baclofen / Generic mfg. - LARVOL DELTA

Multicenter Retrospective Cohort Study Evaluating the Efficacy of Extracorporeal Therapies Versus Medical Therapy for the Treatment of Severe Baclofen Intoxication in Dogs. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "ECT is associated with high survival despite large estimated exposure doses. Although ECT was associated with a shorter duration of MV, no difference was found in survival or hospitalization time."

Journal • Retrospective data

028: Spasticity Management in Post-Stroke Recovery: Discussing Different Case Presentations (ISC 2026) - "Other conventional therapies include oral antispasmodics, botulinum toxin injections, baclofen pumps, and casting...We also plan to have an American Heart Association stroke survivor representative who is a neurologist herself who suffers from chronic spasticity, and her perspective can help in learning about the real-world therapeutics she has used to improve her quality of life and functional outcomes. The session's goal is to increase audience interaction through a case-based approach to the presentation that will lead to practical improvements in functional outcomes and symptom control for patients."

Clinical • Cardiovascular • Movement Disorders

Post-Stroke Spasticity: Gaps in Documentation, Treatment, and Recovery (ISC 2026) - "Treatments included PT/OT (n=14, 41.2%), oral baclofen (n=11, 32.4%), and botulinum toxin injections (n=6, 17.6%), with adherence rates of 92.9%, 81.8%, and 50% respectively...Race was associated with spasticity (p=0.034), with higher rates in African Americans; sex, age, and ethnicity did not differ.This preliminary analysis showed functional differences in post-stroke patients with spasticity and highlights variations in documentation, timing, and treatment practices. Expanding to a larger cohort will clarify these patterns and inform strategies to improve long-term recovery."

Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Movement Disorders

Reproductive stress response in male black molly Poecilia sphenops: Evidence for receptor specific regulation by GABA. (PubMed, J Neuroendocrinol) - "Furthermore, selective receptor activation with muscimol (a GABAA receptor agonist) and baclofen (a GABAB receptor agonist) significantly enhanced cortisol secretion from the head-kidney, while gabazine and CGP-35348 suppressed cortisol production, indicating direct peripheral GABAergic modulation. These findings demonstrate a dual role for GABA in stress regulation, involving central activation of the GABAergic neuronal system and peripheral stimulation of cortisol secretion. The study provides novel insights into the GABA-mediated suppression of testicular spermatogenesis and steroidogenesis under stress, particularly through GABAA receptors, and suggests that pharmacological antagonism of GABAA receptors may help mitigate stress-induced reproductive dysfunction in viviparous teleosts."

Journal

Comparing the Effects of Baclofen, Transcutaneous Electrical Nerve Stimulation, and Sustained Stretch for Treating Spasticity After Traumatic Spinal Cord Injury: A Randomized Clinical Trial. (PubMed, Cureus) - "Baclofen provided the fastest relief, while sustained stretch showed delayed but comparable efficacy, without adverse effects. These findings suggest that sustained stretch may serve as a non-pharmacological alternative to baclofen for managing spasticity in SCI patients."

Clinical • Journal • CNS Disorders • Movement Disorders • Orthopedics

Unravelling GABA Dysfunction in Autism: Pathophysiological Insights and Emerging Treatments. (PubMed, Int J Dev Neurosci) - "Among these, GABAB receptor agonists, including arbaclofen and baclofen, show the most promise in improving social behaviour and reducing core ASD symptoms. Conversely, some agents that elevate GABA levels, such as vigabatrin and valproic acid, may exacerbate ASD-like features under certain conditions. Collectively, the data suggest that targeted modulation of GABAergic pathways, particularly GABAB receptor signalling, offers a viable avenue for therapeutic intervention in ASD. However, further mechanistic studies and well-designed clinical trials are required to elucidate the optimal strategies for harnessing GABA modulation in ASD management."

Journal • Review • Autism Spectrum Disorder • Genetic Disorders

Selecting Neuromodulation Devices For Chronic Pain Conditions: A Narrative Review. (PubMed, Pain Physician) - "Neuromodulation continues to advance at the intersection of neuroscience, bioengineering, and clinical practice. Harmonizing definitions, classifications, and education will guide future innovation and help ensure that neuromodulation fulfills its promise of safe, effective, and equitable patient care."

Journal • Review • CNS Disorders • Diabetic Neuropathy • Migraine • Musculoskeletal Pain • Neuralgia • Pain

Targeting the SIRT1-NAT10-GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane-Induced Cognitive Impairment in Aging. (PubMed, CNS Neurosci Ther) - "SIRT1 alleviates POCD by deacetylating NAT10 to reduce Gababr1 mRNA acetylation, thereby normalizing synaptic inhibition and restoring metabolic-autophagic balance. The SIRT1-NAT10-GABABR1 axis represents a novel therapeutic target for anesthesia-related neurotoxicity."

