PanChol (live attenuated oral cholera vaccine) / Brigham and Womens Hospital - LARVOL DELTA

Results of the Phase 1 Trial of PanChol, a rapid-acting live attenuated Oral Cholera Vaccine (ASTMH 2024) - No abstract available

P1 data • Cholera

94 - Solving the Supply Shortage: Present and Future Prospects for Cholera Vaccines (ASTMH 2024) - "Additional presentations will include the Phase 1 trial results of PanChol a genetically engineered rapid-acting live attenuated Oral Cholera Vaccine, and the Phase 1 trial results of a Cholera Conjugate Vaccine (CCV) based on the immunodominant protective antigen of cholera, the O-specific polysaccharide (OSP) component of LPS, linked to a carrier protein to generate T cell dependent responses...Finally, the development plan of a novel oral capsule vaccine, DuoChol, that combines inactivated whole cell bacteria and recombinant cholera toxin B will be presented including the results of country workshops in South Asia and Sub-Saharan Africa to assess feasibility, cost and policy implications of a capsule vaccine. This highly thermostable and light weight vaccine is expected to have efficacy similar to Dukoral but significantly reduce delivery costs and challenges. A phase 1 trial is expected in early 2025."

Cholera

COLECTOMY INDICATIONS DURING ULCERATIVE COLITIS : A TWENTY-YEAR RETROSPECTIVE FROM A UNIVERSITY HOSPITAL CENTER (UEGW 2024) - "The majority were pancholic and 35% were left-handed. The study confirms changes in colectomy criteria for chronic ulcerative colitis over the past two decades, with a decrease in treatment-resistant cases and an increase in severe acute colitis or dysplasia/cancer cases, while laparoscopy usage has increased, reducing morbidity despite biotherapies usage."

Retrospective data • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammatory Bowel Disease • Oncology • Ulcerative Colitis

"Still waiting @yyCBEdu @AlbertaEd cc @LauraHack34 @danacaresyyc @FreshAirAB @CanPaedSociety @CAPE_ACME @AdrianaLaGrange @demetriosnAB @pancholi_rakhi @luanne_metz #IAQ" (@ClaireKraatz)

"@A_R_TforPEACE @RahulBanerjeeMD @pancholi_rakhi @Z_u_l_u_i_n_k @sweetirish01" (@BruceRawji)

"@JanisIrwin, @DanielleLarivee, @luanne_metz, @GandalfIf, @pancholi_rakhi, @SPhillipsAB, @MarieFrRenaud, @chantal_SMC, @KarenShaw_, @LoriSigurdson, @heathersweetab, @lizettendp, @JTweedleRD, @PeggyBevClare …3/3" (@LisboaYYC)

"@AACR blog (12/8): "The Fungi Within Us: The Mycobiome’s Emerging Role in Cancer" by Neha J. Pancholi, PhD https://t.co/TFqGWcBnVN" (@GMaPR1N)

Oncology