dorzolamide/timolol / Generic mfg. - LARVOL DELTA

Choroidal Detachment in a Patient on a CPAP Therapy. (PubMed, Case Rep Ophthalmol Med) - "The patient was diagnosed with choroidal detachment and was treated with topical dexamethasone 0.1% and cyclopentolate...The patient received a combination of dorzolamide and timolol in addition to the aforementioned treatment...The CPAP treatment is a possible, though unproven, contributor to the choroidal detachment. The patient improved during corticosteroid, cycloplegic, and IOP-lowering treatment."

Journal • Eye Cancer • Obstructive Sleep Apnea • Ocular Melanoma • Oncology • Respiratory Diseases • Sleep Disorder

Dorzolamide/Brimonidine/Timolol Impact on Ocular Surface, Glaucoma Progression & Chatbot Follow-up: GLAUCO-TECH (clinicaltrials.gov) - P4 | N=140 | Active, not recruiting | Sponsor: Tecnoquimicas

New P4 trial • Cardiovascular • Glaucoma • Ophthalmology

ICRF-Assisted Box-Behnken Design and Optimization for Rapid UPLC-PDA Determination of Dorzolamide Hydrochloride and Timolol Maleate in an Ophthalmic Preparation. (PubMed, J AOAC Int) - "The study demonstrates the effectiveness of composite response-based chemometric optimization in enhancing analytical efficiency in pharmaceutical drug analysis."

Journal • Ophthalmology

Comprehensive Analytical Method Development for Related Substance Determination in Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solutions: Multi-Method Approach and Regulatory Compliance. (PubMed, Biomed Chromatogr) - "The novelty of this work lies in the use of three complementary chromatographic approaches that significantly improve specificity, selectivity, and impurity profiling in complex ophthalmic matrices during the aqueous in-process of both phases (aqueous and polymer mixing phase). In addition, the study provides a comparative assessment between preservative-free and preserved formulations, supporting regulatory compliance, stability evaluation, and bioequivalence assessment of generic ophthalmic products."

Compliance • Journal • Ophthalmology

RENOIR: Efficacy and Safety of DNN.31.19.026 for Ocular Hypertension or Primary Open-Angle Glaucoma (clinicaltrials.gov) - P3 | N=336 | Not yet recruiting | Sponsor: Ache Laboratorios Farmaceuticos S.A.

New P3 trial • Cardiovascular • Glaucoma • Ophthalmology

Importance of History in the Management of New-Onset Hyperkalemia. (PubMed, Cureus) - "The patient presented for a second opinion on the hyperkalemia, and after a thorough history and chart review, it was determined that the patient's dorzolamide-timolol eye drops were the cause of the hyperkalemia. Discontinuation of the eye drops resolved the hyperkalemia."

Journal • Nephrology

The role of adjunctive aqueous suppressants for anti-vascular endothelial growth factor therapy: A systematic review. (PubMed, Surv Ophthalmol) - "Our goal is to determine whether adjunctive aqueous suppressants (topical β-blockers, carbonic anhydrase inhibitors, or oral acetazolamide) enhance outcomes of anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME), retinal vein occlusion (RVO), and neovascular age-related macular degeneration (nAMD), focusing on retinal thickness, visual acuity, injection burden, intraocular pressure (IOP), and safety...In DME, 3 of 4 trials showed greater thickness reduction with adjunctive dorzolamide (±timolol), although visual gains were inconsistent...Adjunct aqueous suppressants may provide limited short-term anatomical benefit, particularly in DME and refractory nAMD, but consistent functional or durability effects are not found in this study. Larger, longer-term randomized studies are needed."

Journal • Review • Age-related Macular Degeneration • Diabetic Macular Edema • Macular Degeneration • Ophthalmology • Retinal Disorders • Retinal Vein Occlusion • Wet Age-related Macular Degeneration

Can Generalist Large Language Models Translate Glaucoma Clinical Notes Written in English into Patient-Friendly Spanish Summaries? (ARVO 2026) - "The only potentially harmful inaccurate fact was a laterality error in one summary, where a combined dorzolamide–timolol drop documented in one eye was described as used in both eyes...We found that the AI's summaries were usually very accurate and easy to read, with only rare mistakes that a doctor could detect. These results suggest that AI tools can help doctors and clinics offer clear, personalized information in Spanish, improve understanding and participation for patients with glaucoma, and still keep human review to protect patient safety."

Clinical • Glaucoma • Ophthalmology

Acute Intraocular Pressure Elevation During Hemodialysis in a Patient with Glaucoma: A Case Highlighting the Need for Prompt Recognition and Surgical Intervention (NKF-SCM 2026) - "On admission, treatment was geared towards use of acetazolamide with increase in dosing until intraocular goal pressure is achieved...Maximal medical therapy (latanoprost, cosopt, brimonidine, pilocarpine, prednisolone, atropine) reduced IOP to 58 mmHg...Timely surgical intervention preserved eyesight and avoided delays in hemodialysis, emphasizing interdisciplinary management between nephrology and ophthalmology for at-risk patients. Intra-HD tonometry allowed us to ascertain the diagnosis, expedite surgery and monitor the efficacy of the surgical intervention."

