micro-RNA 206 / Phio Pharma, Viridian Therap - LARVOL DELTA

Expression analysis of multiple microRNAs in each patient with scleroderma (Exp Dermatol) - P=NA, N=15; PMID: 23800063; "We also found the combination of serum levels of miR-206 and miR-21 was more useful in distinguishing patients with scleroderma from normal subjects than either miR-206 or miR-21 alone. Our study is the first to demonstrate different expression profiles of multiple microRNAs in each patient with scleroderma and examine its clinical significance."

Biomarker • Fibrosis

Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma. (PubMed) - J Hum Genet - "Moreover, overexpression of EGFR and c-MET was observed in HNSCC clinical specimens. The identification of targets modulated by tumor-suppressive miR-1 and miR-206 may lead to a better understanding of molecular pathogenesis of HNSCC.Journal of Human Genetics advance online publication, 12 May 2016; doi:10.1038/jhg.2016.47."

Journal • Biosimilar • Head and Neck Cancer • Oncology

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma. (PubMed) - J Allergy Clin Immunol - "Subsets of circulating miRNAs are uniquely expressed in patients with AR and asthmatic patients and have potential for use as noninvasive biomarkers to diagnose and characterize these diseases."

Biomarker • Journal • Asthma • Biosimilar • Immunology

miR-375 exhibits a more effective tumor-suppressor function in laryngeal squamous carcinoma cells by regulating KLF4 expression compared with simple co-transfection of miR-375 and miR-206. (PubMed) - Oncol Rep - "Taken together, miR-375 is possibly a tumor suppressor in LSCC by regulating KLF4. In addition, simple overexpression of several miRNAs did not entail higher efficacy than a single miRNA, similar to co-transfecions of miR-375 and miR-206."

Journal • Biosimilar • Oncology

Ultraviolet radiation-induced tumor necrosis factor alpha, which is linked to the development of cutaneous SCC, modulates differential epidermal microRNAs expression. (PubMed) - Oncotarget - "Few of the differentially expressed miRNAs (miR-31-5p, miR-196a-5p, miR-127-3p, miR-206-3p, miR-411-5p, miR-709, and miR-322-5p) were also observed in UVR-induced SCC. Finally, bio-informatics analysis using DIANA, MIRANDA, Target Scan, and miRDB algorithms revealed a link with major UVR-induced pathways (MAPK, PI3K-Akt, transcriptional mis-regulation, Wnt, and TGF-beta)."

Journal • Biosimilar • Melanoma

A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas. (PubMed) - Lab Invest - "In addition, a tight linear progression of miRNA expression was identified from normal fat to dedifferentiated liposarcoma. These results suggest that miRNA expression profiles could elucidate classes of miRNAs that may elicit tumor-relevant activities in specific sarcoma subtypes.Laboratory Investigation advance online publication, 15 February 2016; doi:10.1038/labinvest.2015.168."

Journal • Biosimilar • Oncology • Sarcoma

Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. (PubMed) - "These results significantly imply that miR-125b-5p and miR223-3p could be used as novel non-invasive biomarkers of HBV-positive HCC in very early, even at CHB stage of liver disease."

Biomarker • Fibrosis