pregabalin / Generic mfg. - LARVOL DELTA

When Constipation Becomes a Renal Emergency: Stercoral Proctocolitis With Fecaloma-Induced Bilateral Hydroureteronephrosis and Obstructive Acute Kidney Injury (ACG 2026) - "Her medications included hydroxyzine, carbamazepine, mirtazapine, primidone, pregabalin, deutetrabenazine, and venlafaxine, contributing to a high anticholinergic burden. Massive fecal impaction causing stercoral proctocolitis and obstructive uropathy. Figure Footnote: The distended colon compresses the distal ureters resulting in bilateral hydroureteronephrosis (arrows)."

Acute Kidney Injury • Bipolar Disorder • Cardiovascular • CNS Disorders • Constipation • Endocrine Disorders • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hypotension • Infectious Disease • Inflammatory Bowel Disease • Movement Disorders • Nephrology • Parkinson's Disease • Renal Disease

Medical and non‑medical gabapentinoid use in fatal drug poisonings in Norway: Linked postmortem toxicology and prescription data. (PubMed, Forensic Sci Int) - "Gabapentinoids were increasingly detected in fatal drug poisonings in Norway. Non-medical use became more common over time, particularly for pregabalin. Because 24% of cases were not captured by the standard EUDA definition, the contribution of gabapentinoids to drug-related mortality may be underestimated."

Journal

Multimodal Pharmacologic Strategies for Chronic Cancer Pain: A Systematic Review. (PubMed, Cureus) - "In one trial, duloxetine was associated with clinically meaningful pain-response rates, although its primary mean pain-score analysis was not statistically significant. Low-dose gabapentin plus imipramine reduced pain and rescue-morphine use. Pregabalin reduced the morphine dose required to maintain pain control in one crossover trial, while other pregabalin studies showed numerical or non-significant benefits. Neither nabiximols trial met its primary efficacy endpoint, and nefopam did not significantly improve pain response or morphine consumption...Overall, the evidence remains heterogeneous and insufficient to support a standard multimodal pharmacological regimen. Selected antidepressant and gabapentinoid strategies, particularly in neuropathic cancer pain, may benefit selected patients."

Journal • Review • Addiction (Opioid and Alcohol) • Oncology • Pain

Conformational polymorphism in cocrystal of pregabalin and octanoic acid. (PubMed, Acta Crystallogr B Struct Sci Cryst Eng Mater) - "Negative thermal expansion is observed along the shortest unit-cell axis in form III. Ultimately, subsequent transitions to form II and form I lead to positive thermal expansion in every principal strain axis."

Journal

Evolving Concepts in the Diagnosis and Management of Fibromyalgia: A Moving Target. (PubMed, J Pain Res) - "Pharmacological therapies, including pregabalin, duloxetine, milnacipran, and cyclobenzaprine, are Food and Drug Administration-approved and provide clinically meaningful benefits to patients with FM. Although tramadol may be considered, the use of other opioids is generally not recommended because of their limited efficacy and potential risks...Therefore, this narrative review aims to provide a concise, updated, and clinically relevant overview of the current evidence regarding the pathogenesis, diagnosis, and multidisciplinary management of FM to improve diagnostic accuracy and support individualized patient management. Furthermore, future directions should prioritize improving diagnostic precision and developing mechanism-based interventions targeting the underlying pathophysiology of FM."

Journal • Review • CNS Disorders • Cognitive Disorders • Fatigue • Fibromyalgia • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Psychiatry • Rheumatology • Sleep Disorder

Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia (clinicaltrials.gov) - P=N/A | N=200 | Not yet recruiting | Sponsor: Haydarpasa Numune Training and Research Hospital | Initiation date: May 2026 ➔ Oct 2026

Trial initiation date • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

Gabapentin-Induced Severe Vivid Nightmares: A Case Series and Brief Review. (PubMed, Psychopharmacol Bull) - "Management strategies included medication discontinuation and transition to pregabalin. Both patients experienced resolution of nightmares following intervention. This report reviews the existing literature on gabapentin's effects on sleep architecture and discusses potential mechanisms, clinical implications, and management approaches."

Journal • Review • CNS Disorders • Musculoskeletal Pain • Neuralgia • Pain • Psychiatry • Sleep Disorder

Discovering repurposable drugs for Alzheimer's disease and related dementias: target trial emulation using decentralised real-world data. (PubMed, EBioMedicine) - "20 widely used medications may be associated with reduced progression from MCI to ADRD and represent promising candidates for clinical evaluation as repurposed therapies for dementia."

