ciprofloxacin IV / Generic mfg. - LARVOL DELTA

TRAUMA-ASSOCIATED CHYRESOBACTERIUM INDOLOGENES (CHEST 2025) - "Patient was treated with IV Ciprofloxacin... C. Indologenes is a rare nosocomial pathogen with a high mortality due to its high frequency for multidrug resistance. Early consideration, detection and treatment is crucial in trauma patients."

Acute Respiratory Distress Syndrome • Chronic Obstructive Pulmonary Disease • Hepatology • Human Immunodeficiency Virus • Hypotension • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Pulmonary Emphysema • Respiratory Diseases

A CASE REPORT: PYOPNEUMOTHORAX SECONDARY TO PSEUDOMONAS AERUGINOSA INFECTION IN A YOUNG VAPER (CHEST 2025) - "He was started on levofloxacin and metronidazole. His pleural fluid cultures isolated pan-sensitive Pseudomonas Aeruginosa, hence his antibiotics were converted to intravenous ciprofloxacin...Pleural tissue cultures grew Pseudomonas Aeruginosa intermediately sensitive to Piperacillin/Tazobactam and ciprofloxacin, therefore antibiotics were changed, and he completed 4 weeks of meropenem with clinical improvement... Doctors should routinely query the history of vaping in working up patients with fever and consider expanding antimicrobial coverage to cover Pseudomonas aeruginosa if patients have significant history of e-cigarette use."

Case report • Clinical • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock

TRAUMA-ASSOCIATED CHRYSEOBACTERIUM INDOLOGENES (CHEST 2025) - "Patient was treated with IV Ciprofloxacin... C. Indologenes is a rare nosocomial pathogen with a high mortality due to its high frequency for multidrug resistance. Early consideration, detection and treatment is crucial in trauma patients."

Acute Respiratory Distress Syndrome • Chronic Obstructive Pulmonary Disease • Hepatology • Human Immunodeficiency Virus • Hypotension • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Pulmonary Emphysema • Respiratory Diseases

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) (clinicaltrials.gov) - P2/3 | N=900 | Recruiting | Sponsor: Monash University

New P2/3 trial • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology

Evaluation of the therapeutic effect of a fly maggot antimicrobial peptide in a Staphylococcus aureus-induced mouse mastitis model. (PubMed, Open Vet J) - "ICR mice were randomly allocated into four groups, with 30 mice in each group: Group I (healthy control), Group II (disease control), Group III (AMP treatment), and Group IV (ciprofloxacin treatment)...AMP administration (10 µl at a concentration of 25.36 µg/ml) resulted in alleviation of clinical symptoms, reduction in bacterial load, and decreased TNF-ɑ levels, accompanied by significant amelioration of histopathological alterations compared with the disease control group. This study demonstrated that maggot-derived AMP holds promise as a potential alternative to conventional antibiotics for the treatment of bovine mastitis, offering a viable therapeutic strategy to address antimicrobial resistance and improve clinical outcomes."

Journal • Preclinical • Review • Infectious Disease

Persistent Vesiculopustular Eruption of Inflammatory Bowel Disease (VPE-IBD) on the scalp that responded to intravenous immunoglobulins and retinoids - A Challenging Case (EADV 2025) - "The patient received antibiotic therapy (IV Ciprofloxacin, p.os Clindamycin 300mgx2 /d for 4 weeks) and antifungal therapy (Itraconazole 200mg/d for 7 weeks) with topical and systemic corticosteroids gradually reduced from 30mg/day...Due to another relapse shortly after the first IvIG infusion,oral isotretinoin 20mg/d was added with a slow dosage reduction and topical combinations of calcipotriol/ betamethasone diproprionate 0.5% and erythromycin/benzoyl peroxide... This is a very rare case as ulcerative colitis was in remission despite the intense dermatological clinical picture, making the treatment challenging. The use of intravenous immunoglobulin with oral retinoids and concomitant topical therapy of calipotriol/corticosteroid/benzoyl peroxide proved to be an effective combination for the treatment of the patient. This combination has not been previously reported in the literature for the corresponding dermatological entity."

Clinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pneumonia • Ulcerative Colitis • IL17A • IL22

Seminal vesicle abscess with orchitis and emphysematous cystitis following traumatic urethral injury from accidental urinary catheter dislodgement. (PubMed, Infect Dis Health) - "Traumatic urinary catheter removal increases the risk of urethral injury and infection; therefore, appropriate measures to prevent catheter dislodgement are essential. Additionally, in urinary tract infections following catheter-related urethral injury, the possibility of progression to an SVA should be considered. Early imaging-based diagnosis, targeted antibiotic therapy, and drainage, when necessary, are crucial for improving patient outcomes."

