retardation

RAKGEOCBT: The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective. (clinicaltrials.gov) - P1 | N=107 | Active, not recruiting | Sponsor: Rakitzi, Stavroula | Recruiting ➔ Active, not recruiting | N=40 ➔ 107

Enrollment change • Enrollment closed • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Obsessive-Compulsive Disorder • Personality Disorder • Post-traumatic Stress Disorder • Psychiatry • Schizophrenia

Autism spectrum disorder comorbid with epilepsy: Etiology, mechanism, and therapy. (PubMed, Neural Regen Res) - "Environmentally, factors such as imbalanced nutrient intake and prenatal exposure to sodium valproate are notably associated with this comorbidity...This review helps enhance the understanding of treatment mechanisms by examining the causes and development of autism spectrum disorder and epilepsy. It recommends a clinical approach based on the "etiology-mechanism-treatment" model."

IO biomarker • Journal • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Psychiatry

Infantile Epsilon-Sarcoglycan (SGCE) Myoclonus-Dystonia: Diagnostic Pitfalls and Poor Response to Pharmacologic Treatment. (PubMed, Cureus) - "Trials with zonisamide, carbamazepine, sodium valproate, and clonazepam were ineffective; however, motor and cognitive development remained within the average range. Genetic testing was essential for diagnosis, pharmacologic response was limited, and functional outcome remained favorable. The later emergence of behavioral symptoms underscores the need for long-term multidisciplinary follow-up."

Journal • CNS Disorders • Dystonia • Epilepsy • Mental Retardation • Movement Disorders • Psychiatry

Food Packaging Materials for One-Dose Packaging for Enhanced Stability of Hygroscopic Medications. (PubMed, Pharmaceuticals (Basel)) - "We evaluated the barrier performance of food packaging materials against moisture and oxygen and investigated their potential to enhance the physical stability of the highly hygroscopic sodium valproate, under stressed storage conditions...Tablets packaged in cellophane-laminated polyethylene exhibited deliquescence, with visible deformation and stickiness within 3 days, rendering them unmeasurable. Food packaging materials with high barrier performance offer a practical, safe, and effective solution for one-dose packaging of hygroscopic medications, potentially expanding their clinical use and improving adherence."

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Effect of Treatment with a Combination of Dichloroacetate and Valproic Acid on Adult Glioblastoma Patient-Derived Primary Cells Xenografts on the Chick Embryo Chorioallantoic Membrane. (PubMed, Pharmaceutics) - "This study aimed to investigate the effectiveness of sodium dichloroacetate (NaDCA) and a sodium valproate NaDCA combination (NaVPA-NaDCA) on formed patients' primary cell tumors on the chick embryo chorioallantoic membrane (CAM). The treatment with NaVPA-NaDCA significantly reduced the expression of PCNA, p53, EZH2 and vimentin in the tested tumors. Data demonstrated an antitumor effect of NaVPA-NaDCA in an in vivo model of a patient's primary glioblastoma cells."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • EZH2 • FAP • GFAP • PCNA • TP53 • VIM

Analysing ocular structural morbidities in younger adults using anti-seizure drugs: a cross-sectional study. (PubMed, Int Ophthalmol) - "Prolonged ASD treatment is linked to observable changes in ocular structure, including dry eye disease, myopia, macular edema, and RNFL thinning. These outcomes highlight the necessity for routine ophthalmic evaluation and collaborative care to prevent irreversible visual impairment in individuals with epilepsy."

Journal • Observational data • CNS Disorders • Dry Eye Disease • Epilepsy • Macular Edema • Ophthalmology

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury. (PubMed, Br J Clin Pharmacol) - "Valproate has pharmacological properties that point to its potential repositioning as an adjuvant in improving several outcomes in AKI and potentially avoiding progression to chronic kidney disease."

Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Epilepsy • Hypertension • Nephrology • Renal Disease

Sodium Valproate Versus Levetiracetam in Pediatric Generalized Epilepsy: A Comparative Study. (PubMed, Cureus) - "Conclusion VPA was found to be more efficacious in controlling seizures in children with generalized epilepsy than LEV. With respect to safety, both treatments had specific issues."

