indomethacin & phosphatidylcholine (PL 4500) / PLx Pharma - LARVOL DELTA

Multifunctional Indomethacin Conjugates for the Development of Nanosystems Targeting Cancer Treatment. (PubMed, Int J Nanomedicine) - "While free IND was active at a concentration of 270.5 μM, in the form of the phospholipid conjugate (IND-OA-PC), it inhibited the growth of cancer cells at 67.5 μM and after conjugate encapsulation (IND-OA-PC-NLC) it was effective at only 10.3 μM. Our study revealed that the conjugation of NSAID with phosphatidylcholine and its combination with nanotechnology techniques create opportunities to repurpose well-known drugs from this group for new therapeutic applications."

Journal • Breast Cancer • Gastrointestinal Disorder • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • HER-2

"Not using much Cangrelor. If IV antiplt is needed, I go with bolus 2b3a or bolus + short infusion." - SVRaoMD

Biosimilar

Polymer/lipid interplay in altering in vitro supersaturation and plasma concentration of a model poorly soluble drug. (PubMed, Eur J Pharm Sci) - "Solution viscosity, solid-state properties and morphology of ASDs were related to the results. This study revealed fundamental mechanisms of PVP/PC mixture effect on IND supersaturation and oral bioavailability, demonstrating that polymer/lipid mixture could be used as a promising carrier to alter supersaturation profile and oral bioavailability of SDDS products."

Journal • Preclinical