Vitaros (alprostadil + novel excipient) / Seelos Therap - LARVOL DELTA

Efficacy and safety of treatment with the use of intraurethral alprostadil (Vitaros©) on demand in men with spinal cord injury and multiple sclerosis (ESGURS-ESAU 2023) - No abstract available

Clinical • CNS Disorders • Multiple Sclerosis • Orthopedics

"Bayer, pues no si puedo evitaros." (@moles_cia19)

Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study. (PubMed, Int J Impot Res) - "Topical alprostadil 300 μg/100 mg (Virirec®) was the treatment assigned to Group A, while the combination therapy with the last PDE5I taken (at the maximum recommended dose) plus topical alprostadil 300 μg/100 mg (Virirec®) was assigned to Group B. After 3 months from assignment to groups were evaluated IIEF-5, SEP-2 and SEP-3 regarding the last sexual intercourse, and Global Assessment Questionnaire-Questions 1 and 2 (GAQ-1 and GAQ-2)...Fifty-two patients were previously treated with sildenafil 100 mg (30.6%), 6 with vardenafil 20 mg (3.5%), 56 with tadalafil 20 mg (32.9%), and 56 with avanafil 200 mg (32.9%)...No statistically significant difference was recorded between the AEs of the two groups, except for facial flushing that was reported only in Group B (p = 0.021). The combination therapy with topical alprostadil and PDE5I seems to be more effective than topical alprostadil alone without worsening the safety of the treatment."

Clinical • Combination therapy • Journal • Erectile Dysfunction

"The @US_FDA @FDA_Drug_Info denial of #Vitaros is a clear example of #BigPharma buying out the corrupt FDA" (@JWildman85)

Biosimilar

"¡Quiero invitaros a un evento muy especial que estaré junto con @novonordisk y @fundiabetes ! 👇 Nos vemos el 17 de noviembre en Madrid 🤙 #MuévetePorlaDiabetes #KilianMeyer" (@KilianMeyerPrat)

Assessment of the erectile function and patients' perception of improvement in Spanish patients with erectile dysfunction (PubMed, Rev Int Androl) - "Hardness of erection is just another factor of erectile function, but it is not the only one influencing improvement perception by patients."

Clinical • Journal

The intra-meatal application of alprostadil cream (Vitaros®) improves drug efficacy and patient's satisfaction: results from a randomized, two-administration route, cross-over clinical trial. (PubMed, Int J Impot Res) - "Based on the study findings it is evident that the NEW.AR is more efficacious than the ST.AR in improving IIEF-5 and SEP scores from baseline to control visit (IIEF-5: +3.8 vs +6.3; p < 0.001; positive response to SEP-2: 10 vs 27; p = 0.002) and in terms of PSAE (a significant improvement from the baseline in 31% of patients; p < 0.001). As regards the safety profile, no difference in terms of local and systemic side effects was found."

Clinical • Journal