Flarex (fluorometholone acetate ophthalmic suspension) / Novartis, Harrow Health - LARVOL DELTA

Replacement names for junior homonyms in ants (Hymenoptera, Formicidae). (PubMed, Zookeys) - "nov., Camponotites flarex nom...nov.; Pseudoneoponera vidua (Smith, 1857), and Diacamma solitaria (Smith, 1860b), comb. nov."

Journal

Exposure to synthetic steroid hormones and precocious puberty in girls: A case-control study. (PubMed, Ecotoxicol Environ Saf) - "Prednisolone (0.31), fluorometholone acetate (0.24), and dexamethasone acetate (0.12) had the highest weight. In conclusion, precocious puberty was associated with halcinonide and budesonide exposure, but not steroid hormone mixture among girls. It highlighted the management of the residual synthetic steroid hormones in the environment and provided a direction for the prevention of precocious puberty."

Journal • Pediatrics

Effectiveness of Fluorometholone Acetate (FA) 0.1% Topical Eye Drops in Improving IOL Objective Measurements through Corneal Rehabilitation (ASCRS-ASOA 2023) - "Purpose Show how FA (3x/d) and FreshKote PF (FPF; 3x/d, 5 min post FA dosing) may improve pre-operative IOL values by: Δ in total corneal refractive power (TCRP) magnitude >0.30 D or axis >5°; Δ in total corneal irregular astigmatism 4 mm HOA of ≥10%; Δ in corneal keratometry SimK readings >0.30 D or axis >5°; Δ in spherical aberration Z40 6 mm zone >10%.MethodsIn this single-arm, single-site, unmasked, controlled study, each subject underwent a screening visit (Visit 1) to determine study eligibility.At Visit 1, preoperative IOL topography measurements (including SPEED questionnaire, Snellen visual acuity, biomicroscopy, topography using Pentacam images [TCRP and Ks], adverse event [AE] assessment) were evaluated prior to use of FA and FKPF.At Visit 2 (Day 25 ±4 days after initiation of FA and FPF), ophthalmic evaluations of safety and efficacy conducted at Visit 1 were repeated.Ongoing serious AEs not resolved at Visit 2, were followed..."

Astigmatism • Cataract • Ophthalmology

Effect of fluorometholone acetate, an ophthalmic steroid-ester, on ocular surface mucins (ARVO 2022) - "Fluorometholone acetate causes a moderate increase in mucin 1 levels in human corneal epithelial cells but does not modulate mucin 4 or 16 protein levels in human corneal and conjunctival epithelial cells."

Ocular Inflammation • Ophthalmology • MUC1 • MUC4

Improving Critical Pre-Operative IOL Measurements By Treating Ocular Surface Inflammation through a Corneal Rehabilitation Protocol (ASCRS-ASOA 2022) - "Purpose The primary objective of this study is to demonstrate the effectiveness of fluorometholone acetate 0.1% topical eyedrops and Freshkote PF lubricant drops to improve critical pre-operative IOL measurements by change in total corneal spherical aberration, change in total corneal irregular astigmatism, change in corneal keratometry and Sim K readings. Conclusion Expected conclusion would be the optimization of IOL class (multifocal, EDOF, monofocal) asphericity of IOL, and potential modification of IOL power, toxicity, and axis of astigmatism. Optimization of corneal surface parameters pre IOL selection for cataract surgery using defined Pentacam values will allow more specificity in IOL selection."

Clinical • Astigmatism • Cataract • Dry Eye Disease • Immunology • Inflammation • Ocular Inflammation • Ophthalmology

"So it says that Flarex has the treatment of DED signs on its label??? The FDA granted label?" (@chooblaykhan)

FDA event

[VIRTUAL] Rare Presentation of Perilimbal Cysts in Vernal Keratoconjunctivitis (AAOPT 2020) - "Additionally, Flarex (Flourometholone acetate 0.1%) was added to her treatment dosed at four times daily...The cause of perilimbal cyst development with VKC is unknown. These cysts should be further monitored as complications can develop."