Journal • CNS Disorders • Epilepsy • Pediatrics

Two Cases of Psychiatric Symptoms Associated with Zonisamide Antiepileptic Treatment. (PubMed, Clin Psychopharmacol Neurosci) - "In Case 2, despite escalating antipsychotic medications (risperidone, clozapine), psychotic symptoms persisted, likely due to ongoing zonisamide use. Clinicians should monitor for mental health changes during zonisamide treatment and consider drug discontinuation or substitution with alternative antiepileptics (e.g., sodium valproate) if psychiatric adverse effects emerge. Awareness of this association is crucial to avoid misdiagnosis and optimize epilepsy management."

Journal • CNS Disorders • Epilepsy • Insomnia • Psychiatry • Sleep Disorder

Lingual Dyskinesia Developing after the First Dose of Methylphenidate Treatment in a Child with Neurodevelopmental Disorders: Genetic Predispositions. (PubMed, Clin Psychopharmacol Neurosci) - "Methylphenidate is generally well tolerated, but it often causes sleep disturbances, less commonly suppresses appetite, and may lead to neurological and movement disorders such as tics, dyskinesia, and psychosis. Furthermore, the presence of epilepsy diagnosis, sodium valproate use, and multiple neurodevelopmental disorders in our case is noteworthy. While our case demonstrates that dyskinesia can occur even at standard low treatment doses after the first dose, it emphasizes the importance of considering dyskinesia as a potential side effect in cases with a family history of similar drug-related side effects and epilepsy comorbidity."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Immunology • Movement Disorders • Psychiatry • Sleep Disorder

Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice. (PubMed, Nutrition) - "The probiotics alone had minimal effects on seizure thresholds, but they enhanced the antiseizure efficacy of valproate, which may be linked to increased SCFA production and altered gut metabolism. These findings support further studies on probiotics as a complementary strategy in epilepsy treatment."

Journal • Preclinical • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry

Randomised Controlled Trial on Sodium Valproate and Levetiracetam in Children with New-Onset Epilepsy. (PubMed, Indian J Pediatr) - "No difference was noted between sodium valproate and levetiracetam in seizure control. With a favorable side-effect profile, levetiracetam can be safely considered as initial maintenance monotherapy in children with new-onset epilepsy."

Journal • CNS Disorders • Epilepsy • Pediatrics • Steven-Johnson Syndrome

Optical coherence tomography findings of patients on bipolar disorder treatment: What does OCT say about lithium? A cross-sectional study. (PubMed, Psychiatr Danub) - "This study compared the OCT parameters of euthymic state BD type 1 subjects with the HC group and showed that RNFL, GCL and IPL were decreased in the BD group, while CT was increased. It has been suggested that the use of Li may play a more effective role in protecting the RNFL subsectors, GCL and IPL than the use of SV-VPA and AP alone."

Journal • Observational data • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Diagnosis of suid herpesvirus encephalitis using next-generation sequencing: A case report. (PubMed, Medicine (Baltimore)) - "Patients with pork contact and clinical, laboratory, and imaging examinations suggesting viral encephalitis should be considered to have suid herpesvirus encephalitis, which can be confirmed by next-generation sequencing."

Biomarker • Journal • Next-generation sequencing • CNS Disorders • Critical care • Epilepsy • Infectious Disease • Pain • Urinary Incontinence • Urology

The crossroad of delirium, mania, and catatonia: A case series on delirious mania. (PubMed, Indian J Psychiatry) - "All showed clinical improvement with lorazepam, sodium valproate, and atypical antipsychotics, while one required electroconvulsive therapy for full resolution. DM should be considered in bipolar patients presenting with catatonia and delirium. Early recognition and multimodal treatment, including electroconvulsive therapy (ECT) when needed, ensure favorable outcomes."

Journal • Bipolar Disorder • Cardiovascular • CNS Disorders • Cognitive Disorders • Hypertension • Metabolic Disorders • Mood Disorders • Psychiatry

Moringa oleifera ameliorates oxidative damage caused by sodium valproate in the small intestine. (PubMed, Arch Physiol Biochem) - "However, histological examinations showed that VPA caused structural damage to the small intestine, while MO treatment alleviated this effect. Overall, MO exhibited significant protective and antioxidant properties against VPA-induced intestinal injury."