Clinical • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Diabetic Nephropathy • Diabetic Retinopathy • Glaucoma • Hypertension • Immunology • Nephrology • Ophthalmology • Renal Disease • Respiratory Diseases • Retinal Disorders

Cost-effectiveness of Stepwise Eye Drop Strategies for Open-Angle Glaucoma: A Markov Model Analysis From the Japanese Healthcare Perspective. (PubMed, Value Health Reg Issues) - "For brand-name drugs, latanoprost followed by timolol or a timolol-first strategy with dorzolamide were the most cost-effective. For generics, starting with latanoprost or timolol, and following fixed combinations, were cost-effective. A timolol-first strategy followed by dorzolamide was cost-effective for brand-name drugs but not for generics."

HEOR • Journal • Glaucoma • Ophthalmology

Anterior Segment, Static and Dynamic Pupillography Changes in Patients with Primary Open-Angle Glaucoma Using Different Types of Topical Antiglaucomatous Agents. (PubMed, Photodiagnosis Photodyn Ther) - "This study demonstrated that the most commonly used antiglaucomatous agents increased ACD and ACA but did not affect other anterior segment structures, such as CCT, CV, or ACV. On the ocular surface, antiglaucomatous agents had significant negative effects. Meibography revealed adverse effects on the eyelids. Both first and mean NCTBUT were shortened. In pupillography, both static and dynamic pupil diameters were significantly smaller than those in the control group."

Journal • Glaucoma • Ophthalmology

Using selective laser trabeculoplasty to manage glaucoma in a child with phakomatosis pigmentovascularis. (PubMed, Am J Ophthalmol Case Rep) - "Three months after SLT, the right eye IOP was successfully reduced to 19 mmHg after the discontinuation of acetazolamide. She maintained an IOP of 18 mmHg in the right eye 11 months after SLT on latanoprost and dorzolamide-timolol only. Glaucoma filtering procedures in cases of PPV pose a high risk of complications and SLT offers a less-invasive, potentially clinic-based alternative. While the patient did develop a choroidal effusion post-SLT, suspected to be secondary to decreased IOP, this resolved with medical management alone without the need for incisional surgery thus illustrating both the risks and benefits of SLT in treating patients with phakomatoses-associated glaucoma."

Journal • Glaucoma • Ophthalmology • Pediatrics • GNA11 • GNAQ

Comparative safety and efficacy of brinzolamide/timolol and dorzolamide/timolol in the treatment of glaucoma patients: A systematic review and meta-analysis. (PubMed, Eur J Ophthalmol) - "Considering these findings, the choice of treatment usually depends on the patient's tolerance to higher initial ocular irritation in DT or blurring of vision in BT. Longer-term trials with 24-h IOP and preference are needed to assess these outcomes meaningfully."

Journal • Retrospective data • Review • Glaucoma • Ophthalmology

A Case Report of Carotid Cavernous Fistula: A Commonly Missed Diagnosis. (PubMed, J Educ Teach Emerg Med) - "Emergent surgical decompression was deferred due to chronicity of symptoms, and patient was started on dorzolamide/timolol and brimonidine eye drops as well as intravenous (IV) acetazolamide with subsequent improvement in IOP. This case is a good example of how non-traumatic causes of OCS can lead to misdiagnosis and how surgical decompression could potentially be deferred in subacute OCS. Ocular compartment syndrome, carotid cavernous fistula, eye pain, eye swelling, vision loss."

Journal • Achromatopsia • Ophthalmology • Pain

Real-World Transition to a Preservative-Free Fixed Combination of Dorzolamide/Timolol: Impact on the Ocular Surface Microenvironment, Safety, Tolerability, and Efficacy. (PubMed, Medicina (Kaunas)) - "Satisfaction regarding comfort (≥80%) and handling (≥50%) was high, with 88.0% preferring PF-DT. Transitioning to PF-DT improved ocular surface health while maintaining IOP control, supporting the benefits of preservative-free formulations in restoring microenvironment homeostasis and enhancing tolerability and patient satisfaction."

Journal • Real-world evidence • Dry Eye Disease • Glaucoma • Ophthalmology

Effect of prophylactic dorzolamide-timolol on intraocular pressure spikes following phacoemulsification. (PubMed, Can J Ophthalmol) - "Prophylactic dorzolamide-timolol reduces mean postoperative IOP and POD1 pressure spikes, independent of glaucoma comorbidities."

