Elestrin (estradiol transdermal gel) / Viatris - LARVOL DELTA

Comparison of clinical outcomes between use of estradiol transdermal gel and oral estradiol valerate in patients undergoing frozen-thaw embryo transfer: an observational study. (PubMed, Arch Gynecol Obstet) - "Estradiol transdermal gel is a safe and feasible alternative for endometrial preparation in frozen embryo transfer cycles, yielding comparable ongoing pregnancy rates to the standard oral regimen."

Clinical data • Journal • Observational data

In Vitro Percutaneous Absorption of Permeation-Enhancing Estrogen Formulations. (PubMed, Pharmaceuticals (Basel)) - "The objective of this in vitro study is to evaluate the percutaneous absorption of compounded estradiol 0.06% and bi-est E3/E2 0.1%/0.06% in aqueous and anhydrous proprietary permeation-enhancing bases, in comparison with the commercially available estradiol transdermal gel (ESTROGel®). The compounded bases facilitated a steady percutaneous absorption of estradiol, without quick peaking or declining, which is one of the desired characteristics in HRT. Compounding pharmacists and practitioners may consider estradiol compounded formulations as a viable option for hormone delivery to patients."

Journal • Preclinical

"@DrJPLow @MachadoIsidrin @atman_ci @drwillanderson @SumantaDas_7 @girlscouter @pembeoltulu @celestrinmd @kriyer68" (@FionaMacPath)

"Tagging @celestrinmd!" (@anueru432)

[VIRTUAL] THE ROLE OF NEUROKININ B IN THE PATHOPHYSIOLOGICAL MECHANISMS OF VASOMOTOR SYMPTOMS AND SLEEP DISORDERS IN POSTMENOPAUSAL WOMEN. (EMAS 2021) - "Group I received MHT 17-β estradiol transdermal gel 0.75 mg daily and micronized progesterone 100 mg daily vaginally. Patients of the I and II groups were comparable in age, postmenopause duration and anthropometric indicators. NKB levels in Groups I and II were significantly higher compared to the control group (P1 <0.001, P2= 0.003). NKB levels in Group I were 2.3 times higher than in Group II (P3 <0.001)."

Clinical • CNS Disorders • Sleep Disorder

"Follow @AnneMillsMD @AnnieMcLeanDMD @AmyOxentenkoMD @InduPartha @jessicahalem @drjessigold @InvictaOrtho @gradydoctor @uche_blackstock @oni_blackstock @DrFNA @LJTafeMD @celestrinmd @CArnold_GI @NicoleJacksonMD @vi_monappa @Gagandeepk5MD @endocrine_witch @pedsmd2b @sanamloghavi 😁" (@anueru432)

"Tagging @JMGardnerMD @celestrinmd !! 😁" (@anueru432)

"Tagging @celestrinmd @DucktorCezzy @bkzMD @vita_pathologia !" (@anueru432)

"@ZHOUSEH @MattieFarzin @rennmont @DrJPLow @DrGeeONE @TheKarenPinto @ALBoothMD @Dr_Brian_Cox @celestrinmd @ariella8 @bgizem_oz @JMGardnerMD @ChancellorA95 @vhnguyenmd @WKemp_MT_FPDoc @labmedinno @kis_lorand @kkuanMD @DrMarkOng @MarcosLepeMD @Teclis82 @smlungpathguy @MAHoureih" (@TristanRutland7)

"@ZHOUSEH @MattieFarzin @rennmont @DrJPLow @DrGeeONE @TheKarenPinto @ALBoothMD @Dr_Brian_Cox @celestrinmd @ariella8 @bgizem_oz @JMGardnerMD @ChancellorA95 @vhnguyenmd @WKemp_MT_FPDoc @labmedinno @kis_lorand @kkuanMD @DrMarkOng @MarcosLepeMD @Teclis82 @smlungpathguy @MAHoureih" (@TristanRutland7)

"Dear @IPathC Council, do tell if pathologists introverts and never see other people at work? @KMirza @01sth02 @JMGardnerMD @celestrinmd @thejourneymate @DrGeeONE @HeardSheard49 @PathologyHouse @ProfRScolyerMIA @ProsserNj @ac_pathgal @drparomitaroy @Histopatolomon @Vik_deshpandeMD" (@GuptaRuta)

