patupilone (EPO 906) / Novartis - LARVOL DELTA

AI-driven multi-omics integration of cancer-associated fibroblasts for prognostic modeling and therapeutic target discovery in head and neck squamous cell carcinoma. (PubMed, NPJ Precis Oncol) - "Furthermore, therapeutic vulnerabilities were explored by integrating drug sensitivity prediction, AI-assisted cMAP screening, and molecular docking validation, which identified Epothilone B as a promising agent targeting HBEGF. Overall, this research shows that understanding the heterogeneity of CAFs with AI-enabled multi-omics modeling can reveal prognostic biomarkers and therapeutic targets for overcoming resistance, with the ultimate goal of improving precision oncology for HNSCC."

Journal • Tumor mutational burden • Head and Neck Cancer • Microsatellite Instability • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • HBEGF • MSI • TMB

Fast-adapting graph neural network with prior knowledge for drug response prediction across preclinical and clinical data. (PubMed, J Pharm Anal) - "Additionally, metaDRP's inherent interpretability offers reliable insights into drug mechanisms of action, such as elucidating the pathways and molecular targets of drugs like epothilone B and pemetrexed. This work provides a promising approach to overcoming data scarcity and out-of-distribution challenges in drug response prediction, while promoting the integration of few-shot learning in this field."

Clinical data • Journal • Preclinical • Oncology

In Vivo Local Administration of Para-Amino-Bebblistatin to the Injured Spinal Cord Fails to Improve the NaChBac-Expressing DRGs Transplantation. (PubMed, Int J Mol Sci) - "We employ, alone or in combination, blebbistatin and epothilone B, tested in vitro...Nevertheless, when applied in vivo in a model of SCI, local and single para-amino-blebbistatin (a stable analogue of blebbistatin) administration and the transplanted NaChBac expressing sensory neurons limit the functional recovery enabled by neuronal transplantation alone. Thus, despite the beneficial outputs of isolated neuronal cultures that allow selection of in vivo combinatory strategies, the multifaced characteristics of CNS injuries limit the potential success of single and local treatment administration, demanding extended and sustained treatments."

Journal • Preclinical • CNS Disorders • Orthopedics • Transplantation

In situ structural mechanism of epothilone-B-induced CNS axon regeneration. (PubMed, Nature) - "These microtubule shoots serve as scaffolds for various types of vesicles and endoplasmic reticulum, facilitating the supply of materials necessary for axon repair until membrane tension normalizes. We demonstrate the unexpected ability of neuronal cells to adjust to strain induced by epothilone B, which creates homeostatic imbalances and activates axons to regeneration mode."

Journal

Targeted environmental enrichment is more effective than bipedal treadmill training after thoracic spinal cord injury. (PubMed, Brain Commun) - "Our findings indicate that targeted environmental enrichment outperforms bipedal training across several behavioural measures which produced a ceiling effect that epothilone B could not overcome. Therefore, these results suggest that targeted environmental enrichment may be a more effective rehabilitation approach than B-TMT and should be considered for application in models of severe spinal cord injury."

Journal • CNS Disorders • Musculoskeletal Diseases • Orthopedics

Expression of Concern: Epothilone B Benefits Nigrostriatal Pathway Recovery by Promoting Microtubule Stabilization After Intracerebral Hemorrhage. (PubMed, J Am Heart Assoc) - "The editors and Scientific Publishing Committee are in communication with the authors regarding the integrity of the image data, and Loma Linda University has confirmed the concerns are being reviewed. While we await the outcome of this review, we are publishing this Expression of Concern to indicate that the data and statements in the article may not be reliable."

Journal • Cerebral Hemorrhage • Hematological Disorders

Prognostic risk model of gastric adenocarcinoma based on exosome-related genes. (PubMed, Medicine (Baltimore)) - "Drug sensitivity analysis indicated that bortezomib, docetaxel, and epothilone B were more effective in the high-risk group. The exosome-related risk model constructed in this study can effectively predict the prognosis of patients with STAD."

Biomarker • Journal • Gastric Adenocarcinoma • Gastric Cancer • Oncology • Solid Tumor • APOA1 • APOD • SERPINE1

Construction of a prognostic model for hepatocellular carcinoma based on necrosis by sodium overload-related genes and identification of ANKRD13B as a new prognostic marker. (PubMed, Funct Integr Genomics) - "Drug sensitivity analysis identified eight chemotherapeutic agents with heightened sensitivity in high-risk patients: BI.2536, Bleomycin, Cisplatin, Doxorubicin, Epothilone B, Gemcitabine, Mitomycin C, and Paclitaxel. We established a novel NECSO prognostic model demonstrating good predictive capacity for HCC prognosis and therapeutic responsiveness. This model helps with personalized clinical management."