Journal • Real-world evidence • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Pain

Clinical Studies on the Efficacy and Safety of Crisugabalin and Pregabalin in Relieving Chronic Itchy Skin Diseases (EADV 2026) - No abstract available

Clinical • Dermatology • Pruritus

Letter to the Editors on "Analysis of the effects of combined electrical spinal cord stimulation and pregabalin therapy in patients with herpes zoster trigeminal neuralgia" by Jiang et al. (PubMed, J Clin Neurosci) - No abstract available

Journal • Herpes Zoster • Neuralgia • Pain • Varicella Zoster

Cross national pharmacovigilance analysis of drug-induced delirium: a comparative study using the US FAERS, Japanese JADER, and canadian CVAR datasets. (PubMed, Front Pharmacol) - "Duloxetine, lamotrigine, pregabalin, quetiapine fumarate, and zolpidem demonstrated consistent signals across databases. Time-to-onset analysis demonstrated early-onset clustering, suggesting an acute temporal pattern. Cross-database consistency in drug class signals and early-onset temporal patterns highlights the need for medication review and risk mitigation in high-risk populations."

Adverse events • Journal • CNS Disorders • Cognitive Disorders • Pain

Multicentre, 2×2 factorial, randomised, open-label trial of neuromodulators and cough control therapy for refractory or unexplained chronic cough: the FORTITUDE trial protocol. (PubMed, BMJ Open) - P4 | "Patients ≥18 years old with either refractory or unexplained chronic cough will undergo independent 1:1 randomisation to pharmacotherapy-either low-dose morphine (up to 5 mg two times per day) or pregabalin (up to 150 mg two times per day)-and concurrent cough control therapy (CCT) or no CCT. Results of the main trial and the observational extension will be published as manuscripts in peer-reviewed journals. NCT07288528."

Clinical protocol • Journal • Chronic Cough • Cough • Pulmonary Disease • Respiratory Diseases

The Role of the Antidepressants in Managing Chemotherapy-Induced Neuropathic Pain: A Systematic Review. (PubMed, Pharmacol Res Perspect) - "Combination therapies involving duloxetine and agents such as tapentadol, pregabalin, mirogabalin, or amitriptyline were associated with additional reductions in pain intensity; however, current evidence remains insufficient to establish additive or synergistic effects. Current evidence supports antidepressants, particularly duloxetine, associated with reductions in pain intensity in heterogeneous studies, whereas evidence for CIPN prevention remains inconclusive. These findings support their continued use in clinical practice and highlight the need for larger, well-designed randomized controlled trials to optimize treatment strategies and further define the role of combination therapies in CIPN management."

Journal • Review • Neuralgia • Oncology • Pain • Peripheral Neuropathic Pain

Validation of the Neogen® ELISA Gabapentin Kit for Blood and Urine. (PubMed, J Anal Toxicol) - "The assay was reliably able to detect gabapentin without interference from matrix components or other substances routinely detected in authentic case samples with the exception of levamisole in urine if present at unusually high concentrations. Other case sample results were comparable to those obtained with liquid chromatography tandem high-resolution mass spectrometry or liquid chromatography tandem mass spectrometry for blood and urine, respectively. The Neogen® Gabapentin kit exhibited minimal cross-reactivity for pregabalin and demonstrated excellent precision and appropriate sensitivity in both whole blood and urine, making it an efficient and reliable method to screen for gabapentin."

Journal

SLEEP APNEA SIGNALS ASSOCIATED WITH GABAPENTIN AND PREGABALIN: A DISPROPORTIONALITY ANALYSIS, 2020-2026 (CHEST 2026) - No abstract available

Obstructive Sleep Apnea • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Perioperative pregabalin within an enhanced recovery pathway and postoperative quality of recovery after head and neck cancer surgery with free-flap reconstruction: A pilot study. (PubMed, Auris Nasus Larynx) - "Perioperative pregabalin administration was associated with improved postoperative QoR following HNS-FTTR, particularly in the domains of physical comfort and physical independence, despite limited effects on postoperative pain intensity. Given the retrospective design, small sample size, and potential for residual confounding, these findings should be considered preliminary and hypothesis-generating and warrant confirmation in prospective randomized controlled trials."

Journal • Addiction (Opioid and Alcohol) • Head and Neck Cancer • Oncology • Pain • Solid Tumor • CRP

Pregabalin for Chronic Pelvic Pain in Women (clinicaltrials.gov) - P=N/A | N=308 | Not yet recruiting | Sponsor: Beijing Tiantan Hospital

New trial • Gynecology • Musculoskeletal Pain • Pain

Comparative Effectiveness of Pregabalin With Duloxetine Versus Pregabalin With Amitriptyline in Chronic Low Back Pain With Radiculopathy: A Prospective Comparative Study. (PubMed, Health Sci Rep) - "In this non-randomized cohort, the pregabalin-duloxetine combination was associated with greater crude improvement, and duloxetine-treated participants reported fewer episodes of sedation and drowsiness; however, the apparent efficacy advantage was substantially attenuated after accounting for baseline imbalance, and because adverse-event ascertainment was open-label and incomplete, the tolerability signal also remains exploratory. These findings should be regarded as hypothesis-generating and require confirmation in adequately powered randomized trials."

