pregabalin / Generic mfg. - LARVOL DELTA

Gabapentinoids and Neuropathic Pain: Evaluation of the Quality of Randomised Controlled Trials: An Umbrella Review. (PubMed, Fundam Clin Pharmacol) - "According to AMSTAR 2, the highest-quality meta-analysis was the one published in the Cochrane Database of Systematic Reviews and concluded that more participants had substantial benefit (at least 50% pain relief or patient global impression change very much improved) with gabapentin at 1200 mg daily or greater than with placebo (in postherpetic neuralgia: RR = 1.8 [95% CI 1.5 to 2.1] and in painful diabetic neuropathy: RR = 1.9 [95% CI 1.5 to 2.3]). One limitation of this work is the inconsistent use of the term neuropathic pain, which may be defined differently across studies."

Journal • Review • Diabetic Neuropathy • Neuralgia • Pain

Utility and sensitivity of wett-SA53 to measure dysgeusia associated with talquetamab, a GPRC5D×CD3 bispecific antibody, in Relapsed/Refractory multiple myeloma: Preliminary data from the talisman study (ASH 2025) - P2 | "Experimental prophylaxes include dexamethasone [Dex] mouthwash, oral pregabalin, orclonazepam orally dissolving tablets. In this randomized, phase 2 study utilizing the WETT SA-53 assessment tool for the first timein pts with MM, WETT scores appeared to be highly sensitive with the ability to objectively capture abroader spectrum of taste changes throughout Tal treatment compared with CTCAE grading. Preliminarydata showed the WETT scale was able to detect dysgeusia, and importantly, objective improvements indysgeusia by cycle 8. Results from this study will help characterize and guide management of dysgeusiaassociated with GPRC5D treatment and may establish the WETT assessment as an important objectivetool for cancer agents impacting taste."

IO biomarker • Dental Disorders • Hematological Malignancies • Mucositis • Multiple Myeloma • Stomatitis • Xerostomia

Dissecting the difference between positive and negative brain health sentiment using X data. (PubMed, Front Digit Health) - "These X-posts also mention coping strategies like using medications such as lorazepam and simvastatin, or consuming comfort foods like pizza. In contrast, positive sentiments emphasize resilience and improvement, with mentions of mindfulness, supplements, and medications like doxycycline and pregabalin. The study also highlights the risk of disseminating information about dietary and drug supplements that may not be suitable for public use due to serious side effects, such as Chaga mushrooms, which, despite being associated with positive sentiment, are known to cause renal failure in certain cases. Overall, the study profiles the use of positive and negative brain health sentiment of X, which underscores both the advantages and risks of using X (formerly Twitter) as a platform for sharing brain health-related information."

Journal • CNS Disorders • Cognitive Disorders • Infectious Disease • Inflammation • Mood Disorders • Novel Coronavirus Disease • Psychiatry • Renal Disease

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document. (PubMed, Eur J Heart Fail) - "The review examines the pathophysiological mechanisms, clinical evidence, and guideline-based recommendations for several drug classes, including antidiabetic agents (e.g. thiazolidinediones, dipeptidyl peptidase-4 inhibitors), antiarrhythmics (particularly Class I and III), calcium channel blockers, non-steroidal anti-inflammatory drugs, antifungals (e.g. itraconazole, amphotericin B), macrolide antibiotics, antihypertensives (e.g. α1-blockers, centrally acting sympatholytics), neurological and psychiatric medications (e.g. carbamazepine, pregabalin, lithium), and selected anaesthetic and anticancer agents such as anthracyclines and vascular endothelial growth factor inhibitors. The goal is to empower clinicians, pharmacists and nurses to optimize HF treatment while reducing the risk of drug-induced deterioration. Awareness of these pharmacologic pitfalls is critical to improving clinical outcomes and minimizing preventable adverse events and HF hospitalizations."

