doxepin / Generic mfg. - LARVOL DELTA

Pharmacotherapy of psychiatric inpatients with mental and behavioral disorders caused by sedatives or hypnotics (F13): Results from an observational pharmacovigilance program between 2000 and 2017. (PubMed, Addict Sci Clin Pract) - "We found high rates of non-SHA drugs among patients treated for SHA-SUD. The prevalent use of psychotropic drugs with strong sedating properties indicates a symptom-oriented treatment approach, which is often "off-label" but may be clinically necessary. Main limitation is the cross-sectional design of the AMSP databank. Therefore, we cannot provide any follow up data on the patient collective especially regarding outcome."

Adverse events • Journal • Addiction (Opioid and Alcohol) • Behavior Disorders • CNS Disorders • Mental Retardation • Mood Disorders • Psychiatry

Design strategies for titanium surfaces to adsorb and release drugs: An in vitro study. (PubMed, Biomed Mater Eng) - "The results suggest that a rougher or ionically charged surface does not guarantee drug adsorption. In contrast, the use of a transport vehicle such as a polyvinyl coating ensures the release of the drug, initiating its therapeutic effect within the first minutes, and maintained for a period of between 120 and 180 min."

Journal • Preclinical • Inflammation • Pain

Carbon Materials in Voltammetry: An Overview of Versatile Platforms for Antidepressant Drug Detection. (PubMed, Micromachines (Basel)) - "Moreover, the combination of voltammetric approaches with the unique characteristics of carbon and its derivatives has led to the development of powerful electrochemical sensing tools for detecting antidepressant drugs, which are highly desirable in healthcare, environmental monitoring, and the pharmaceutical industry. In this review, carbon-based materials, such as glassy carbon and boron-doped diamond, and a wide spectrum of carbon nanoparticles, including graphene, graphene oxides, reduced graphene oxides, single-walled carbon nanotubes, and multi-walled carbon nanotubes were described in terms of the sensing performance of agomelatine, alprazolam, amitriptyline, aripiprazole, carbamazepine, citalopram, clomipramine, clozapine, clonazepam, desipramine, desvenlafaxine, doxepin, duloxetine, flunitrazepam, fluoxetine, fluvoxamine, imipramine, nifedipine, olanzapine, opipramol, paroxetine, quetiapine, serotonin, sertraline, sulpiride, thioridazine, trazodone, venlafaxine,..."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Personality Disorder • Psychiatry

The effect of doxepin 3 mg on sleep latency: a pooled analysis of two phase 3 trials. (PubMed, Sleep Breath) - "Doxepin 3 mg has a statistically significant effect on sleep latency on the first night of treatment in adults with insomnia that did not reach the clinical significance threshold."

Clinical • Journal • P3 data • Retrospective data • CNS Disorders • Insomnia • Sleep Disorder

Trazodone versus doxepin as a pharmacologic sleep aid in psychiatric inpatients: A retrospective cohort study. (PubMed, Ment Health Clin) - "After treatment failure with trazodone 50 mg, there was no statistically significant difference in efficacy or tolerability between trazodone 100 mg and doxepin 25 mg for insomnia. A prospective trial would be necessary to directly compare the 2 treatment options."

Journal • Retrospective data • CNS Disorders • Insomnia • Psychiatry • Sleep Disorder

High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring. (PubMed, Front Pharmacol) - "In this paper, we developed a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method to study simultaneously TDM and clinical pharmacokinetics of 23 antidepressants and active metabolites: sertraline, escitalopram, fluvoxamine, paroxetine, duloxetine, milnacipran, fluoxetine, venlafaxine, O-desmethylvenlafaxine, mirtazapine, trazodone, bupropion, hydroxybupropione, norfluoxetine, vortioxetine, agomelatine, mianserin, doxepine, desmethyldoxepin, clomipramine, desmethylclomipramine, amitriptyline and nortriptyline hydrochloride...Validation of the developed method was carried out based on the Chinese Pharmacopoeia guidelines for bioanalytical method validation, including assessment of specificity, calibration curves, carryover, accuracy, crosstalk, precision, stability, recovery, dilution integrity and matrix effect. The results showed that a simple, fast, reliable and specific HPLC'MS/MS method was developed and validated, and all the..."