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Antiglycative Properties of Anti-Dementia Drugs-In Vitro, In Silico Studies and a Systematic Literature Review. (PubMed, Antioxidants (Basel)) - "This study evaluated the antiglycative and antioxidative effects of donepezil, rivastigmine, galantamine, memantine, lamotrigine, sodium valproate, and carbamazepine using bovine serum albumin (BSA) as a model protein. Docking revealed a high affinity of donepezil for RAGE (-7.2 kcal/mol), possibly explaining its impact on carbonyl stress. Overall, anti-dementia drugs showed weak to moderate antiglycative potential, with lamotrigine being the most effective."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Dementia

Clinical and genetic analysis of a child with intellectual developmental disorder and seizures associated with variant of AP2M1 gene (PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi) - "The c.508C>T (p.Arg170Trp) variant of the AP2M1 gene may underlie the intellectual retardation and seizure in this child."

Journal • Ataxia • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Mental Retardation • Movement Disorders • Pediatrics • Psychiatry • AP2M1

Efficacy of Different Combination Therapies for Mania in Bipolar Disorder: A Systematic Review and Meta-Analysis. (PubMed, Brain Behav) - "Although the efficacy of ziprasidone plus mood stabilizers is comparable to that of olanzapine plus mood stabilizers in the treatment of manic episodes of bipolar disorder, ziprasidone offers advantages in improving manic symptoms (YMRS scores), reducing adverse events, and enhancing neuroendocrine indicators. It may serve as a favorable alternative in clinical practice. Further high-quality, multicenter, large-sample studies are needed to confirm its efficacy and safety."

Clinical • Journal • Retrospective data • Review • Bipolar Disorder • CNS Disorders • Endocrine Cancer • Mood Disorders • Psychiatry • BDNF

Efficacy and Safety of Adjunctive Cenobamate in Chinese Participants with Focal Seizure. (PubMed, Adv Ther) - P3 | "Cenobamate demonstrated a very favorable efficacy and safety profile in Chinese participants with focal seizures. The combination of cenobamate with both SCB and non-SCB treatments was effective in reducing seizure frequency and improved responder rates compared to placebo."

Clinical • Journal • CNS Disorders • Epilepsy

Capability, opportunity and motivation for shared decision-making about valproate as an antiseizure medication treatment for epilepsy in women with pregnancy potential: A qualitative study of patient perspectives. (PubMed, Br J Health Psychol) - "Comprehensive SDM when valproate is considered clinically appropriate could support informed, patient-centred decision-making. Equipping clinicians to navigate multifaceted risk/benefit discussions and empowering patients with clear, tailored information can help ensure treatment decisions align with reproductive goals. This study highlights the need to embed SDM in valproate prescribing consultations and throughout treatment duration."

Journal • CNS Disorders • Epilepsy

Anticonvulsant biotargets of digoxin: in silico study and in vivo verification. (PubMed, Ceska Slov Farm) - "To confirm the in silico results in vivo pharmacological studies under conditions of acute bicuculline-induced seizures and pentylenetetrazole kindling in mice have been carried out. It was established that digoxin shows high affinity to GABAergic biotargets and an identical to retigabine affinity to voltage-gated potassium channels KCNQ2 in silico...At the same time, the ability of digoxin to maximally enhance the anticonvulsant potential of sodium valproate has been revealed. Thus, it has been proven that the anticonvulsant properties of digoxin are most likely related to the ability to enhance the inhibitory properties of GABA and GABAergic agents."

Journal • Preclinical • CNS Disorders • Epilepsy

Neuroprotective Effect of Palmatine Against Anti-Epileptic Drug Induced Autism in Wistar Rat Pups. (PubMed, Int J Dev Neurosci) - "It was concluded that palmatine produced neuroprotective activity in autistic male rat pups possibly through amelioration of brain oxidative stress, inhibition of acetylcholinesterase and MAO-A activities and decrease of plasma corticosterone concentration."

Journal • Preclinical • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Pain • Psychiatry • CAT

Sodium Valproate Drives Propionylation-Mediated Epigenetic Reprogramming to Enhance Mesothelin CAR-T Cell Therapy in Solid Tumors. (PubMed, Mol Ther) - "In xenograft models of ovarian and triple-negative breast cancer, VPA significantly improved tumor control and survival without added toxicity. These findings support metabolic-epigenetic modulation as a strategy to improve CAR-T therapy in solid tumors."

Journal • Breast Cancer • Hematological Disorders • Hematological Malignancies • Oncology • Ovarian Cancer • Refractory Ovarian Cancer • Solid Tumor • Triple Negative Breast Cancer • LOX • MSLN