Journal • Cardiovascular • Glaucoma • Ophthalmology

Peripapillary retinoschisis associated with open angle glaucoma responding to dorzolamide. (PubMed, Retin Cases Brief Rep) - "We present a case of peripapillary retinoschisis in a phakic patient that developed during treatment with a topical prostaglandin analogue. The schisis resolved after switching the prostaglandin analogue to a topical carbonic anhydrase inhibitor. We suggest that the prostaglandin may have had a role in initiating peripapillary retinoschisis associated with glaucomatous optic neuropathy and that carbonic anhydrase inhibitors are a potential treatment for this condition."

Journal • Glaucoma • Inherited Retinal Dystrophy • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Retinal Disorders

Combined procedure with Paul's glaucoma implant and reopening of previous filtering surgery in a patient with hypertensive uveitis crisis and juvenile glaucoma (SOE 2025) - "Hypotensive treatment was prescribed with a good response, but 1 week later she presented with the same condition, so oral acetazolamide was added.With the diagnosis of juvenile glaucoma + hypertensive uveitis crisis in the right eye, a complete laboratory work-up was performed with negative serology except for IgG VZV and IgG CMV which was positive...During the postoperative period she presented with hypertensive peaks requiring the following procedures: surgery to unknot the suture + partial removal of the tutor (7th week); complete removal of the tutor in consultation (9th week); topical dorzolamide-timolol and Molteno´s antifibrotic therapy for 6 weeks (3 weeks after removal of the tutor)...The coexistence of pre-existing juvenile glaucoma with an episode of severe, treatment-refractory hypertensive uveitis has not been described as a risk factor. Our hypothesis is that the trabecular meshwork, which has already been altered by juvenile glaucoma, is the target..."

Clinical • Surgery • Glaucoma • Ocular Inflammation • Ophthalmology • Uveitis

Cat scratch disease: ocular manifestations (SOE 2025) - "Initial therapy was Agapurin, Milgamma, Betaxolol drops and Nurofen...Dexamethasone, Dorzolamide, Timolol and Bromfenac eye drops were added... Cat scratch disease is an infectious illness primarily caused by the bacterium Bartonella henselae, commonly transmitted through scratches or bites from infected cats. While typically characterized by swollen lymph nodes, it can present with diverse range of symptoms. Ocular manifestations can serve as the sole or initial presentation of the disease."

Ophthalmology

Improvement of concomitant ocular surface disease in glaucoma patients after switching to a preservative-free fixed combination in a real-world transition context (SOE 2025) - "Purpose: To evaluate changes in ocular surface signs and symptoms and their impact on the efficacy of treatment for primary open-angle glaucoma (POAG) in patients with concomitant ocular surface disease (OSD) after switching from a preserved to a preservative-free Dorzolamide 2% + Timolol 0.5% (PF-DT). An experimental, prospective, single-arm, open-label, multicenter trial was conducted... It was demonstrated that switching from a preserved to a PF-DT formulation improved OSD signs and symptoms in patients with POAG, and this strengthened the hypotensive efficacy of the treatment."

Clinical • Real-world • Real-world evidence • Glaucoma • Ophthalmology

Hemodialysis and glaucoma (case report) (SOE 2025) - "A combined topical β-blocker and carbonic anhydrase inhibitor (Cosopt®) and a prostaglandin analog (Travatan®) were prescribed to both eyes when the intraocular pressure reached 38 and 34 mm Hg in the right and left eyes, respectively. Hemodialysis was performed routinely five times a week for 2 hours and 40 minutes using a central venous catheter. After failure of ocular treatment, glucose was administered intravenously (20% glucose 100 mL/h) during dialysis to prevent an increase in IOP."

Case report • Clinical • Cataract • Glaucoma • Ophthalmology

Intraoperative optical coherence tomography in glaucoma surgery with Ex-PRESS® implant. (PubMed, Eur J Ophthalmol) - "Our patient was being treated with dorzolamide-timolol eyedrops twice daily and bimatoprost eyedrops once daily in both eyes. I-OCT can help surgeons to locate the correct placement of implants in cases with media opacity (such as corneal opacification or gerontoxon) or in phakic patients, where it is important to avoid lens contact. This instrument is helpful in the training of ophthalmologists."

Journal • Cataract • Glaucoma • Ophthalmology

Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost (clinicaltrials.gov) - P4 | N=70 | Recruiting | Sponsor: Prairie Eye Center | Not yet recruiting ➔ Recruiting

Enrollment open • Glaucoma • Ophthalmology

Investigating clues of cystoid macular edema from a vascular perspective under long-term latanoprost usage. (PubMed, Int Ophthalmol) - "This study demonstrates that latanoprost, the first prostaglandin analog known for its edema-inducing effect on the macula, does not have a long-term impact on macular vascularity. However, this result should be supported with longer and larger studies."

Journal • Glaucoma • Macular Edema • Ophthalmology

Drugs for open-angle glaucoma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Glaucoma • Ophthalmology