ciprofloxacin IV / Generic mfg. - LARVOL DELTA

Antibiotic Therapy for Pseudomonas aeruginosa in Primary Ciliary Dyskinesia: Effectiveness and Key Influencing Factors (ERS 2026) - "AT, following cystic fibrosis protocols, included mainly inhaled tobramycin or colistin with oral ciprofloxacin or intravenous combination therapy guided by the antimicrobial susceptibility report. AT for PsA infections in pPCD demonstrates high efficacy and frequently achieves a durable response, even in recurrent or chronic cases. Ongoing data analysis, focusing on various influencing factors, will be presented at the conference."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases

Suspected Infected Renal Cyst in Autosomal Dominant Polycystic Kidney Disease Presenting With Predominant Gastrointestinal Symptoms (ACG 2026) - "Given ADPKD with flank pain, urinary findings, systemic illness, nondiagnostic imaging, and gastrointestinal symptoms potentially confounded by PLD, suspected infected renal cyst versus complicated urinary tract infection was treated with intravenous ciprofloxacin...Antibiotics were transitioned to oral amoxicillin-clavulanate to complete a 14-day course...Clinicians should maintain a high index of suspicion for renal cyst infection in patients with ADPKD who present with gastrointestinal symptoms, flank pain, urinary abnormalities, and systemic illness. Figure: Axial noncontrast CT abdomen demonstrating extensive polycystic liver disease with innumerable hepatic cysts in a patient with autosomal dominant polycystic kidney disease, contributing to diagnostic overlap with gastrointestinal and hepatobiliary etiologies."

Acute Kidney Injury • Autosomal Dominant Polycystic Kidney Disease • Cardiovascular • Chronic Kidney Disease • Genetic Disorders • Hematological Disorders • Hepatology • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

The Cyst Behind the Obstruction: A Rare Adult Presentation of Duodenal Duplication Cyst (ACG 2026) - "The patient was transferred to a tertiary hepatobiliary center, completed a 5-day course of IV ciprofloxacin and metronidazole, and underwent resection of an 8-cm duodenal cyst with Roux-en-Y gastrectomy...Duodenal duplication cysts should remain in the differential diagnosis for unexplained proximal bowel obstruction or pancreatitis like presentation in adults. Figure: Duodenal Duplication Cyst Ultrasound"

Clinical • Anorexia • Constipation • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Immunology • Pancreatitis • Small Intestinal Carcinoma

Malignant External Otitis Complicated by Severe Allergic Reaction to Antibiotic Therapy. (PubMed, Cureus) - "Following stabilization, treatment was resumed with intravenous ciprofloxacin and vancomycin, resulting in progressive clinical improvement and complete recovery after prolonged outpatient therapy. This case highlights the importance of individualized therapeutic strategies in MEO, particularly in elderly patients with atypical presentations and treatment-limiting complications."

Journal • Allergy • Dermatitis • Dermatology • Immunology • Infectious Disease • Metabolic Disorders • Otorhinolaryngology

Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2 (clinicaltrials.gov) - P3 | N=600 | Recruiting | Sponsor: Major Extremity Trauma Research Consortium | N=1200 ➔ 600 | Trial completion date: Mar 2027 ➔ Mar 2029 | Trial primary completion date: Sep 2026 ➔ Sep 2028

Enrollment change • Trial completion date • Trial primary completion date • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Ruptured Community-acquired Methicillin-Resistant Staphylococcus aureus (MRSA) Hepatic Abscess in an Immunocompetent Child Treated Successfully with Culture-guided Antibiotic Therapy: A Case Report. (PubMed, Acta Med Philipp) - "He was treated noninvasively with ciprofloxacin (intravenous at 10 mg/kg every 12 hours for 14 days followed by oral at 15 mg/kg every 12 hours for 28 days), and clindamycin (intravenous at 10 mg/kg every 6 hours for 14 days followed by oral at 10 mg/kg every 6 hours for 28 days), resulting in the resolution of the hepatic abscess and its associated symptoms. CA-MRSA hepatic abscess is extremely rare in immuno-competent children, and an appropriate diagnostic approach involving imaging and culture studies is crucial in its diagnosis and management."

Journal • Hepatology • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

When First-Line Therapies Fail: Surgical Site Infections and the Declining Antimicrobial Utility in a Resource-Limited Nation. (PubMed, Microbiologyopen) - "AMR is prevalent in Belize, with rapidly expanding ESBL rates and significant therapeutic limitations. Urgent interventions are needed, including updated treatment guidelines, targeted antimicrobial stewardship, and enhanced infection control in high-burden areas."