Journal • Anesthesia • Cardiovascular • Congestive Heart Failure • Heart Failure • Oncology • Psychiatry

PS11 Successful treatment of chronic pruritus and secondary ulceration with aprepitant. (PubMed, Br J Dermatol) - "Pregabalin was commenced in the community for neuropathic pain...Significant impact on quality of life has been demonstrated with aprepitant in a wide variety of underlying causes of pruritus including chronic kidney disease, solid organ tumours, lymphoma and mycosis fungoides, and neuropathic disease such as brachioradial pruritus. Here we demonstrate the benefit of aprepitant in compulsive skin picking secondary to pruritus."

Journal • Borderline Personality Disorder • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Cutaneous T-cell Lymphoma • Dermatology • Diabetes • Genetic Disorders • Hematological Malignancies • Hypertension • Immunology • Infectious Disease • Lymphoma • Metabolic Disorders • Mood Disorders • Musculoskeletal Pain • Mycosis Fungoides • Nephrology • Neuralgia • Obesity • Oncology • Pain • Personality Disorder • Prurigo Nodularis • Pruritus • Renal Disease • Solid Tumor • Type 2 Diabetes Mellitus

Ketamine's uncertain efficacy and pregabalin's heart failure risk: lessons for safer pain care in older adults. (PubMed, Ann Med Surg (Lond)) - No abstract available

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Pain

Case Report: Development of persistent genital arousal disorder due to a possible combination of medications. (PubMed, Front Psychiatry) - "We present a unique case of a menopausal woman who developed PGAD after combined pharmacotherapy with trazodone, pregabalin, vaginal estriol, and depot medroxyprogesterone acetate (DMPA). This case supports the hypothesis that combined modulation of serotonergic, neuronal, and hormonal systems can trigger PGAD in predisposed menopausal women. Recognition of potential pharmacological interactions is crucial for diagnosis and management of PGAD."

Journal • Psychiatry • Sexual Disorders

Phosphodiesterase-4 Inhibition: An Experimental Approach to Overcome Drug Resistance in a Rotenone-Corneal 6 Hz Kindling Mouse Model of Drug-Resistant Epilepsy. (PubMed, Mol Neurobiol) - "Standard anti-seizure medications (ASMs) such as pregabalin, levetiracetam, carbamazepine, phenytoin, and lamotrigine were used for resistance validation. Roflumilast as PDE4 inhibitor significantly manage DRE as evidenced by reducing seizure severity, improving cognitive functions and restoring neurochemical alterations. Its ability to modulate oxidative stress and provide neuroprotection in RCK mice underscores its promise as a novel adjunct treatment for DRE."

Journal • Preclinical • CNS Disorders • Epilepsy • Inflammation • CAT

Disproportionality and time-to-onset analyses of drug-induced weight gain using the Japanese Adverse Drug Event Report database. (PubMed, Drug Discov Ther) - "Pregabalin showed the earliest median onset at 19 days (early failure), followed by olanzapine and risperidone at 1-2 months, pioglitazone at 2 months, and clozapine at 6 months, all classified as random failure types. These findings underscore the need for careful weight monitoring during treatment, particularly early with pregabalin and long-term with clozapine and pioglitazone. Prospective studies are warranted to clarify causal relationships and clinical implications."

Adverse events • Journal • Cardiovascular • CNS Disorders • Genetic Disorders • Metabolic Disorders • Obesity

Y-4 to Treat the Postherpetic Neuralgia (clinicaltrials.gov) - P2 | N=160 | Not yet recruiting | Sponsor: Neurodawn Pharmaceutical Co., Ltd.

New P2 trial • Neuralgia • Pain

Management of Small Fiber Neuropathy: A Clinical Perspective. (PubMed, Muscle Nerve) - "First-line medications include amitriptyline, nortriptyline, gabapentin, and pregabalin. Second-line treatments can include serotonin-norepinephrine reuptake inhibitors and selective serotonin reuptake inhibitors such as duloxetine and venlafaxine, as well as lidocaine patches and capsaicin."

