BGC-201531 / Ariel, Boston Scientific - LARVOL DELTA

Prostaglandin E a postulated mediator of neurovascular coupling, at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles. (PubMed, Prostaglandins Other Lipid Mediat) - "In functionally intact parenchymal arterioles lower concentrations of PGE (from 10 to 10 mol/l) caused significant, endothelium-independent vasorelaxation, which was inhibited by the EP4 receptor blocker BGC201531...PGE at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles. This bimodal vasomotor response is consistent with both the proposed vasodilator role of PGE during functional hyperemia and its putative role in cerebral vasospasm associated with subarachnoid hemorrhage in human patients."

Journal • Hematological Disorders • Subarachnoid Hemorrhage