Journal • Retrospective data • Infectious Disease • Pneumonia

Intravenous Ciprofloxacin Versus Intravenous Ceftriaxone: Spontaneous Bacterial Peritonitis in Cirrhosis of Liver (clinicaltrials.gov) - P=N/A | N=310 | Completed | Sponsor: Shahida Islam Medical Complex

New trial • Fibrosis • Immunology • Liver Cirrhosis

Vascular prosthetic infection by Francisella tularensis: a unique case report. (PubMed, IDCases) - "Cultures from the prosthesis, anastomosis, fluid, and subcutaneous tissue were uniformly positive for F. tularensis.Antibiotic therapy was initiated in collaboration with internal medicine, consisting of intravenous gentamicin and ciprofloxacin for two weeks during hospitalization, followed by four additional weeks of intravenous ciprofloxacin via a home-hospitalization program. Reported cases in the literature are limited to joint prostheses, cardiac valves, and a single aortic endograft. Optimal management requires complete graft removal, wide surgical debridement, and targeted antimicrobial therapy."

Journal • Anorexia • Infectious Disease • Pain

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) (clinicaltrials.gov) - P2/3 | N=900 | Recruiting | Sponsor: Monash University | Not yet recruiting ➔ Recruiting

Enrollment open • Trial initiation date • Chronic Lymphocytic Leukemia • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology

Catheter-Related Bloodstream Infection with Leclercia adecarboxylata and Enterobacter cloacae Complex Co-Infection: A Case Report and Literature Review. (PubMed, Microorganisms) - "The patient achieved complete clinical recovery following intravenous ciprofloxacin therapy and prompt removal of the chemoport. This case highlights the emerging clinical relevance of Leclercia adecarboxylata and Enterobacter cloacae complex as potential pathogens capable of causing polymicrobial bloodstream infections in immunocompromised hosts and underscores the importance of considering rare environmental Gram-negative organisms as potential causes of catheter-related infections, particularly in patients with malignancy or long-term vascular access."

Journal • Breast Cancer • Infectious Disease • Oncology • Solid Tumor

Pulmonary Abscess Caused by Neisseria meningitidis: A Case Report. (PubMed, Cureus) - "Directed therapy with intravenous ciprofloxacin (400 mg every eight hours) was initiated, and the patient was maintained under contact isolation, with subsequent clinical and laboratory improvement...Prompt recognition is essential for adequate antibiotic therapy and public health measures. This case highlights the importance of considering N. meningitidis in the differential diagnosis of cavitary lung lesions, reinforcing the need for microbiological surveillance, multidisciplinary management, and targeted therapy."

Journal • Anorexia • Cardiovascular • Chronic Cough • CNS Disorders • Cough • Gastroenterology • Heart Failure • Hematological Disorders • Infectious Disease • Lung Cancer • Meningococcal Infections • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Blastocystis hominis infection inducing gut microbiome dysbiosis and aggravating Parkinson's disease symptoms: a case report. (PubMed, J Med Case Rep) - "This case highlights the need to consider parasitic infections in patients with Parkinson's disease presenting with chronic diarrhea. While we hypothesize that B. hominis infection may transiently worsen Parkinson's disease symptoms through inflammatory or microbiota-mediated pathways, this remains speculative in the absence of microbiome sequencing or objective neurologic evaluation. Further studies integrating clinical, microbiological, and microbiome analyses are warranted."

Journal • Anorexia • CNS Disorders • Fatigue • Infectious Disease • Movement Disorders • Pain • Parkinson's Disease

Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2) (clinicaltrials.gov) - P3 | N=0 | Withdrawn | Sponsor: Tourcoing Hospital | N=280 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal • Inflammation

Seventeen Years of an Antibiotic Stewardship Programme: Trends in Antibiotic Prescribing and Gram-Negative Bacilli Susceptibility at a Quaternary Healthcare Institution. (PubMed, Antibiotics (Basel)) - " We demonstrated sustained improvement in appropriateness of seven broad-spectrum IV antibiotics, accompanied by significant reductions in IV ciprofloxacin, cefepime, and ertapenem use (p < 0.05). With an evolving, multi-pronged stewardship approach, antibiotic prescribing and GNB susceptibility to most antibiotics have improved. In a rapidly evolving healthcare landscape, ASPs must remain agile, continually refining priorities and employing innovative strategies."

Journal • Infectious Disease

TRAUMA-ASSOCIATED CHYRESOBACTERIUM INDOLOGENES (CHEST 2025) - "Patient was treated with IV Ciprofloxacin... C. Indologenes is a rare nosocomial pathogen with a high mortality due to its high frequency for multidrug resistance. Early consideration, detection and treatment is crucial in trauma patients."