HEOR • Journal • Anesthesia • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Optimizing Gabapentin Use in a Tertiary Care Teaching Hospital: A Pharmacist-Led Initiative (PAINWeek 2026) - "Acknowledgements (financial assistance and/or AI assistance) : No financial assistance was received for this project. From July 1 to August 31, 2025, 1,664 patients with an active gabapentinoid prescription were identified at VA San Juan. After excluding inpatient prescriptions, short-term prescriptions of less than 30 days, and patients with pregabalin only, 1,410 patients remained eligible. Using a 90% confidence level and a 10% margin of error, the calculated sample size was 65 patients, but 100 patients were reviewed to maximize the opportunity for interventions."

Clinical • Back Pain • CNS Disorders • Depression • Epilepsy • Lumbar Back Pain • Migraine • Musculoskeletal Pain • Neuralgia • Peripheral Neuropathic Pain

Marfan-Like Clinical Features in DLG4 (Discs Large MAGUK Scaffold Protein 4)-Related Synaptopathy: A Brazilian Case Report. (PubMed, Cureus) - "He continues to undergo multidisciplinary follow-up and remains on pregabalin therapy for symptomatic pain control...Clinicians should consider this diagnosis in individuals presenting with neurodevelopmental manifestations, sensory disturbances, and marfanoid features. Early recognition and comprehensive genetic evaluation may support diagnostic clarification, guide management, and improve clinical outcomes."

Journal • Autism Spectrum Disorder • CNS Disorders • Constipation • Developmental Disorders • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genetic Disorders • Immunology • Mental Retardation • Movement Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Sleep Disorder • DLG4

Continuous-Flow Synthesis of Antiepileptic Drugs: Process Intensification, Sustainability Metrics, and Scalable Manufacturing. (PubMed, ACS Omega) - "The review will examine examples of recent advances in continuous-flow processing of major molecules, including pregabalin, levetiracetam, lacosamide, and brivaracetam. In addition, the review will discuss the obstacles preventing a complete transition to an automated, environmentally friendly, and continuous-flow process for producing AEDs."

Journal • Review

Improving Clinical Trial Design in Low Back Pain: Insights from Studies of Gabapentinoids. (PubMed, Pain Ther) - "The clinical community continues to improve the terminology, such as the recent International Association for the Study of Pain (IASP) definition of "spine-related leg pain" updating the older diagnosis of "sciatica." Defining or further stratifying a patient population (for example, using neuropathic screening tool scores) and then evaluating multiple treatments effective for nociceptive or neuropathic pain may improve a study's discriminatory power while reducing the number of patients required. Once initial drug efficacy has been established in randomized, placebo-controlled trials, additional study designs targeting specific patient populations can still provide valuable insight into key clinical questions, often requiring substantially fewer resources."

Journal • Review • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Neuralgia • Pain

Tramadol for Refractory Restless Legs Syndrome Following Methadone Intolerance: A Case Report. (PubMed, Cureus) - "We present a 52-year-old woman with refractory RLS who failed multiple pharmacologic therapies, including ropinirole, carbidopa/levodopa, gabapentin, and pregabalin. Transition to tramadol 50 mg nightly resulted in sustained symptom control without recurrence of these adverse effects, allowing discontinuation of gabapentin and improved daytime functioning. This case highlights the importance of individualized opioid selection in refractory RLS and suggests that tramadol may be an effective alternative for carefully selected patients with methadone intolerance."

Journal • CNS Disorders • Insomnia • Migraine • Mood Disorders • Movement Disorders • Pain • Psychiatry • Restless Legs Syndrome • Sleep Disorder

PrEgabalin for Treatment Resistant generalised Anxiety disorder (PETRA): study protocol for a double-blind randomised controlled trial set in the UK. (PubMed, Trials) - "The trial findings will inform primary care prescribing practice by providing an accurate and generalisable estimate of the clinical and cost-effectiveness of prescribing pregabalin to individuals with generalised anxiety who have not responded or only partially responded to antidepressant treatment."

Clinical protocol • Journal • CNS Disorders • General Anxiety Disorder • Mood Disorders • Psychiatry • Suicidal Ideation

Utility and sensitivity of wett-SA53 to measure dysgeusia associated with talquetamab, a GPRC5D×CD3 bispecific antibody, in Relapsed/Refractory multiple myeloma: Preliminary data from the talisman study (ASH 2025) - P2 | "Experimental prophylaxes include dexamethasone [Dex] mouthwash, oral pregabalin, orclonazepam orally dissolving tablets. In this randomized, phase 2 study utilizing the WETT SA-53 assessment tool for the first timein pts with MM, WETT scores appeared to be highly sensitive with the ability to objectively capture abroader spectrum of taste changes throughout Tal treatment compared with CTCAE grading. Preliminarydata showed the WETT scale was able to detect dysgeusia, and importantly, objective improvements indysgeusia by cycle 8. Results from this study will help characterize and guide management of dysgeusiaassociated with GPRC5D treatment and may establish the WETT assessment as an important objectivetool for cancer agents impacting taste."

IO biomarker • Dental Disorders • Hematological Malignancies • Mucositis • Multiple Myeloma • Stomatitis • Xerostomia