Biomarker • IO biomarker • Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor

Machine learning-based characterization of a PANoptosis-associated model for enhancing prognosis and immunotherapy response in lung adenocarcinoma patients. (PubMed, Discov Oncol) - "The present study developed a PRS using 101 machine learning combination algorithms, which could aid in risk stratification and prognosis for LUAD patients. The candidate drugs and target may provide new insights in the treatment of high PRS group patients."

IO biomarker • Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • TRPA1

m6A-Mediated Methylation Patterns and Their Association With Obstructive Sleep Apnea in Lung Adenocarcinoma. (PubMed, Cancer Rep (Hoboken)) - "Analyses confirmed m6A modification's role in LUAD progression, immune regulation, and outcomes. The m6A score is a valuable prognostic marker associated with survival, OSAHS incidence, and drug sensitivity. These findings highlight m6A's potential as a therapeutic target and biomarker, particularly for LUAD patients with OSAHS."

Biomarker • IO biomarker • Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Obstructive Sleep Apnea • Oncology • Respiratory Diseases • Sleep Disorder • Solid Tumor

Epothilone B from Aspergillus fumigatus with a strong antiproliferative and anti-tubulin polymerizing activities; apoptosis, and cell cycle analyses. (PubMed, BMC Microbiol) - "The level of released LDH of HepG-2 cells was increased exponentially with the Epothilone concentration, ensuring their negative effect on the plasma membrane permeability. From the docking results, the binding energy of Epothilone B with the tubulin-β was -9.96 kcal/mol, that was lower than Taxol (-7.87 kcal/mol), ensuring the higher affinity of Epothilone B to bind with the β-tubulin protein."

Journal • Oncology • CASP9

Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine. (PubMed, Front Immunol) - "Furthermore, drug sensitivity analysis indicated that high-risk patients were more sensitive to Thapsigargin, Docetaxel, AKT inhibitor VIII, Pyrimethamine, and Epothilone B, while showing higher resistance to drugs such as I-BET-762, PHA-665752, and Belinostat. This study provides a comprehensive analysis of NRGs in BC and establishes reliable ML-based diagnostic and prognostic models. The findings highlight the clinical relevance of NRGs in BC progression, immune regulation, and therapy response, offering potential targets for personalized treatment strategies."

Biomarker • Gene Signature • IO biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • CD2 • IL21 • PRDX1 • ULBP2

Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer (clinicaltrials.gov) - P2 | N=349 | Active, not recruiting | Sponsor: National Cancer Institute (NCI) | Trial completion date: Mar 2025 ➔ Mar 2026

Trial completion date • Carcinosarcoma • Endometrial Adenocarcinoma • Endometrial Cancer • Endometrial Serous Adenocarcinoma • Oncology • Sarcoma • Solid Tumor • Uterine Cancer • AKT1

Sialyltransferase gene signature as a predictor of prognosis and therapeutic response in kidney renal clear cell carcinoma. (PubMed, Discov Oncol) - "This study successfully developed a prognostic model based on SRGs, effectively predicting the prognosis and drug response of KIRC patients. The model demonstrated significant predictive performance and potential clinical application value. Furthermore, the study highlighted the critical role of sialylation in KIRC, offering new insights into its underlying mechanisms in tumor biology. These findings could guide personalized treatment strategies for KIRC patients, emphasizing the importance of sialylation in cancer prognosis and therapy."

Gene Signature • Journal • Clear Cell Carcinoma • Clear Cell Renal Cell Carcinoma • Oncology • Renal Cell Carcinoma • Solid Tumor • CD4

Effect of epothilone B on the expression of neuroproteins after anastomosis of the sciatic nerve transection in the rat. (PubMed, BMC Surg) - "The expression of fibronectin (FN) was significantly lower in the EpoB group, while the expression of Tau, neurofilament-M (NF-M), and growth-associated protein-43 (GAP-43) was significantly higher. In conclusion, EpoB treatment significantly increases the expression of Tau, NF-M, and GAP-43, suggesting a positive effect on axonal regeneration and repair."

Journal • Preclinical • Oncology • FN1

Poster Session: Abnormal GSK3β activity affects Drosophila vision. (PubMed, J Vis) - "To test whether this was due to MT unbundling, flies were fed with the MT-stabilising drug, Epothilone B (EpoB). The drug did not rescue the visual defects but instead led to adverse effects. Taken together, these results suggest that GSK3β dysregulation leads to neuronal dysfunction in the fly visual system, but MT unbundling may not be the sole mechanism underlying these visual defects."