Acute Respiratory Distress Syndrome • Chronic Obstructive Pulmonary Disease • Hepatology • Human Immunodeficiency Virus • Hypotension • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Pulmonary Emphysema • Respiratory Diseases

A CASE REPORT: PYOPNEUMOTHORAX SECONDARY TO PSEUDOMONAS AERUGINOSA INFECTION IN A YOUNG VAPER (CHEST 2025) - "He was started on levofloxacin and metronidazole. His pleural fluid cultures isolated pan-sensitive Pseudomonas Aeruginosa, hence his antibiotics were converted to intravenous ciprofloxacin...Pleural tissue cultures grew Pseudomonas Aeruginosa intermediately sensitive to Piperacillin/Tazobactam and ciprofloxacin, therefore antibiotics were changed, and he completed 4 weeks of meropenem with clinical improvement... Doctors should routinely query the history of vaping in working up patients with fever and consider expanding antimicrobial coverage to cover Pseudomonas aeruginosa if patients have significant history of e-cigarette use."

Case report • Clinical • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock

TRAUMA-ASSOCIATED CHRYSEOBACTERIUM INDOLOGENES (CHEST 2025) - "Patient was treated with IV Ciprofloxacin... C. Indologenes is a rare nosocomial pathogen with a high mortality due to its high frequency for multidrug resistance. Early consideration, detection and treatment is crucial in trauma patients."

Acute Respiratory Distress Syndrome • Chronic Obstructive Pulmonary Disease • Hepatology • Human Immunodeficiency Virus • Hypotension • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Pulmonary Emphysema • Respiratory Diseases

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) (clinicaltrials.gov) - P2/3 | N=900 | Recruiting | Sponsor: Monash University

New P2/3 trial • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology

Evaluation of the therapeutic effect of a fly maggot antimicrobial peptide in a Staphylococcus aureus-induced mouse mastitis model. (PubMed, Open Vet J) - "ICR mice were randomly allocated into four groups, with 30 mice in each group: Group I (healthy control), Group II (disease control), Group III (AMP treatment), and Group IV (ciprofloxacin treatment)...AMP administration (10 µl at a concentration of 25.36 µg/ml) resulted in alleviation of clinical symptoms, reduction in bacterial load, and decreased TNF-ɑ levels, accompanied by significant amelioration of histopathological alterations compared with the disease control group. This study demonstrated that maggot-derived AMP holds promise as a potential alternative to conventional antibiotics for the treatment of bovine mastitis, offering a viable therapeutic strategy to address antimicrobial resistance and improve clinical outcomes."

Journal • Preclinical • Review • Infectious Disease

Persistent Vesiculopustular Eruption of Inflammatory Bowel Disease (VPE-IBD) on the scalp that responded to intravenous immunoglobulins and retinoids - A Challenging Case (EADV 2025) - "The patient received antibiotic therapy (IV Ciprofloxacin, p.os Clindamycin 300mgx2 /d for 4 weeks) and antifungal therapy (Itraconazole 200mg/d for 7 weeks) with topical and systemic corticosteroids gradually reduced from 30mg/day...Due to another relapse shortly after the first IvIG infusion,oral isotretinoin 20mg/d was added with a slow dosage reduction and topical combinations of calcipotriol/ betamethasone diproprionate 0.5% and erythromycin/benzoyl peroxide... This is a very rare case as ulcerative colitis was in remission despite the intense dermatological clinical picture, making the treatment challenging. The use of intravenous immunoglobulin with oral retinoids and concomitant topical therapy of calipotriol/corticosteroid/benzoyl peroxide proved to be an effective combination for the treatment of the patient. This combination has not been previously reported in the literature for the corresponding dermatological entity."

Clinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pneumonia • Ulcerative Colitis • IL17A • IL22

Seminal vesicle abscess with orchitis and emphysematous cystitis following traumatic urethral injury from accidental urinary catheter dislodgement. (PubMed, Infect Dis Health) - "Traumatic urinary catheter removal increases the risk of urethral injury and infection; therefore, appropriate measures to prevent catheter dislodgement are essential. Additionally, in urinary tract infections following catheter-related urethral injury, the possibility of progression to an SVA should be considered. Early imaging-based diagnosis, targeted antibiotic therapy, and drainage, when necessary, are crucial for improving patient outcomes."

Journal • Infectious Disease • Nephrology • Respiratory Diseases

Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Gadjah Mada University | Not yet recruiting ➔ Recruiting

Enrollment open • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Febrile Neutropenia • Hematological Malignancies • Leukemia • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology

Developing tailored dosing recommendations for ciprofloxacin in critically ill children using a population approach based on total and unbound concentrations. (PubMed, Clin Microbiol Infect) - "Standard dosing regimens of ciprofloxacin (20-30 mg/kg per day) fail to achieve adequate target attainment in non-ventilated critically ill children with a normal or elevated renal function. Further research should prospectively evaluate the efficacy and safety of intensified ciprofloxacin dosing regimens."

Journal • Critical care • Pediatrics

Pharmacokinetics of Intraperitoneal and Intravenous Meropenem, Ampicillin, Aztreonam and Ciprofloxacin in Automated Peritoneal Dialysis Patients Without Peritonitis (clinicaltrials.gov) - P2/3 | N=24 | Completed | Sponsor: Karl Landsteiner Insitute for Nephrology and Haemato-Oncology

New P2/3 trial