Journal • Infectious Disease • Nephrology • Respiratory Diseases

Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Gadjah Mada University | Not yet recruiting ➔ Recruiting

Enrollment open • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Febrile Neutropenia • Hematological Malignancies • Leukemia • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology

Developing tailored dosing recommendations for ciprofloxacin in critically ill children using a population approach based on total and unbound concentrations. (PubMed, Clin Microbiol Infect) - "Standard dosing regimens of ciprofloxacin (20-30 mg/kg per day) fail to achieve adequate target attainment in non-ventilated critically ill children with a normal or elevated renal function. Further research should prospectively evaluate the efficacy and safety of intensified ciprofloxacin dosing regimens."

Journal • Critical care • Pediatrics

Pharmacokinetics of Intraperitoneal and Intravenous Meropenem, Ampicillin, Aztreonam and Ciprofloxacin in Automated Peritoneal Dialysis Patients Without Peritonitis (clinicaltrials.gov) - P2/3 | N=24 | Completed | Sponsor: Karl Landsteiner Insitute for Nephrology and Haemato-Oncology

New P2/3 trial

A Case of Severe Septicemia With Chromobacterium violaceum in Bangladesh. (PubMed, Clin Case Rep) - "The patient was treated empirically with intravenous ciprofloxacin and ceftriaxone, leading to full recovery despite resistance to ceftriaxone. This case highlights the need for careful antibiotic selection based on clinical response and sensitivity patterns. Moreover, increasing awareness among healthcare professionals, particularly in tropical and subtropical regions, is vital for early detection and successful treatment of this rare, life-threatening infection."

Journal • Infectious Disease

Intracameral Povidone-Iodine for Multidrug-Resistant Pseudomonas aeruginosa Exogenous Endophthalmitis: A Case Report and Literature Review. (PubMed, Case Rep Ophthalmol) - "The patient had anterior chamber washout, along with aqueous and vitreous tapping with intravitreal vancomycin, ceftazidime, and intravenous ciprofloxacin...Intracameral PI may offer a solution for endophthalmitis cases where standard antibiotics are ineffective. This case supports the potential role of PI in managing resistant intraocular infections."

Journal • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders

Pharmacokinetic and Pharmacodynamic Modeling of Enrofloxacin and Its Metabolite Ciprofloxacin in Pregnant Goats. (PubMed, Vet Sci) - "The aims of this study were (1) to evaluate the pharmacokinetics of enrofloxacin and ciprofloxacin by intravenous and intramuscular administration of 7.5 mg/kg in pregnant goats; (2) to determine the placental transfer of enrofloxacin and ciprofloxacin; (3) to conduct a PK/PD analysis to calculate the PK/PD cutoff of different dose regimens; and (4) to evaluate the tentative epidemiological cutoff values for coagulase-negative staphylococci wild-type isolates from goats. MIC values of coagulase-negative staphylococci isolates (n = 90) were obtained, and tentative epidemiological cutoffs were calculated at 0.25 and 0.5 mg/L for enrofloxacin and ciprofloxacin. According to PK/PDco values, an intravenous dose regimen of 10 mg/kg/day was considered the most appropriate, but based on the PK/PDco, culture, and AST data, an effective dosing regimen with the lowest possible dose could be selected to minimize the potential risk of fetal exposure to enrofloxacin."

Journal • PK/PD data

Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Gadjah Mada University

New P4 trial • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Febrile Neutropenia • Hematological Malignancies • Leukemia • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology

INFECTION THAT MIMICS APPENDICITIS (ESPID 2025) - "MEFV gene – M694V/- SAA1 gen a/b ANA IgG <40 AU/ml 28.1 Anti-ds-DNA IgG <30 IU/ml 2.6 ANCA IgG <1.0 index 0.4 Anti-tTg IgA <10 U/ml 3.7 Ig A 0.34-2.2 g/l 1.76 Ig M 0.45-1.78 g/l 1.43 Ig G 5.95-13.1 g/l 17.0 Treatment Child received ceftriaxone I/V, metronidazole I/V , ciprofloxacin I/V, dexamethasone I/V, azithromycin p/os, pain management. Conclusions/Learning Points Acute yersiniosis can mimic appendicitis and present with right lower quadrant abdominal pain, fever, vomiting, elevated leucocytes, and diarrhea. Patients taken for surgery demonstrate inflammation of the terminal ileum and mesenteric lymph node with a normal appendix."

Infectious Disease • Septic Shock • SAA1

AMYAND'S HERNIA AS A RARE CAUSE OF ABDOMINAL PAIN WITH EARLY APPENDICITIS AND DIVERTICULITIS (SSAT 2025) - "Patient started on IV ciprofloxacin and metronidazole...The patient subsequently returned for elective bilateral herniorrhaphy with mesh repair.ConclusionThis case demonstrates the successful management of Amyand's hernia complicated by diverticulitis using a conservative approach with IV antibiotics and careful monitoring. This strategy reduced the risk of incarcerated Amyand's hernia with acute appendicitis, while allowing for elective repair to prevent recurrence."