Journal • CNS Disorders • Depression • Psychiatry

Circadian antidepressant treatments in depression: A systematic review and meta-analysis. (PubMed, Chronobiol Int) - "The optimal time of maximum efficacies in 5 out of 15 drugs in the 10 studies was at zeitgeber time (ZT) 2, including fluoxetine, sertraline, citalopram, doxepin, and agomelatine. The best therapeutic effects of mirtazapine, trazodone, and agomelatine were at ZT10, while maximum efficacies of venlafaxine and fluvoxamine were at ZT6 and ZT13, respectively...More prospective randomized trials or randomized experiments are demanded to establish recommendations for optimal circadian timing of depression based on zeitgeber time. It would be of interest to further evaluate this time-selection as a potential viable novel therapeutic in future research."

Journal • Retrospective data • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Heterocyclic Antidepressants with Antimicrobial and Fungicide Activity. (PubMed, Molecules) - "In addition, there is a serious problem of increasing resistance of microorganisms to antibiotics. In this article, we found that almost all of the antidepressants considered (except moclobemide, haloperidol, and doxepin) have antimicrobial activity and can suppress the growth of not only pathogenic microorganisms but also the growth of bacteria that directly affect mental health (such as Lactobacillus, Lactococcus, Streptococcus, Enterococcus, and Bifidobacterium)."

Journal • Review

Incidence and Predictors of Long-term Hypnotic Receipt among Patients with Chronic Obstructive Pulmonary Disease. (PubMed, Ann Am Thorac Soc) - "Despite guideline recommendations, long-term hypnotic receipt is common among patients with COPD. Future work to prevent long-term hypnotic prescriptions should consider the role that respiratory symptoms and mental health comorbidities may have in driving this practice."

Journal • Chronic Obstructive Pulmonary Disease • CNS Disorders • Depression • Immunology • Insomnia • Major Depressive Disorder • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • Pulmonary Disease • Respiratory Diseases • Sleep Disorder

Psychotropic Drugs in Dermatology Part 1: Anti-depressants and Mood Stabilisers. (PubMed, Indian J Dermatol) - "These include selective serotonin reuptake inhibitors like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, alongside selective serotonin norepinephrine reuptake inhibitors such as venlafaxine, desvenlafaxine, and duloxetine. Additionally, norepinephrine dopamine reuptake inhibitors like bupropion; tricyclic antidepressants including doxepin, amitriptyline, imipramine, and clomipramine; and tetracyclic antidepressants like mirtazapine are commonly employed. Supplementary medications like anti-convulsants (e.g., gabapentin and pregabalin) further enrich the therapeutic landscape in psycho-dermatology...After screening 2287 records, 26 studies met the inclusion criteria. The findings underscore the potential role of psychotropic drugs in managing dermatological conditions, highlighting the need for further research to strengthen the evidence base in psycho-dermatology."

Journal • Review • CNS Disorders • Dermatology • Mental Retardation • Psychiatry

Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin. (PubMed, Cureus) - "Conclusion In psychiatric patients, trazodone was the most successful medication for enhancing sleep quality; however, other groups cannot use it due to its adverse effects. For patients who were more likely to have side effects, melatonin was a safer option, but doxepin offered a good balance between effectiveness and tolerability."

Journal • CNS Disorders • Hypotension • Psychiatry • Sleep Disorder • Xerostomia

Insights into prescribing patterns for antidepressants: an evidence-based analysis. (PubMed, BMC Med Inform Decis Mak) - "Our findings provide valuable insights into the nuanced factors that shape evidence-based antidepressant prescribing practices, offering a foundation for more personalized, effective depression treatment. Further research is needed to validate these models in other extant databases. These findings contribute to a more comprehensive understanding of antidepressant prescribing practices and have the potential to improve patient outcomes in the management of depression."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Insomnia • Nicotine Addiction • Pain • Psychiatry • Sleep Disorder • Tobacco Addiction

Utilization of Potentially Inappropriate Sedative-Hypnotic and Atypical Antipsychotic Medications among Elderly Individuals with Insomnia and Alzheimer's Disease. (PubMed, Sleep) - "Substantial utilization of PIM-OSHAA was observed in EI and ADI cohorts. PIM-OSHAA use was associated with higher HCRU and costs. These findings underscore the importance of appropriate treatment strategies for insomnia in the elderly population especially in those with concurrent AD."