"@ZHOUSEH @MattieFarzin @rennmont @DrJPLow @DrGeeONE @TheKarenPinto @ALBoothMD @Dr_Brian_Cox @celestrinmd @ariella8 @bgizem_oz @JMGardnerMD @ChancellorA95 @vhnguyenmd @WKemp_MT_FPDoc @labmedinno @kis_lorand @kkuanMD @DrMarkOng @MarcosLepeMD @Teclis82 @smlungpathguy @MAHoureih" (@TristanRutland7)

"@celestrinmd @Sara_Jiang @endocrine_witch @peachynatividad @CArnold_GI @DrFNA @HermelinMD @LJTafeMD @Pathology36 @emckaymd @bjmagnani @AmyOxentenkoMD @DevikaDasMD @DrOniBee @uche_blackstock @drjessigold @jessicahalem @drjessigold are few of the women of medicine who inspire me!" (@anueru432)

Clinical

"Loved this radiology-pathology correlation! Tagging @celestrinmd !!" (@anueru432)

"The logo competition @IPathC is getting hot @DrGeeONE @celestrinmd @Santosh34632205 @PAPatilMD @elattar_hicham @ProfRScolyerMIA @CaDxPath @SkinFitLife @VarshaManuchaMD @froggatc @drbruceashford @oreoimc @GeronimoJrLapac @RadOncDoc_Gee @candace_scanlan @CEKanakisMD @kriyer68" (@GuptaRuta)

"1. Discussion: @emma_furth @pezhouh @CArnold_GI @debpratik @Mvgs1706 @ariella8 @KarrsJeremiah @Dr_Brian_Cox @celestrinmd @seyma_buyucek et al Thanks for the input here. Thought this was a nice case of autoimmune metaplastic atrophic gastritis (AMAG)." (@Teclis82)

Clinical • Immunology

"3/3 More pics and discussion to follow. @ALBoothMD @natzpat @DrGeeONE @kkuanMD @CArnold_GI @ggchen_MD @MLisaZhang @ariella8 @celestrinmd @RunjanChetty" (@Teclis82)

"Tagging @DermwizGuy @thenerdyderma @celestrinmd @JMGardnerMD @kkuanMD @Gagandeepk5MD @anjuthevirgo @5_3shivani @padmapathology1 @luishcruzc @ac_pathgal @DrGeeONE" (@anueru432)

"Thanks @01sth02 1. Wanna be #PedSurg but happily change to #PediPath Pathologist. #PathfoodTwitter 2. Don't forget to reach out when you need help. Any of #PathTwitter Family can be reach/DM for advise. 3. @twmarkc @WKemp_MT_FPDoc @DrPayelMondal @celestrinmd @MarcelaSaebL" (@vhnguyenmd)

"You’re most welcome @celestrinmd! #dowhatyoulove #lovewhatyoudo" (@KRoSlideReview)

"@celestrinmd doc look at the gross on this one 🤔" (@anueru432)

"Working on our national medical association talk for med students about a career in pathology - all title suggestions welcome @marcusdabner @DrBuiPathology @Sara_Jiang @JMGardnerMD @ac_pathgal @tucker_pe @ProsserNj @ac_pathgal @celestrinmd @cmketcham @CatrionaMckenz5" (@GuptaRuta)

"@IHC_guy @celestrinmd @CArnold_GI @LizMontgomeryMD" (@cloud_nebula)

Meda enters partnership for Elestrin in the US market (The Wall Street Journal) - "Meda has entered into a promotion agreement with Mission Pharmacal, a company active in the women's health area, for Meda's topical estrogen replacement therapy product Elestrin. 'Through this partnership, we optimize sales efforts for Elestrin and at the same time increase our focus on the respiratory area'..."

Licensing / partnership • Vaginal Atrophy

"Inviting strong #WomenOfPathology to join in! @RoncinMD @celestrinmd @nusrat_xahra @Pathology3636 @padmapathology1 @GagandeepkMD @vi_monappa @CArnold_GI @Sara_Jiang @PathologySayah @emckaymd @Sinchita_Roy @jhuntpath I hope you can join and invite #HeForShe as well 😁" (@anueru432)

Clinical