Journal • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Neuralgia • Pain

The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With Fibromyalgia (clinicaltrials.gov) - P=N/A | N=750 | Recruiting | Sponsor: Beijing Tiantan Hospital | N=384 ➔ 750

Enrollment change • Monotherapy • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

The Efficacy and Safety of Pregabalin and Crisugabalin in Patients With Fibromyalgia (clinicaltrials.gov) - P=N/A | N=1116 | Recruiting | Sponsor: Beijing Tiantan Hospital | N=362 ➔ 1116

Enrollment change • Monotherapy • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

A systematic review of pregabalin: Therapeutic benefits, psychological risks, and case reports analysis. (PubMed, Trop Doct) - "Sexual disinhibition and dependency cases were reported, especially in substance-dependent patients. Effective management involved tapering doses gradually, adjunct psychiatric treatment, and close monitoring."

Journal • Review • CNS Disorders • Depression • Epilepsy • Mental Retardation • Mood Disorders • Neuralgia • Pain • Psychiatry

Dramatic Response to Lidocaine Infusion Therapy for Chronic Generalized Pain Secondary to Multiple Large Keloids. (PubMed, Cureus) - "Conventional treatments, including surgical excision with intralesional corticosteroids, duloxetine, meloxicam, amitriptyline, and acupuncture, provided only transient relief. Moderate pain relief was achieved with pregabalin, nortriptyline, topical lidocaine, and medical marijuana, resulting in a visual analog scale (VAS) score of 8/10. The subsequent addition of intravenous (IV) lidocaine infusions (5 mg/kg administered over one hour) produced significant pain reduction (VAS 3/10) and notable improvements in quality of life and functional capacity, enabling her to maintain employment. The interval between infusions was later extended to every four months while maintaining pain relief, without neuroexcitatory or cardiac complications. This case suggests that periodic IV lidocaine infusions may offer a safe and effective therapeutic option for sustained analgesia in patients with chronic keloid-related pain."

Journal • Fibrosis • Infectious Disease • Mood Disorders • Musculoskeletal Pain • Neuralgia • Pain • Varicella Zoster

Association of Aggression and Anti-seizure Medications in Pediatric Patients: Disproportionality Analysis Using the FDA Adverse Event Reporting System. (PubMed, Eur J Pharmacol) - "Signals of aggression related to different ASMs were identified. Significantly strong signals were observed for perampanel, levetiracetam and brivaracetam. Compared to infants and preschooler, ASMs-associated aggression is more common in school children and teenagers."

Adverse events • Journal • CNS Disorders • Epilepsy • Pediatrics

Peer research with populations of people who use street tablets in areas over-represented by drug-related harms in the UK: a case study. (PubMed, Harm Reduct J) - "Collaborating with the peer workforce in areas of high need relating to drug harms was an acceptable way of engaging some of the most vulnerable individuals at risk from mortality and morbidity in the research process. Our data highlights this population's complex, high-dose, polydrug use. There was an appetite to develop harm reduction interventions for illicit street tablet usage amongst the population sampled. Further work should develop tailored harm reduction advice for complex issues such as street tablets and opioid co-use."

Journal

Patients on Regular Preoperative Weak Opioid Intake Can Achieve Successful Surgical Outcomes After Posterior Decompression Surgery for Cervical Spondylotic Myelopathy. (PubMed, Clin Spine Surg) - "Patients receiving regular weak opioids preoperatively can achieve successful surgical outcomes after posterior decompression surgery for cervical spondylotic myelopathy."

Journal • CNS Disorders • Musculoskeletal Pain • Orthopedics • Pain

Capsaicin in the Management of Peripheral Neuropathy: A Review. (PubMed, Curr Pain Headache Rep) - "Capsaicin provides more significant relief than placebo and is non-inferior to pregabalin in the treatment of peripheral neuropathy...Capsaicin is an effective treatment with significant reduction in both diabetic and non-diabetic neuropathic pain. Due to its topical application, it is associated with fewer systemic adverse events and therefore, an attractive option in the treatment of peripheral neuropathy."

