AZD6621 / AstraZeneca - LARVOL DELTA

ACTIVATED-4-PC: A Phase 1/2 study of AZD6621, a T cell-engaging antibody targeting STEAP2, CD3, and CD8, in patients with metastatic prostate cancer (PC) (ESMO 2026) - No abstract available

Clinical • Metastases • P1/2 data • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • STEAP2

D8020C00003: A study to learn how safe AZD6621 is, how well it works, and how it moves throughout the body over time, in adult male participants with Metastatic Prostate Cancer (clinicaltrialsregister.eu) - P1/2 | N=45 | Not yet recruiting | Sponsor: AstraZeneca AB

New P1/2 trial • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor

AZD6621: Improving the therapeutic index for prostate cancer T cell engagers with a next-generation CD8-guided format (AACR 2025) - "Furthermore, when matched for anti-tumor activity in an intravenous 22Rv1 xenograft model, systemic cytokine levels were significantly reduced in AZD6621-treated mice compared to a conventional TCE. These data provide reason to believe that AZD6621 can improve the therapeutic index of conventional TCEs via CD8-guided, affinity-optimized CD3 engagement of STEAP2 on prostate cancer cells and support a first-in-human clinical trial planned to start in 2025."

First-in-human • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor • CD4 • CD8 • STEAP1 • STEAP2

ACTIVATED-4-PC: A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer (clinicaltrials.gov) - P1/2 | N=52 | Recruiting | Sponsor: AstraZeneca | Not yet recruiting ➔ Recruiting

Enrollment open • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

ACTIVATED-4-PC: A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer (clinicaltrials.gov) - P1/2 | N=52 | Not yet recruiting | Sponsor: AstraZeneca

New P1/2 trial • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor