ecraprost (AS-013) / LTT Bio-Pharma - LARVOL DELTA

Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis. (PubMed, Arch Dermatol Res) - "This study preliminarily clarified the causal effect of skin microbiome on osteomyelitis. Strains that may significantly trigger or suppress the outcome of osteomyelitis were figured out, which may provide promising insights for the genesis and progression of osteomyelitis, thereby benefiting relevant clinical prevention and treatment."

Causal relationship • Journal • Infectious Disease • Inflammation

Unveiling the skin microbial guardians and assailants in psoriasis subtypes: a Mendelian randomization study. (PubMed, Arch Dermatol Res) - "hominis], corynebacterium, clostridiales, flavobacteriaceae, anaerococcus, asv013 [S. epidermidis] were associated with increased risk. Our findings suggest potential causal relationships between certain skin microbiota and different subtypes of psoriasis, highlighting their potential as novel biomarkers for diagnosing different subtypes of psoriasis, and offering promising avenues for developing microbiome-based diagnostics and targeted therapies for diverse psoriasis subtypes."

Journal • Dermatology • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Pustular Psoriasis • Rheumatology • Seronegative Spondyloarthropathies

Reporting Mental Health and Associated Disorders from Trials of Bimekizumab in Patients with Active Axial Spondyloarthritis and Psoriatic Arthritis (ACR Convergence 2024) - P3 | " Treatment-emergent adverse events (TEAEs) reported for pooled phase 2/3 axSpA/PsA trial populations (BE AGILE 1 & 2, BE MOBILE 1 & 2, BE MOVING, AS0013; BE ACTIVE 1 & 2, BE OPTIMAL, BE COMPLETE, BE VITAL)...BE OPTIMAL included an active reference arm (sc adalimumab 40 mg Q2W) to provide a reference for BKZ benefit/risk profile... Across trials of BKZ in pts with axSpA and PsA, eC-SSRS and PHQ-9 scores were low and similar to PBO to Wk 16. Adjudicated SIB, anxiety, and depression rates remained low to 1 yr, despite impacts of the COVID-19 pandemic."

Clinical • Ankylosing Spondylitis • CNS Disorders • Depression • Immunology • Infectious Disease • Inflammatory Arthritis • Mood Disorders • Novel Coronavirus Disease • Psoriatic Arthritis • Psychiatry • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis • Suicidal Ideation • IL17A