Cardiovascular • Dermatology • Gastroenterology • Gastrointestinal Disorder • Pain

AMYAND'S HERNIA AS A RARE CAUSE OF ABDOMINAL PAIN WITH EARLY APPENDICITIS AND DIVERTICULITIS (DDW 2025) - "Patient started on IV ciprofloxacin and metronidazole...Conclusion This case demonstrates the successful management of Amyand's hernia complicated by diverticulitis using a conservative approach with IV antibiotics and careful monitoring. This strategy reduced the risk of incarcerated Amyand's hernia with acute appendicitis, while allowing for elective repair to prevent recurrence."

Cardiovascular • Dermatology • Gastroenterology • Gastrointestinal Disorder • Pain

A case of Helicobacter cinaedi pleuritis and continuous ambulatory peritoneal dialysis-related peritonitis diagnosed by simultaneous-onset bacteremia. (PubMed, IDCases) - "He was admitted, and the levofloxacin was switched to intravenous ciprofloxacin...After three-week intravenous meropenem administration, ten-days of intravenous tazobactam/piperacillin plus vancomycin plus oral minocycline, followed by twelve-days of intravenous cefepime plus oral minocycline were administrated due to hospital-acquired pneumonia...cinaedi infection did not recur thereafter. To our knowledge, this report is the first case of H. cinaedi pleuritis and continuous ambulatory peritoneal dialysis-related peritonitis diagnosed by simultaneous-onset of bacteremia."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

APPEAL: Antibiotic Prophylaxis Before Shock Wave Lithotripsy (clinicaltrials.gov) - P4 | N=1732 | Completed | Sponsor: Clinical Urology and Epidemiology Working Group | Recruiting ➔ Completed

Trial completion • Infectious Disease • Nephrology • Renal Calculi

Comparative study of the inhibitory effects of different antibiotic administration routes on bone healing in a rat tibial infection model. (PubMed, Front Cell Infect Microbiol) - "After six weeks, rats were treated with vancomycin (intravenous), cefazolin (intravenous), ciprofloxacin (oral), or ciprofloxacin combined with rifampin (oral). Intravenous administration of vancomycin demonstrated superior efficacy in controlling bone infection, reducing inflammation, and preserving bone structure compared to oral treatments. While ciprofloxacin and the ciprofloxacin-rifampin combination showed some efficacy, they were less effective than intravenous vancomycin, likely due to lower bioavailability and insufficient drug penetration in bone tissue."

Clinical • Journal • Preclinical • Fibrosis • Immunology • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics

A Case Report of Neisseria sicca Endocarditis in a Patient with Tissue Aortic Valve: Favorable Outcome Following Prompt Multidisciplinary Team Management. (PubMed, Br J Hosp Med (Lond)) - "As per microbiology advice, his antibiotic treatment was adjusted to oral ciprofloxacin and intravenous ceftriaxone for 6 weeks given this organism's sensitivity. Involving acute medicine, microbiology, and cardiology teams as part of a multidisciplinary team (MDT) led to good clinical outcomes and patients remained alive and well on follow-ups. So far only 27 cases have been documented and we think our work would increase insights into management strategies for this condition particularly the utilization of the MDT approach."

Journal • Cardiovascular

"Unmasking the Uncommon": A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates. (PubMed, F1000Res) - "Antibiotic susceptibility testing (AST) revealed resistance to Piperacillin/Tazobactam, but sensitivity to Vancomycin, Levofloxacin, and Minocycline...Intravenous Ciprofloxacin was initiated with clinical improvement and negative follow-up blood cultures...A combination of Levofloxacin and Colistin was added, and blood cultures were negative after seven days, with clinical improvement...Clinicians must have a high degree of suspicion of E. meningoseptica for gram-negative bacilli causing sepsis and meningitis in high-risk patients. Recent technological advances have enabled accurate speciation to guide therapy and reduce morbidity and mortality rates."

Journal • Acute Respiratory Distress Syndrome • CNS Disorders • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock • CRP

BRP30: Antibiotic Prophylaxis for HDR Brachytherapy in the Treatment of Prostate Cancer (clinicaltrials.gov) - P3 | N=158 | Terminated | Sponsor: CR-CSSS Champlain-Charles-Le Moyne | N=255 ➔ 158 | Suspended ➔ Terminated; Covid-19 pandemic

Enrollment change • Trial termination • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Meckel's Diverticulitis-Induced Perforation (ACG 2024) - "Post operatively, she was managed with a nasogastric tube, intravenous ciprofloxacin and metronidazole for a 5-day duration...Despite the rarity of Meckel's diverticulitis, this case also highlighted the treatment of choice for symptomatic Meckel's diverticulum being surgical resection. Figure: Figure 1: A & B both demonstrating calcification near terminus of the blind-ending tubular structure (Meckel's enterolith within diverticulum)"

Gastrointestinal Disorder • Oncology • Pain

Gastrointestinal Complications of Weight Loss Medications: Phentermine-Induced Ischemic Colitis (ACG 2024) - "She was treated with IV ciprofloxacin and metronidazole. CT scan of the abdomen showing sigmoid colon with wall thickening Figure 2. Colonoscopy showing ischemic colitis and colon stripe sign in the sigmoid colon"

Constipation • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Pain • Xerostomia