Journal • Review • Diabetic Neuropathy • Neuralgia • Pain • Peripheral Neuropathic Pain

Impact of pregabalin reclassification as a controlled substance in Egypt on gabapentinoid and opioid utilization: A repeated cross-sectional study. (PubMed, PLoS One) - "Reclassifying pregabalin effectively reduced its utilization but prompted a shift to gabapentin use. Our findings highlight the complexity of drug policy interventions, underscoring the need for continuous monitoring to mitigate unintended substitution effects and better understand policy impacts of the treatment of pain."

Journal • Observational data • Pain

Analgesic antibacterial anti-inflammatory pregabalin-functionalized hyaluronic acid-chitosan hydrogel for painless burn wound repair. (PubMed, Int J Biol Macromol) - "Notably, a 42-day behavioral test demonstrated that CHP hydrogel effectively alleviated pain in mice following burn injury by reducing mechanical pain sensitization. This study highlighted the potential of the CHP hydrogel as a promising therapeutic strategy for burn wound management, offering a novel approach for pain-related tissue repair and treatment."

Journal • Infectious Disease • Pain • Thermal Injury

Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs. (PubMed, Basic Clin Pharmacol Toxicol) - "The greater the individual weight loss, the greater the concentration increase in hydrophilic drugs that undergo glomerular filtration, for example, pregabalin and gabapentin, suggesting that this reflects decreased glomerular hyperfiltration. By contrast, for highly lipophilic drugs, for example, mirtazapine and sertraline, the greater the individual creatinine and cystatin C loss, the greater the decrease in drug concentration, interpreted as increased drug metabolism based on decreased liver inflammation and steatosis. Venlafaxine/O-desmethylvenlafaxine displayed a complicated pattern suggesting the involvement of both glomerular filtration and metabolism. Serum concentrations of modestly lipophilic drugs, for example, duloxetine and (es)citalopram, were not significantly affected by the diet. In conclusion, hydrophilicity- and lipophilicity-related changes in drug concentrations over the diet period covary with markers of changes in hyperfiltration and metabolism,..."

Journal • Genetic Disorders • Inflammation • CST3

A Comparative Study on the Efficacy, Safety and Cost Effectiveness of Gabapentin and Pregabalin in the Treatment of Neuropathic Pain. (PubMed, Cureus) - "Such comparisons, including expense analysis, are limited in the literature. Our study plays a role in substantiating PG as a better analgesic in many respects for neuropathic pain while also proposing a possibility for evaluating combination therapies and to provide an optimize healthcare resource allocation."

HEOR • Journal • Neuralgia • Pain

Use of oral neuromodulators in chronic pelvic painNumber 8 - 2025. (PubMed, Rev Bras Ginecol Obstet) - "•Pregabalin is the medication with the best pharmacokinetic profile; nortriptyline has the best adverse effects profile; duloxetine is the most widely used and has the lowest risks; and venlafaxine should be used as a second-line inhibitor. •Although the drug classes can be combined to reduce the total doses and minimize side effects, maximizing the analgesic effect, monotherapies are recommended as the first line to avoid polypharmacy."

Journal • Review • Gynecology • Musculoskeletal Pain • Neuralgia • Pain

Clinical Management of Herpes Zoster Complicated by MRSA Infection. (PubMed, Clin Cosmet Investig Dermatol) - "After a clear diagnosis, antiviral treatment with valacyclovir and pain relief with pregabalin was administered...Based on the drug sensitivity results, cefuroxime combined with levofloxacin was administered for anti-infection treatment...Herpes zoster combined with MRSA infection makes the treatment more complicated. This case illustrates the complexities of managing herpes zoster with MRSA and highlights the importance of comprehensive diagnostic and treatment strategies."

Journal • Herpes Zoster • Infectious Disease • Musculoskeletal Pain • Pain • Varicella Zoster