novel immune-evasive CAR T / Cellectis - LARVOL DELTA

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing. (PubMed, Nat Commun) - "Here, we describe the development of a novel immune-evasive universal CAR T-cells scaffold using precise TALEN-mediated gene editing and DNA matrices vectorized by recombinant adeno-associated virus 6...This highly efficient gene editing process enables the engineered T-cells to evade NK cell and alloresponsive T-cell attacks and extend their persistence and antitumor activity in the presence of cytotoxic levels of NK cell in vivo and in vitro, respectively. This scaffold could enable the broad use of universal CAR T-cells in allogeneic settings and holds great promise for clinical applications."

CAR T-Cell Therapy • Journal • Oncology • B2M • HLA-C • HLA-E