Journal • GSK3B

Ixabepilone and Temsirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery (clinicaltrials.gov) - P1 | N=22 | Active, not recruiting | Sponsor: National Cancer Institute (NCI) | Trial completion date: Mar 2025 ➔ Mar 2026

Trial completion date • Oncology • Solid Tumor

Ixabepilone in Treating Participants With Significant Residual Disease of HER2/Neu Negative Invasive Breast Cancer After Systemic Therapy (clinicaltrials.gov) - P2 | N=116 | Active, not recruiting | Sponsor: M.D. Anderson Cancer Center | Trial completion date: Dec 2024 ➔ Dec 2026 | Trial primary completion date: Dec 2024 ➔ Dec 2026

Trial completion date • Trial primary completion date • Breast Cancer • HER2 Breast Cancer • HER2 Negative Breast Cancer • Oncology • Solid Tumor • CTCs • HER-2

A novel HER2 targeting nanoagent self-assembled from affibody-epothilone B conjugate for cancer therapy. (PubMed, J Nanobiotechnology) - "Moreover, the abundant presence of ZHER2:342 on the surface effectively enhances the targeting capacity and tumor accumulation of the drug. Z-E ADCN can be internalized by cancer cells via HER2 receptor-mediated endocytosis followed by Epo B release in response to high levels of ROS, resulting in excellent anticancer efficacy in HER2-positive tumor models."

Journal • Oncology • HER-2

Production and bioprocessing of epothilone B from Aspergillus niger, an endophyte of Latania loddegesii, with a conceivable biosynthetic stability: anticancer, anti-wound healing activities and cell cycle analysis. (PubMed, Microb Cell Fact) - "The epothilone productivity by A. niger was reduced by ~ 2.4 folds by 6 months storage as a slope culture at 4 °C, however, the epothilone productivity was slightly restored with ethylacetate extracts of L. loddegesii, confirming the plant-derived chemical signals that partially triggers the biosynthetic genes of A. niger epothilones. So, this is the first report emphasizing the metabolic potency of A. niger, an endophyte of L. loddegesii, to produce epothilone B, that could be a new platform for industrial production of this drug."

Journal • Oncology • Solid Tumor

Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats. (PubMed, eNeuro) - "Anesthetic gases including isoflurane bind to cytoskeletal microtubules (MTs) and dampen their quantum optical effects, potentially contributing to causing unconsciousness. This finding has potential clinical implications for understanding how taxane chemotherapy interferes with anesthesia in humans, and more broadly for avoiding anesthesia failures during surgery. Our results are also theoretically important because they provide support for microtubule-based theories of anesthetic action and consciousness."

Journal • Preclinical • Anesthesia • Oncology

Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer (clinicaltrials.gov) - P2 | N=349 | Active, not recruiting | Sponsor: National Cancer Institute (NCI)

Metastases • Trial completion date • Endometrial Adenocarcinoma • Endometrial Cancer • Endometrial Serous Adenocarcinoma • Oncology • Solid Tumor • Uterine Cancer • AKT1

Establishment of Golgi apparatus-related genes signature to predict the prognosis and immunotherapy response in gastric cancer patients. (PubMed, Medicine (Baltimore)) - "Notably, the low-risk group exhibited higher sensitivity to epothilone.B, metformin, and tipifarnib compared to the high-risk group. The nomogram incorporating these factors demonstrated improved performance in predicting gastric cancer prognosis. Our study established risk features derived from GARGs that hold potential clinical utility in prognostic assessment and immune therapy response evaluation of gastric cancer patients."

IO biomarker • Journal • Tumor mutational burden • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • ABCG1 • CHAC1 • NGF • TMB

Ixabepilone and Temsirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery (clinicaltrials.gov) - P1 | N=22 | Active, not recruiting | Sponsor: National Cancer Institute (NCI)

Metastases • Surgery • Trial completion date • Gastrointestinal Cancer • Oncology • Solid Tumor

Deciphering disulfidptosis: Uncovering a lncRNA-based signature for prognostic assessment, personalized immunotherapy, and therapeutic agent selection in lung adenocarcinoma patients. (PubMed, Cell Signal) - "The current study established a powerful prognostic DISULncSig signature for LUAD that was also valid for most pan-cancers. This signature could serve as a potential target for immunotherapy and might help the more efficient application of drugs to specific populations."

IO biomarker • Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • BTLA • CD40LG • IL10 • IL2 • KIR2DL3 • SELP