nitric oxide (AIT-CF) / Beyond Air - LARVOL DELTA

Gait Characterization in Duchenne Muscular Dystrophy (DMD) Using a Single-Sensor Accelerometer: Classical Machine Learning and Deep Learning Approaches. (PubMed, Sensors (Basel)) - "ML approaches using temporospatial gait CFs and raw data varied in effectiveness at differentiating between DMD and TD controls at different speeds, with an accuracy of up to 100%. We demonstrate that by using ML with accelerometer data from a consumer-grade smartphone, we can capture DMD-associated gait characteristics in toddlers to teens."

Journal • Machine learning • Duchenne Muscular Dystrophy • Genetic Disorders • Muscular Dystrophy

Gait Characterization in Duchenne Muscular Dystrophy (DMD) Using a Single-Sensor Accelerometer: Classical Machine Learning and Deep Learning Approache (MDA 2024) - "ML approaches using temporospatial gait CFs and raw data varied in effectiveness at differentiating between DMD and TD controls at different speeds, with an accuracy of up to 100%. We demonstrate that by using ML with accelerometer data from a consumer-grade smartphone, we can capture DMD-associated gait characteristics in toddlers to teens."

Machine learning • Duchenne Muscular Dystrophy • Genetic Disorders • Muscular Dystrophy

Beyond Cancer Presents Positive Preclinical Data for Ultra-High Concentration Nitric Oxide (UNO) Therapy in Solid Tumors During the American Association for Cancer Research (AACR) 2023 Annual Meeting (GlobeNewswire) - "Beyond Cancer, Ltd...announced promising new in vivo and in vitro data that support the potential of the company’s novel UNO therapy to treat various types of solid tumors as a single agent and in combination with checkpoint inhibitors. These data were presented today at the American Association for Cancer Research (AACR) Annual Meeting 2023, which is being held in Orlando, Florida from April 14th to 19th via poster presentations for abstract numbers 6327 and 6363...'We look forward to the readout of our first-in-human Phase 1 study later this year. Additional trial sites are being activated throughout Israel to expedite enrollment, increase the diversity of patients, and expand awareness of the safe and effective administration of our UNO technology'."

New P1 trial • Preclinical • Oncology • Solid Tumor

Cow activity measurements can be used to define new fertility traits for use in genetic evaluation. (PubMed, JDS Commun) - "The trait CFHA showed significant genetic variation with a heritability of 0.05 (0.01). This trait reflects the cow's ability to return to estrus cycle and show estrus after calving, which are important aspects of cow fertility."

Journal

"#FDAapproves first generics of Alimta (pemetrexed): https://t.co/LOzAITcFc8" (@FDA_Drug_Info)

FDA event

Beyond Air to Present New Nitric Oxide Data in an e-Poster Presentation at the North America Conference on Lung Cancer 2020 (NACLC 2020) (GlobeNewswire) - "Beyond Air, Inc...announced that an e-poster presentation has been accepted at the International Association for the Study of Lung Cancer’s (IASLC) upcoming North America Conference on Lung Cancer 2020 (NACLC 2020) being held from October 16^th to 17^th...Title:...New Class of Cancer Vaccination Using a Single Injection of Nitric Oxide Shows Promising Results in a Lung Cancer Mouse Model"

Preclinical • Lung Cancer • Oncology

Beyond Air Announces Positive Preclinical Data Supporting High Concentration Nitric Oxide as a Potential Treatment for Solid Tumors (GlobeNewswire) - "The data were presented by Dr. Hila Confino of Beyond Air in an e-poster poster titled, 'Gaseous Nitric Oxide at High Concentration is a Powerful Anti-Tumor Agent both in-vitro and in-vivo' at the American Association for Cancer Research (AACR) Virtual Annual Meeting II....Three studies were conducted to characterize the anti-tumor effects of gNO in vivo. In the first study, subcutaneous colon cancer tumors were treated locally with high-dose gNO delivered by intratumoral injection or direct external exposure. Tumor ablation was successful in five of 30 mice."

Preclinical • Oncology

Synergistic Effect of Nitric Oxide with Antibiotics Against Mycobacterium Abscessus in Vitro (ATS 2019) - "CONCLUSIONS These findings demonstrate a synergistic antibacterial effect against Mabs when NO is combined with clofazimine. This suggests a potential role for high-dose NO in combination with clofazimine in treatment of NTM lung infection."

Preclinical