GTx-878 / Oncternal Therap - LARVOL DELTA

Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery. (PubMed, Acta Pharm Sin B) - "Here, we report the design and production of small molecule conjugates containing selective non-steroid ERβ agonists Gtx878 or genistein...We further uncovered the benefits of ERβ conjugates in the skin using two inducible skin injury mouse models, showing increased skin basal cell proliferation, epidermal thickness, and wound healing. Therefore, our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health."

Journal • Oncology • ER