genistein
/ Astellas, Kazia
- LARVOL DELTA
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October 22, 2025
Genistein enhances anti-PD-1 efficacy in melanoma by suppressing regulatory T cell differentiation and activity
(Nature)
- "Genistein showed a synergistic effect with anti-PD-1 therapy in B16-F10 melanoma models, achieving enhanced immune infiltration and functional reprogramming of the tumor microenvironment. This combinatorial strategy not only reduced intratumoral Tregs but also elevated the CD8+/Treg ratio. At the mechanistic level, genistein effectively suppressed critical Treg surface markers, which are indispensable for Treg-mediated immunosuppression. Furthermore, it disrupted Treg differentiation by attenuating PI3K/AKT signaling phosphorylation."
Preclinical • Melanoma
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