Journal • Alzheimer's Disease • CNS Disorders • Insomnia • Sleep Disorder

Doxepin Solution for Alleviation of Stubborn Breakthrough Pain Induced by Swallowing in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma (clinicaltrials.gov) - P=N/A | N=178 | Recruiting | Sponsor: Nanfang Hospital, Southern Medical University | Trial completion date: Sep 2024 ➔ Feb 2026 | Trial primary completion date: Aug 2024 ➔ Feb 2026

Trial completion date • Trial primary completion date • Head and Neck Cancer • Nasopharyngeal Carcinoma • Oncology • Pain • Solid Tumor

Spontaneous formation of small and ultrasmall unilamellar vesicles in mixtures of drug surfactant and phospholipid: Effect of chemical structure of phospholipid tails on vesicle size. (PubMed, J Colloid Interface Sci) - "Binary drug surfactant-phospholipid mixtures with four different phospholipids with identical headgroups (two saturated phospholipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, 14:0) and 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, 16:0), and two unsaturated lipids 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC, 18:1) and 1,2-Dierucoyl-sn-Glycero-3-Phosphatidylcholine (DEPC, 22:1)) combined with two different tricyclic antidepressant drugs (amitriptyline hydrochloride (AMT) and doxepin hydrochloride (DXP)) have been investigated with small-angle neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM)...Moreover, bilayer vesicles predominated over micelles in a much wider range of concentrations for DOPC and DEPC mixtures as a result of having a smaller phospholipid mole fraction in the aggregates at the micelle-to-vesicle transition. Our results have been theoretically rationalized by combining solution thermodynamics with bending..."

Journal

Ni(0)-Catalyzed Efficient, Regioselective Synthesis of Dibenzo[b,e]oxepines and Dibenzo[c,f][1,2]oxathiepine 6,6-Dioxides: Mechanistic Study by DFT Calculation and Docking Interactions. (PubMed, ACS Omega) - "We validate the experimentally proposed reaction mechanism using the density functional theory method. Further, molecular docking interactions were investigated accommodating some of our synthesized molecules."

Journal

Doxepin as OCT2 inhibitor ameliorates inflammatory response and modulates PI3K/Akt signaling associated with cisplatin-induced nephrotoxicity in rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In addition, pre- and co-treatment with DOX significantly reduced the CP-mediated apoptotic effect by reducing the renal tissue expression of BAX and caspase-3 levels, upregulating the expression of Bcl-2, and modulating the phosphorylation of PI3K/Akt signaling cascade. DOX exerts a nephroprotective impact against CP-mediated nephrotoxicity via the inhibition of OCT2, suppression of inflammation, oxidative stress, and apoptotic markers, and modulation of PI3K/Akt signaling cascade."

IO biomarker • Journal • Preclinical • Inflammation • BAX • BCL2 • CASP3 • IL1B • IL2 • IL6 • SLC22A2 • TNFA

Evolving trends of pharmaceutical poisonings associated with QRS complex prolongation. (PubMed, Clin Toxicol (Phila)) - "Amitriptyline, nortriptyline, doxepin, imipramine, noxiptiline, bupropion, flecainide, carvedilol, propranolol, diphenhydramine, and lamotrigine poisonings were independent predictors of QRS complex prolongation...Bupropion, diphenhydramine, and antidysrhythmics are increasingly common causes of QRS complex prolongation, each associated with numerous severe outcomes in poisoning. Greater safety measures to protect patients from cardiovascular toxicity from these pharmaceuticals are warranted."

