genistein / Astellas, Kazia - LARVOL DELTA

Genistein enhances anti-PD-1 efficacy in melanoma by suppressing regulatory T cell differentiation and activity (Nature) - "Genistein showed a synergistic effect with anti-PD-1 therapy in B16-F10 melanoma models, achieving enhanced immune infiltration and functional reprogramming of the tumor microenvironment. This combinatorial strategy not only reduced intratumoral Tregs but also elevated the CD8+/Treg ratio. At the mechanistic level, genistein effectively suppressed critical Treg surface markers, which are indispensable for Treg-mediated immunosuppression. Furthermore, it disrupted Treg differentiation by attenuating PI3K/AKT signaling phosphorylation."

Preclinical • Melanoma