SAT-93 / Satya Pharma - LARVOL DELTA

Rare occurrence of liver failure secondary to sickle cell crisis and It's management (ASH 2025) - "Ferritin greater than 16,500 with percent sat 93...However these recommendations are not well studied and mostly based on case reports and observational data. Further research is needed to elucidate optimal management of SCIC to establish a formal standard of care."

Cardiovascular • Cholestasis • Genetic Disorders • Heart Failure • Hematological Disorders • Hepatology • Inflammation • Liver Failure • Metabolic Disorders • Sickle Cell Disease • HP

LINKAGE BETWEEN LIVER BLOOD FLOW AND HEMODYNAMICS IN FONTAN-ASSOCIATED LIVER DISEASE - Yuli Y. Kim (ACC 2025) - "Healthy individuals (n=50) were controls. FC participants (mean (SD) age 31 (7) yr) had CI 2.6 (0.5) ml/min/m2, Fontan pressure 14 (3) mmHg, and O2 sat 93 (3)%... Higher Fontan pressure and desaturation are associated with decreased PV and compensatory increased HA flows. HepQuant tests could be useful in measuring hepatic impairment and shunting in FALD."

Hepatology

Weekend Woes - Alone In Interventional Radiology With A "Simple" Procedure And Then A Code (ASA 2023) - "She is taking methotrexate, sulfasalazine, pregabalin, duloxetine, and an oral contraceptive...She was diagnosed with pneumonia, right sided effusion, elevated LFT's, and was transferred to your Children's Hospital last night.BP 113/62, P 96-132, RR 16-32, T 98, Pox 97%Admission Labs: ABG 7.35/pCO229/pO279/HCO316/Sat 93%/-8.4 ➔ Lactic acid 70Na 134/K 5.2/Cl 107/HCO3 16/Gluc 116/ BUN 38/Cr 0.95WBC 22, HCT 34, PLT 39AST 1667, ALT 1426, T. Bili 2.0PT 34, INR 3.2, PTT 46, Fib 60 Ammonia - Normal at 27What additional information would you like to know?...Would you encourage the IR doctor to use local anesthetic?You initiate an infusion of propofol 150 mcg/kg/min without a bolus and draw up ondansetron...Normal LV and RV thicknessTroponin 0.108 (0.012-0.034), CRP 14Multiple vasoactive medications were initiated but the patient's unstable hemodynamics required ECMO support on the following day. The liver biopsy demonstrates necrotic tissue - possibly due to..."

Anesthesia • Cardiomyopathy • Cardiovascular • CNS Disorders • Critical care • Crohn's disease • Depression • Fibromyalgia • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Liver Failure • Mood Disorders • Musculoskeletal Pain • Obesity • Pain • Pneumonia • Psychiatry • Respiratory Diseases • Rheumatology • Thrombosis

Weekend Woes - Alone In Interventional Radiology With A "Simple" Procedure And Then A Code (ASA 2023) - "She is taking methotrexate, sulfasalazine, pregabalin, duloxetine, and an oral contraceptive...She was diagnosed with pneumonia, right sided effusion, elevated LFT's, and was transferred to your Children's Hospital last night.BP 113/62, P 96-132, RR 16-32, T 98, Pox 97%Admission Labs: ABG 7.35/pCO229/pO279/HCO316/Sat 93%/-8.4 ➔ Lactic acid 70Na 134/K 5.2/Cl 107/HCO3 16/Gluc 116/ BUN 38/Cr 0.95WBC 22, HCT 34, PLT 39AST 1667, ALT 1426, T. Bili 2.0PT 34, INR 3.2, PTT 46, Fib 60 Ammonia - Normal at 27What additional information would you like to know?...Would you encourage the IR doctor to use local anesthetic?You initiate an infusion of propofol 150 mcg/kg/min without a bolus and draw up ondansetron...Normal LV and RV thicknessTroponin 0.108 (0.012-0.034), CRP 14Multiple vasoactive medications were initiated but the patient's unstable hemodynamics required ECMO support on the following day. The liver biopsy demonstrates necrotic tissue - possibly due to..."

Anesthesia • Cardiomyopathy • Cardiovascular • CNS Disorders • Critical care • Crohn's disease • Depression • Fibromyalgia • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Liver Failure • Mood Disorders • Musculoskeletal Pain • Obesity • Pain • Pneumonia • Psychiatry • Respiratory Diseases • Rheumatology • Thrombosis

When chest infection hits the neck (EUSEM 2023) - "A 40-year-old patient presented to ED with fever, hoarse voice and generally unwell for few days.Was discharged from ED one week earlier after been diagnosed with Flu A.On initial assessment,NEWS 11A: At risk, hoarse voice (new), No oedema nor erythema.B: RR 38, SAT of 84 on RA and 96 on face mask 60%, right base and mid-zone crepitation and bronchial breathingC: HR 137, BP 89/45 and CRT of 4 secD: GCS 15/15, PEARL and no focal neurologyE: Localised area of cellulitis on the base of neck, just above the sternal notch about 1X4 inch (collar like)ABG: SAT 93%- 94% and PO2 9.5 on 60% O2, lactate of 5.4ECG: sinus tachycardiaCXR: Right sided lobar pneumonia Imp: Sepsis 2ry to pneumonia (bacterial on top of viral Flu A)Started on IV fluids and ABx and O2 to keep SATs between 94% and 98%Reviewed by ITU team to assess her airway (beside the stridor, she is overweight, with short neck) and the ITU team had no immediate concerns regarding the airwayNo clear explanation for this..."

Cardiovascular • Dermatology • Infectious Disease • Obesity • Pneumonia • Respiratory Diseases • Septic Shock