Journal • Cardiovascular • Critical care

Development and characterization of a non-enzymatic electrochemical biosensor for rapid determination of sorbent-based extracted trazodone and doxepin in complicated samples. (PubMed, Anal Chim Acta) - "PVAc acts as a cross-linking agent for PVA, and their mixture is effective for sample preparation and pre-concentration of analytes in complex matrices. Also, adding CuO NPs to this polymeric mixture enhanced the adsorption efficiency. Taking advantage of the high surface area of MnO NPs and the high electrical conductivity of B-rGO, and considering the superiority of their simultaneous utilization, the constructed electrochemical biosensor is both cost-effective and rapid. It demonstrates excellent stability, repeatability, and sensitivity for the simultaneous determination of TRZ and DOX under optimal conditions. This biosensor, the first of its kind, is specifically designed for the simultaneous determination of TRZ and DOX in human plasma and serum samples, representing a significant advancement in biosensing technology."

Journal

Anticholinergic deprescribing: A case report demonstrating improved cognition and function with minimal adverse withdrawal effects. (PubMed, Br J Clin Pharmacol) - "The patient decided to abruptly stop taking doxepin, despite a planned careful taper with twice weekly monitoring, but did not experience any severe anticholinergic ADWE and subsequently had significantly improved cognitive function. Future research should focus on better understanding the risk of anticholinergic ADWE so that anticholinergic deprescribing decisions, including how often and by how much to taper, can be made confidently and safely."

Biomarker • Clinical • Clinical guideline • Journal • Observational data • Retrospective data • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia

Binding characteristics of the doxepin E/Z-isomers to the histamine H1 receptor revealed by receptor-bound ligand analysis and molecular dynamics study. (PubMed, J Mol Recognit) - "Furthermore, MD simulations revealed that the hydroxyl group of T1123.37 did not form hydrogen bonds with the E-isomer, but with the adjacent residues in the binding pocket. Analysis of the receptor-bound doxepin and MD simulations suggested that the hydroxyl group of T1123.37 contributes to the formation of a chemical environment in the binding pocket, which is slightly more favorable for the Z-isomer without hydrogen bonding with doxepin."

Journal

PHARMACOLOGICAL TREATMENT OF PEDIATRIC INSOMNIA--A SUCCESSFUL TRIAL OF DOXEPIN (SLEEP 2024) - "He previously trialed clonidine, guanfacine, trazodone, melatonin, and mirtazapine without significant ben efit... Up to now, there are no FDA approved medications for the treatment of insomnia in the pediatric population. A prior study of patients with ASD and ADHD demonstrated the use of doxepin provided clinical improvement in sleep onset and maintenance insomnia based on subjective evidence with paren tal report. In this case, doxepin improved subjective report of insomnia and correlated with objective findings on actigraphy."

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Insomnia • Psychiatry • Sleep Disorder

THE EFFECT OF DOXEPIN 3 MG ON SLEEP LATENCY: RESULTS FROM A META-ANALYSIS OF TWO PHASE 3 TRIALS (SLEEP 2024) - "Doxepin 3 mg may be an effective option to treat sleep latency in adults with insomnia symptoms, especially those with a long latency to persistent sleep"

P3 data • Retrospective data • CNS Disorders • Insomnia • Sleep Disorder

The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use. (PubMed, Ther Adv Psychopharmacol) - "Amitriptyline, clomipramine, dothiepin/dosulepin, doxepin, trimipramine and imipramine showed broadly similar toxicity and were usually reported to be less toxic than desipramine...With respect to the risk of cardiovascular events at clinically relevant exposure, amitriptyline, nortriptyline and lofepramine were associated with a greater risk of in-use cardiotoxicity. All measures of overdose toxicity were subject to external influences and confounding. The continued use of TCAs in depression and other conditions should be minimized when considering their undoubted toxicity in overdose and possible toxicity in normal clinical use."

Journal • Review • Cardiovascular • CNS Disorders • Depression • Psychiatry

Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry. (PubMed, J Pharmacol Toxicol Methods) - "D2, H1, and mACh receptor occupancy by olanzapine increased in a dose-dependent manner, reaching 70-95%, 19-43%, and 12-45%, respectively, at an olanzapine dose range of 3-10 mg/kg. These results suggest that simultaneous determination of in vivo D2, H1, and mACh receptor occupancy is possible using LC-MS/MS."

Journal • CNS Disorders