Conjunctivitis • Corneal Abrasion • Dry Eye Disease • Keratitis • Ocular Inflammation • Ophthalmology

[VIRTUAL] Abscess Formation Secondary to Dacryocystitis in a Patient with Chronic Ocular Allergies (AAOPT 2020) - "Quick management of abscess is key to avoid severe complications, such as sepsis, and prevent future episodes of dacryocystitis. Case History 50 y.o African American maleCC: eyelids swollen shut OD with yellow discharge, pain, and a large bump near the nose for one dayPain of 9.5 out of 10Ocular Hx: chronic allergic conjunctivitis, dry eye syndromePatient using Pazeo BID OU, Flarex TID OD/BID OS, OcuSoft lid wipes and warm compressesHistory of sinus issuesNo systemic meds Pertinent Findings Initial visit:3+ periorbital cellulitis OD3+ dacryocystitis, erythema OD3+ conjunctival injection and 3+ SPK ODCopious mucopurulent drainageRed cap culture: abnormal, heavy growth of Staphylococcus aureus2nd visit (2 days later):Pain resolvedSwelling improved, puncta normal1+ conjunctival injection Differential Diagnosis Primary diagnosis: Acute dacryocystitisOthers:Preseptal cellulitisOrbital cellulitisAcute ethmoid sinusitis Diagnosis and Discussion..."

Clinical • Conjunctivitis • Dry Eye Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Why Choose Flarex? (eyetube) - "Laura Periman, MD, and Derek Cunningham, OD, discuss key aspects of Flarex (Eyevance Pharmaceuticals), a topical ophthalmic treatment for ocular surface inflammation and dry eye disease."

Audio

Impact of Ocular Surface Disease Treatment in Patients with Glaucoma. (PubMed, Clin Ophthalmol) - "A treatment for OSD with eyelid hygiene, fluorometholone acetate 0.1%, preservative-free lubricants, free-acid supplementation and oral tetracyclin derivate was started, and the same evaluation was performed...The prevalence of OSD signs and symptoms was high in glaucoma patients under medical treatment. Short-term OSD treatment may improve ocular surface disease and IOP control, with no need to discontinue glaucoma medications."

Clinical • Journal

Don’t shy away from steroid use for surgery patients (Optometry Times) - "Lotemax SM was also designed to be patient-friendly with the moisturizing ingredients glycerin and propylene glycol, a pH close to that of human tears and the lowest preservative percentage (0.003% benzalkonium chloride), in a loteprednol etabonate formulation. The same was done by Kala Pharmaceuticals with the introduction of its steroid Inveltys (loteprednol etabonate ophthalmic suspension 1%), which utilized Kala’s proprietary AMPPLIFY Drug Delivery Technology to enhance penetration into target tissues of the eye."

Online posting

The Impact of Ocular Surface Disease Treatment in Patients with Glaucoma (ARVO 2019) - "OSD treatment consisting of eyelid hygiene twice day, fluorometholone acetate 0,1%, preservative-free lubricant every 2 hours, fatty acid supplementation, and oral doxycycline 100 milligrams per day along with glaucoma topical medications. Conclusions OSD signs and symptoms represent a challenge in glaucoma patients. Treatment can improve ocular surface parameters and symptoms improving compliance and the IOP control."

Clinical

Cool Crosslinking: ' Riboflavin at 4o C for the Management of Pain After Crosslinking for Keratoconus Patients.” (ARVO 2019) - "...Postoperative treatment included moxifloxacin) (Vigamox, Alcon) 1 gtt every 8 hours, fluormetholone (Flarex, Alcon) every 8 hours hyaluronic acid drops 0.15% (Thea) as needed and ketorolac 10mgs (Supradol,Liomont) as needed...One of the pitfalls of this treatment is inmediate postoperative pain. Our study demonstrates that impregnation with riboflavin at 4oC reduces patient discomfort and pain significantly."

Clinical

Medication exposure and cataract risk using a medication-wide association study approach (ARVO 2019) - "...The top medications (P< 10-30) were mostly ocular medications such as homatropine hydrobromide, fluorometholone acetate, latanoprost, tobramycin etc. Conclusions This study has shown the validity of utilising an innovative MWAS method to investigate the associations between environmental risks and common diseases...We used a new approach, named MWAS (medication- wide association study), to identify which medications may increase the risk of getting cataracts. This approach has found some medications might be related to cataracts which have not been found by earlier research."