Journal • Alzheimer's Disease • Anesthesia • Cognitive Disorders • NAT10

sAPPα inhibits neurite outgrowth in primary mouse neurons via GABA B Receptor subunit 1a. (PubMed, eNeuro) - "In mouse primary hippocampal neurons of either sex, the GABABR agonist baclofen reduced axon length; whereas, its antagonist CGP54626 increased axon length in primary hippocampal neurons...In this study, we uncover a previously unrecognized role of the GABA B Receptor in mediating the inhibitory effects of sAPPα on neurite outgrowth. These findings provide mechanistic insight into how disruptions in APP signaling could influence both normal brain development and pathological processes in neurodevelopmental disorders and Alzheimer's disease."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Developmental Disorders • Psychiatry • APP

Opisthotonus: Revisiting a classic movement disorder. (PubMed, J Neurol Sci) - "Identifying the underlying etiology of opisthotonus is important to guide therapeutic strategies. Benzodiazepines, baclofen, anticholinergics, and botulinum toxin are common pharmacological options, whereas deep brain stimulation and surgical correction of the underlying cause should be considered in selected cases."

Journal • Review • CNS Disorders • Dystonia • Epilepsy • Infectious Disease • Metabolic Disorders • Movement Disorders • Tetanus • FTL

GABA Receptor Activation in Müller Glia as a Molecular Switch for Controlling VEGF-A in the Retina. (PubMed, ASN Neuro) - "Cells were exposed to GABA and selective agonists or antagonists of GABAA (muscimol, gabazine) and GABAB receptors (baclofen, CGP55845)...To assess Ca2+ involvement, we used Ca2+-free Ringer-Krebs solution and the L-type channel blocker nimodipine, and examined MAPK signaling with the ERK1/2 inhibitor FR180204...Short-term assays revealed that GABA rapidly elevates VEGF-A protein and secretion within ∼30 minutes. Together, these findings identify a Ca2+- and GABAA-dependent pathway through which Müller glia regulate VEGF-A production and release, providing new insight into glial signaling and neurotransmitter-driven modulation of retinal angiogenic factors."

Journal • Developmental Disorders • VEGFA

BABET: Baclofen for Improving Benzodiazepine Titration in Benzodiazepine Dependence (clinicaltrials.gov) - P2/3 | N=93 | Recruiting | Sponsor: Hospices Civils de Lyon | Not yet recruiting ➔ Recruiting | Trial completion date: Sep 2027 ➔ Oct 2028 | Trial primary completion date: Sep 2027 ➔ Oct 2028

Enrollment open • Trial completion date • Trial primary completion date

The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster (clinicaltrials.gov) - P=N/A | N=750 | Recruiting | Sponsor: Beijing Tiantan Hospital

New trial • Herpes Zoster • Pain • Varicella Zoster

Multimodal analysis study on intrathecal baclofen infusion therapy for hereditary spastic paraplegia (ChiCTR) - P4 | N=20 | Not yet recruiting | Sponsor: The University of Hongkong - Shenzhen Hospital; The University of Hongkong - Shenzhen Hospital

New P4 trial • Genetic Disorders

The role of auxiliary GABAB receptor subunit KCTD16 in pain modulation. (PubMed, Neurobiol Dis) - "The GABAB receptor agonist Baclofen produced strong analgesic effects in WT mice under both basal and inflammatory conditions, whereas its anti-allodynic efficacy was significantly reduced in KO animals...These findings indicate that KCTD16 plays a critical role in presynaptic modulation of inhibitory control in the spinal dorsal horn, affecting the balance between the excitation and inhibition in nociceptive circuits. Collectively, these results demonstrate that KCTD16 modulates GABAB receptor-dependent inhibitory control of nociceptive signaling and highlight the GABAB receptor-KCTD16 complex as a promising new molecular target for effective pain treatments."

Journal • Inflammation • Pain

Quantitative Electroencephalogram in Persons with Alcohol Dependence Syndrome: A Pre- and Post-Treatment Findings. (PubMed, Clin EEG Neurosci) - "Baclofen was offered post-detoxification with regular follow-ups...Absolute power trends were similar, with a statistically significant reduction noted in the delta wave (p-value=.024). No significant correlation was found between severity of dependence and wave powers, except for gamma in the fronto-parietal region (p-value=.01) and beta in the central region (p-value=.021).ConclusionqEEG changes with detoxification and abstinence may serve as an objective indicator for assessing treatment efficacy and abstinence status in alcohol dependence."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders

Adverse drug events from paediatric use of extemporaneously compounded medicines in community pharmacy settings: a scoping review. (PubMed, BMJ Paediatr Open) - "This review highlights the importance of thoroughly verifying active ingredients and their concentrations when compounding paediatric formulations in community pharmacies."

Adverse events • Journal • Pediatrics

Clinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review. (PubMed, CNS Drugs) - "Baclofen toxicity and withdrawal can become severe or life threatening, underscoring the need for prompt recognition and careful medical management. Clinicians should exercise caution when prescribing baclofen, particularly at higher doses (≥ 300 mg/day). Prospective studies and standardized clinical guidelines are needed to enhance patient safety and optimize outcomes. PROSPERO number CRD420251155708."

Journal • Review • Addiction (Opioid and Alcohol) • CNS Disorders • Critical care • Depression • Epilepsy • Mental Retardation • Movement Disorders • Psychiatry

The influence of intrathecal baclofen pumps on outcomes following spinal fusion in non-ambulatory patients with cerebral palsy. (PubMed, Spine Deform) - "The presence of ITBP did not increase the general risk of complications for children with ITBP. However, children with ITBP experienced more surgical site infections, longer surgery durations, and a higher percentage of blood loss. Results will improve counseling between surgeons, children, and caregivers regarding the risk of spinal fusion surgery when ITBPs are present."

Journal • Cerebral Palsy • CNS Disorders • Infectious Disease • Movement Disorders • Orthopedics • Pediatrics

Response to bilateral globus pallidus interna (GPi) deep brain stimulation in a woman with dystonia due to ATP1A3 p.Arg756Cys (ACMG 2026) - "Treatment and Management After earlier treatment with botulinum toxin and baclofen and unsuccessful trials of carbidopa-levodopa, the patient underwent bilateral GPi DBS placement at age 17...She remains on clonazepam, which has shown efficacy for her dystonia...Her epilepsy is responsive to levetiracetam monotherapy...Diagnostic Workup In childhood, she underwent extensive genetic and metabolic workup for neurodegenerative diseases, including muscle biopsy and CSF studies. ATP1A3 was tested in a research lab with negative results before ATP1A3 p.Arg756Cys was found via gene panel at age 28."

Clinical • Ataxia • CNS Disorders • Depression • Dystonia • Epilepsy • Infectious Disease • Movement Disorders • Parkinson's Disease • Postpartum Depression

Bridging Genomics and Pharmacoepidemiology to Expand Treatment Options for Alcohol Use Disorder. (PubMed, medRxiv) - "An evaluation of the real-world effectiveness of baclofen using national EHR data from the United States Department of Veterans Affairs provided evidence that baclofen-exposed patients reduced alcohol consumption more than propensity-score-matched unexposed patients. This approach, which aligns genomic findings with real-world clinical data, provides an efficient method for identifying promising drug repurposing candidates and prioritizing those that merit evaluation in randomized trials to ultimately advance pharmacotherapies for AUD."

Journal • Addiction (Opioid and Alcohol)

Baclofen Potentiates Neurological Impairment in Dialysis Disequilibrium Syndrome. (PubMed, Cureus) - "These findings suggest that in the setting of poor renal excretion in ESRD, a residual level of baclofen remained after HD that was sufficient to lower the magnitude of BUN reduction necessary to elicit the patient's symptoms of DDS. Therefore, it is recommended that when baclofen and dialysis are co-administered to first-time HD patients, dialysis length and flow rate should not be arbitrarily set or modified but instead titrated to BUN levels so that each daily clearance of BUN is ≤20 mg/dL."

Journal • Chronic Kidney Disease • CNS Disorders • Depression • Movement Disorders • Nephrology • Psychiatry • Renal Disease

Effect of high-dose baclofen on post-traumatic stress disorder symptoms five years after hospitalization among critically ill patients with unhealthy alcohol use. (PubMed, Sci Rep) - P | "High-dose baclofen administered during mechanical ventilation did not reduce the 5-year prevalence of PTSD symptoms, nor did it impact quality of life or symptoms of anxiety and depression. Further research is needed to explore alternative strategies for preventing long-term psychological consequences in this population.Trial registration : NCT05877807, 03 april 2023, retrospectively registered."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Critical care • Depression • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

AN UNUSUAL CASE OF CEREBELLAR ISCHEMIC STROKE INITIALLY PRESENTING AS ISOLATED HEMIFACIAL SPASM WITHOUT OTHER NEUROLOGICAL SYMPTOMS AND SIGNS (ADPD 2026) - "Her symptoms were improved by atorvastatin, antiplatelet medication and symptomatic medications including baclofen and clonazepam. For now, we report for the first time a rare manifestation of cerebellar ischemic stroke initially presenting isolated hemifacial spasm without other neurological symptoms and signs. As like this case, if there are abrupt-onset isolated hemifacial spasm, it should be considered diagnosis of cerebellar ischemic stroke."

Clinical • Cardiovascular • Ischemic stroke

DIVERSE ALZHEIMER'S DISEASE GENETICS AND MULTI-OMICS DATA FUEL TARGET AND DRUG DISCOVERY: A CASE STUDY FROM THE NIH/NIA AI/ML CONSORTIUM (ADPD 2026) - "We demonstrated that EC5026 (a first-in-class, picomolar EPHX2 inhibitor) improves cognition in a 5xFAD mouse model. Combining genetics and multi-omics data via AI/ML technologies identifies ancestry-specific therapeutic targets and medicines for Alzheimer's disease."

Case study • Clinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • p-tau181